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Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanoneIC502800.0 [1], 3100.0 [2], 4700.0 [3], 4800.0 [4], 35000.0 [5]
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)IC5024.0 [1], 49.0 [2], 64.0 [3]
1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)IC508000.0 [1], 10000.0 [2]
1,4-Bis(4-(pyrrolidinyl)piperidinyl)benzamideIC5048.0 [1], 71.0 [2]
UNC 926 hydrochlorideIC503200.0 [1], 4100.0 [2]
(3-Bromophenyl)-(4-pyrrolidin-2-ylpiperidin-1-yl)methanoneIC5030000.0 [1]
[6-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)naphthalen-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50450.0 [1], 690.0 [2]
[5-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)furan-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50310.0 [1], 530.0 [2]
[5-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)thiophen-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5068.0 [1], 96.0 [2]
[3-(Benzylamino)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5039.0 [1], 50.0 [2]
[3-Benzyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5048.0 [1], 51.0 [2]
[3-Phenoxy-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5053.0 [1], 58.0 [2]
[3-Phenyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5061.0 [1], 66.0 [2]
N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)benzamideIC50350.0 [1], 370.0 [2]
2-Anilino-N-(2-ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamideIC50160.0 [1], 170.0 [2]
3-Anilino-N-(2-ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamideIC50130.0 [1], 140.0 [2]
N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamideIC50160.0 [1], 170.0 [2]
[3-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50290.0 [1], 360.0 [2]
[2-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50350.0 [1], 1100.0 [2]
[3,4-Bis(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50110.0 [1], 120.0 [2]
(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)sulfonylphenyl]methanoneIC5097.0 [1], 99.0 [2]
(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]methanoneIC50150.0 [1], 170.0 [2]
(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-[(4-pyrrolidin-1-ylpiperidin-1-yl)methyl]phenyl]methanoneIC50130.0 [1], 140.0 [2]
(4-Piperidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC50160.0 [1], 230.0 [2]
[4-(Azepan-1-yl)piperidin-1-yl]-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC50210.0 [1], 270.0 [2]
[4-(4-Morpholin-4-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC501100.0 [1], 1500.0 [2]
(4-Cyclohexylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC501600.0 [1], 2400.0 [2]
[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50180.0 [1], 310.0 [2]
[4-[4-(1-Methylpyrrolidin-1-ium-1-yl)piperidine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5081.0 [1], 140.0 [2]
[4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-2-ylpiperidin-1-yl)methanoneIC5092.0 [1], 120.0 [2]
(4-Piperidin-4-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC50740.0 [1], 800.0 [2]
[4-(4-Cyclopentylpiperazine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC503200.0 [1], 3800.0 [2]
[4-[4-(1-Methylpiperidin-4-yl)piperazine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50770.0 [1], 830.0 [2]
[4-[1-(4-Methylpiperazin-1-yl)ethyl]piperidin-1-yl]-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC50250.0 [1], 300.0 [2]
(4-Pyrrolidin-1-ylazepan-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC5074.0 [1], 96.0 [2]
[4-(3-Pyrrolidin-1-ylazetidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50300.0 [1], 330.0 [2]
(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(3-pyrrolidin-1-ylpyrrolidine-1-carbonyl)phenyl]methanoneIC50220.0 [1], 250.0 [2]
4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)-N-(3-pyrrolidin-1-ylpropyl)benzamideIC50340.0 [1], 680.0 [2]
[4-(2,7-Diazaspiro[3.4]octane-2-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC502700.0 [1], 3600.0 [2]
[4-(2,7-Diazaspiro[4.4]nonane-2-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC501800.0 [1], 2200.0 [2]
[4-(2,8-Diazaspiro[4.5]decane-8-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50560.0 [1], 620.0 [2]
[4-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC503100.0 [1], 3500.0 [2]
N-(2-Methyl-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-yl)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)benzamideIC504500.0 [1], 4600.0 [2]
[4-(4-Pyrrolidin-1-ylazepane-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylazepan-1-yl)methanoneIC50110.0 [1]
[4-[4-(Azetidin-1-yl)piperidine-1-carbonyl]phenyl]-[4-(azetidin-1-yl)piperidin-1-yl]methanoneIC50350.0 [1], 400.0 [2]
[4-(4-Pyrrolidin-2-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-2-ylpiperidin-1-yl)methanoneIC50640.0 [1], 800.0 [2]
[4-[4-(1-Methylpyrrolidin-2-yl)piperidine-1-carbonyl]phenyl]-[4-(1-methylpyrrolidin-2-yl)piperidin-1-yl]methanoneIC501700.0 [1], 1900.0 [2]
[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]-[4-(dimethylamino)piperidin-1-yl]methanoneIC508000.0 [1], 10000.0 [2]
[6-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)pyridin-3-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5061.0 [1], 110.0 [2]
[3-Nitro-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5088.0 [1], 160.0 [2]
[3-Amino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50220.0 [1], 230.0 [2]
(4-Pyrrolidin-1-ylpiperidin-1-yl)-[2,3,5,6-tetrafluoro-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanoneIC50130.0 [1], 210.0 [2]
[2,5-Dimethyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC50210.0 [1], 240.0 [2]
[4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)naphthalen-1-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5043.0 [1], 72.0 [2]
(3-Bromophenyl)-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octan-3-yl)methanoneIC503200.0 [1], 3600.0 [2]
N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)benzamideIC50150.0 [1], 240.0 [2]
[4-(8-Pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5092.0 [1], 160.0 [2]
[4-(8-Pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)phenyl]-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octan-3-yl)methanoneIC50280.0 [1], 400.0 [2]
[3-Bromo-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanoneIC5074.0 [1], 120.0 [2]
ChlorpheniramineIC5042000.0 [1]
OxybutyninIC5054000.0 [1]
MaprotilineIC5085000.0 [1]
4-Methyl-N-[3-(1-pyrrolidinyl)propyl]benzenesulfonamideIC5057000.0 [1]
N,N-Dimethyl-4-(1-methyl-9H-pyrido[3,4-b]indol-4-yl)butan-1-amineIC505700.0 [1]
1-(N-Methylamino)-4-phenylbutaneIC50100000.0 [1]
4-(2-Methoxy-4-methylphenoxy)-N-methylbutan-1-amineIC5084000.0 [1]
4-(4-Benzylphenoxy)-N-methylbutan-1-amineIC50100000.0 [1]
1-(7-Bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-3-(dimethylamino)propan-1-oneIC50100000.0 [1]
2-Isopropyl-5-(methylamino)-2-o-tolylpentanenitrileIC50100000.0 [1]
3-Chloro-N-(3-(diethylamino)propyl)-4-fluorobenzenesulfonamideIC5030000.0 [1]
5-Bromo-N-(5-(pyrrolidin-1-YL)pentyl)nicotinamideIC5028000.0 [1]
1-Phenyl-4-pyrrolidin-1-ylpiperidineIC5013000.0 [1]
4-(Dimethylamino)butan-2-yl 5-(1-phenylethyl)furan-2-carboxylateIC5075000.0 [1]
4-(Pyrrolidin-1-Yl)-1-{4-[2-(Pyrrolidin-1-Yl)ethyl]phenyl}piperidineIC5062.0 [1]
3-Bromo-N-(2-ethyl-1,3-dihydroisoindol-5-yl)benzamideIC501200.0 [1]
7-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]-1,4-dioxa-7-azaspiro[4.4]nonaneIC50650.0 [1]
6-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]-2-oxa-6-azaspiro[3.3]heptaneIC50270.0 [1]
1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]pyrrolidine-3-carbonitrileIC50360.0 [1]
1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]azepaneIC50100.0 [1]
1-[3-Chloro-4-(2-pyrrolidin-1-ylethyl)phenyl]-4-pyrrolidin-1-ylpiperidineIC5037.0 [1]
4-Piperidin-1-yl-1-[4-(2-pyrrolidin-1-ylethyl)phenyl]piperidineIC50580.0 [1]
4-Pyrrolidin-1-yl-1-[4-(3-pyrrolidin-1-ylpropyl)phenyl]piperidineIC5070.0 [1]
4-Pyrrolidin-1-yl-1-[3-(2-pyrrolidin-1-ylethyl)phenyl]piperidineIC50120.0 [1]
[3-(Hydroxymethyl)-1-[2-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]azetidin-3-yl]methanolIC5059.0 [1]
4-Pyrrolidin-1-yl-1-[4-(pyrrolidin-1-ylmethyl)phenyl]piperidineIC50350.0 [1]
1-[[4-(2-Pyrrolidin-1-ylethyl)phenyl]methyl]pyrrolidineIC501300.0 [1]
4-Pyrrolidin-1-yl-1-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]piperidineIC50320.0 [1]
4-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]morpholineIC50850.0 [1]
1-[4-[2-(Azetidin-1-yl)ethyl]phenyl]-4-pyrrolidin-1-ylpiperidineIC5048.0 [1]
1-[4-[2-(3,3-Difluoroazetidin-1-yl)ethyl]phenyl]-4-pyrrolidin-1-ylpiperidineIC501000.0 [1]
1-[4-(2-Piperidin-1-ylethyl)phenyl]-4-pyrrolidin-1-ylpiperidineIC5080.0 [1]
4-Pyrrolidin-1-yl-1-[3-(pyrrolidin-1-ylmethyl)phenyl]piperidineIC50120.0 [1]
1-Pyrrolidin-1-yl-3-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]propan-1-oneIC502400.0 [1]
Pyrrolidin-1-yl-[3-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]methanoneIC502400.0 [1]
1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]pyrrolidin-3-oneIC50390.0 [1]
N-(3-(Diethylamino)propyl)-2,5-dimethoxybenzenesulfonamideIC5048000.0 [1]
(3-Bromophenyl)-[4-(dimethylamino)piperidin-1-yl]methanoneIC5030000.0 [1]
(3-Bromophenyl)-(4-piperidin-1-ylpiperidin-1-yl)methanoneIC5030000.0 [1]
1-(3-Bromophenyl)sulfonyl-4-pyrrolidin-1-ylpiperidineIC503700.0 [1]
(3-Bromophenyl)-(4-cyclopentylpiperazin-1-yl)methanoneIC5030000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/lethal-3-malignant-brain-tumor-like-protein-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lethal-3-malignant-brain-tumor-like-protein-3-inhibitors-ic50-ki.
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