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Legumain Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
7-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-sulfanyl-3,7-dihydro-1H-purine-2,6-dioneIC50370.0 [1]
7-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-sulfanyl-3,7-dihydro-1H-purine-2,6-dioneKi105.0 [1]
8-MercaptocaffeineIC50180.0 [1]
CID 90656796IC500.9 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-tert-butylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5071.0 [1]
(3S)-3-[2-[(4-Bromophenyl)methyl-methylsulfonylamino]propanoylamino]-3-cyanopropanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50356.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(2-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50128.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(3-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC502259.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(4-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC501035.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(4-fluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50323.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-chlorophenyl)sulfonylpyrrolidine-2-carboxamideIC5073.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC501459.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3,4-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50252.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(3,4-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC506296.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3,5-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC501359.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[methylsulfonyl-[[4-(3-propan-2-yloxyphenyl)phenyl]methyl]amino]propanoyl]amino]propanamideIC50882.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[methylsulfonyl-[[4-(3-propan-2-yloxyphenyl)phenyl]methyl]amino]propanoyl]amino]propanamideIC505050.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-methylsulfonylamino]butanoyl]amino]propanamideIC505854.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(3,5-difluorophenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC509249.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-fluorophenyl)sulfonylpyrrolidine-2-carboxamideIC50269.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamideIC5010000.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-2-[[4-(3-fluorophenyl)phenyl]methyl-methylsulfonylamino]pentanamideIC504384.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-2-[[4-(2,3-difluorophenyl)phenyl]methyl-methylsulfonylamino]pentanamideIC507749.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-bromophenyl)sulfonylpyrrolidine-2-carboxamideIC50282.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(3,4-dichlorophenyl)sulfonylpyrrolidine-2-carboxamideIC5010000.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(trifluoromethyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC50332.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[3-fluoro-4-(4-fluorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5067.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[2-fluoro-4-(4-fluorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5023.0 [1]
(3S)-3-Cyano-3-[[2-[[4-(3-fluorophenyl)phenyl]methyl-methylsulfonylamino]acetyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[2-[[4-(2,3-difluorophenyl)phenyl]methyl-methylsulfonylamino]acetyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[ethylsulfonyl-[[4-(3-fluorophenyl)phenyl]methyl]amino]propanoyl]amino]propanamideIC503889.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-tert-butylphenyl)sulfonylpyrrolidine-2-carboxamideIC5010000.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(1,3-benzodioxol-5-yl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5049.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[3-chloro-4-(4-chlorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC506.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-ethylsulfonylamino]propanoyl]amino]propanamideIC501086.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-fluorophenyl)phenyl]methyl-propylsulfonylamino]propanoyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-propylsulfonylamino]propanoyl]amino]propanamideIC506745.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-fluorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5033.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-fluorophenyl)phenyl]methyl-methylsulfonylamino]butanoyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-fluorophenyl)phenyl]methyl-(2-methylpropylsulfonyl)amino]propanoyl]amino]propanamideIC502272.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(2,3-difluorophenyl)phenyl]methyl-(2-methylpropylsulfonyl)amino]propanoyl]amino]propanamideIC501818.0 [1]
(3S)-3-[[(2S)-2-[Benzenesulfonyl-[[4-(3-fluorophenyl)phenyl]methyl]amino]propanoyl]amino]-3-cyanopropanamideIC5010000.0 [1]
(3S)-3-[[(2S)-2-[Benzenesulfonyl-[[4-(2,3-difluorophenyl)phenyl]methyl]amino]propanoyl]amino]-3-cyanopropanamideIC5010000.0 [1]
(3S)-3-[2-[[4-(3-Chlorophenyl)phenyl]methyl-methylsulfonylamino]propanoylamino]-3-cyanopropanamideIC50425.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[methylsulfonyl-[[4-[3-(trifluoromethyl)phenyl]phenyl]methyl]amino]propanoyl]amino]propanamideIC50601.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[methylsulfonyl-[[4-[3-(trifluoromethyl)phenyl]phenyl]methyl]amino]propanoyl]amino]propanamideIC5010000.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-methoxyphenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50378.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(3-methoxyphenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC505854.0 [1]
(3S)-3-Cyano-3-[[(2S)-2-[[4-(3-ethoxyphenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC50586.0 [1]
(3S)-3-Cyano-3-[[(2R)-2-[[4-(3-ethoxyphenyl)phenyl]methyl-methylsulfonylamino]propanoyl]amino]propanamideIC5010000.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[2-chloro-4-(4-chlorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC50169.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-[3-(trifluoromethyl)phenyl]phenyl]sulfonylpyrrolidine-2-carboxamideIC5093.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(2,4-dichlorophenyl)sulfonylpyrrolidine-2-carboxamideIC50593.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-[4-(trifluoromethyl)phenyl]phenyl]sulfonylpyrrolidine-2-carboxamideIC50121.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-methoxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC506.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-ethoxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5073.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-propan-2-yloxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC50969.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamideIC5012.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-[4-(trifluoromethoxy)phenyl]phenyl]sulfonylpyrrolidine-2-carboxamideIC5010000.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-cyanophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5033.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(3-fluorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5047.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(2-chlorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5035.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-chlorophenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5045.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-methylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5032.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-ethylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC5071.0 [1]
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-propan-2-ylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamideIC505.0 [1]
1-Benzyl-8-mercapto-3,7-dimethyl-1H-purine-2,6(3H,7H)-dioneIC50170.0 [1]
Ethyl (E)-3-[(2-amino-2-oxoethyl)-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]carbamoyl]oxyprop-2-enoateIC5031.0 [1]
[(E)-3-[Benzyl(methyl)amino]-3-oxoprop-1-enyl] N-(2-amino-2-oxoethyl)-N-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]carbamateIC5055.0 [1]
[(E)-3-(Benzylamino)-3-oxoprop-1-enyl] N-(2-amino-2-oxoethyl)-N-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]carbamateIC501000.0 [1]
Benzyl (E)-3-[(2-amino-2-oxoethyl)-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]carbamoyl]oxyprop-2-enoateIC5038.0 [1]
1-Ethyl-8-mercapto-3,7-dimethyl-1H-purine-2,6(3H,7H)-dioneIC50160.0 [1]
Benzyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50140.0 [1]
(2-Bromophenyl)methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50192.0 [1]
(3-Bromophenyl)methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50108.0 [1]
(4-Bromophenyl)methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50282.0 [1]
(3-Phenylphenyl)methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50138.0 [1]
(4-Phenylphenyl)methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5018.0 [1]
[4-(3-Methylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5049.0 [1]
[4-(4-Methylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5028.0 [1]
[4-(4-Ethylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50169.0 [1]
[4-(3-Propan-2-ylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5049.0 [1]
[4-(4-Propan-2-ylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5097.0 [1]
[4-(3-Tert-butylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5083.0 [1]
[4-(4-Tert-butylphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50348.0 [1]
[4-(3-Fluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5060.0 [1]
[4-(4-Fluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC505.0 [1]
[4-(3,5-Difluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5079.0 [1]
[4-(2,3-Difluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5029.0 [1]
[4-(3,4-Difluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5011.0 [1]
[4-(2,4-Difluorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5041.0 [1]
[4-(3-Chlorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC509.0 [1]
[4-(4-Chlorophenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC50124.0 [1]
[4-[2-(Trifluoromethyl)phenyl]phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC501640.0 [1]
[4-[3-(Trifluoromethyl)phenyl]phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5065.0 [1]
[4-[4-(Trifluoromethyl)phenyl]phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5015.0 [1]
[4-(4-Methoxyphenyl)phenyl]methyl (2S)-2-[[(1S)-3-amino-1-cyano-3-oxopropyl]carbamoyl]pyrrolidine-1-carboxylateIC5041.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Legumain Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/legumain-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Legumain Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/legumain-inhibitors-ic50-ki.
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