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L-lactate dehydrogenase A chain Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
7-Benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthalene-1-carboxylic AcidIC5040000.0 [1], 500000.0 [2]
7-Benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthalene-1-carboxylic AcidKi50.0 [1], 300.0 [2], 8000.0 [3]
Oxamic acidIC5057200.0 [1]
Oxamic acidKi26000.0 [1], 136000.0 [2], 138000.0 [3]
3-[[3-(Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acidIC502.6 [1], 38.0 [2]
3-[[3-(Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acidKi4.8 [1]
2',6'-Dichloro-4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-oneIC50870.0 [1], 2370.0 [2], 100000.0 [3]
3-[5-[(E)-[(3,4,5-Trimethoxybenzoyl)hydrazono]methyl]-2-furyl]benzoic acidIC5037000.0 [1], 42000.0 [2]
3-[5-[(E)-[(3,4,5-Trimethoxybenzoyl)hydrazono]methyl]-2-furyl]benzoic acidKi39000.0 [1], 47000.0 [2]
(2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-oneIC5010.0 [1], 424.0 [2]
Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylateIC5010500.0 [1], 14700.0 [2]
Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylateKi5100.0 [1]
1-Hydroxy-4-(trifluoromethyl)-6-phenyl-1H-indole-2-carboxylic acidIC50500000.0 [1]
1-Hydroxy-4-(trifluoromethyl)-6-phenyl-1H-indole-2-carboxylic acidKi4700.0 [1], 8900.0 [2]
CID 56844254IC50500.0 [1], 1020.0 [2], 1340.0 [3]
6-[3-[(2R,3R,4R,5R)-6-[4-[[2-(5-Carboxypyridin-2-yl)sulfanylacetyl]amino]-2-chloro-5-methoxyphenoxy]-2,3,4,5-tetrahydroxyhexoxy]-5-fluorophenyl]pyridine-3-carboxylic acidIC50220.0 [1], 325.0 [2], 440.0 [3]
GossypolKi1900.0 [1]
2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-carboxylic acidKi2000.0 [1], 3000.0 [2]
3-{5-[(Pyridine-3-carbonyl)-hydrazonomethyl]-furan-2-yl}-benzoic acidIC5043000.0 [1], 200000.0 [2]
4-((2-Chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-oneIC504000.0 [1], 4600.0 [2]
2-[[4-(4-Chlorophenyl)-5-cyano-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)propanamideIC50480.0 [1]
2,3-Dihydroxy-6,7-dimethyl-4-propyl-1-naphthoic acidKi100.0 [1]
2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carboxylic AcidKi1000.0 [1], 6000.0 [2]
2,3-Dihydroxy-4-isopropyl-6-methyl-7-benzylnaphthalene-1-carboxylic acidKi200.0 [1], 700.0 [2]
2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxylic AcidKi22000.0 [1], 34000.0 [2]
2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carboxylic AcidKi4000.0 [1], 13000.0 [2]
2,3-Dihydroxy-4-isopropyl-6,7-dimethylnaphthalene-1-carboxylic acidKi1000.0 [1], 2000.0 [2]
7-Benzyl-2,3-dihydroxy-4,6-dimethyl-naphthalene-1-carboxylic AcidKi500.0 [1], 8000.0 [2]
Ldh-IN-1IC5032.0 [1]
2-[[4-(4-Chlorophenyl)-5-cyano-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)acetamideIC501900.0 [1], 8800.0 [2]
4-Hydroxy-1,2,5-thiadiazole-3-carboxylic acidIC5010000.0 [1], 450000.0 [2]
6-[3-[[(2R,3R,4R,5R)-6-[4-[[2-(5-Carboxypyridin-2-yl)sulfanylacetyl]amino]-2-chloro-5-methoxyphenoxy]-2,3,4,5-tetrahydroxyhexyl]amino]-5-fluorophenyl]pyridine-3-carboxylic acidIC50120.0 [1]
Methyl 6-phenyl-4-(trifluoromethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyindole-2-carboxylateKi37800.0 [1]
3-[5-Amino-6-[[(1R)-1-(4-chlorophenyl)ethyl]amino]pyrazin-2-yl]-4-methylbenzoic acidIC50500.0 [1]
2-(5-Methyl-3-phenylpyrazol-1-yl)-1,3-thiazole-4-carboxylic acidIC5015400.0 [1], 57000.0 [2]
5-Hydroxy-4-((2-nitrophenyl)thio)-1,6-dihydro-[1,1'-biphenyl]-3(2H)-oneIC50880.0 [1], 1700.0 [2]
2-[5-(3,4-Difluorophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50672.0 [1]
2-[5-(3,4-Difluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50150.0 [1], 57000.0 [2]
2-[3-Phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC50176.0 [1], 177.0 [2]
2-[3-(3-Phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5038.0 [1]
2-[3-Phenyl-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5091.0 [1]
2-[3-(3-Phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5053.0 [1]
2-[3-Phenyl-5-pyridin-4-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC506230.0 [1]
2-[5-[3-(2-Fluorophenyl)phenyl]-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50754.0 [1]
2-[5-Cyclopropyl-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5027.0 [1]
2-[5-Amino-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5065.0 [1]
2-[3-(3,4-Difluorophenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5095.0 [1]
2-[3-Oxo-5-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50349.0 [1]
2-[5-Cyclopropyl-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5019.0 [1]
2-[3-(3-Phenylphenyl)-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5057.0 [1]
2-(3-Oxo-5-phenyl-1H-pyrazol-2-yl)-1,3-thiazole-4-carboxylic acidIC50144.0 [1], 57000.0 [2]
2-[5-(3-Bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC502370.0 [1]
2-[5-(2,4-Difluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC5084.0 [1], 57000.0 [2]
2-[5-(3,5-Difluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50110.0 [1], 57000.0 [2]
2-[3-Phenyl-5-pyridin-3-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC50349.0 [1]
2-[5-(Cyclopropylmethyl)-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC509.0 [1]
2-[5-Cyclopropyl-3-(3-phenylphenyl)-4-(4-sulfamoylphenoxy)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC50110.0 [1]
2-[5-[3-(2-Fluorophenyl)phenyl]-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC5095.0 [1], 57000.0 [2]
2-[5-(4-Fluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC5095.0 [1], 57000.0 [2]
2-[3-(4-Fluorophenyl)-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5023400.0 [1], 32300.0 [2]
2-[5-(4-Methoxyphenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50229.0 [1], 57000.0 [2]
3-[5-[(E)-[(3,4,5-Trimethoxybenzoyl)hydrazinylidene]methyl]furan-3-yl]benzoic acidIC5032000.0 [1], 52000.0 [2]
3-[5-[(E)-[(3,4,5-Trimethoxybenzoyl)hydrazinylidene]methyl]thiophen-2-yl]benzoic acidIC5041000.0 [1], 105000.0 [2]
3-[5-[(E)-[[3-(Hydroxymethyl)benzoyl]hydrazinylidene]methyl]furan-2-yl]benzoic acidIC5046000.0 [1], 200000.0 [2]
3-[5-[(E)-(1H-Indazole-5-carbonylhydrazinylidene)methyl]furan-2-yl]benzoic acidIC5041000.0 [1], 200000.0 [2]
3-[5-[(E)-(1H-Indole-5-carbonylhydrazinylidene)methyl]furan-2-yl]benzoic acidIC5038000.0 [1], 100000.0 [2]
3-[5-[(E)-[(2-Cyanoacetyl)hydrazinylidene]methyl]furan-2-yl]benzoic acidIC5048000.0 [1], 115000.0 [2]
4-[5-[(E)-[(3,4,5-Trimethoxybenzoyl)hydrazinylidene]methyl]furan-2-yl]benzoic acidIC50125000.0 [1], 134000.0 [2]
3,8,9,10-Tetrahydroxy-5H-benzo[h]chromene-2,6-dioneKi5460.0 [1], 56000.0 [2]
2-[3-(3-Chlorophenyl)-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5057000.0 [1]
2-[3-(2-Chlorophenyl)-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5057000.0 [1]
2-[5-(3-Fluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50162.0 [1], 57000.0 [2]
2-(5-Naphthalen-1-yl-3-oxo-1H-pyrazol-2-yl)-1,3-thiazole-4-carboxylic acidIC50213.0 [1], 57000.0 [2]
2-(5-Cyclohexyl-3-oxo-1H-pyrazol-2-yl)-1,3-thiazole-4-carboxylic acidIC501100.0 [1], 57000.0 [2]
2-(3-Oxo-5-pyridin-2-yl-1H-pyrazol-2-yl)-1,3-thiazole-4-carboxylic acidIC501020.0 [1], 57000.0 [2]
2-(5-Acetamido-3-phenylpyrazol-1-yl)-1,3-thiazole-4-carboxylic acidIC509570.0 [1], 57000.0 [2]
2-[5-(3-Chlorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50168.0 [1], 57000.0 [2]
2-(3-Phenyl-5-propan-2-ylpyrazol-1-yl)-1,3-thiazole-4-carboxylic acidIC5057000.0 [1]
2-[5-(2-Fluorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50134.0 [1], 57000.0 [2]
2-[3-Oxo-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50189.0 [1], 57000.0 [2]
2-[3-Oxo-5-(3-phenylphenyl)-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50266.0 [1], 57000.0 [2]
2-(3-Oxo-5-pyridin-4-yl-1H-pyrazol-2-yl)-1,3-thiazole-4-carboxylic acidIC50669.0 [1], 57000.0 [2]
2-[5-(Difluoromethyl)-3-phenylpyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5057000.0 [1]
2-[3-Oxo-5-[3-(trifluoromethoxy)phenyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50299.0 [1], 57000.0 [2]
2-[5-(3,4-Dichlorophenyl)-3-oxo-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acidIC50106.0 [1], 57000.0 [2]
2-(5-Amino-3-phenyl-1H-pyrazol-1-yl)-1,3-thiazole-4-carboxylic acidIC5026700.0 [1], 57000.0 [2]
1-Hydroxy-5-phenyl-1H-indole-2-carboxylic AcidKi10400.0 [1], 15700.0 [2]
1-Hydroxy-6-phenyl-1H-indole-2-carboxylic AcidKi19800.0 [1], 35400.0 [2]
2-[3-(4-Chlorophenyl)-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC5026600.0 [1], 27700.0 [2]
4-[5-[(E)-[(2-Cyanoacetyl)hydrazinylidene]methyl]furan-2-yl]benzoic acidIC5037000.0 [1], 200000.0 [2]
1-Hydroxy-4-(4-phenyltriazol-1-yl)indole-2-carboxylic acidKi28000.0 [1], 44000.0 [2]
4-[4-(3-Carboxyphenyl)triazol-1-yl]-1-hydroxyindole-2-carboxylic acidKi57000.0 [1], 86000.0 [2]
6-[4-(3-Carboxyphenyl)triazol-1-yl]-1-hydroxyindole-2-carboxylic acidKi45000.0 [1], 50000.0 [2]
6-[4-[3-[1-(2-Carboxy-1-hydroxyindol-6-yl)triazol-4-yl]propyl]triazol-1-yl]-1-hydroxyindole-2-carboxylic acidKi20000.0 [1], 37000.0 [2]
SodiumIC50130600.0 [1]
Adenosine monophosphateIC50500000.0 [1]
RutinIC50500000.0 [1]
1-Hydroxy-2-naphthoic acidIC50500000.0 [1]
2-(Pyridin-3-yl)-1H-benzo[d]imidazoleIC50500000.0 [1]
Gossylic iminolactoneKi2500.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ L-lactate dehydrogenase A chain Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/l-lactate-dehydrogenase-a-chain-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ L-lactate dehydrogenase A chain Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/l-lactate-dehydrogenase-a-chain-inhibitors-ic50-ki.
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