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Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
(3S)-3-Amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-oneIC5023.0 [1]
(3S)-3-Amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-oneKi14.0 [1]
(5S)-5-Amino-7-hydroxy-2-phenyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5024.3 [1]
(5S)-5-Amino-7-hydroxy-2-phenyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneKi1.9 [1]
(5S)-5-Amino-7-hydroxy-3-[(3-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5065.6 [1]
(5S)-5-Amino-7-hydroxy-3-[(3-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneKi22.0 [1]
(5S)-5-Amino-2-benzyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5059.4 [1]
(5S)-5-Amino-2-benzyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneKi23.0 [1]
(6S)-6-Amino-1-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC5022.5 [1]
(6S)-6-Amino-1-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneKi12.0 [1]
(6S)-6-Amino-1-benzyl-4-hydroxy-3-(trifluoromethyl)-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC5042.7 [1], 43.7 [2]
(6S)-6-Amino-1-benzyl-4-hydroxy-3-(trifluoromethyl)-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneKi48.0 [1]
(3S)-3-Amino-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-oneIC5022.0 [1]
(5S)-5-Amino-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC50329.0 [1]
(5S)-5-Amino-3-benzyl-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5063.7 [1]
(5S)-5-Amino-3-benzyl-7-hydroxy-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneKi32.0 [1]
(6S)-6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC5085.0 [1]
(6S)-6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneKi41.0 [1]
(5S)-5-Amino-7-hydroxy-3-[(4-methoxyphenyl)methyl]-1-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC50440.0 [1]
(5S)-5-Amino-7-hydroxy-2-[(4-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5028.3 [1]
(6S)-6-Amino-2-benzyl-4-hydroxy-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC50182.0 [1]
(5S)-5-Amino-3-benzyl-2-ethyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5024.3 [1]
(5S)-5-Amino-7-hydroxy-2-[2-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5038.8 [1]
(5S)-5-Amino-7-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5031.6 [1]
(5S)-5-Amino-7-hydroxy-2-methyl-3-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5037.0 [1]
(5S)-5-Amino-2-benzyl-7-hydroxy-3-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5081.6 [1]
(5S)-5-Amino-7-hydroxy-2-[(3-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC508.93 [1]
(5S)-5-Amino-7-hydroxy-2-[(2-methoxyphenyl)methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5050.2 [1]
(5S)-5-Amino-7-hydroxy-2-(naphthalen-2-ylmethyl)-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC50117.0 [1]
(5S)-5-Amino-7-hydroxy-2-(naphthalen-1-ylmethyl)-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5036.0 [1]
(5S)-5-Amino-2-cyclobutyl-7-hydroxy-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5081.3 [1]
(5S)-5-Amino-7-hydroxy-2-propan-2-yl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC50153.0 [1]
(6S)-6-Amino-4-hydroxy-3-methyl-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC502010.0 [1]
(5S)-5-Amino-3-benzyl-7-hydroxy-2-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5011.5 [1]
(5S)-5-Amino-7-hydroxy-2-methyl-3-[[3-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5042.2 [1]
(5S)-5-Amino-7-hydroxy-2-methyl-3-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5040.7 [1]
(5S)-5-Amino-3-benzyl-7-hydroxy-2-propan-2-yl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5063.0 [1]
(5S)-5-Amino-7-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5074.7 [1]
(5S)-5-Amino-7-hydroxy-2-[[4-(trifluoromethoxy)phenyl]methyl]-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5043.6 [1]
(2S)-6-(4-Aminopiperazin-1-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acidIC501000.0 [1]
(3S)-3-Amino-1-hydroxy-6-phenoxy-3,4-dihydroquinolin-2-oneIC5023.0 [1]
(3S)-3-Amino-3,4-dihydro-1H-quinolin-2-oneIC5010000.0 [1]
3-Amino-1-hydroxy-3-methyl-4H-quinolin-2-oneIC5010000.0 [1]
(3S,4S)-3-Amino-1-hydroxy-4-methyl-3,4-dihydroquinolin-2-oneIC503280.0 [1]
(3S)-3-Amino-1-methoxy-3,4-dihydroquinolin-2-oneIC5010000.0 [1]
(3S)-3-Amino-7-chloro-1-hydroxy-3,4-dihydroquinolin-2-oneIC5029.0 [1]
(2R)-6-(4-Aminopiperazin-1-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acidIC501500.0 [1]
(3S)-3-Amino-1-hydroxy-6-(trifluoromethyl)-3,4-dihydroquinolin-2-oneIC5029.0 [1]
(3S)-3-Amino-1-hydroxy-8-(trifluoromethyl)-3,4-dihydroquinolin-2-oneIC50174.0 [1]
(3S)-1-Hydroxy-3-amino-5-methyl-3,4-dihydroquinoline-2(1H)-oneIC50319.0 [1]
(3S)-3-Amino-5-fluoro-1-hydroxy-3,4-dihydroquinolin-2-oneIC5045.0 [1]
(3S)-3-Amino-1-hydroxy-6-methyl-3,4-dihydroquinolin-2-oneIC5030.0 [1]
(3S)-3-Amino-6-chloro-1-hydroxy-3,4-dihydroquinolin-2-oneIC5036.0 [1]
(3S)-3-Amino-1-hydroxy-7-methyl-3,4-dihydroquinolin-2-oneIC5037.0 [1]
(3S)-3-Amino-1-hydroxy-8-methoxy-3,4-dihydroquinolin-2-oneIC50572.0 [1]
(3S)-3-Amino-1-hydroxy-8-methyl-3,4-dihydroquinolin-2-oneIC501050.0 [1]
(3S)-3-Amino-8-chloro-1-hydroxy-3,4-dihydroquinolin-2-oneIC50252.0 [1]
(3S)-3-Amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-oneKi1.6 [1]
(3S)-3-Amino-8-fluoro-1-hydroxy-3,4-dihydroquinolin-2-oneIC5040.0 [1]
(3S)-3-Amino-1-hydroxy-5-methoxy-3,4-dihydroquinolin-2-oneIC50179.0 [1]
(3S)-3-Amino-5-chloro-1-hydroxy-3,4-dihydroquinolin-2-oneIC50349.0 [1]
(3R)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2-oneIC50219.0 [1]
(3S)-3-Amino-1-hydroxy-5-(trifluoromethyl)-3,4-dihydroquinolin-2-oneIC5010000.0 [1]
(3S)-3-Amino-1-hydroxy-7-methoxy-6-phenoxy-3,4-dihydroquinolin-2-oneIC5037.0 [1]
6-Amino-4-hydroxy-2-phenyl-6,7-dihydropyrazolo[4,3-b]pyridin-5-oneIC5085.0 [1]
(5R)-5-Amino-3-benzyl-7-hydroxy-2-methyl-4,5-dihydropyrazolo[3,4-b]pyridin-6-oneIC5063.7 [1]
Items per page: 1 - 10 of 66
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References

This online tool may be cited as follows

MLA

"Quest Database™ Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/kynurenine-alpha-aminoadipate-aminotransferase-mitochondrial-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kynurenine-alpha-aminoadipate-aminotransferase-mitochondrial-inhibitors-ic50-ki.
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