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Kir3.1/Kir3.4 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
[(1S,2R,3R,4S,5S,7R,8S,9R,10R,11S)-2,7,8-Triacetyloxy-11-(2-acetyloxypropan-2-yl)-5,9-dimethyl-14-oxo-16-oxatetracyclo[7.5.2.01,10.03,7]hexadec-12-en-4-yl] benzoateIC502500.0 [1]
Euphorbiaproliferin CIC504700.0 [1]
1-(4-Bromophenyl)-3-(5-cyclopentyl-2-phenylpyrazol-3-yl)ureaIC504000.0 [1]
1-(5-Cyclopentyl-2-phenylpyrazol-3-yl)-3-(3-fluorophenyl)ureaIC502000.0 [1]
1-(5-Cyclopentyl-2-phenylpyrazol-3-yl)-3-(4-methoxyphenyl)ureaIC503000.0 [1]
1-(5-Cyclopentyl-2-phenylpyrazol-3-yl)-3-(4-methylphenyl)ureaIC505000.0 [1]
1-(4-Chlorophenyl)-3-(5-cyclopentyl-2-phenylpyrazol-3-yl)ureaIC507000.0 [1]
1-[5-(2,2-Difluorocyclopropyl)-2-phenylpyrazol-3-yl]-3-(4-methylphenyl)ureaIC504100.0 [1]
1-[5-(2,2-Difluorocyclopropyl)-2-phenylpyrazol-3-yl]-3-(4-methoxyphenyl)ureaIC501300.0 [1]
1-[5-(2,2-Difluorocyclopropyl)-2-phenylpyrazol-3-yl]-3-(4-fluoro-3-methylphenyl)ureaIC50200.0 [1]
1-[5-(2,2-Difluorocyclopropyl)-2-phenylpyrazol-3-yl]-3-[4-(trifluoromethyl)phenyl]ureaIC501500.0 [1]
1-(4-Fluoro-3-methylphenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC501600.0 [1]
1-(2-Chlorophenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC502100.0 [1]
1-(2-Bromophenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC503200.0 [1]
1-(3,5-Dichlorophenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC501200.0 [1]
1-[2-Phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]-3-[3-(trifluoromethyl)phenyl]ureaIC503500.0 [1]
1-[2-Phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]-3-[2-(trifluoromethyl)phenyl]ureaIC506200.0 [1]
1-(3-Bromophenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC504500.0 [1]
1-(2-Methoxyphenyl)-3-[2-phenyl-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-3-yl]ureaIC5011000.0 [1]
1-(3,4-Difluorophenyl)-3-[5-(1-methylcyclopropyl)-2-phenylpyrazol-3-yl]ureaIC50590.0 [1]
1-(4-Fluoro-3-methylphenyl)-3-[5-(1-methylcyclopropyl)-2-phenylpyrazol-3-yl]ureaIC50930.0 [1]
1-(3-Fluorophenyl)-3-[5-(1-methylcyclopropyl)-2-phenylpyrazol-3-yl]ureaIC50640.0 [1]
1-[5-(1-Methylcyclopropyl)-2-phenylpyrazol-3-yl]-3-(4-methylphenyl)ureaIC501900.0 [1]
1-[5-(1-Methylcyclopropyl)-2-phenylpyrazol-3-yl]-3-(3-methylphenyl)ureaIC50550.0 [1]
1-[5-(1-Methylcyclopropyl)-2-phenylpyrazol-3-yl]-3-[4-(trifluoromethyl)phenyl]ureaIC50850.0 [1]
1-(4-Bromophenyl)-3-[5-(1-methylcyclopropyl)-2-phenylpyrazol-3-yl]ureaIC502400.0 [1]
[(1S,2R,3R,4S,5S,7R,8S,9R,10R,11S)-2,7,8-Triacetyloxy-11-(2-acetyloxypropan-2-yl)-5,9-dimethyl-14-oxo-16-oxatetracyclo[7.5.2.01,10.03,7]hexadec-12-en-4-yl] propanoateIC506700.0 [1]
[(1S,2R,3R,4S,5S,7R,8S,9R,10R,11S,12S,14R,15R)-2,7,8,12,15-Pentaacetyloxy-5,9,12-trimethyl-16-oxo-18-oxapentacyclo[7.7.2.01,10.03,7.011,14]octadecan-4-yl] 2-methylpropanoateIC509700.0 [1]
[(1S,2R,3R,4S,5S,7R,8S,9R,10R,11S,12S,14R,15R)-2,7,8,12-Tetraacetyloxy-5,9,12-trimethyl-15-(2-methylbutanoyloxy)-16-oxo-18-oxapentacyclo[7.7.2.01,10.03,7.011,14]octadecan-4-yl] pyridine-3-carboxylateIC504900.0 [1]
1-[5-(Cyclopropylmethyl)-2-phenylpyrazol-3-yl]-3-(3-fluorophenyl)ureaIC50180.0 [1]
1-(3-Chlorophenyl)-3-(5-cyclobutyl-2-phenylpyrazol-3-yl)ureaIC50480.0 [1]
1-(3-Chloro-4-fluorophenyl)-3-[5-(cyclopropylmethyl)-2-phenylpyrazol-3-yl]ureaIC50310.0 [1]
1-(5-Cyclobutyl-2-phenylpyrazol-3-yl)-3-[3-(trifluoromethyl)phenyl]ureaIC50690.0 [1]
1-(3-Bromophenyl)-3-(5-cyclobutyl-2-phenylpyrazol-3-yl)ureaIC50720.0 [1]
1-(3-Chlorophenyl)-3-[5-(cyclopropylmethyl)-2-phenylpyrazol-3-yl]ureaIC50340.0 [1]
1-[5-(Cyclopropylmethyl)-2-phenylpyrazol-3-yl]-3-(3-methylphenyl)ureaIC50250.0 [1]
1-(5-Cyclobutyl-2-phenylpyrazol-3-yl)-3-(3,4-difluorophenyl)ureaIC5030000.0 [1]
1-[5-(Cyclopropylmethyl)-2-phenylpyrazol-3-yl]-3-[3-(trifluoromethyl)phenyl]ureaIC50250.0 [1]
1-(3-Chloro-4-fluorophenyl)-3-(5-cyclobutyl-2-phenylpyrazol-3-yl)ureaIC50610.0 [1]
1-[5-(Cyclopropylmethyl)-2-phenylpyrazol-3-yl]-3-(3,4-difluorophenyl)ureaIC50560.0 [1]
1-[5-(Cyclopropylmethyl)-2-phenylpyrazol-3-yl]-3-(4-fluorophenyl)ureaIC50270.0 [1]
1-(3,4-Difluorophenyl)-3-(2,5-diphenylpyrazol-3-yl)ureaIC5030000.0 [1]
1-(3,4-Difluorophenyl)-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)ureaIC501400.0 [1]
1-(5-Cyclopentyl-2-phenylpyrazol-3-yl)-3-(3,4-difluorophenyl)ureaIC504100.0 [1]
1-(3,4-Difluorophenyl)-3-[2-phenyl-5-(trifluoromethyl)pyrazol-3-yl]ureaIC5030000.0 [1]
1-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-3-(3-methylphenyl)ureaIC5030000.0 [1]
1-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-3-(3-fluorophenyl)ureaIC5030000.0 [1]
1-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-3-(3-methylsulfanylphenyl)ureaIC5030000.0 [1]
1-(2-Phenyl-5-propan-2-ylpyrazol-3-yl)-3-[3-(trifluoromethyl)phenyl]ureaIC501300.0 [1]
1-(3-Fluorophenyl)-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)ureaIC50780.0 [1]
1-(3-Methylphenyl)-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)ureaIC50850.0 [1]
1-(4-Methylphenyl)-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)ureaIC501800.0 [1]
4-[[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]methyl]benzonitrileIC50150.0 [1]
1,3,3,5-Tetramethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC501400.0 [1]
N-Methyl-N-[2-[pyridin-4-ylmethyl-[3-[(1,3,3,5-tetramethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]amino]ethyl]benzamideIC502150.0 [1]
1,3,3,5-Tetramethyl-7-[3-[(2-methylphenyl)methyl-(2-pyridin-3-ylethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50460.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[(3-methylpyridin-4-yl)methyl-(2-pyridin-3-ylethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50970.0 [1]
1-Ethyl-7-[3-[furan-2-ylmethyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dioneIC50270.0 [1]
7-[3-[Benzyl(2-pyridin-3-ylethyl)amino]propoxy]-1-ethyl-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dioneIC50590.0 [1]
3-[[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(2-pyridin-3-ylethyl)amino]methyl]benzonitrileIC50690.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl-[(2-pyridin-3-ylphenyl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50220.0 [1]
4-[[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]methyl]benzonitrileIC50490.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-[[4-(trifluoromethyl)phenyl]methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50330.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[(2-methylphenyl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50490.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(thiophen-2-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50980.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC503200.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC505200.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC5050.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(4-methylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC501500.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50500.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[(4-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC502400.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50790.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-propylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50370.0 [1]
N-[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-N-(2-pyridin-3-ylethyl)benzenesulfonamideIC502500.0 [1]
7-[3-[(2,6-Dimethylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1-ethyl-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dioneIC50170.0 [1]
N-[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-N-(2-pyridin-3-ylethyl)benzamideIC508400.0 [1]
N-[3-[(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-N-[2-(1-oxoisoquinolin-2-yl)ethyl]benzenesulfonamideIC50490.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50930.0 [1]
3,3,5-Trimethyl-1-propyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC503600.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxoisoquinolin-2-yl)ethyl-(thiophen-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC5091.0 [1]
1,5-Diethyl-3,3-dimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochlorideIC50720.0 [1]
1,3,3,5-Tetramethyl-7-[3-[2-pyridin-3-ylethyl(quinolin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochlorideIC501500.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC505100.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxoisoquinolin-2-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50250.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochlorideIC502900.0 [1]
1-Ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxoquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dioneIC50920.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Kir3.1/Kir3.4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/kir3-1-kir3-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Kir3.1/Kir3.4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kir3-1-kir3-4-inhibitors-ic50-ki.
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