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Kininogen-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideIC500.2 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideKi2.6 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideIC500.2 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideKi5.4 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideIC504.0 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideKi23.8 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]pyrimidine-5-carboxamideIC500.4 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]pyrimidine-5-carboxamideKi4.8 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-1,2-oxazole-5-carboxamideIC502.7 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-1,2-oxazole-5-carboxamideKi11.8 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-3-methyl-1,2-oxazole-5-carboxamideIC504.3 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-3-methyl-1,2-oxazole-5-carboxamideKi25.7 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-3-methoxy-1,2-oxazole-5-carboxamideIC500.4 [1]
N-[3-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]oxetan-3-yl]-3-methoxy-1,2-oxazole-5-carboxamideKi3.6 [1]
Tert-butyl N-[1-[[3-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]carbamateIC505.8 [1]
Tert-butyl N-[1-[[3-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]carbamateKi63.2 [1]
1-Amino-N-[3-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]cyclopropane-1-carboxamideIC5061.1 [1]
1-Amino-N-[3-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]cyclopropane-1-carboxamideKi210.8 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideIC500.2 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideKi4.5 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-3-methyl-1,2-oxazole-5-carboxamideIC500.4 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-3-methyl-1,2-oxazole-5-carboxamideKi6.3 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideIC500.3 [1]
N-[1-[[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideKi3.5 [1]
1-Amino-N-[6-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]cyclopropane-1-carboxamideIC5017.4 [1]
1-Amino-N-[6-[5-chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]cyclopropane-1-carboxamideKi264.4 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-5-methyl-1,3,4-oxadiazole-2-carboxamideIC504.8 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-5-methyl-1,3,4-oxadiazole-2-carboxamideKi12.2 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamideIC500.2 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamideKi4.8 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-1,2-oxazole-5-carboxamideIC500.5 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-1,2-oxazole-5-carboxamideKi7.1 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideIC500.2 [1]
N-[1-[[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideKi4.4 [1]
Methyl 2-[1-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateIC502250.0 [1]
Methyl 2-[1-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateKi2170.0 [1]
N-[5-[3,5-Dichloro-2-(2,2-difluoroethoxy)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC5076.8 [1]
N-[5-[3,5-Dichloro-2-(2,2-difluoroethoxy)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi146.0 [1]
Methyl 2-chloro-6-[1-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateIC5047.4 [1]
Methyl 2-chloro-6-[1-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateKi123.0 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC502.0 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi20.2 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.6 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi6.2 [1]
Methyl 2-chloro-6-[(1S)-1-[[3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateIC50455.0 [1]
Methyl 2-chloro-6-[(1S)-1-[[3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carbonyl]amino]-2,3-dihydro-1H-inden-5-yl]benzoateKi381.0 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carboxamideIC5028.6 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carboxamideKi37.4 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carboxamideIC5024.4 [1]
N-[(1S)-5-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]-3-[(2,2,2-trifluoroacetyl)amino]oxetane-3-carboxamideKi30.3 [1]
N-[6-[3,5-Dichloro-2-(2,2-difluoroethoxy)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC5082.6 [1]
N-[6-[3,5-Dichloro-2-(2,2-difluoroethoxy)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi236.0 [1]
Methyl 2-chloro-6-[5-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]benzoateIC50118.0 [1]
Methyl 2-chloro-6-[5-[[1-[(2,2,2-trifluoroacetyl)amino]cyclopropanecarbonyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]benzoateKi522.0 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC504.0 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi41.6 [1]
N-[3-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.5 [1]
N-[3-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi4.4 [1]
N-[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.5 [1]
N-[3-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi9.5 [1]
N-[7-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-3,4-dihydro-2H-chromen-4-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC5024.8 [1]
N-[7-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-3,4-dihydro-2H-chromen-4-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi212.0 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.5 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi11.0 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-1-methyl-2,3-dihydroinden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.6 [1]
N-[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-1-methyl-2,3-dihydroinden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi5.9 [1]
N-[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC503.6 [1]
N-[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi24.0 [1]
N-[5-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-1-methyl-2,3-dihydroinden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.5 [1]
N-[5-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-1-methyl-2,3-dihydroinden-1-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi6.7 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC502.3 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi9.5 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC504.5 [1]
N-[6-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1-benzofuran-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi33.3 [1]
N-[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideIC500.8 [1]
N-[6-[5-Chloro-3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamideKi6.6 [1]
Tert-butyl N-[1-[[(1S)-5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]carbamateIC50332.0 [1]
Tert-butyl N-[1-[[(1S)-5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]carbamateKi669.0 [1]
1-Amino-N-[(1S)-5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]cyclopropane-1-carboxamideIC505.0 [1]
1-Amino-N-[(1S)-5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]cyclopropane-1-carboxamideKi36.4 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamideIC500.1 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamideKi3.1 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyridazine-4-carboxamideIC500.4 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyridazine-4-carboxamideKi3.6 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-1,2-oxazole-5-carboxamideIC500.3 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-1,2-oxazole-5-carboxamideKi4.1 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-5-methyl-1,3,4-oxadiazole-2-carboxamideIC503.4 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-5-methyl-1,3,4-oxadiazole-2-carboxamideKi9.5 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideIC500.1 [1]
N-[1-[[(1S)-5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideKi3.9 [1]
Tert-butyl N-[1-[[5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]carbamateIC50135.3 [1]
Tert-butyl N-[1-[[5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]carbamateKi475.4 [1]
1-Amino-N-[5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]cyclopropane-1-carboxamideIC5095.6 [1]
1-Amino-N-[5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]cyclopropane-1-carboxamideKi458.0 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideIC500.5 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-2-methoxypyrimidine-5-carboxamideKi18.9 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyridazine-4-carboxamideIC500.6 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]pyridazine-4-carboxamideKi15.1 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideIC500.5 [1]
N-[1-[[5-[5-Chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-7-fluoro-2,3-dihydro-1H-inden-1-yl]carbamoyl]cyclopropyl]-3-methoxy-1,2-oxazole-5-carboxamideKi17.1 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Kininogen-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/kininogen-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Kininogen-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kininogen-1-inhibitors-ic50-ki.
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