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Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-4-fluoro-2-methylphenolIC502100.0 [1]
VandetanibIC50400.0 [1]
CabozantinibIC50190.0 [1]
LenvatinibIC5010.0 [1]
4-[3-Hydroxyanilino]-6,7-dimethoxyquinazolineIC50380.0 [1]
2-Methyl-5-[(6,7-dimethoxyquinazoline-4-yl)amino]phenolIC50500.0 [1]
N-(4-Bromo-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amineIC501700.0 [1]
2-Chloro-5-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC50940.0 [1]
5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-4-fluoro-2-methylphenolIC5041.0 [1]
N-(3H-Benzimidazol-5-yl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]quinazolin-4-yl]amino]-2-methylphenolIC505900.0 [1]
4-Fluoro-3-[[6-methoxy-7-[2-(methylamino)ethoxy]quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2-fluorophenolIC50570.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2-methylphenolIC506300.0 [1]
2-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-6-methylphenolIC50460.0 [1]
2-Bromo-3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC502400.0 [1]
4-Fluoro-3-[[6-methoxy-7-(3-methoxypropoxy)quinazolin-4-yl]amino]-2-methylphenolIC502000.0 [1]
3-[[7-(2-Aminoethoxy)-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC5010000.0 [1]
3-[[7-[2-(Dimethylamino)ethoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC5010000.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,6-difluorophenolIC502000.0 [1]
2-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC501900.0 [1]
4-Fluoro-3-[[6-methoxy-7-(2-morpholin-4-ylethoxy)quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,4-difluorophenolIC50120.0 [1]
4-Fluoro-3-[[6-methoxy-7-[2-(4-methylpiperazin-1-yl)ethoxy]quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[7-[2-(3-fluoropyrrolidin-1-yl)ethoxy]-6-methoxyquinazolin-4-yl]amino]-2-methylphenolIC501300.0 [1]
4-Fluoro-3-[[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-yl]amino]-2-methylphenolIC504600.0 [1]
4-Fluoro-3-[[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]amino]-2-methylphenolIC505100.0 [1]
4-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylphenolIC503600.0 [1]
3-[[7-(3-Aminopropoxy)-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-(2-piperazin-1-ylethoxy)quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]-2-methylphenolIC504000.0 [1]
2-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluorophenolIC50260.0 [1]
4-Fluoro-3-[[6-methoxy-7-(pyridin-3-ylmethoxy)quinazolin-4-yl]amino]-2-methylphenolIC501100.0 [1]
4-Fluoro-3-[[6-methoxy-7-(3-piperazin-1-ylpropoxy)quinazolin-4-yl]amino]-2-methylphenolIC507600.0 [1]
4-Fluoro-3-[[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-2-methylphenolIC501200.0 [1]
4-Fluoro-3-[[6-methoxy-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl]amino]-2-methylphenolIC504100.0 [1]
4-Fluoro-3-[[6-methoxy-7-[3-(methylamino)propoxy]quinazolin-4-yl]amino]-2-methylphenolIC506500.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-5-fluoro-2-methylphenolIC502100.0 [1]
3-[[7-[3-(Dimethylamino)propoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC504600.0 [1]
4-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-fluorophenolIC50270.0 [1]
4-Fluoro-3-[[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-(oxolan-2-ylmethoxy)quinazolin-4-yl]amino]-2-methylphenolIC501800.0 [1]
4-Fluoro-3-[[6-methoxy-7-[3-[2-(trifluoromethyl)pyrrolidin-1-yl]propoxy]quinazolin-4-yl]amino]-2-methylphenolIC50600.0 [1]
4-Chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC5085.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-4-methylphenolIC50460.0 [1]
2,4-Dichloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC502200.0 [1]
2,4-Dichloro-5-[(6,7-dimethoxyquinazolin-4-yl)amino]phenolIC501400.0 [1]
5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2-methoxyphenolIC501900.0 [1]
5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2-fluorophenolIC50490.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-5-fluorophenolIC50200.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)-methylamino]phenolIC507200.0 [1]
3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenolIC50620.0 [1]
1-(6,7-Dimethoxyquinazolin-4-yl)-2,3-dihydroindol-4-olIC504940.0 [1]
3-[[7-[2-(1,1-Dioxo-1,4-thiazinan-4-yl)ethoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC5010000.0 [1]
3-[[7-[3-(1,1-Dioxo-1,4-thiazinan-4-yl)propoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC5010000.0 [1]
3-[[7-[2-(1,4-Diazepan-1-yl)ethoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC506700.0 [1]
3-[[7-[3-(1,4-Diazepan-1-yl)propoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenolIC506400.0 [1]
N-[3-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]methanesulfonamideIC5010000.0 [1]
N-(1H-Indol-4-yl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
4-Fluoro-3-[[6-methoxy-7-[2-[2-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinazolin-4-yl]amino]-2-methylphenolIC502100.0 [1]
4-Fluoro-3-[[6-methoxy-7-[(1-methylimidazol-2-yl)methoxy]quinazolin-4-yl]amino]-2-methylphenolIC5010000.0 [1]
N-(1H-Indazol-6-yl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
N-(1H-Indazol-5-yl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
6,7-Dimethoxy-4-(3-hydroxyphenylthio)quinazolineIC502000.0 [1]
5-[(6,7-Dimethoxyquinazolin-4-yl)amino]-2,4-difluorophenolIC5053.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]-4-fluorophenolIC5053.0 [1]
N-[3-(Difluoromethyl)phenyl]-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
3-[(6,7-Dimethoxyquinazolin-4-yl)amino]benzene-1,2-diolIC501100.0 [1]
N-(1H-Indol-6-yl)-6,7-dimethoxyquinazolin-4-amineIC5010000.0 [1]
N-(1H-Indazol-4-yl)-6,7-dimethoxyquinazolin-4-amineIC504600.0 [1]
3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-5-methylphenolIC501500.0 [1]
Items per page: 1 - 10 of 73
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References

This online tool may be cited as follows

MLA

"Quest Database™ Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/kinesin-1-heavy-chain-tyrosine-protein-kinase-receptor-ret-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/kinesin-1-heavy-chain-tyrosine-protein-kinase-receptor-ret-inhibitors-ic50-ki.
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