![](https://images.aatbio.com/dataset/ic50/ketohexokinase_a5c5bae0fd3ddf532506780bb4f7f125.svg) | Khk-IN-1 | IC50 | 12.0 [1], 400.0 [2], 500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_f6263aae3ccd813ced6011d25d2cbec1.svg) | N-[3-(Methylsulfanyl)-1-Phenyl-1h-Indazol-6-Yl]piperidine-4-Carboxamide | IC50 | 330.0 [1], 590.0 [2], 5000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_e5582fa1dd553626342de806825dcc30.svg) | 6-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)-3-ethyl-1-phenylindazole | IC50 | 590.0 [1], 5360.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9b45dbb1259994d474b26cf96a473b56.svg) | 8-N-(Cyclopropylmethyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 8.0 [1], 360.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_42e78fbef5064cfab7ab7527bf89c65e.svg) | Khk-IN-2 | IC50 | 316.23 [1], 389.05 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_148c940a4aa5c24409ea0858a35d888e.svg) | 3-Methyl-1-phenyl-6-piperidin-4-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 6100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_e4ebb6bbd5ccdec1ca2a34656922f23f.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 210.0 [1], 2400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_33c2786ee0087665614bf17e0825cd46.svg) | 4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-yl-8-N-(pyridin-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 9.8 [1], 270.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9b20e8b6002bb1f96413860dfb6b2b6b.svg) | 3-Ethyl-1-phenyl-6-(4-pyrrolidin-3-ylpiperazin-1-yl)indazole | IC50 | 920.0 [1], 2060.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_3c3eec8b4756030311b6de396da9e4c3.svg) | 3-Methylsulfanyl-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazole | IC50 | 670.0 [1], 680.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_18d15fb35580b02e1616d48e5ed98b09.svg) | 8-N-(2-Methoxyethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 7.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_4ddf0d9a02b78e5015cc59f425b418c9.svg) | 4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 7.1 [1], 78.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_8718bf87656c03fda05ec6b3d3495d38.svg) | [4-(3-Methylsulfanyl-1-phenylindazol-6-yl)piperazin-1-yl]-piperidin-4-ylmethanone | IC50 | 830.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b5e4635e4dc06a7a6e3f43a1b0a3e48d.svg) | 1-(4-Fluorophenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 23.0 [1], 230.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9c539372dc176ae8a9388a0c65560160.svg) | 4-[3-Methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazol-1-yl]aniline | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_35d18c727c17e70c0642a736f40eee05.svg) | N-(3-Methylsulfanyl-1-phenylindazol-6-yl)azetidine-3-carboxamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_0a0efd6a73306a06f08979fadb3c4108.svg) | 3-Ethyl-6-(4-methylpiperazin-1-yl)-1-phenylindazole | IC50 | 4520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_487d557ed040421dcbe17200dc2f5c16.svg) | N-(3-Ethyl-1-phenyl-1H-indazol-6-yl)-1H-benzo[d]imidazole-5-carboxamide | IC50 | 940.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_a45150f7dadc8274127c2b4846a12981.svg) | 1-(3-Fluorophenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 42.0 [1], 360.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_39743f067a25f127da721c589df53d10.svg) | 3-Ethyl-1-phenyl-6-(4-piperazin-1-ylphenyl)indazole | IC50 | 9800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9bfdd1b73fe149b6eb271edbbfa37daf.svg) | 3-Methylsulfanyl-1-phenyl-6-piperidin-4-yloxyindazole | IC50 | 710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_4338263563a303dee819486f716d5080.svg) | 1-(4-Methylphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 40.0 [1], 440.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_362b34eb54c173c315d2fb8892619cee.svg) | 3-Ethyl-1-phenyl-6-(piperazin-1-yl)-1H-indazole | IC50 | 570.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_0d1b7153400ba9d005fe3597adf50484.svg) | 3-Carbamimidoyl-N-(3-ethyl-1-phenylindazol-6-yl)benzamide | IC50 | 680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_2f6d1d0fd0bc7f406e6dbee87a76d986.svg) | 6-(2,5-Diazabicyclo[2.2.1]heptan-2-yl)-3-methylsulfanyl-1-phenylindazole | IC50 | 710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_c57de76e9725c9761e5ee4b37603c9e5.svg) | 3-Ethyl-6-(4-ethylpiperazin-1-yl)-1-phenylindazole | IC50 | 11500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_3ff271d2f9decddb80b8bb38f2a6c407.svg) | 3-Ethyl-1-phenyl-6-(4-pyridin-4-ylpiperazin-1-yl)indazole | IC50 | 3510.0 [1], 3520.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_18189ca300f41a090c6ef95b5715d668.svg) | N-(3-Methylsulfanyl-1-phenylindazol-6-yl)pyrrolidine-3-carboxamide | IC50 | 590.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_66a4dfa6da4caaab80b233293f8d1e10.svg) | 1-(4-Methoxyphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 87.0 [1], 90.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_fc04c30a5ca950c658c03d16b9967183.svg) | 3-Methyl-1-phenyl-6-(piperazin-1-yl)-1H-indazole | IC50 | 1280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9f373acc441d19d69cbc498120389565.svg) | 3-Methoxy-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazole | IC50 | 1380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_da5ada653e7bdc6bf8f557ed7fa60700.svg) | 3-Methylsulfanyl-1-phenyl-6-piperazin-1-ylindazole | IC50 | 560.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_f32c02040b5fc0f75a29af9f8338c1d1.svg) | 3-Methylsulfanyl-1-phenyl-6-pyridin-4-ylindazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_5cb0567e019b81451c7b88a9da6d23ed.svg) | 3-Methylsulfanyl-1-(4-nitrophenyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 480.0 [1], 490.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_80713803a9427ee0fec4909351c901bd.svg) | N-(3-Methylsulfanyl-1-phenylindazol-6-yl)piperidine-3-carboxamide | IC50 | 310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_c194239d2ed0d496ea8770dac400cc68.svg) | N-(3-Methylsulfanyl-1-phenylindazol-6-yl)-3-piperazin-1-ylpropanamide | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_8c99a78fbaa7d7d277b678c3dda31581.svg) | 3-Ethyl-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazole | IC50 | 560.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_2db63bf843dd1ae757a248a1e43cf3b6.svg) | 3-Ethyl-6-(3-methylpiperazin-1-yl)-1-phenylindazole | IC50 | 860.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b60ea5646bbd7cc1960d0622350b7bc3.svg) | 8-N-(Cyclopropylmethyl)-2-(2,6-diazaspiro[3.4]octan-6-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 2.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_9d4eaf7aa2b613eb219ddf58b0e42cb5.svg) | 4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-yl-8-N-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 16.0 [1], 270.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_1238a075ee0e2902b215a5d224c47830.svg) | 2-[3-(Aminomethyl)azetidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 30.0 [1], 590.0 [2] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_e2b972a3a9274872b98b0c092b153f31.svg) | 3-(Trifluoromethyl)quinoxalin-2-ol | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_6f32378401865e2834abbe24337fac5f.svg) | 4,6-Dimethyl-2-(morpholin-4-yl)pyridine-3-carbonitrile | IC50 | 316227.77 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_90d6b9d222027b9c43f3a2fae377c791.svg) | CID 129900195 | IC50 | 120226.44 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_321693581578db4c2929624fcae05343.svg) | 7-[(3S)-3-Hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile | IC50 | 676.08 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_0e66b034db1a4696911e8a0686c20bce.svg) | 6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile | IC50 | 1030.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_5805a83d3a62066d72ef3434a5eb91ee.svg) | 6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-[3-(hydroxymethyl)piperidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile | IC50 | 16790.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_cb264eeed2dd54716997eaf475f9d922.svg) | 7-[(3R)-3-Hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile | IC50 | 23988.33 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_0f59b5d14594d50c4d22fa92b0986b39.svg) | 2-Ethyl-7-(3-hydroxy-3-methylpyrrolidin-1-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile | IC50 | 1584.89 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_cdcc54a471a702c64a7a9268f89ecd35.svg) | 1-(3-Methylphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 34.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_c56359505b2e1b907127e6c3e39a2e3f.svg) | 3-Methylsulfanyl-1-phenyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_ceb15ff2855b2d92491867b9fb31eb3a.svg) | 3-Methylsulfanyl-1-phenyl-7-(1,2,3,6-tetrahydropyridin-4-yl)indazole | IC50 | 11500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_275782622d462ca171bccfea14fbc4b9.svg) | 3-Methylsulfanyl-1-phenyl-7-piperidin-4-yloxyindazole | IC50 | 1680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_2652bd8438decfc82ccae613cdc78c67.svg) | 1-Ethyl-3-phenyl-6-piperazin-1-ylimidazo[1,5-a]pyridine | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_c96424b46c33f0b4858bbc03bdacbc7e.svg) | N-(3-Methylsulfanyl-1-phenylindazol-6-yl)-2-piperidin-4-ylacetamide | IC50 | 680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_e03b9afc21bd070da51c81987861a954.svg) | 3-Methylsulfanyl-1-phenyl-7-(piperidin-4-ylmethoxy)indazole | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_37b65c02f8a5b34d04bfd00003eedb11.svg) | 3-Methylsulfanyl-1-phenyl-6-piperidin-4-ylindazole | IC50 | 330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_dd3611646d50fd8022b39629418bffc7.svg) | 3-Methylsulfanyl-1-phenyl-6-(piperidin-4-ylmethoxy)indazole | IC50 | 440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b270359147fd6eb8800330c57164bef7.svg) | 3-Methyl-1-phenyl-6-(4-piperazin-1-ylpiperidin-1-yl)indazole | IC50 | 3200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_1c4951767147f4ede352919edae98d3d.svg) | 1-Methyl-3-phenyl-5-piperazin-1-ylindazole | IC50 | 1280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_63638c72b9dbd770304ed27f1b8e66a6.svg) | 8-N-(Cyclopropylmethyl)-2-(3-methylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_7da95d790be70e51e08a81b97b10bb43.svg) | 8-N-(Cyclopropylmethyl)-2-[(2R)-2-methylpiperazin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 58.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_a5d16343deca0284a722c5ead74963df.svg) | 8-N-(Cyclopropylmethyl)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b4b4322bb0e63c2816a52ee254c749f1.svg) | 8-N-(Cyclopropylmethyl)-2-(3,3-dimethylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_d37866737a59966b3bc0cb04c8737573.svg) | 8-N-(Cyclopropylmethyl)-2-N-methyl-4-N-(2-methylsulfanylphenyl)-2-N-(piperidin-4-ylmethyl)pyrimido[5,4-d]pyrimidine-2,4,8-triamine | IC50 | 66.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_8053973824350403b23faf240950d643.svg) | 8-N-(Cyclopropylmethyl)-2-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_8d337dbf3bb2040408ff6b12e1882d4e.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_1c6e0d92e8ca0ce2be658fe2110d1548.svg) | 8-N-(Cyclopropylmethyl)-2-(2,7-diazaspiro[4.4]nonan-2-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 43.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_cf3e122c30b786485a3534f54f5aad7b.svg) | 8-N-(Cyclopropylmethyl)-2-(3,9-diazaspiro[5.5]undecan-3-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_264a7157e80f6120303d9f2e2d1c561f.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperidin-4-ylpiperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 48.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_c6a822cedc5d1565354105157a27763f.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperazin-1-ylpiperidin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_5e1941e01fbfb4c465ef670a893e4b14.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperidin-4-ylpiperidin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_974f27b22974fa7a390f0002491a380a.svg) | 8-N-(Cyclopropylmethyl)-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_a809fc889315bf16b613a34da247e0a0.svg) | 8-N-Methyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_4f0915a5c2c91bb327445a39b82e872a.svg) | 8-N-(Cyclopropylmethyl)-4-N-(3-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 2800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_f16690e96b779c192df7696e2d7b36a0.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methoxyphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_70e8efd297f7ac91ce862d9a3f2e733e.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-fluorophenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_a98142d4a13c276b88a73e1639a8c58e.svg) | 4-N-(2-Chlorophenyl)-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 540.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_40f3fef04b1d1a70e2e6a8552a8d19f7.svg) | 4-N-Cyclopropyl-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_17fd28f07704d55e8dc624ebeb41ac8f.svg) | 8-N-Cyclohexyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 2300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_76ee21df90e9c9fada946ebc80db740d.svg) | 8-N-Benzyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_e3f2dabe1fb167e1c44be4bc705644c7.svg) | 4-N-(2-Methylphenyl)-2-piperazin-1-yl-8-N-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 60.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b9a62c9e82c0f180c707344fd4c432cf.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfonylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_7b6f0a62de4432cbfc44c4c1815541ac.svg) | 2-(3-Amino-8-azabicyclo[3.2.1]octan-8-yl)-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_b73db685873f99b8fdabc088f4234acc.svg) | 8-N-(Cyclopropylmethyl)-4-N-phenyl-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 3200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_59b2739ca400fc823ca41e4ef166aa9f.svg) | 8-N-(Cyclopropylmethyl)-4-N-(3-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_4c8c8e990a72e2e641a2b722ff5f41cf.svg) | 8-N-(Cyclopropylmethyl)-2-piperazin-1-yl-4-N-[2-(trifluoromethylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_877e78153a559cf17903ecc3ed434fd0.svg) | 8-N-(Cyclopropylmethyl)-2-piperazin-1-yl-4-N-(2-propan-2-ylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_94689275267986f151c0496965022447.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-cyclopropylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_1055f21ac9a521b5ab6708f7c6a82343.svg) | 4-N-Cyclohexyl-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_7de2026c101399ece23d9d0846680e4b.svg) | 2-[(3S)-3-Aminopiperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 23.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_1836744b892c6d3d34a2aca29ddc57ba.svg) | 8-N-(Cyclopropylmethyl)-2-[4-[(dimethylamino)methyl]piperidin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_129bb0ac51ce76fd6e3d737bd40134db.svg) | 8-N-(Cyclopropylmethyl)-2-(4-methylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_cada964eb974e1b3bf3e35340bf5d247.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-ethylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_09d3a1380db0f2162058f6cd25294176.svg) | 2-(4-Aminopiperidin-1-yl)-8-N-(cyclopropylmethyl)-4-N-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_0a4195046f641577347312b4b82889ec.svg) | 2-[(4Ar,7aR)-2,3,4,4a,5,6,7,7a-octahydropyrrolo[3,4-b]pyridin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_650176ccc739b1d58f9806c9119f05b4.svg) | 8-N-(Cyclopropylmethyl)-4-N-(2-ethylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_dbd127faa6ff69b85646fd68645b857b.svg) | 2-[4-(Aminomethyl)piperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_eb091283e9dd21268ca708696051f882.svg) | 8-N-(Cyclobutylmethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/ketohexokinase_27570a5d874339e689e679d44a9b81ef.svg) | 2-[(3R)-3-Aminopiperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine | IC50 | 18.0 [1] |