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Ketohexokinase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Khk-IN-1IC5012.0 [1], 400.0 [2], 500.0 [3]
N-[3-(Methylsulfanyl)-1-Phenyl-1h-Indazol-6-Yl]piperidine-4-CarboxamideIC50330.0 [1], 590.0 [2], 5000.0 [3]
6-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)-3-ethyl-1-phenylindazoleIC50590.0 [1], 5360.0 [2]
8-N-(Cyclopropylmethyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC508.0 [1], 360.0 [2]
Khk-IN-2IC50316.23 [1], 389.05 [2]
3-Methyl-1-phenyl-6-piperidin-4-yl-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC506100.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50210.0 [1], 2400.0 [2]
4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-yl-8-N-(pyridin-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC509.8 [1], 270.0 [2]
3-Ethyl-1-phenyl-6-(4-pyrrolidin-3-ylpiperazin-1-yl)indazoleIC50920.0 [1], 2060.0 [2]
3-Methylsulfanyl-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazoleIC50670.0 [1], 680.0 [2]
8-N-(2-Methoxyethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC507.0 [1], 140.0 [2]
4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC507.1 [1], 78.0 [2]
[4-(3-Methylsulfanyl-1-phenylindazol-6-yl)piperazin-1-yl]-piperidin-4-ylmethanoneIC50830.0 [1]
1-(4-Fluorophenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5023.0 [1], 230.0 [2]
4-[3-Methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazol-1-yl]anilineIC50160.0 [1]
N-(3-Methylsulfanyl-1-phenylindazol-6-yl)azetidine-3-carboxamideIC50220.0 [1]
3-Ethyl-6-(4-methylpiperazin-1-yl)-1-phenylindazoleIC504520.0 [1]
N-(3-Ethyl-1-phenyl-1H-indazol-6-yl)-1H-benzo[d]imidazole-5-carboxamideIC50940.0 [1]
1-(3-Fluorophenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5042.0 [1], 360.0 [2]
3-Ethyl-1-phenyl-6-(4-piperazin-1-ylphenyl)indazoleIC509800.0 [1]
3-Methylsulfanyl-1-phenyl-6-piperidin-4-yloxyindazoleIC50710.0 [1]
1-(4-Methylphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5040.0 [1], 440.0 [2]
3-Ethyl-1-phenyl-6-(piperazin-1-yl)-1H-indazoleIC50570.0 [1]
3-Carbamimidoyl-N-(3-ethyl-1-phenylindazol-6-yl)benzamideIC50680.0 [1]
6-(2,5-Diazabicyclo[2.2.1]heptan-2-yl)-3-methylsulfanyl-1-phenylindazoleIC50710.0 [1]
3-Ethyl-6-(4-ethylpiperazin-1-yl)-1-phenylindazoleIC5011500.0 [1]
3-Ethyl-1-phenyl-6-(4-pyridin-4-ylpiperazin-1-yl)indazoleIC503510.0 [1], 3520.0 [2]
N-(3-Methylsulfanyl-1-phenylindazol-6-yl)pyrrolidine-3-carboxamideIC50590.0 [1]
1-(4-Methoxyphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5087.0 [1], 90.0 [2]
3-Methyl-1-phenyl-6-(piperazin-1-yl)-1H-indazoleIC501280.0 [1]
3-Methoxy-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazoleIC501380.0 [1]
3-Methylsulfanyl-1-phenyl-6-piperazin-1-ylindazoleIC50560.0 [1]
3-Methylsulfanyl-1-phenyl-6-pyridin-4-ylindazoleIC5010000.0 [1]
3-Methylsulfanyl-1-(4-nitrophenyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC50480.0 [1], 490.0 [2]
N-(3-Methylsulfanyl-1-phenylindazol-6-yl)piperidine-3-carboxamideIC50310.0 [1]
N-(3-Methylsulfanyl-1-phenylindazol-6-yl)-3-piperazin-1-ylpropanamideIC50380.0 [1]
3-Ethyl-1-phenyl-6-(4-piperidin-4-ylpiperazin-1-yl)indazoleIC50560.0 [1]
3-Ethyl-6-(3-methylpiperazin-1-yl)-1-phenylindazoleIC50860.0 [1]
8-N-(Cyclopropylmethyl)-2-(2,6-diazaspiro[3.4]octan-6-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC502.0 [1], 150.0 [2]
4-N-(2-Methylsulfanylphenyl)-2-piperazin-1-yl-8-N-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5016.0 [1], 270.0 [2]
2-[3-(Aminomethyl)azetidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5030.0 [1], 590.0 [2]
3-(Trifluoromethyl)quinoxalin-2-olIC50100000.0 [1]
4,6-Dimethyl-2-(morpholin-4-yl)pyridine-3-carbonitrileIC50316227.77 [1]
CID 129900195IC50120226.44 [1]
7-[(3S)-3-Hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrileIC50676.08 [1]
6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrileIC501030.0 [1]
6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-[3-(hydroxymethyl)piperidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrileIC5016790.0 [1]
7-[(3R)-3-Hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrileIC5023988.33 [1]
2-Ethyl-7-(3-hydroxy-3-methylpyrrolidin-1-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrileIC501584.89 [1]
1-(3-Methylphenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5034.0 [1]
3-Methylsulfanyl-1-phenyl-6-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5080.0 [1]
3-Methylsulfanyl-1-phenyl-7-(1,2,3,6-tetrahydropyridin-4-yl)indazoleIC5011500.0 [1]
3-Methylsulfanyl-1-phenyl-7-piperidin-4-yloxyindazoleIC501680.0 [1]
1-Ethyl-3-phenyl-6-piperazin-1-ylimidazo[1,5-a]pyridineIC5020000.0 [1]
N-(3-Methylsulfanyl-1-phenylindazol-6-yl)-2-piperidin-4-ylacetamideIC50680.0 [1]
3-Methylsulfanyl-1-phenyl-7-(piperidin-4-ylmethoxy)indazoleIC50240.0 [1]
3-Methylsulfanyl-1-phenyl-6-piperidin-4-ylindazoleIC50330.0 [1]
3-Methylsulfanyl-1-phenyl-6-(piperidin-4-ylmethoxy)indazoleIC50440.0 [1]
3-Methyl-1-phenyl-6-(4-piperazin-1-ylpiperidin-1-yl)indazoleIC503200.0 [1]
1-Methyl-3-phenyl-5-piperazin-1-ylindazoleIC501280.0 [1]
8-N-(Cyclopropylmethyl)-2-(3-methylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5070.0 [1]
8-N-(Cyclopropylmethyl)-2-[(2R)-2-methylpiperazin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5058.0 [1]
8-N-(Cyclopropylmethyl)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50110.0 [1]
8-N-(Cyclopropylmethyl)-2-(3,3-dimethylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5040.0 [1]
8-N-(Cyclopropylmethyl)-2-N-methyl-4-N-(2-methylsulfanylphenyl)-2-N-(piperidin-4-ylmethyl)pyrimido[5,4-d]pyrimidine-2,4,8-triamineIC5066.0 [1]
8-N-(Cyclopropylmethyl)-2-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC504600.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC506000.0 [1]
8-N-(Cyclopropylmethyl)-2-(2,7-diazaspiro[4.4]nonan-2-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5043.0 [1]
8-N-(Cyclopropylmethyl)-2-(3,9-diazaspiro[5.5]undecan-3-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5015.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperidin-4-ylpiperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5048.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperazin-1-ylpiperidin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5028.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-(4-piperidin-4-ylpiperidin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5050.0 [1]
8-N-(Cyclopropylmethyl)-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5030.0 [1]
8-N-Methyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50400.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(3-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC502800.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methoxyphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50100.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-fluorophenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC501500.0 [1]
4-N-(2-Chlorophenyl)-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50540.0 [1]
4-N-Cyclopropyl-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC509000.0 [1]
8-N-Cyclohexyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC502300.0 [1]
8-N-Benzyl-4-N-(2-methylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50400.0 [1]
4-N-(2-Methylphenyl)-2-piperazin-1-yl-8-N-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5060.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-methylsulfonylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC509000.0 [1]
2-(3-Amino-8-azabicyclo[3.2.1]octan-8-yl)-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50800.0 [1]
8-N-(Cyclopropylmethyl)-4-N-phenyl-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC503200.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(3-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC502000.0 [1]
8-N-(Cyclopropylmethyl)-2-piperazin-1-yl-4-N-[2-(trifluoromethylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamineIC503000.0 [1]
8-N-(Cyclopropylmethyl)-2-piperazin-1-yl-4-N-(2-propan-2-ylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC505000.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-cyclopropylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50380.0 [1]
4-N-Cyclohexyl-8-N-(cyclopropylmethyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC509000.0 [1]
2-[(3S)-3-Aminopiperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5023.0 [1]
8-N-(Cyclopropylmethyl)-2-[4-[(dimethylamino)methyl]piperidin-1-yl]-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50140.0 [1]
8-N-(Cyclopropylmethyl)-2-(4-methylpiperazin-1-yl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50110.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-ethylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC509000.0 [1]
2-(4-Aminopiperidin-1-yl)-8-N-(cyclopropylmethyl)-4-N-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50200.0 [1]
2-[(4Ar,7aR)-2,3,4,4a,5,6,7,7a-octahydropyrrolo[3,4-b]pyridin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC50440.0 [1]
8-N-(Cyclopropylmethyl)-4-N-(2-ethylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC50130.0 [1]
2-[4-(Aminomethyl)piperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5070.0 [1]
8-N-(Cyclobutylmethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamineIC5018.0 [1]
2-[(3R)-3-Aminopiperidin-1-yl]-8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamineIC5018.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ketohexokinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/ketohexokinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Ketohexokinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ketohexokinase-inhibitors-ic50-ki.
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