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Keap1/Nrf2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2,2'-(Naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acidIC5024.0 [1], 25.0 [2], 29.0 [3], 30.8 [4]
N,N'-Naphthalene-1,4-Diylbis(4-Methoxybenzenesulfonamide)IC50940.0 [1], 1800.0 [2]
(1S,2R)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC502300.0 [1], 3000.0 [2]
[(4-Methoxyphenyl)sulfonyl](4-{[(4-methoxyphenyl)sulfonyl]amino}phenyl)amineIC5025000.0 [1]
2-[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-N-(4-methoxyphenyl)sulfonylanilino]acetic acidIC50980.0 [1], 1448.0 [2]
2,2'-(Naphthalene-1,4-Diylbis(((4-Methoxyphenyl)sulfonyl)azanediyl))diacetamideIC5063.0 [1]
1-[3-[3-[(1S)-1-Cyclohexylethoxy]phenyl]phenyl]-5-[(1R,2R)-2-(1-methyltriazol-4-yl)cyclopropyl]pyrazole-4-carboxylic acidIC5010.0 [1]
(1R,2S)-2-[1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC503000.0 [1]
N-[4-(Benzenesulfonamido)naphthalen-1-yl]benzenesulfonamideIC5025000.0 [1]
2-[[1-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]isoquinolin-4-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC5060.0 [1]
(1S,2R)-2-[(1S)-5-Methyl-1-[(3-oxo-1H-isoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC50750.0 [1]
[(4-Chlorophenyl)sulfonyl](4-{[(4-chlorophenyl)sulfonyl]amino}naphthyl)amineIC5025000.0 [1]
2-[[(1S)-2-[(1R,2S)-2-(2H-Tetrazol-5-yl)cyclohexanecarbonyl]-3,4-dihydro-1H-isoquinolin-1-yl]methyl]isoindole-1,3-dioneIC507400.0 [1]
(1S,2R)-2-[(1S)-1-[(3-Oxo-1H-isoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC501100.0 [1]
N-[(4-Methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycineIC5061.0 [1]
2-[[(1S)-2-(Cyclohexanecarbonyl)-3,4-dihydro-1H-isoquinolin-1-yl]methyl]isoindole-1,3-dioneIC50100000.0 [1]
(1R,2S)-2-[(1S)-5-Methyl-1-[(3-oxo-1H-isoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC50750.0 [1]
N,N'-[2-(2-Oxopropyl)naphthalene-1,4-Diyl]bis(4-Ethoxybenzenesulfonamide)IC506200.0 [1]
2-[4-[Carboxymethyl-(4-methylphenyl)sulfonylamino]-N-(4-methylphenyl)sulfonylanilino]acetic acidIC50966.0 [1]
2-[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-N-(4-methoxyphenyl)sulfonyl-3-methylanilino]acetic acidIC501666.0 [1]
2-[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-N-(4-methoxyphenyl)sulfonyl-2,5-dimethylanilino]acetic acidIC5010170.0 [1]
2-[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-3-methoxy-N-(4-methoxyphenyl)sulfonylanilino]acetic acidIC50602.0 [1]
2-[[4-[Carboxymethyl-(4-methylphenyl)sulfonylamino]naphthalen-1-yl]-(4-methylphenyl)sulfonylamino]acetic acidIC5018.1 [1]
2-[[4-[Carboxymethyl-(4-fluorophenyl)sulfonylamino]naphthalen-1-yl]-(4-fluorophenyl)sulfonylamino]acetic acidIC5054.3 [1]
2-[[4-[Carboxymethyl-(4-chlorophenyl)sulfonylamino]naphthalen-1-yl]-(4-chlorophenyl)sulfonylamino]acetic acidIC5042.3 [1]
2-[(4-Bromophenyl)sulfonyl-[4-[(4-bromophenyl)sulfonyl-(carboxymethyl)amino]naphthalen-1-yl]amino]acetic acidIC5036.5 [1]
2-[(4-Acetamidophenyl)sulfonyl-[4-[(4-acetamidophenyl)sulfonyl-(carboxymethyl)amino]naphthalen-1-yl]amino]acetic acidIC5014.4 [1]
2-[(4-Tert-butylphenyl)sulfonyl-[4-[(4-tert-butylphenyl)sulfonyl-(carboxymethyl)amino]naphthalen-1-yl]amino]acetic acidIC5050.2 [1]
2-[[4-[Carboxymethyl-(2,4,6-trimethylphenyl)sulfonylamino]naphthalen-1-yl]-(2,4,6-trimethylphenyl)sulfonylamino]acetic acidIC50979.0 [1]
2-[Benzenesulfonyl-[4-[benzenesulfonyl(carboxymethyl)amino]naphthalen-1-yl]amino]acetic acidIC5034.3 [1]
2-[[4-[Carboxymethyl-[4-(trifluoromethoxy)phenyl]sulfonylamino]naphthalen-1-yl]-[4-(trifluoromethoxy)phenyl]sulfonylamino]acetic acidIC50179.0 [1]
2-[[4-[Carboxymethyl(naphthalen-1-ylsulfonyl)amino]naphthalen-1-yl]-naphthalen-1-ylsulfonylamino]acetic acidIC5047.4 [1]
2-[[4-[Carboxymethyl-[4-(trifluoromethyl)phenyl]sulfonylamino]naphthalen-1-yl]-[4-(trifluoromethyl)phenyl]sulfonylamino]acetic acidIC50122.0 [1]
2-[[4-[Carboxymethyl-(3-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-(3-methoxyphenyl)sulfonylamino]acetic acidIC5066.1 [1]
2-[[4-[Carboxymethyl-(4-cyanophenyl)sulfonylamino]naphthalen-1-yl]-(4-cyanophenyl)sulfonylamino]acetic acidIC50118.0 [1]
2-[(4-Butylphenyl)sulfonyl-[4-[(4-butylphenyl)sulfonyl-(carboxymethyl)amino]naphthalen-1-yl]amino]acetic acidIC5042.2 [1]
2-[[5-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC501860.0 [1]
3-Methoxy-N-[4-[(3-methoxyphenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC50630.0 [1]
4-(Trifluoromethyl)-N-[4-[[4-(trifluoromethyl)phenyl]sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC5025000.0 [1]
3-(Trifluoromethyl)-N-[4-[[3-(trifluoromethyl)phenyl]sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC5025000.0 [1]
N-[4-[(3,4-Dimethoxyphenyl)sulfonylamino]naphthalen-1-yl]-3,4-dimethoxybenzenesulfonamideIC501100.0 [1]
4-(Dimethylamino)-N-[4-[[4-(dimethylamino)phenyl]sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC50190.0 [1]
4-Fluoro-N-[4-[(4-fluorophenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC50660.0 [1]
Ethyl 2-[[4-[(2-ethoxy-2-oxoethyl)-(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-(4-methoxyphenyl)sulfonylamino]acetateIC5025000.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonyl-prop-2-enylamino]naphthalen-1-yl]-N-prop-2-enylbenzenesulfonamideIC5025000.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonyl-methylamino]naphthalen-1-yl]-N-methylbenzenesulfonamideIC5025000.0 [1]
N-Ethyl-N-[4-[ethyl-(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-4-methoxybenzenesulfonamideIC5025000.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonyl-prop-2-ynylamino]naphthalen-1-yl]-N-prop-2-ynylbenzenesulfonamideIC5025000.0 [1]
N-[4-(Benzenesulfonamido)naphthalen-1-yl]-4-methoxybenzenesulfonamideIC5025000.0 [1]
N-[4-[(4-Methoxyphenyl)sulfonylamino]naphthalen-1-yl]-4-(trifluoromethyl)benzenesulfonamideIC5025000.0 [1]
N-[4-(Benzenesulfonamido)naphthalen-1-yl]-4-(trifluoromethyl)benzenesulfonamideIC5025000.0 [1]
3-Methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC50410.0 [1]
Ethyl 2-[(4-methoxyphenyl)sulfonyl-[4-[(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]amino]acetateIC5085.0 [1]
2-[(4-Methoxyphenyl)sulfonyl-naphthalen-1-ylamino]acetic acidIC5025000.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]naphthalen-2-yl]benzenesulfonamideIC5025000.0 [1]
4-Methoxy-N-[3-[(4-methoxyphenyl)sulfonylamino]naphthalen-2-yl]benzenesulfonamideIC5025000.0 [1]
2-[[4-[(2-Amino-2-oxoethyl)-(4-methoxyphenyl)sulfonylamino]naphthalen-2-yl]-(4-methoxyphenyl)sulfonylamino]acetamideIC5025000.0 [1]
2-[[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]naphthalen-2-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC505500.0 [1]
2-[(4-Methoxyphenyl)sulfonyl-[3-[(4-methoxyphenyl)sulfonylamino]naphthalen-2-yl]amino]acetamideIC5025000.0 [1]
4-Methoxy-N-[4-[(4-methoxybenzoyl)amino]naphthalen-1-yl]benzamideIC5025000.0 [1]
2-[1,4-Bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]acetic acidIC50320.0 [1]
(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-Acetamido-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acidIC50875.0 [1]
2-[1,4-Bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidIC50200.0 [1]
3-[1,4-Bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]propanoic acidIC50230.0 [1]
Methyl 2-[1,4-bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetateIC50720.0 [1]
4-Ethoxy-N-[4-[(4-ethoxyphenyl)sulfonylamino]-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]benzenesulfonamideIC501300.0 [1]
(4S)-4-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-Acetamido-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-5-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC50634.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]-3-(2-oxopropyl)naphthalen-1-yl]benzenesulfonamideIC503200.0 [1]
4-[1,4-Bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]butanoic acidIC50150.0 [1]
4-Ethoxy-N-[4-[(4-ethoxyphenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC502800.0 [1]
4-Methyl-N-[4-[(4-methylphenyl)sulfonylamino]naphthalen-1-yl]benzenesulfonamideIC50890.0 [1]
2-[[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]phthalazin-1-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC501100.0 [1]
4-Methoxy-N-[8-[(4-methoxyphenyl)sulfonylamino]quinolin-5-yl]benzenesulfonamideIC5025000.0 [1]
2-[[3-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-5-phenylphenyl]methyl-(4-methoxyphenyl)sulfonylamino]acetic acidIC5025000.0 [1]
2-[[2-[[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]methyl]phenyl]methyl-(4-methoxyphenyl)sulfonylamino]acetic acidIC5025000.0 [1]
2-[[8-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]quinolin-5-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC50101.0 [1]
2-[[7-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]-1H-indol-4-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC501300.0 [1]
(2S,3R)-3-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]piperidine-2-carboxylic acidIC5069700.0 [1]
4-Methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]phthalazin-1-yl]benzenesulfonamideIC5025000.0 [1]
2-[4-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]but-2-enyl-(4-methoxyphenyl)sulfonylamino]acetic acidIC5025000.0 [1]
4-Methoxy-N-[7-[(4-methoxyphenyl)sulfonylamino]-1H-indol-4-yl]benzenesulfonamideIC5025000.0 [1]
2-[[6-[Carboxymethyl-(4-methoxyphenyl)sulfonylamino]pyridin-3-yl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC5025000.0 [1]
2-[[2-[Carboxymethyl-(4-methoxyphenyl)sulfonylcarbamoyl]benzoyl]-(4-methoxyphenyl)sulfonylamino]acetic acidIC5025000.0 [1]
(1S,2R)-2-[(1R)-1-Benzyl-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC50100000.0 [1]
1-[3-[3-[(2R)-2-Butylpyrrolidine-1-carbonyl]phenyl]phenyl]-5-cyclopropylpyrazole-4-carboxylic acidIC5010.0 [1]
(1R,2S)-2-[(1S)-1-[(1,3-Dioxoisoindol-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]cyclohexane-1-carboxylic acidIC502300.0 [1]
3-[[4-[(3-Carboxyphenyl)sulfonylamino]naphthalen-1-yl]sulfamoyl]benzoic acidIC5025000.0 [1]
(2S)-2-[[(2S)-4-Carboxy-2-[[2-[[(2S,3R)-2-[[(2S)-4-carboxy-2-[[(2S)-1-[(2S)-3-carboxy-2-(octadecanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]butanoyl]amino]-4-methylpentanoic acidIC5022.0 [1]
4-Methoxy-N-(1-naphthyl)benzenesulfonamideIC5025000.0 [1]
Items per page: 1 - 10 of 89
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References

This online tool may be cited as follows

MLA

"Quest Database™ Keap1/Nrf2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/keap1-nrf2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Keap1/Nrf2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/keap1-nrf2-inhibitors-ic50-ki.
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