![](https://images.aatbio.com/dataset/ic50/jak3-jak1_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | IC50 | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_7c73239bc31d4875fd802deba6fd37c5.svg) | Filgotinib | IC50 | 148.0 [1], 154.0 [2], 2140.0 [3] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_499d1b0d435cf587d6ff8c3cc8ded015.svg) | Jak-IN-1 | IC50 | 31.0 [1], 1008.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | IC50 | 23.0 [1], 1850.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_c0ff4e3dfe8e08fa2c67203215e88178.svg) | Baricitinib | IC50 | 67.0 [1], 259.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_dbd3ed1b80e21bd85c700e0d0e711b46.svg) | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | IC50 | 511.0 [1], 1298.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_bb1c2e58a3a6e686936e484e0ce882b8.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 328.0 [1], 805.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_1195bea21f0149ddf95f17142bd9dfbe.svg) | Jak3-IN-6 | IC50 | 280.0 [1], 5100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_3fc673a176e48cd789da2ad3346d3976.svg) | 4-Amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide | IC50 | 548.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_6187f0cd5da7efa9a80dbd6afd9a67f7.svg) | 2-Cyclopropyl-N-[(2s)-3-Hydroxy-3-Methylbutan-2-Yl]-5h-Pyrrolo[2,3-B]pyrazine-7-Carboxamide | IC50 | 2230.0 [1], 15700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_5d814490ce5f45b330c6ea4ce1d7f36d.svg) | N-[(1R)-2-(3-Cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 30.0 [1], 511.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_4e5ee4d1920cf282d5f648d2a9a377a3.svg) | N-[(1R)-2-[(3S)-3-Cyanopyrrolidin-1-yl]-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 28.0 [1], 1150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_b67e063e7cea4a8f6ed939bce8c980d9.svg) | 4-Amino-2-[4-(Tert-Butylsulfamoyl)phenyl]-N-Methylthieno[3,2-C]pyridine-7-Carboxamide | IC50 | 625.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_d6fbe8afa9b3d11dea53d861435957d5.svg) | 2-Cyclopropyl-N-[(2s)-3,3-Dimethylbutan-2-Yl]-5h-Pyrrolo[2,3-B]pyrazine-7-Carboxamide | IC50 | 211.0 [1], 2460.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_e806d8abbe3334790c3ecbbe0736904e.svg) | N-[(2S)-3-Cyano-3-methylbutan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 214.0 [1], 1090.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_aee2f291c3a9c812df10b73058653898.svg) | 4-Amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_2463408b1d21b45a7e74f9aeba103628.svg) | 4-Amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-morpholin-4-ylethyl)thieno[3,2-c]pyridine-7-carboxamide | IC50 | 7300.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_48c9caa3b21b9c51fd529c197cfbfb11.svg) | 4-Amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-methoxyethyl)thieno[3,2-c]pyridine-7-carboxamide | IC50 | 4450.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_cf03725817fe84eaab92391db2d272ad.svg) | N-[(2R)-1-(3-Cyanopyrrolidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 553.0 [1], 5020.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_e01c1eb4eb9de5e4ba160c5722d9b7e9.svg) | Bms-911543 | IC50 | 990.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_4dca88aa08927c7f18d35895207aad16.svg) | Decernotinib | IC50 | 932.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_e63bb9bb954b02c8ddbeae716cd660ba.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone | IC50 | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_1540d7c33fc0027c045136048a59f206.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(4-fluorophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 420.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_0599086a0dec67f16c1baa4de0d8c5e3.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyrimidin-5-ylpyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_ad7ee2929e657d85130006a66bb8279a.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-fluoropyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_5090f2d8af25d137b88aeb10104f914c.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-methoxyphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_b64e758ab7ca36b9f108402d2c49dfc1.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-methylphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_64dcab9040930a84c51e3b0b14d33296.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-fluoropyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_4ca696224312be3581fd874dfd3a3c87.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-methoxyphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_074ce6955f769444a78df570ecfa0e8a.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-cyanophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_035a0b0eb2fa063435c0ed4fae2751a2.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-propan-2-yloxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_3cd53472fec7cbae2b7268f964c2f024.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-fluoropyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 270.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_028bead870efadbc503611896f2d45f5.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(4-cyanophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 66.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_d0e494951886fb1cc503d8276e35982b.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-cyanopyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 430.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_b1e51b0564d1726fe963856d93d3f7f2.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(1H-pyrazol-5-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 81.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_c83697b3afbce5c862e66be16cb5be76.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-4-ylpyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 56.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_636e1311b0c8ee33350f7eda2f6bbdff.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-fluorophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_6fdbe7a89389a8b7579db29c99436916.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(4-methoxyphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 170.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_17a49a4847f633d20d189ded95b4f047.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-fluorophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 630.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_60f37fdc6414ab118aa4614d79bc8b79.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-methylpyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 84.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_8bfca5f65a00e63cc92ae95b432e7984.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-chlorophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 780.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_9b710c0ff678e1f4a2173d35ea786bc1.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-methylphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 490.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_94615c9ba52de29f11dcf7b9714af6bd.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-ethoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_2c09a3cd6a3637e554b005c010e59e7b.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-methylpyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 75.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_310f44073ba1abf8da70331421ef1a0c.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(4-methylphenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_79c4378c372c503fae5dc004df8488f1.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-methoxypyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_af3a22655cfb92690f1f02d0707d291d.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(5-fluoropyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_14a04b5a53df783afc8b4ed933159692.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_1acc7186af0df39f0e01405bd5a12848.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-chlorophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_3f9c1d376bba0b2ccac73ff851aca4f8.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-cyanophenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_303caa089b849c30b86c01b3c160dbe5.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(2-methylpyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 55.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_295fd9dd49c5d7f79b2a1721211dcdae.svg) | 3-Amino-7-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]-5-[(2R)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one | IC50 | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_c97fbd184a627a144aed8a16e6b84fd9.svg) | 6-Anilino-4-[[3-(prop-2-enoylamino)phenyl]methylamino]pyridine-3-carboxamide | IC50 | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_a949592aa9c3b31d65caeff39894939c.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_9bdb4a923b09a8ee1a235446bb806b31.svg) | 2-[[(3R)-3-Acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 1750.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_f549b50c964e162f382838ca442ad09f.svg) | CID 67008828 | IC50 | 700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_33eb655092edfbecdf74a6d4f2e529cf.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_a6ad7a339757bbc138c18dc1ab15c8a2.svg) | 2-(6-Chloro-4-fluoro-1-methylindazol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 430.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_6e07e833521a13e34cd60fafcf7a2cba.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-methoxy-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 180.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_2d925e36359ba4d5182fe533add62574.svg) | 2-(6-Chloro-1-methylindazol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_54afdb4bb604678bbaec04602cf6e54a.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6,8-difluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 1290.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_9274e24ae268baaf341dc427edeb9d88.svg) | 2-(6-Chloro-1-methylindol-3-yl)-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_ae1dd9c7ad366fd5952b3439fca2a6a9.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-(6-fluoroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_3b14f58dfea1e60e66f9d2994171b8c7.svg) | 2-[[(3R)-3-Acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 7410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_239bc5726498b35e94e50d44b1ec2cea.svg) | 4-[(5-Hydroxy-2-adamantyl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide;hydrobromide | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_3e712172209b4a2e58b6acda5feb8827.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_b0fb235fd87fc65bba18417cc060002a.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-3-ylpyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak3-jak1_98c14c74cbe33331de76cb424b968ac3.svg) | 4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(4-methylpyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide | IC50 | 97.0 [1] |