![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_c0ff4e3dfe8e08fa2c67203215e88178.svg) | Baricitinib | IC50 | 15.0 [1], 28.7 [2], 29.0 [3] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_dbd3ed1b80e21bd85c700e0d0e711b46.svg) | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | IC50 | 189.0 [1], 2511.0 [2], 6450.0 [3] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | IC50 | 194.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_7c73239bc31d4875fd802deba6fd37c5.svg) | Filgotinib | IC50 | 436.0 [1], 1500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_e63bb9bb954b02c8ddbeae716cd660ba.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone | IC50 | 620.0 [1], 4200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_4dca88aa08927c7f18d35895207aad16.svg) | Decernotinib | IC50 | 1290.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_07a9a7dadcb6403aa1be2fdac16a78df.svg) | JAK3 covalent inhibitor-1 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_eb7450818c05c94eda590570345c4791.svg) | [(1S)-6-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_295fd9dd49c5d7f79b2a1721211dcdae.svg) | 3-Amino-7-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]-5-[(2R)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one | IC50 | 65.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_bf2b35c6d76d6144a7fb7a32dac28750.svg) | N-Butyl-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 645.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_0eaeba9e5864885cae7503a39bb0a451.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 750.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_2f30c8775c8a6a1073474f11db737917.svg) | 2-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide | IC50 | 628.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_c97fbd184a627a144aed8a16e6b84fd9.svg) | 6-Anilino-4-[[3-(prop-2-enoylamino)phenyl]methylamino]pyridine-3-carboxamide | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fe8511badacf4c854f8feb59b02cf456.svg) | 1-Cyclobutyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 199.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_39fa5e98c3bb0bd2d970b354f63ce5bd.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]cyclopropanesulfonamide | IC50 | 89.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_8ba6292a7e8ac2cb3f9a547636a0c314.svg) | 4-[[3-[[Cyclopropyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine | IC50 | 186.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fde41f0c548be4bd163a48da2fa41e75.svg) | 3-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide | IC50 | 601.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_d8832dc0d4fd0af17225211a66430e08.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide | IC50 | 256.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_8c951a0b4da5a6e1a3c3eb284d08c63e.svg) | 4-[[3-[[Ethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine | IC50 | 207.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_10daf403f326bec0adb031639d6668c2.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-phenylmethanesulfonamide | IC50 | 2480.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_c53226ad2db3aa54fa7f5aac9a5a183e.svg) | 4,4,4-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide | IC50 | 367.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fb184c2d2f8382c6eb437afe74f4d60a.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]piperidine-1-sulfonamide | IC50 | 1189.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_1af528dac00f2353c25c8aa703c87036.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide | IC50 | 930.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_10ad6af4f26f314b0e680410bf2166e1.svg) | N-(Cyclopropylmethyl)-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 148.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_d3ebb2f6e6c762cf62bb19403a339238.svg) | 4-Fluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide | IC50 | 107.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_0f2014d67a6a2c623e91ce402d7fb5e9.svg) | N-Methyl-N-[3-(pyrrolidin-1-ylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 211.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_c2db7ef893890cd1b6a7acd1f94ca146.svg) | 3,3,3-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide | IC50 | 692.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fc7b5373aaff32260cb9c3b9a3f842a4.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide | IC50 | 156.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_4a614d58d06ee92def9091e24bd87985.svg) | 1-N-Methyl-3-N-(propylsulfamoyl)-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine | IC50 | 331.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_7c893e20dbbd457827c4b453dfaf3685.svg) | 3-Cyano-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide | IC50 | 216.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_eefd2daedc96218d06c9fd9b53e72b7b.svg) | N-[3-(Ethylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 721.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_c4a4374d204bc28db1123832ff1bdd33.svg) | [(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 2815.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_85d96b2bc682df4a5f90ad0454faac58.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-4-methoxybenzenesulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_1b60ac6ea5f0778a919f423833f5ed81.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]methanesulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_9195481149e28f3c059402c50df16cb7.svg) | [(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 7843.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_da43a042876e39d35d5303eb92a52ec0.svg) | N-[3-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]prop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_4af1cc2dbf497d9ac1ed053062e03ff4.svg) | 3-Cyano-N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]benzenesulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_781d4e2efc2480346cf720a202895038.svg) | 2,2-Difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3H-1,4-benzoxazine-4-carbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fcdb27069d2defe5415ede7f1d899220.svg) | [(1S,3R)-3-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_a56f63e43eeb073efb5541d66a79c53c.svg) | N-Methyl-N-[3-(propylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_fca8200ace2315e4601ed26076e1ad68.svg) | N-[3-(Butylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 155.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_cd99100597ae4d6e489c71d0bd8c4c33.svg) | 2,2,2-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide | IC50 | 147.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_8b3dd9062da2c0a41390f8d651fc123d.svg) | 2-Methyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide | IC50 | 212.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_a47e00ea8e8694ff9c331447e54cc1c2.svg) | N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-(oxetan-3-yl)methanesulfonamide | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_5040f429615a8ddee53c066f46eebc4a.svg) | 1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 259.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_e3e4840532489dc454b06452e4406145.svg) | 3-N-(Cyclopropylmethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine | IC50 | 773.0 [1] |
![](https://images.aatbio.com/dataset/ic50/jak1-tyk2_a3a61a4ef703f7e1c848d600b08b4d11.svg) | 4-[[3-[[2-Cyanoethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine | IC50 | 141.0 [1] |