Isoprenylcysteine carboxyl methyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Cysmethynil	IC50	1500.0 [1], 1900.0 [2], 2089.3 [3], 2400.0 [4]
	4-[Naphthalen-2-yl(thiophen-2-yl)methylidene]oxane	IC50	1500.0 [1]
	4-[Naphthalen-2-yl(thiophen-2-yl)methylidene]oxane	Ki	1100.0 [1], 2900.0 [2]
	N-Ethyl-N-[(5-fluoro-1-octylindol-3-yl)methyl]ethanamine	IC50	4100.0 [1], 4420.0 [2]
	2-(5-(3-Ethoxyphenyl)-1-octyl-1H-indol-3-yl)acetamide	IC50	1300.0 [1], 2187.76 [2]
	2-(1-(3-(Trifluoromethyl)benzyl)-5-m-tolyl-1H-indol-3-yl)acetamide	IC50	2500.0 [1], 7943.28 [2]
	2-(5-m-Tolyl-1H-indol-3-yl)acetamide	IC50	33000.0 [1], 100000.0 [2]
	2-(1-Octyl-5-p-tolyl-1H-indol-3-yl)acetamide	IC50	1000.0 [1], 10715.19 [2]
	N-Ethyl-N-[[5-(3-methylphenyl)-1-octylindol-3-yl]methyl]ethanamine	IC50	700.0 [1], 2180.0 [2]
	Methyl 3-[(E)-3-methyl-5-[4-[2-(4-phenylphenyl)ethyl]triazol-1-yl]pent-2-enyl]sulfanylpropanoate	IC50	400.0 [1], 800.0 [2]
	N-[3-(2,2-Dimethyloxan-4-yl)-3-(2-methoxyphenyl)propyl]-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide	IC50	2300.0 [1], 3500.0 [2]
	Salirasib	IC50	25500.0 [1]
	N-Benzyl-N-(2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl)furan-2-carboxamide	IC50	120.0 [1]
	3-Methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyloxan-4-yl)ethyl]aniline	IC50	1.0 [1]
	5-[3-(Diethylaminomethyl)-1-octylindol-5-yl]pyrimidin-2-amine	IC50	860.0 [1]
	Aplysamine 6	IC50	14000.0 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-octylindol-3-yl]acetamide	IC50	7079.46 [1]
	2-[1-[(4-Tert-butylphenyl)methyl]-5-(3-ethoxyphenyl)indol-3-yl]acetamide	IC50	12589.25 [1]
	2-[1-[(4-Tert-butylphenyl)methyl]-5-(3-fluorophenyl)indol-3-yl]acetamide	IC50	5011.87 [1]
	2-[5-(3-Fluorophenyl)-1-octylindol-3-yl]acetamide	IC50	2398.83 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-[(4-tert-butylphenyl)methyl]indol-3-yl]acetamide	IC50	29512.09 [1]
	2-[5-(2-Methoxyphenyl)-1-octylindol-3-yl]acetamide	IC50	6025.6 [1]
	2-[1-[(4-Tert-butylphenyl)methyl]-5-(3-chloro-4-fluorophenyl)indol-3-yl]acetamide	IC50	7585.78 [1]
	4-[Phenyl(thiophen-2-yl)methylidene]oxane	IC50	50000.0 [1]
	7-[Oxan-4-yl(thiophen-2-yl)methyl]quinolin-8-ol	IC50	14000.0 [1]
	2-[Oxan-4-yl(thiophen-2-yl)methyl]naphthalen-1-ol	IC50	18000.0 [1]
	2-[Oxan-4-ylidene(thiophen-2-yl)methyl]naphthalen-1-ol	IC50	7700.0 [1]
	Naphthalen-2-yl-(oxan-4-yl)-thiophen-2-ylmethanol	IC50	2200.0 [1]
	4-[Naphthalen-2-yl(thiophen-2-yl)methyl]piperidine	IC50	50000.0 [1]
	4-[Naphthalen-2-yl(phenyl)methylidene]oxane	IC50	50000.0 [1]
	4-(Naphthalen-2-ylmethyl)oxane	IC50	50000.0 [1]
	Oxan-4-yl-phenyl-thiophen-2-ylmethanol	IC50	50000.0 [1]
	1-Methyl-4-[naphthalen-2-yl(thiophen-2-yl)methyl]piperidine	IC50	50000.0 [1]
	Benzyl (2R)-2-[[4-[(1H-imidazol-5-ylmethylamino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoate	IC50	500.0 [1]
	2-[N-[2-(2,2-Dimethyl-4-phenyloxan-4-yl)ethyl]anilino]-1-(furan-2-yl)ethanone	IC50	310.0 [1]
	(2R)-3-[(2Z)-6-Methyl-3-[2-(4-phenylphenyl)ethyl]hepta-2,5-dienyl]sulfanyl-2-[(2-phenoxybenzoyl)amino]propanoic acid	IC50	2500.0 [1]
	(2R)-2-(Adamantane-1-carbonylamino)-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	12400.0 [1]
	(2R)-2-[(2-Phenoxybenzoyl)amino]-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	6200.0 [1]
	(2R)-2-[(3,5-Dinitrobenzoyl)amino]-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	14300.0 [1]
	(2R)-2-[[5-(4-Methoxyphenyl)furan-2-carbonyl]amino]-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	17400.0 [1]
	(2R)-2-(1-Benzothiophene-2-carbonylamino)-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	20300.0 [1]
	(2R)-2-[(4-Nitrobenzoyl)amino]-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	16600.0 [1]
	(2R)-2-[(3,5-Dichlorobenzoyl)amino]-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid	IC50	23000.0 [1]
	4-[[(2E)-3-(3,5-Dibromo-4-methoxyphenyl)-2-hydroxyiminopropanoyl]amino]-N-[4-[3-[[(2E)-3-(3,5-dibromo-4-methoxyphenyl)-2-hydroxyiminopropanoyl]amino]propyl-methylamino]butyl]-N-methylbutanamide	IC50	1900.0 [1]
	2-[5-(3-Methylphenyl)-1-(2-methylpropyl)-1H-indol-3-yl]acetamide	IC50	15848.93 [1]
	2-[1-(Cyclopropylmethyl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide	IC50	9120.11 [1]
	2-[1-Hexyl-5-(3-methylphenyl)-1H-indol-3-yl]acetamide	IC50	7413.1 [1]
	2-[1-Benzyl-5-(3-methylphenyl)-1H-indol-3-yl]acetamide	IC50	6456.54 [1]
	2-{5-(3-Methylphenyl)-1-[(naphthalen-2-yl)methyl]-1H-indol-3-yl}acetamide	IC50	17378.01 [1]
	2-[5-(3-Methylphenyl)-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Fluorophenyl)-1-(2-methylpropyl)indol-3-yl]acetamide	IC50	3715.35 [1]
	2-[1-(Cyclopropylmethyl)-5-(3-fluorophenyl)indol-3-yl]acetamide	IC50	14791.08 [1]
	2-[5-(3-Fluorophenyl)-1-hexylindol-3-yl]acetamide	IC50	12882.5 [1]
	2-[1-Benzyl-5-(3-fluorophenyl)indol-3-yl]acetamide	IC50	10715.19 [1]
	2-[5-(3-Fluorophenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	5754.4 [1]
	2-[5-(3-Fluorophenyl)-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Fluorophenyl)-1H-indol-3-yl]acetamide	IC50	39810.72 [1]
	2-[5-(4-Methylphenyl)-1-(2-methylpropyl)indol-3-yl]acetamide	IC50	9772.37 [1]
	2-[1-(Cyclopropylmethyl)-5-(4-methylphenyl)indol-3-yl]acetamide	IC50	11220.18 [1]
	2-[1-Hexyl-5-(4-methylphenyl)indol-3-yl]acetamide	IC50	7413.1 [1]
	2-[5-(4-Methylphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	6456.54 [1]
	2-[5-(4-Methylphenyl)-1-(naphthalen-2-ylmethyl)indol-3-yl]acetamide	IC50	19498.45 [1]
	2-[5-(4-Methylphenyl)-1H-indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Ethoxyphenyl)-1-(2-methylpropyl)indol-3-yl]acetamide	IC50	6165.95 [1]
	2-[1-(Cyclopropylmethyl)-5-(3-ethoxyphenyl)indol-3-yl]acetamide	IC50	6456.54 [1]
	2-[5-(3-Ethoxyphenyl)-1-hexylindol-3-yl]acetamide	IC50	6606.93 [1]
	2-[1-Benzyl-5-(3-ethoxyphenyl)indol-3-yl]acetamide	IC50	7762.47 [1]
	2-[5-(3-Ethoxyphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	4897.79 [1]
	2-[5-(3-Ethoxyphenyl)-1-(naphthalen-2-ylmethyl)indol-3-yl]acetamide	IC50	8317.64 [1]
	2-[5-(3-Ethoxyphenyl)-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Ethoxyphenyl)-1H-indol-3-yl]acetamide	IC50	100000.0 [1]
	1-(2-Methylpropyl)-5-(2-methoxyphenyl)-1H-indole-3-acetamide	IC50	21877.62 [1]
	2-[1-(Cyclopropylmethyl)-5-(2-methoxyphenyl)indol-3-yl]acetamide	IC50	16218.1 [1]
	2-[1-Hexyl-5-(2-methoxyphenyl)indol-3-yl]acetamide	IC50	8128.31 [1]
	2-[1-Benzyl-5-(2-methoxyphenyl)indol-3-yl]acetamide	IC50	13182.57 [1]
	2-[5-(2-Methoxyphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	6165.95 [1]
	2-[5-(2-Methoxyphenyl)-1-(naphthalen-2-ylmethyl)indol-3-yl]acetamide	IC50	29512.09 [1]
	2-[5-(2-Methoxyphenyl)-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(2-Methoxyphenyl)-1H-indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-(2-methylpropyl)indol-3-yl]acetamide	IC50	9120.11 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-(cyclopropylmethyl)indol-3-yl]acetamide	IC50	5754.4 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-hexylindol-3-yl]acetamide	IC50	9332.54 [1]
	2-[1-Benzyl-5-(3-chloro-4-fluorophenyl)indol-3-yl]acetamide	IC50	10471.29 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	6165.95 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-(3-Chloro-4-fluorophenyl)-1H-indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-(2-methylpropyl)indol-3-yl]acetamide	IC50	25703.96 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-(cyclopropylmethyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-octylindol-3-yl]acetamide	IC50	37153.52 [1]
	2-[1-Benzyl-5-[3,5-bis(trifluoromethyl)phenyl]indol-3-yl]acetamide	IC50	33113.11 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-(naphthalen-2-ylmethyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1-(3-phenoxypropyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[5-[3,5-Bis(trifluoromethyl)phenyl]-1H-indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[1-(2-Methylpropyl)-5-(4-phenoxyphenyl)indol-3-yl]acetamide	IC50	5888.44 [1]
	2-[1-(Cyclopropylmethyl)-5-(4-phenoxyphenyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[1-Hexyl-5-(4-phenoxyphenyl)indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[1-Benzyl-5-(4-phenoxyphenyl)indol-3-yl]acetamide	IC50	9332.54 [1]
	2-[5-(4-Phenoxyphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indol-3-yl]acetamide	IC50	100000.0 [1]
	2-[1-(Naphthalen-2-ylmethyl)-5-(4-phenoxyphenyl)indol-3-yl]acetamide	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Isoprenylcysteine carboxyl methyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/isoprenylcysteine-carboxyl-methyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Isoprenylcysteine carboxyl methyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/isoprenylcysteine-carboxyl-methyltransferase-inhibitors-ic50-ki.
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