![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_3019aa8d93b5ff33a58d354b1cb7370a.svg) | (4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one | IC50 | 3800.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_4e52777e9c509e9e4d57e88b70ec516b.svg) | 4-N-[2-(1,1-Difluoroethyl)pyridin-4-yl]-2-N-propan-2-yl-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_4adc982c18affb73bbfb74fbcd3cc509.svg) | 3-Fluoro-5-[[4-[(2-hydroxy-2-methylpropyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]benzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_a9e02dfd38d5fac4f143b13db3483561.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0fd0cbc9c7cf27fcc6d7151895453333.svg) | 1-[[4-(3,5-Difluoroanilino)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]-2-methylpropan-2-ol | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0e4916a35783ca31b93b0ec31be90ee7.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-[(3,3-difluorocyclopentyl)amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_12a78c09a6d17184455e24859776d815.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-[[(1R)-1-cyclopropylethyl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_bb3817047a84337133907dd3541a9269.svg) | 3-[[4-(Tert-butylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]benzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_1929ca7f0aca276bbddae0030681468c.svg) | 3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-2,2-dimethylpropanenitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2cc5f72969456dd588f02584d08ba8f5.svg) | 3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_c6d16476cc11f14dec0a28bff16d0785.svg) | 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(1-cyclopropylpropyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_348e0c03b907f1fb7f647f273409a8ef.svg) | 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(3,3-difluorocyclopentyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_dbb3bc4a793efd26c901f631d7aaf804.svg) | 2-N,4-N-Bis[(1R)-1-cyclopropylethyl]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_c139680eddce6c75a6222aa033e5175d.svg) | 4-N-(3,3-Difluorocyclopentyl)-2-N-[3-(4-fluorophenyl)cyclobutyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_69fe292daa833852fbb1e872bc1a6458.svg) | 4-N-[(1R)-1-Cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_cd371787679b6f45766bfb17f93a84c2.svg) | 2-N-[(1R)-1-Cyclopropylethyl]-4-N-(2-phenoxyethyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_ac3f34ef1cdde362507a0d347cbf8b7f.svg) | 2-N-Tert-butyl-4-N-[2-(1,1-difluoroethyl)pyridin-4-yl]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_cb619d4b08afd29d3c69742097ba0ce6.svg) | 1-[[4-(3-Chloroanilino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-2-methylpropan-2-ol | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_e6a02d174d9b3ecae7d93117d21b33ef.svg) | 4-N-[(1R)-1-Cyclopropylethyl]-2-N-(dicyclopropylmethyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0b6b3ddd09034dc7fcafa30616153213.svg) | 3-[[4-(Tert-butylamino)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_69d834911a5ccd601e5a68d540b0d5c6.svg) | Vorasidenib | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2b0df68585623883896475c6e72f8c09.svg) | 6-(6-Chloropyridin-2-yl)-4-N-[(2R)-1,1,1-trifluoropropan-2-yl]-2-N-[(2S)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_827f1d775305e0b41e14ee1b5d1ce63d.svg) | (2S)-N-[(1S)-5-Chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-1-(4-cyanopyridin-2-yl)-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_affee829c0444bb3b1b0a81e26197340.svg) | (2S)-1-(4-Cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-5-oxopyrrolidine-2-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_cb7266b27a629f5777dcbc3a34af9570.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_835393578e7eb9c5a7cad2d146f31479.svg) | 2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-(3,6-difluoropyridin-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_d9927c359a12babbe431aa7e7f3bb209.svg) | 1-[4-[[4-[(2,2-Difluorospiro[3.3]heptan-6-yl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_e423f925184d4bf7536c5227bf5799e4.svg) | 6-(6-Chloropyridin-2-yl)-2-N-(3,3-difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_3e151fc88170c433f093099484c02c82.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-(3,5-difluorophenyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_f3198335153b06b6a949563ad7d980a8.svg) | 6-(6-Chloropyridin-2-yl)-4-N-(cyclopropylmethyl)-2-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2816bd77785d854b61c295f263910e2f.svg) | 2-N-(4,4-Difluorocyclohexyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_b9de123931a9ee670caad12cf56c604f.svg) | 2-N-(4,4-Difluorocyclohexyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_e67902f8cdfd43025da0215325b162e6.svg) | 4-N-(Cyclopropylmethyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-2-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_c3d2075f6f25deac8ba91c39d9060ace.svg) | 2-N-(3,3-Difluorocyclobutyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_1fc3340b440542f1d5675c4c79c380f0.svg) | 1-[4-[[4-[(2-Hydroxy-2-methylpropyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_befa03775353b868aa49af9d3ac90620.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_cdee5daa1629df49b829c6f37ffab6d1.svg) | 2-N-(3,3-Difluorocyclopentyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_27932cec41d218f806db0bdb2a93f5ae.svg) | 4-N-[(2,2-Difluorocyclopropyl)methyl]-2-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2500649a6207ab1a8398351b0dadd885.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-4-N-[2-(1,1-difluoroethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_5b71ef5d0ec418cebe5905c09355114c.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_f27d93554c50a05b4b1aaba3c7ac4ca4.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[2-(trifluoromethyl)pyrimidin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_c665ec7181539639dc51eacefc6e9372.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_92577a346f17191d9df601ed1269e1ee.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_b3180ed797eb7706a3c79de4cf08e6e7.svg) | 2-N-(2,2-Difluorospiro[3.3]heptan-6-yl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_3d795784f41922f5933988fcc6a110b9.svg) | 3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_3fa490ed4f08ab04ec782c9ed90cc5ac.svg) | 4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_4a96e184ea5ce784a5b91e995064b7a0.svg) | 6-[6-(Trifluoromethyl)pyrazin-2-yl]-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_b81230c66a92e3cc88b6f1ebff3b4536.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-[5-(trifluoromethyl)pyridin-3-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_a75556de185264836692bb2da6d64f5d.svg) | 1-[4-[[4-[6-(1,1-Difluoroethyl)pyridin-2-yl]-6-[[(2S)-1,1,1-trifluoropropan-2-yl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0e2e431ef8c96ff59982eed439aae050.svg) | 2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_27a34c9b716b9f4bb0056ad498d43139.svg) | 1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[2-(trifluoromethyl)pyrimidin-4-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_563c67fb32f10b4fdf4ee92b36f55986.svg) | 4-N-[2-(Trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_8e2af67d69914f4a53cd4bf6cb497918.svg) | 4-N-[(1S)-3,3-Difluorocyclopentyl]-2-N-[(1R)-3,3-difluorocyclopentyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0a81ae94d5b9c8b82bcb942945f1983f.svg) | 6-(6-Amino-3-fluoropyridin-2-yl)-2-N-(4,4-difluorocyclohexyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_d588f4560e42d1589f5c7ff3d83acad6.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[2-(trifluoromethyl)pyrimidin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_e5c5720889db5d640a67c5559714c406.svg) | 4-N-[2-(4-Chlorophenyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_41304ef05748b164ada2a85e61469f18.svg) | 2-N-(4,4-Difluorocyclohexyl)-4-N-[2-(1,1-difluoroethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_76f03089afe8e1780bb0bc6e0db49f4d.svg) | 1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_b42cb778f11acd757c2d50ea57aabf85.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_7fd01f1658ee0532ddb9e71ebbbcc49e.svg) | 1-[4-[[4-[(4,4-Difluorocyclohexyl)amino]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0c2eef6c4ee2bcc019aba218b3c24445.svg) | 3-[[4-[6-(1,1-Difluoroethyl)pyridin-2-yl]-6-[(2-hydroxy-2-methylpropyl)amino]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_275839ebf546d59f372d4cf2c0416dd9.svg) | 1-[4-[[4-[6-(1,1-Difluoroethyl)pyridin-2-yl]-6-[[(2R)-1,1,1-trifluoropropan-2-yl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_d51181676141ce9efd485acf733b3d23.svg) | 4-[4-[[4-[6-(Trifluoromethyl)pyridin-2-yl]-6-[[(2R)-1,1,1-trifluoropropan-2-yl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]benzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_73a2bc32df9823d7e305f80962f64c38.svg) | 4-[[4-[(2-Hydroxy-2-methylpropyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_dc311c663b8509402836b7a47c480d4a.svg) | 2-N-(3,3-Difluorocyclobutyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_fc1ae329f86da85064abee37d3670cb7.svg) | 3-[[4-(Cyclopropylmethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_1a22ecb11a0fb178109f3b15361aeb14.svg) | 3-[4,6-Bis[[(1R)-1-cyclopropylethyl]amino]-1,3,5-triazin-2-yl]phenol | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_cdfa2842f7f32ef8f4711b056d999c9e.svg) | 1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_bdd052ef4770988b53a757fb053dd5dd.svg) | 2-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]propanenitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_4097e773df78b00d3f7ea13f5e448e84.svg) | 4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0e0299088a6febc3b51a3483f63c8904.svg) | 4-N-[2-(4-Fluorophenyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_bcdd1413abdc695ffbcef57315c5e7ec.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-(2,2,2-trifluoroethylamino)-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_134fbb7469bdd22adb93e6ce7f9ce65e.svg) | 4-N-(2-Phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_e3a8761e9ea572b608158057cf4ca0d8.svg) | 1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(1,1-difluoroethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_5aab1628ddc90273e7905dd41a50f0f7.svg) | 3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_b1215c342e33d23ecd90037dcf0f232d.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_6ef1ea4b46ce6b14ad8d6d0f77cb9860.svg) | 6-(6-Amino-3-fluoropyridin-2-yl)-2-N-(3,3-difluorocyclopentyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_5a425fa7e012249aaf2c9ad9a9dd66c3.svg) | 3-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_84d3f1a5c1d4c192f98188dc90727893.svg) | 1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2c67011ba9de1cd7e10dacf812b7c7c7.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_bb7145abae1e2d1878800bac6dfcc03d.svg) | 4-N-[(3,3-Difluorocyclobutyl)methyl]-2-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_07d7a77911a0dace41aa1e2949fa1aba.svg) | 3-[[4-[[(1R)-1-Cyclopropylethyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_853c893c4e041d84c574bb71221ed338.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2168aaac340d363441a3a4af707008fc.svg) | 6-(6-Amino-3-fluoropyridin-2-yl)-2-N,4-N-bis(4,4-difluorocyclohexyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_bf50157b5f2bdb6f5ac7154f540bd541.svg) | 1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0f0d677e0448a436cea39b9ecb5dd640.svg) | 1-[[4-[6-(1,1-Difluoroethyl)pyridin-2-yl]-6-[3-fluoro-5-(trifluoromethyl)anilino]-1,3,5-triazin-2-yl]amino]-2-methylpropan-2-ol | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_3e8d4051677bd01483246b5e7718902a.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-4-N-[2-(1,1-difluoroethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_0e9ccb4409f1ecd254c305670c8737de.svg) | 4-[[4-(Tert-butylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_fac68a728d563d32657ce68a9197f897.svg) | 1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_5bd202acb53588e8b87917cc119da95f.svg) | 1-[4-[[4-[(4,4-Difluorocyclohexyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_9b96a66cf973c0987bb986175700037a.svg) | 1-[4-[[4-(2,2,2-Trifluoroethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_c732744e0ce072ad85906a8df6cd8f07.svg) | 2-N-(2,2-Difluorospiro[3.3]heptan-6-yl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_6a032aa74a8861097e09593fce2bc8ba.svg) | 1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_092157f9987365eb8685a08f8d322c20.svg) | 6-(6-Chloropyrazin-2-yl)-2-N-(3,3-difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_addc60d32730b3d5e2a61a54d751b26a.svg) | 6-(6-Chloropyrazin-2-yl)-2-N-(3,3-difluorocyclopentyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_09ebff1e525313a13a3928ee48f6ee70.svg) | 3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-3-methylbutanenitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_2437f9eb5ed5a2f2211994ebf36bb110.svg) | 1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_12b3c47cf77adc62f486efd024336221.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[2-(trifluoromethyl)-1,3-thiazol-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_5db2c97037b85c20d223a9691588748e.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(trifluoromethoxy)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-mitochondrial_ceea4752a7809555c46d15a7a3e000a4.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[6-(difluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |