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Isocitrate dehydrogenase [NADP] cytoplasmic Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-2-(2-Chlorophenyl)-2-[[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-(5-fluoropyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)acetamideIC5012.0 [1]
6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-OneIC50120.0 [1], 190.0 [2], 30000.0 [3]
6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-OneKi190.0 [1]
CID 56645356IC5080.0 [1]
VorasidenibIC5050.0 [1]
(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-oneIC5024.0 [1]
4-N-(3,3-Difluorocyclopentyl)-2-N-[3-(4-fluorophenyl)cyclobutyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-Hydroxy-6-(4-Hydroxybenzyl)-4-Methylpyridin-2(1h)-OneIC509700.0 [1]
1-Hydroxy-6-(4-Hydroxybenzyl)-4-Methylpyridin-2(1h)-OneKi280.0 [1]
6-Benzyl-1-hydroxypyridin-2(1H)-oneIC508500.0 [1]
6-Benzyl-1-hydroxypyridin-2(1H)-oneKi5900.0 [1]
5-Benzyl-1-hydroxy-2H-pyridin-2-olIC502400.0 [1]
5-Benzyl-1-hydroxy-2H-pyridin-2-olKi8200.0 [1]
1-[4-[[4-[(4,4-Difluorocyclohexyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
6-Benzyl-1-hydroxy-4-propan-2-ylpyridin-2-oneKi9500.0 [1]
6-(6-Chloropyridin-2-yl)-4-N-[(2R)-1,1,1-trifluoropropan-2-yl]-2-N-[(2S)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-[4-[[4-[(2,2-Difluorospiro[3.3]heptan-6-yl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
6-(6-Chloropyridin-2-yl)-2-N-(3,3-difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(3,3-Difluorocyclopentyl)-4-N-(3,5-difluorophenyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(4,4-Difluorocyclohexyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(3,3-Difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-[(1S)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-[4-[[4-(6-Chloropyridin-2-yl)-6-[(3,3-difluorocyclopentyl)amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrileIC5050.0 [1]
2-N-[(1R)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-3-methylbutanenitrileIC5050.0 [1]
1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[6-(difluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(1-cyclopropylpropyl)-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(3,3-difluorocyclopentyl)-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(4,4-Difluorocyclohexyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis[(1R)-1-cyclopropylethyl]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
4-N,6-N-Bis[(1R)-1-cyclopropylethyl]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrimidine-4,6-diamineIC50100.0 [1]
2-N,4-N-Bis[(1R)-3,3-difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
4-N-[(1R)-1-Cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis[3-(4-fluorophenyl)cyclobutyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC50100.0 [1]
6-(6-Chloropyridin-2-yl)-2-N,4-N-bis[(2S)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
4-N-(3,3-Difluorocyclopentyl)-2-N-(2,2-difluorospiro[3.3]heptan-6-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
6-(6-Chloropyrazin-2-yl)-2-N,4-N-bis(4,4-difluorocyclohexyl)-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(3,3-Difluorocyclobutyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[6-(1,1-difluoroethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis[(1R)-1-cyclopropylethyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
1-[4-[[4-[6-(Trifluoromethyl)pyridin-2-yl]-6-(1,1,1-trifluoropropan-2-ylamino)-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(difluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
N-Cyclopentyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamideIC5050.0 [1], 90.0 [2], 390.0 [3], 580.0 [4], 7700.0 [5]
N-Cyclohexyl-2-(3-fluoro-N-[2-(1H-indol-3-yl)acetyl]anilino)-2-(2-methylphenyl)acetamideIC5030.0 [1], 60.0 [2], 90.0 [3], 360.0 [4], 6300.0 [5]
N-Cyclohexyl-2-(3-fluoro-N-[2-(2-methylbenzimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamideIC5040.0 [1], 80.0 [2], 110.0 [3], 240.0 [4], 100000.0 [5]
N-Cyclohexyl-2-(3-fluoro-N-(2-pyridin-4-ylacetyl)anilino)-2-(2-methylphenyl)acetamideIC5050.0 [1], 210.0 [2], 260.0 [3], 19300.0 [4]
N-Cyclohexyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamideIC5030.0 [1], 50.0 [2], 150.0 [3], 190.0 [4], 2900.0 [5]
N-Cyclohexyl-2-(3-fluoro-N-[2-(1,3-thiazol-4-yl)acetyl]anilino)-2-(2-methylphenyl)acetamideIC5060.0 [1], 100.0 [2], 220.0 [3], 290.0 [4], 19700.0 [5]
N-Cyclohexyl-2-(3-fluoro-N-(2-indol-1-ylacetyl)anilino)-2-(2-methylphenyl)acetamideIC5040.0 [1], 70.0 [2], 170.0 [3], 370.0 [4], 100000.0 [5]
2-N-(3,3-Difluorocyclopentyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-(3,6-difluoropyridin-2-yl)-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
6-(6-Chloropyridin-2-yl)-4-N-(cyclopropylmethyl)-2-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 1000.0 [2]
2-N-(4,4-Difluorocyclohexyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
3-Fluoro-5-[[4-[(2-hydroxy-2-methylpropyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]benzonitrileIC5050.0 [1], 100.0 [2], 1000.0 [3]
2-N-(3,3-Difluorocyclobutyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
2-N-[(1R)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
2-N-(3,3-Difluorocyclopentyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrileIC5050.0 [1]
4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrileIC5050.0 [1], 100.0 [2]
4-N-[2-(Trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
4-N-[(1S)-3,3-Difluorocyclopentyl]-2-N-[(1R)-3,3-difluorocyclopentyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1]
6-(6-Amino-3-fluoropyridin-2-yl)-2-N-(4,4-difluorocyclohexyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
1-[4-[[4-(6-Chloropyridin-2-yl)-6-[[(1R)-1-cyclopropylethyl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
3-[[4-(Cyclopropylmethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrileIC5050.0 [1], 100.0 [2]
2-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]propanenitrileIC5050.0 [1], 100.0 [2]
1-[4-[[4-(6-Chloropyridin-2-yl)-6-(2,2,2-trifluoroethylamino)-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1], 100.0 [2]
3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrileIC5050.0 [1], 100.0 [2]
3-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrileIC5050.0 [1]
1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1]
4-N-[(3,3-Difluorocyclobutyl)methyl]-2-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2], 1000.0 [3]
3-[[4-[[(1R)-1-Cyclopropylethyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrileIC5050.0 [1], 100.0 [2]
1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1], 100.0 [2], 1000.0 [3]
6-(6-Amino-3-fluoropyridin-2-yl)-2-N,4-N-bis(4,4-difluorocyclohexyl)-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2], 1000.0 [3]
4-[[4-(Tert-butylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrileIC5050.0 [1]
1-[4-[[4-(2,2,2-Trifluoroethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrileIC5050.0 [1], 100.0 [2]
3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrileIC5050.0 [1], 100.0 [2]
2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[2-(trifluoromethyl)-1,3-thiazol-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
4-N-(3,3-Difluorocyclopentyl)-2-N-(1-pyrimidin-2-ylpyrrolidin-3-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2], 1000.0 [3]
2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[6-(trifluoromethoxy)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2], 1000.0 [3]
4-N-(3,3-Difluorocyclopentyl)-2-N-(1-pyridin-2-ylpyrrolidin-3-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[2-(trifluoromethyl)pyrimidin-4-yl]-1,3,5-triazine-2,4-diamineIC5050.0 [1], 100.0 [2]
6-(6-Chloropyrazin-2-yl)-2-N,4-N-bis(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamineIC5050.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Isocitrate dehydrogenase [NADP] cytoplasmic Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/isocitrate-dehydrogenase-nadp-cytoplasmic-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Isocitrate dehydrogenase [NADP] cytoplasmic Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/isocitrate-dehydrogenase-nadp-cytoplasmic-inhibitors-ic50-ki.
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