![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_39cabc08c9fe38c3b0f9ae22155288c6.svg) | (2S)-2-(2-Chlorophenyl)-2-[[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-(5-fluoropyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)acetamide | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0b33445e9029d3141c92f2db32c81a84.svg) | 6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-One | IC50 | 120.0 [1], 190.0 [2], 30000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0b33445e9029d3141c92f2db32c81a84.svg) | 6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-One | Ki | 190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_ae570ed8e9ade0ea359dd1414493727a.svg) | CID 56645356 | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_69d834911a5ccd601e5a68d540b0d5c6.svg) | Vorasidenib | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_3019aa8d93b5ff33a58d354b1cb7370a.svg) | (4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c139680eddce6c75a6222aa033e5175d.svg) | 4-N-(3,3-Difluorocyclopentyl)-2-N-[3-(4-fluorophenyl)cyclobutyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c75f6125db237a74c1605750bf3c1e08.svg) | 1-Hydroxy-6-(4-Hydroxybenzyl)-4-Methylpyridin-2(1h)-One | IC50 | 9700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c75f6125db237a74c1605750bf3c1e08.svg) | 1-Hydroxy-6-(4-Hydroxybenzyl)-4-Methylpyridin-2(1h)-One | Ki | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_de47cf2ece34e21006b136f64f3d9b78.svg) | 6-Benzyl-1-hydroxypyridin-2(1H)-one | IC50 | 8500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_de47cf2ece34e21006b136f64f3d9b78.svg) | 6-Benzyl-1-hydroxypyridin-2(1H)-one | Ki | 5900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_e2d90fab45d268e272d02af1afc5e0ee.svg) | 5-Benzyl-1-hydroxy-2H-pyridin-2-ol | IC50 | 2400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_e2d90fab45d268e272d02af1afc5e0ee.svg) | 5-Benzyl-1-hydroxy-2H-pyridin-2-ol | Ki | 8200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_5bd202acb53588e8b87917cc119da95f.svg) | 1-[4-[[4-[(4,4-Difluorocyclohexyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c142b4592bbbc8386f918b3265f2fa0e.svg) | 6-Benzyl-1-hydroxy-4-propan-2-ylpyridin-2-one | Ki | 9500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2b0df68585623883896475c6e72f8c09.svg) | 6-(6-Chloropyridin-2-yl)-4-N-[(2R)-1,1,1-trifluoropropan-2-yl]-2-N-[(2S)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_d9927c359a12babbe431aa7e7f3bb209.svg) | 1-[4-[[4-[(2,2-Difluorospiro[3.3]heptan-6-yl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_e423f925184d4bf7536c5227bf5799e4.svg) | 6-(6-Chloropyridin-2-yl)-2-N-(3,3-difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_3e151fc88170c433f093099484c02c82.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-(3,5-difluorophenyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b9de123931a9ee670caad12cf56c604f.svg) | 2-N-(4,4-Difluorocyclohexyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_a9e02dfd38d5fac4f143b13db3483561.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_5b71ef5d0ec418cebe5905c09355114c.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c665ec7181539639dc51eacefc6e9372.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_92577a346f17191d9df601ed1269e1ee.svg) | 2-N-[(1S)-3,3-Difluorocyclopentyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0e2e431ef8c96ff59982eed439aae050.svg) | 2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0e4916a35783ca31b93b0ec31be90ee7.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-[(3,3-difluorocyclopentyl)amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_76f03089afe8e1780bb0bc6e0db49f4d.svg) | 1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b42cb778f11acd757c2d50ea57aabf85.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_4097e773df78b00d3f7ea13f5e448e84.svg) | 4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b1215c342e33d23ecd90037dcf0f232d.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_84d3f1a5c1d4c192f98188dc90727893.svg) | 1-[4-[[4-[[(1R)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_fac68a728d563d32657ce68a9197f897.svg) | 1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_6a032aa74a8861097e09593fce2bc8ba.svg) | 1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_09ebff1e525313a13a3928ee48f6ee70.svg) | 3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-3-methylbutanenitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2437f9eb5ed5a2f2211994ebf36bb110.svg) | 1-[4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_ceea4752a7809555c46d15a7a3e000a4.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[6-(difluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c6d16476cc11f14dec0a28bff16d0785.svg) | 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(1-cyclopropylpropyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_47db7c9228dabd62b21d8bedbd43aec1.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_348e0c03b907f1fb7f647f273409a8ef.svg) | 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis(3,3-difluorocyclopentyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_4c3f44b4df44f03c967ab70fb7eb6fe4.svg) | 2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_3f7596c69191f0c7647dc41aea2e25a0.svg) | 2-N-(4,4-Difluorocyclohexyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_dbb3bc4a793efd26c901f631d7aaf804.svg) | 2-N,4-N-Bis[(1R)-1-cyclopropylethyl]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_f4367b660bf84b43dcd28deec08a85ce.svg) | 4-N,6-N-Bis[(1R)-1-cyclopropylethyl]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrimidine-4,6-diamine | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c30aa08386dd05a1b5db256e6901ea72.svg) | 2-N,4-N-Bis[(1R)-3,3-difluorocyclopentyl]-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_69fe292daa833852fbb1e872bc1a6458.svg) | 4-N-[(1R)-1-Cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_79ff3c2e09d87dac59b1a92459cda624.svg) | 2-N,4-N-Bis[3-(4-fluorophenyl)cyclobutyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_ad19493566e33ba4cac005be837ab3a5.svg) | 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis[(2S)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_eb2cdde808c0e0a28befda8da24948f5.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b0f35aeaed6ffe0d37473b5e85914656.svg) | 4-N-(3,3-Difluorocyclopentyl)-2-N-(2,2-difluorospiro[3.3]heptan-6-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_82c8b9f47e72a2627557a48d7c522ebe.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_dcfde664dd83b995bd234b9f8b9e97f2.svg) | 6-(6-Chloropyrazin-2-yl)-2-N,4-N-bis(4,4-difluorocyclohexyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_dffa8feacf66fc91667101cba8c8cda3.svg) | 2-N-(3,3-Difluorocyclobutyl)-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_d73692fcbe50b36dccd26c1ebb5ef7d1.svg) | 1-[4-[[4-[[(1S)-3,3-Difluorocyclopentyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_62449f079437885557b3e0af796baf45.svg) | 2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[6-(1,1-difluoroethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_a08c31612c20ef4df7bfdea76f451673.svg) | 2-N,4-N-Bis[(1R)-1-cyclopropylethyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_ab1b14171747c62c79c4b556bb0dd19f.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_9977a2396f6a1337873da3ec0b9166af.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(trifluoromethyl)pyrazin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_7c27fae7e8c22afdffca12bcc4ae82cf.svg) | 1-[4-[[4-[6-(Trifluoromethyl)pyridin-2-yl]-6-(1,1,1-trifluoropropan-2-ylamino)-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_ea7e3a891ed38a1a686ece0f0808e453.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[6-(difluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_f4e98c4cf0c0f07174117ce4dcf550e8.svg) | N-Cyclopentyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamide | IC50 | 50.0 [1], 90.0 [2], 390.0 [3], 580.0 [4], 7700.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_a0305957045fb1de8347858624ef7271.svg) | N-Cyclohexyl-2-(3-fluoro-N-[2-(1H-indol-3-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide | IC50 | 30.0 [1], 60.0 [2], 90.0 [3], 360.0 [4], 6300.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_da517dd316c963b893b7598ba585a6a9.svg) | N-Cyclohexyl-2-(3-fluoro-N-[2-(2-methylbenzimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide | IC50 | 40.0 [1], 80.0 [2], 110.0 [3], 240.0 [4], 100000.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c21d26bab79e75a8c138f475095ea09c.svg) | N-Cyclohexyl-2-(3-fluoro-N-(2-pyridin-4-ylacetyl)anilino)-2-(2-methylphenyl)acetamide | IC50 | 50.0 [1], 210.0 [2], 260.0 [3], 19300.0 [4] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b5f2fee46d966037964e34ed2bf55648.svg) | N-Cyclohexyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamide | IC50 | 30.0 [1], 50.0 [2], 150.0 [3], 190.0 [4], 2900.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_22ccd0c3e8fe06c7d9688b7c4dfabe97.svg) | N-Cyclohexyl-2-(3-fluoro-N-[2-(1,3-thiazol-4-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide | IC50 | 60.0 [1], 100.0 [2], 220.0 [3], 290.0 [4], 19700.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_780721e43d5878d260f679caf47e1ac2.svg) | N-Cyclohexyl-2-(3-fluoro-N-(2-indol-1-ylacetyl)anilino)-2-(2-methylphenyl)acetamide | IC50 | 40.0 [1], 70.0 [2], 170.0 [3], 370.0 [4], 100000.0 [5] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_cb7266b27a629f5777dcbc3a34af9570.svg) | 2-N-(3,3-Difluorocyclopentyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_835393578e7eb9c5a7cad2d146f31479.svg) | 2-N-(3,3-Difluorocyclobutyl)-4-N-(3,5-difluorophenyl)-6-(3,6-difluoropyridin-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_f3198335153b06b6a949563ad7d980a8.svg) | 6-(6-Chloropyridin-2-yl)-4-N-(cyclopropylmethyl)-2-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2816bd77785d854b61c295f263910e2f.svg) | 2-N-(4,4-Difluorocyclohexyl)-4-N-(2-phenylpyridin-4-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_4adc982c18affb73bbfb74fbcd3cc509.svg) | 3-Fluoro-5-[[4-[(2-hydroxy-2-methylpropyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]benzonitrile | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c3d2075f6f25deac8ba91c39d9060ace.svg) | 2-N-(3,3-Difluorocyclobutyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_befa03775353b868aa49af9d3ac90620.svg) | 2-N-[(1R)-3,3-Difluorocyclopentyl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_cdee5daa1629df49b829c6f37ffab6d1.svg) | 2-N-(3,3-Difluorocyclopentyl)-6-[3-(trifluoromethyl)pyrazol-1-yl]-4-N-[2-(trifluoromethyl)pyridin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_3d795784f41922f5933988fcc6a110b9.svg) | 3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_3fa490ed4f08ab04ec782c9ed90cc5ac.svg) | 4-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_563c67fb32f10b4fdf4ee92b36f55986.svg) | 4-N-[2-(Trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2-N-(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_8e2af67d69914f4a53cd4bf6cb497918.svg) | 4-N-[(1S)-3,3-Difluorocyclopentyl]-2-N-[(1R)-3,3-difluorocyclopentyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0a81ae94d5b9c8b82bcb942945f1983f.svg) | 6-(6-Amino-3-fluoropyridin-2-yl)-2-N-(4,4-difluorocyclohexyl)-4-N-(3,5-difluorophenyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_12a78c09a6d17184455e24859776d815.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-[[(1R)-1-cyclopropylethyl]amino]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_fc1ae329f86da85064abee37d3670cb7.svg) | 3-[[4-(Cyclopropylmethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_bdd052ef4770988b53a757fb053dd5dd.svg) | 2-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]propanenitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_bcdd1413abdc695ffbcef57315c5e7ec.svg) | 1-[4-[[4-(6-Chloropyridin-2-yl)-6-(2,2,2-trifluoroethylamino)-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_5aab1628ddc90273e7905dd41a50f0f7.svg) | 3-[[4-[(3,3-Difluorocyclobutyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_5a425fa7e012249aaf2c9ad9a9dd66c3.svg) | 3-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]-5-fluorobenzonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2c67011ba9de1cd7e10dacf812b7c7c7.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[3-(trifluoromethyl)pyrazol-1-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_bb7145abae1e2d1878800bac6dfcc03d.svg) | 4-N-[(3,3-Difluorocyclobutyl)methyl]-2-N-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_07d7a77911a0dace41aa1e2949fa1aba.svg) | 3-[[4-[[(1R)-1-Cyclopropylethyl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_853c893c4e041d84c574bb71221ed338.svg) | 1-[4-[[4-[(3,3-Difluorocyclopentyl)amino]-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2168aaac340d363441a3a4af707008fc.svg) | 6-(6-Amino-3-fluoropyridin-2-yl)-2-N,4-N-bis(4,4-difluorocyclohexyl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_0e9ccb4409f1ecd254c305670c8737de.svg) | 4-[[4-(Tert-butylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridine-2-carbonitrile | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_9b96a66cf973c0987bb986175700037a.svg) | 1-[4-[[4-(2,2,2-Trifluoroethylamino)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]pyridin-2-yl]cyclopropane-1-carbonitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_2cc5f72969456dd588f02584d08ba8f5.svg) | 3-[[4-[[2-(1,1-Difluoroethyl)pyridin-4-yl]amino]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-yl]amino]butanenitrile | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_12b3c47cf77adc62f486efd024336221.svg) | 2-N,4-N-Bis(4,4-difluorocyclohexyl)-6-[2-(trifluoromethyl)-1,3-thiazol-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_b47f33c06957dae84518e1f061078fc6.svg) | 4-N-(3,3-Difluorocyclopentyl)-2-N-(1-pyrimidin-2-ylpyrrolidin-3-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_9afedceca0e1757ea27a233cc353922d.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_5883e2d42af43743ead24d8fad72512c.svg) | 2-N,4-N-Bis(3,3-difluorocyclopentyl)-6-[6-(trifluoromethoxy)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_e7ea76e382a56a6b6e2d2d538cf195f2.svg) | 4-N-(3,3-Difluorocyclopentyl)-2-N-(1-pyridin-2-ylpyrrolidin-3-yl)-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_c02e421f3bd038e93e2a89d48eda7952.svg) | 2-N,4-N-Bis(3,3-difluorocyclobutyl)-6-[2-(trifluoromethyl)pyrimidin-4-yl]-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/isocitrate-dehydrogenase-nadp-cytoplasmic_04eb0553f3a3e4d7660a57e799387287.svg) | 6-(6-Chloropyrazin-2-yl)-2-N,4-N-bis(1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine | IC50 | 50.0 [1] |