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Interleukin-8 receptor B Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
NavarixinIC500.05 [1], 1.0 [2], 2.6 [3], 450.0 [4], 680.0 [5]
NavarixinKi4.0 [1], 5.0 [2]
CID 46897162IC5060.0 [1]
(R)-3-(3,4-Dioxo-2-(1-phenylpropylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamideIC506.8 [1], 48.0 [2]
(R)-3-(3,4-Dioxo-2-(1-phenylpropylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamideKi4.0 [1], 4.4 [2], 4.7 [3]
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)ureaIC5022.0 [1], 30.0 [2], 40.0 [3]
[2-[[5-[(4-Fluorophenyl)carbamoyl]pyridin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acidIC5021.0 [1], 22.0 [2], 130.0 [3]
ElubrixinIC505.1 [1], 260.7 [2], 310.5 [3]
(2R)-2-[[2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanolIC503.98 [1], 4.0 [2]
2-(5-(2,3-Difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-olIC5014.0 [1], 15.85 [2], 25.12 [3]
1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylphenyl)ureaIC500.4 [1], 0.5 [2], 10.0 [3]
3-[[3,4-Dioxo-2-(pentan-3-ylamino)cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideIC505.0 [1], 15.0 [2], 19.1 [3]
ReparixinIC501.0 [1], 100.0 [2]
DanirixinIC505.0 [1], 30000.0 [2]
N-[6,7-Dichloro-3-(5-thiophen-2-ylthiophen-2-yl)quinoxalin-2-yl]-N',N'-diethylbutane-1,4-diamineIC50110.0 [1]
2-Methyl-5-[(phenylsulfanyl)methyl]pyrazolo[1,5-a]pyrimidin-7-olIC502000.0 [1], 10300.0 [2]
1-(2-Hydroxy-4-nitrophenyl)-3-phenylureaIC50320.0 [1]
[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanyl]acetic acidIC501200.0 [1], 5000.0 [2]
3-[[2-[[(1R)-1-(3-Fluorophenyl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideIC504.9 [1]
3-[[2-[[(1R)-1-(3-Fluorophenyl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideKi9.0 [1]
3-[[3,4-Dioxo-2-[[(1R)-1-thiophen-2-ylpropyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideIC506.0 [1]
3-[[3,4-Dioxo-2-[[(1R)-1-thiophen-2-ylpropyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideKi5.0 [1]
1-(4-Cyano-2-hydroxyphenyl)-3-phenylureaIC50200.0 [1]
(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanolIC5013.0 [1]
5-Benzylsulfanyl-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-oneIC504.5 [1], 5.0 [2]
5-[(2,3-Difluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-oneIC501.0 [1]
2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylthiophen-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamideIC505.3 [1]
2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylthiophen-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamideKi5.0 [1]
3-(2-Hydroxyphenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dioneIC50235.0 [1], 476.0 [2]
2-[[2-Amino-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanolIC5012.59 [1], 13.0 [2]
CID 24879232IC505.0 [1], 50.0 [2]
(R)-2-(5-(2,3-Difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-olIC509.5 [1], 25.12 [2]
(2R)-2-[[2-Amino-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-olIC503.0 [1], 3.98 [2]
(2R)-2-[[2-Amino-5-(furan-2-ylmethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-olIC5031.62 [1], 35.0 [2]
4-(3,4-Dioxo-2-(phenylamino)cyclobut-1-enylamino)-3-hydroxybenzonitrileIC503.0 [1], 15.0 [2]
3-(2-Hydroxy-4-nitrophenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dioneIC5022.0 [1], 36.0 [2]
(R)-2-(2-Amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-olIC50120.0 [1]
(R)-2-(2-Amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-olKi160.0 [1]
1-(4-Chloro-2-hydroxy-3-sulfamoyl-phenyl)-3-(2,3-dichlorophenyl)ureaIC502.0 [1], 316.23 [2]
1-(2-Bromophenyl)-3-(4-cyano-2-hydroxyphenyl)ureaIC5025.0 [1]
(2R)-2-[[2-Amino-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-olIC50120.0 [1], 125.89 [2]
1-[4-Chloro-2-hydroxy-3-[(3S)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC505.2 [1], 39.81 [2]
3-(2-(Cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamideIC508.0 [1], 144.8 [2]
3-[(2-Chlorophenyl)amino]-7-nitro-4H-1,2,4-benzothiadiazin-5-ol 1,1-dioxideIC5081.0 [1], 1100.0 [2]
7-Nitro-3-{[2-(phenyloxy)phenyl]amino}-4H-1,2,4-benzothiadiazin-5-ol 1,1-dioxideIC5054.0 [1], 490.0 [2]
7-Chloro-3-(2-chloroanilino)-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazin-5-olIC5092.0 [1], 520.0 [2]
1-(4-Chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)-3-(2,3-dichlorophenyl)ureaIC500.63 [1], 10000.0 [2]
3-[(2-Bromophenyl)amino]-7-nitro-4H-1,2,4-benzothiadiazin-5-ol 1,1-dioxideIC5026.0 [1], 600.0 [2]
1-[4-Chloro-2-hydroxy-3-(3-pyrrolidin-1-ylcyclobutyl)sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.0 [1], 100.0 [2]
1-[4-Chloro-2-hydroxy-3-[(3R)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.0 [1], 158.49 [2]
1-[4-Chloro-2-hydroxy-3-(3-methyloxolan-3-yl)sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.26 [1], 125.89 [2]
1-[4-Chloro-3-[3-(dimethylamino)cyclobutyl]sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.0 [1], 125.89 [2]
1-[4-Chloro-3-(1,1-difluoroethylsulfonyl)-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.4 [1], 630.96 [2]
1-(3-Tert-butylsulfonyl-4-cyano-2-hydroxyphenyl)-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.2 [1], 158.49 [2]
1-[4-Chloro-2-hydroxy-3-[2-(oxan-4-yl)propan-2-ylsulfonyl]phenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.5 [1], 398.11 [2]
1-[4-Chloro-3-[4-(fluoromethyl)oxan-4-yl]sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.26 [1], 251.19 [2]
1-[4-Chloro-3-[1-(2-fluoroethyl)piperidin-4-yl]sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.63 [1], 199.53 [2]
1-[4-Chloro-2-hydroxy-3-(4-methyloxan-4-yl)sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.5 [1], 199.53 [2]
1-[4-Chloro-3-(4-fluorooxan-4-yl)sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.2 [1], 63.1 [2]
Cxcr2-IN-1IC500.5 [1], 25.12 [2]
1-[4-Chloro-2-hydroxy-3-(oxolan-3-ylsulfonyl)phenyl]-3-(2,3-dichlorophenyl)ureaIC500.5 [1], 7.94 [2]
1-[4-Chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]-3-(2,3-dichlorophenyl)ureaIC501.58 [1], 158.49 [2]
1-[4-Chloro-3-(1-ethylpiperidin-4-yl)sulfonyl-2-hydroxyphenyl]-3-(2-chloro-3-fluorophenyl)ureaIC501.26 [1], 158.49 [2]
1-[4-Chloro-2-hydroxy-3-[(3S)-1-methylpyrrolidin-3-yl]sulfonylphenyl]-3-(2,3-dichlorophenyl)ureaIC501.26 [1], 251.19 [2]
1-[4-Chloro-3-(4-ethylpiperazin-1-yl)sulfonyl-2-hydroxyphenyl]-3-(2-chloro-3-fluorophenyl)ureaIC501.0 [1], 1995.26 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-[(3S)-1-methylpyrrolidin-3-yl]sulfonylphenyl]ureaIC500.5 [1], 79.43 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-[(4S)-1-methylazepan-4-yl]sulfonylphenyl]ureaIC500.5 [1], 100.0 [2]
1-[4-Chloro-2-hydroxy-3-(4-methylpiperazin-1-yl)sulfonylphenyl]-3-(2,3-dichlorophenyl)ureaIC500.79 [1], 1000.0 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]ureaIC501.58 [1], 1995.26 [2]
1-[4-Chloro-3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl-2-hydroxyphenyl]-3-(2-chloro-3-fluorophenyl)ureaIC503.98 [1], 3162.28 [2]
1-[4-Chloro-3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl-2-hydroxyphenyl]-3-(2,3-dichlorophenyl)ureaIC5010.0 [1], 15848.93 [2]
1-(4-Chloro-3-ethylsulfonyl-2-hydroxyphenyl)-3-(2,3-dichlorophenyl)ureaIC500.5 [1], 6309.57 [2]
1-(4-Chloro-2-hydroxy-3-propan-2-ylsulfonylphenyl)-3-(2,3-dichlorophenyl)ureaIC500.63 [1], 158.49 [2]
1-[4-Chloro-2-hydroxy-3-(oxan-4-ylsulfonyl)phenyl]-3-(2,3-dichlorophenyl)ureaIC500.79 [1], 6.31 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(piperidine-1-carbonyl)phenyl]ureaIC500.5 [1], 6.31 [2]
1-(3-Tert-butylsulfonyl-4-chloro-2-hydroxyphenyl)-3-(2-chloro-3-fluorophenyl)ureaIC500.5 [1], 39.81 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-[(2-methyl-2-azaspiro[3.3]heptan-6-yl)sulfonyl]phenyl]ureaIC500.4 [1], 630.96 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-[(7-methyl-7-azaspiro[3.5]nonan-2-yl)sulfonyl]phenyl]ureaIC502.0 [1]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-[(3-methyl-3-azaspiro[5.5]undecan-9-yl)sulfonyl]phenyl]ureaIC500.4 [1], 25.12 [2]
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(pyrrolidine-1-carbonyl)phenyl]ureaIC501.0 [1], 7.94 [2]
1-[4-Chloro-3-(1-fluoro-2-methylpropan-2-yl)sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.63 [1], 100.0 [2]
1-[4-Chloro-2-hydroxy-3-(1-methoxypropan-2-ylsulfonyl)phenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.26 [1], 398.11 [2]
1-[4-Chloro-2-hydroxy-3-[2-[(3S)-oxolan-3-yl]propan-2-ylsulfonyl]phenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.58 [1], 316.23 [2]
1-[4-Chloro-3-(1-cyclobutylpiperidin-4-yl)sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.4 [1], 501.19 [2]
1-[4-Chloro-3-[2-(dimethylamino)-1,1-difluoroethyl]sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC502.0 [1], 630.96 [2]
1-[4-Chloro-3-(4-ethyloxan-4-yl)sulfonyl-2-hydroxyphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.32 [1], 398.11 [2]
1-[4-Chloro-2-hydroxy-3-(oxan-3-ylsulfonyl)phenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.58 [1], 251.19 [2]
1-[4-Chloro-2-hydroxy-3-(3-methyloxan-3-yl)sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC502.0 [1], 199.53 [2]
1-(3-Tert-butylsulfonyl-4-chloro-2-hydroxyphenyl)-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC501.0 [1], 316.23 [2]
3-[[4-[[(1R)-2,2-Dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethylbenzamideIC5021.0 [1]
3-[[4-[[(1R)-2,2-Dimethyl-1-(5-methylfuran-2-yl)propyl]amino]-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethylbenzamideKi91.0 [1]
2-[(2,6-Dichlorobenzyl)sulfanyl]-4-hydroxy-6-phenyl-5-pyrimidinecarbonitrileIC504300.0 [1], 30000.0 [2]
Nvp cxcr2 20IC5040.0 [1], 140.0 [2]
2-Hydroxy-N,N-dimethyl-3-[[4-[[(1R)-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-1,2,5-thiadiazol-3-yl]amino]benzamideIC5036.0 [1]
2-Hydroxy-N,N-dimethyl-3-[[4-[[(1R)-2-methyl-1-(5-methylfuran-2-yl)propyl]amino]-1,2,5-thiadiazol-3-yl]amino]benzamideKi2400.0 [1]
4-Tert-butyl-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-1H-pyrimidin-6-oneIC506.31 [1], 580.0 [2]
1-[4-Cyano-2-hydroxy-3-(4,4,4-trifluoro-2-methylbutan-2-yl)sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]ureaIC500.16 [1], 1000.0 [2]
2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)ethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamideIC502.4 [1], 5.4 [2]
2-Benzyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-olIC50330.0 [1], 350.0 [2]
3-[[2-[[(1R)-1-(4-Bromofuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamideIC502.0 [1], 3.5 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Interleukin-8 receptor B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/interleukin-8-receptor-b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Interleukin-8 receptor B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/interleukin-8-receptor-b-inhibitors-ic50-ki.
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