![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_34e9a2aeeafd36b36f14046625d506e2.svg) | N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 5.0 [1], 52.0 [2], 570.0 [3], 3100.0 [4] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_ab692547faff3905450c9f2ebb7baa5d.svg) | 5-(1,3-Benzothiazol-2-Yl)-2-(Morpholin-4-Yl)-6-[(3r)-Piperidin-3-Ylamino]pyrimidin-4(3h)-One | IC50 | 19.0 [1], 187.0 [2], 1900.0 [3], 4200.0 [4] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_a0bef5c9ddc660f9fb6477d5b74e058f.svg) | 6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy- | IC50 | 0.2 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_b50733f49fb52ac1c53c8665f5ebad1b.svg) | 4-[4-[[4-(Dimethylamino)cyclohexyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | IC50 | 4.0 [1], 354.81 [2], 758.0 [3], 13489.63 [4] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0a9995d888ef96e4ef4aed6062777b31.svg) | 4-N,4-N-Dimethyl-1-N-thieno[2,3-d]pyrimidin-4-ylcyclohexane-1,4-diamine | IC50 | 4265.8 [1], 4300.0 [2], 8400.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_fb3644806a8495b9a60b99221696f26a.svg) | 5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.8 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_9291a236541e3808d010687e78918eeb.svg) | 5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.3 [1], 9.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_7e3d166ef232411fc4bfb6f09112be62.svg) | 5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.2 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_8442d8bc6a69fe4087b1ed4ae346dfa7.svg) | 4-N,4-N-Dimethyl-1-N-[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | IC50 | 6.0 [1], 6.17 [2], 59.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_533ccd37afd53dfe965a45fb1be1edc0.svg) | 4-N,4-N-Dimethyl-1-N-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | IC50 | 4.57 [1], 5.0 [2], 140.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_ddc9995646b6987dbc596a48e47f9362.svg) | 4-N,4-N-Dimethyl-1-N-(5-propan-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | IC50 | 4.79 [1], 5.0 [2], 29.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d25c997f187c2667bdf98e4540f7a64b.svg) | 4-N,4-N-Dimethyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | IC50 | 630.96 [1], 640.0 [2], 1400.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_e9b691b25d3efae60b9cac3d434573f7.svg) | 4-N,4-N-Dimethyl-1-N-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)cyclohexane-1,4-diamine | IC50 | 140.0 [1], 490.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_e9b691b25d3efae60b9cac3d434573f7.svg) | 4-N,4-N-Dimethyl-1-N-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)cyclohexane-1,4-diamine | Ki | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_84552df6b8989215b923d22f5e9f5f4a.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 11.0 [1], 375.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_cc864fc3f2c3203983553a248e1268b5.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-pyrrolidin-1-yl-1H-pyrimidin-6-one | IC50 | 18.0 [1], 78.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_af7389d0eaf29d8e16d894e0bac033a4.svg) | 5-(1,3-Benzothiazol-2-yl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-one | IC50 | 7.2 [1], 27.0 [2], 141.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_928afa96a02e4a649bbdf744118110d0.svg) | 2-(Azetidin-1-yl)-5-(1,3-benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-one | IC50 | 67.0 [1], 292.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d26effa7e08bfb5bd754ad2a8228900e.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(3R,5R)-5-hydroxypiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 85.0 [1], 333.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d0157b2f26df64290d3f57b85eb1ed4f.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(3R,6R)-6-methylpiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 93.0 [1], 114.0 [2], 580.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6a2dbc6eb7376995932e758d74cadadb.svg) | 1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanone | IC50 | 93.33 [1], 94.0 [2], 416.87 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_acdd7371b33eb0b96d3fb052ad86d6ea.svg) | 1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanone | IC50 | 21.88 [1], 22.0 [2], 194.98 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0e9917922d949bbc8bf0dc00aee41fa2.svg) | 4-[4-[[4-(Dimethylamino)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]cyclohexane-1-carboxamide | IC50 | 44.67 [1], 331.13 [2], 8500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_ccac4b2af9ac4b07720352f2ff90266c.svg) | N-[2-(4-Methylphenyl)-5-(1-methylsulfonylpiperidin-4-yl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 67.0 [1], 100.0 [2], 2400.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_fd0346a187015cf49805a003bc6e26f3.svg) | N-[5-(4-Methylpiperazin-1-yl)-2-(5-methylpyridin-2-yl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 5.0 [1], 83.0 [2], 100.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_44037f991d19b166606d2377b629fc5e.svg) | N-[7-(4-Hydroxycyclohexyl)oxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamide | IC50 | 7.0 [1], 11.0 [2], 24.0 [3] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 6.19 [1], 34.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_5eb9592b212a82cbeb67d4d11e9750e8.svg) | IRAK inhibitor 1 | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6f18125f2b71613794c71544d3ac1f63.svg) | 6-(1H-Benzo[d]imidazol-1-yl)-N-(piperidin-4-yl)pyridin-2-amine | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d2d8304e31d5c950a57090e1491203ee.svg) | N-(5-Fluoro-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d2d8304e31d5c950a57090e1491203ee.svg) | N-(5-Fluoro-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide | Ki | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d2cbb9f4eeaad96e0d9c534fc4841402.svg) | 4-Imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyrimidin-2-amine | IC50 | 216.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_928d60016a682707f7bdcfd04201f487.svg) | (1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol | IC50 | 27.0 [1], 216.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_2324e08550809a675d90f05b92453f3d.svg) | (1R,2S,3R,5R)-3-[[2-[(2-Cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol | IC50 | 44.0 [1], 341.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_3463aabc566c6bf81b1b2c46ef924a79.svg) | (1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol | IC50 | 8.0 [1], 25.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_ead3b764eb7df5dd472ed5f7fdfeaa9e.svg) | 7-Methoxy-1-[[(2S,3R)-5-oxo-3-propylpyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 1.3 [1], 28.4 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_54e2b7de68ba6e41d008aa37b7c05847.svg) | 1-[[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 0.5 [1], 9.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_521f63ae0ebd40f3b4ad27fa553825ba.svg) | 1-[[(2S,3S,4R)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 1.9 [1], 29.5 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d7637700359ebb4a80ae5d4d8852b892.svg) | 7-Methoxy-1-[[(1S,2S,5R)-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 4.8 [1], 115.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_3e23b5590cf0666a2b7f081bc7c6d543.svg) | 7-Methoxy-1-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 7.6 [1], 347.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_ccd773850552237f0b68fdb0075d7e91.svg) | 1-[[(2S,3S,4R)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 0.1 [1], 6.5 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_5d49bb89eb8b8ab9f422dbcb172b95a4.svg) | 1-[[(2S,3R,4S)-3,4-Dimethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 29.2 [1], 2836.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_3189624c2c85b8cdc46cc1956af89b25.svg) | 7-Ethoxy-1-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 23.9 [1], 672.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_b687a2086977fcdad70e9e4a0776215b.svg) | 6-Methoxy-4-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]quinoline-7-carboxamide | IC50 | 5.9 [1], 2118.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_e2f0717ae7ee1d6f9e3e5d81dacb21d5.svg) | 1-[[(2S,3S,4S)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 0.3 [1], 12.7 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_9e68e95f053ab82ee8d32d7705945cf9.svg) | 1-{[(2s)-5-Oxopyrrolidin-2-Yl]methoxy}-7-[(Propan-2-Yl)oxy]isoquinoline-6-Carboxamide | IC50 | 4.6 [1], 133.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_a8e4bcd24e4ff95cdd93b9b375611f74.svg) | 7-Methoxy-1-[[(2S,3R)-3-(methoxymethyl)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 12.1 [1], 373.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0ec4394edfdb20390ba21f93e137f8af.svg) | 1-[[(2S,3R,4R)-3,4-Dimethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 3.7 [1], 87.1 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_e1b39d072fb2d34bccceb38c0ffbd31a.svg) | 7-Methoxy-1-[[(2S,3R)-3-methyl-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 2.7 [1], 52.3 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_7c589f82a318e2fec13c10fedfabbd7d.svg) | 7-Methoxy-1-[[(1S,2S,5R,6S)-6-methyl-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]isoquinoline-6-carboxamide | IC50 | 2.4 [1], 52.1 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_9315568e2ffffce0a969a2b9d51381b2.svg) | 1-[[(1R,2S,5S,6S)-5-Fluoro-6-methyl-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide | IC50 | 0.6 [1], 16.8 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_2b277ea1fd955b220dfdb3cbc4abfc36.svg) | (1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol | IC50 | 0.74 [1], 55.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_bff1060d3b28ee326f1d9497933ec8b8.svg) | (1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol | IC50 | 4.0 [1], 87.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_998553b3e1e440bffa59be81d5348717.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 2.0 [1], 40.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_c00771f5c671519abe3ef952bcc7bc35.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 5.0 [1], 44.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0b8c333c9bc1dc2871d2af6e073b3012.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 1.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_faa33a765b66fd4c75b809d37feadf6e.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 0.5 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_19e0ecb148490021a5fbbf53e23c3b8b.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 1.0 [1], 25.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_99b7cbc7f2478bd9ea197b1f3ee79f1f.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 0.2 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_2050685967cf760584538c9356b1734c.svg) | 5-[[(1R,2S)-2-Amino-5,5-difluorocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 38.0 [1], 280.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_fffe476e2d264570c0226979eb542e44.svg) | 2-[[(1R,2S)-2-Amino-5,5-difluorocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 3.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_28467dfc084577e5a3cacb342c616f8a.svg) | N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-5-[[(3R)-piperidin-3-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.5 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_67501f5966648af0a37fdb98c5334180.svg) | N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 2.0 [1], 34.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_88809ef0323e76a6926b3332f35cea07.svg) | N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 1.0 [1], 17.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6d8afbcc0bb887fdad521bd371725d40.svg) | N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 0.8 [1], 7.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_cd867fec839b82a8873d31da234b53bd.svg) | N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-5-[[(3R)-piperidin-3-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.5 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6616fed061ecbbd29b582f6cb54f5e2e.svg) | N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 1.0 [1], 24.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_98065d9ec01f1842a015f5638de7a41e.svg) | N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 0.9 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_a0bccab79e5a5e7388cc33d8f6b68c2d.svg) | N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 0.4 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d8cd135ca29671aa744ec331d540515b.svg) | 5-[[(3R)-Azepan-3-yl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.2 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6c50146806003c6035357431dde4fd94.svg) | 2-[[(3R)-Azepan-3-yl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 0.7 [1], 9.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_accec768acbfba0c99cd2f3d08fcb754.svg) | 5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | IC50 | 0.5 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6d6f522021ba5291340ccc9396207383.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 1.0 [1], 26.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0906b65846ef8fb25b15e0d681b74941.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 1.0 [1], 13.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_25d593756449a37e99373cbd1250fb41.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 0.3 [1], 7.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d0b5dcfc1528e1567f5c389b0714a555.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine-7-carboxamide | IC50 | 1.0 [1], 25.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0bcbaf030d35915aa690291fc73e5291.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrrolo[1,2-b]pyridazine-7-carboxamide | IC50 | 0.7 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_9e115f2bce0d44c111537d1c675ee8ab.svg) | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)thieno[2,3-b]pyrazine-7-carboxamide | IC50 | 0.4 [1], 9.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_f4387edcb6d2839b8e3865b9b46198ee.svg) | 4-N,4-N-Dimethyl-1-N-(5-methylthieno[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | IC50 | 2400.0 [1], 4300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_cf0a5fbde1e041ef078e9616ca098821.svg) | 1-[(3R)-Piperidin-3-yl]oxy-7-propan-2-yloxyisoquinoline-6-carboxamide | IC50 | 121.0 [1], 1552.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_4e1107833b11ab2e462f2e3f1f1e47c8.svg) | N-[5-Fluoro-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-nitrobenzamide | Ki | 1.6 [1], 6.4 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_016d0cde3d1f57169ddde1181a3b8f26.svg) | (3As,7aR)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-one | IC50 | 2.0 [1], 42.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_b8e9bfcad37158d152d075328b4411cf.svg) | (3Ar,7aS)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-one | IC50 | 2.0 [1], 38.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6877caa07066f770c7998f6ed4816096.svg) | (3R)-3-[4-[[4-(4-Acetylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | IC50 | 21.38 [1], 141.25 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_20b436f1cded4c734432ec422fc9b416.svg) | 5-(1,3-Benzothiazol-2-yl)-2-(cyclopropylamino)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-one | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_a861eaad86d8109c4622b91664b95e99.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(3S,4S)-4-fluoropiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0974baed9269608e4d957888d79f5216.svg) | 5-(1,3-Benzothiazol-2-yl)-6-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidine-2,4-dione | IC50 | 1487.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_6292ae9ff384ed4fb68d612cb712e358.svg) | 5-(1,3-Benzothiazol-2-yl)-2-cyclobutyloxy-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-one | IC50 | 1686.0 [1], 1688.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_4d64023cea517c4e473d2aa2d5fa0d97.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-piperidin-1-yl-1H-pyrimidin-6-one | IC50 | 43.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_a099a16eea7d34201fc941174f40fc10.svg) | 5-(1,3-Benzothiazol-2-yl)-2-(4,4-difluoropiperidin-1-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-one | IC50 | 134.8 [1], 135.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_5fc3aa50248d956659efeae4be66758d.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-(4-methylpiperazin-1-yl)-1H-pyrimidin-6-one | IC50 | 43.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_69a0ca0aca737d76f47bc57c37808b0b.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-(dimethylamino)-1H-pyrimidin-6-one | IC50 | 490.0 [1], 542.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_f71126f7feee1e1713b97051e9f1faef.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-ethyl-1H-pyrimidin-6-one | IC50 | 972.0 [1], 1162.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_f314d8d743ce027c953a7f9f13e4fa5e.svg) | (3R)-3-[[5-(1,3-Benzothiazol-2-yl)-2-morpholin-4-yl-6-oxo-1H-pyrimidin-4-yl]amino]azepan-2-one | IC50 | 2429.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_c2c3b548329d3e7aa62338822a3da1d7.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,3R)-3-hydroxycyclohexyl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 454.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_72edf0fc96f2a205f54ecc0c0a153ef6.svg) | 4-[[(3R)-Azepan-3-yl]amino]-5-(1,3-benzothiazol-2-yl)-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 79.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_598429f343db59a51630b729c2a5e005.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(3R,6S)-6-methylpiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 565.0 [1], 847.0 [2] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_c804e3f5f914099d7836fa16eb88e800.svg) | 5-(1,3-Benzothiazol-2-yl)-2-morpholin-4-yl-4-(piperidin-4-ylamino)-1H-pyrimidin-6-one | IC50 | 121.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_d7d1c8c84d6802d5960caf97806b7ea7.svg) | 4-[(3-Aminocyclohexyl)amino]-5-(1,3-benzothiazol-2-yl)-2-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 258.0 [1] |
![](https://images.aatbio.com/dataset/ic50/interleukin-1-receptor-associated-kinase-4_0c91cb662c462169195c0eaea2646eb8.svg) | 5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-methylsulfanyl-1H-pyrimidin-6-one | IC50 | 352.0 [1] |