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Interleukin-1 receptor-associated kinase 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC505.0 [1], 52.0 [2], 570.0 [3], 3100.0 [4]
5-(1,3-Benzothiazol-2-Yl)-2-(Morpholin-4-Yl)-6-[(3r)-Piperidin-3-Ylamino]pyrimidin-4(3h)-OneIC5019.0 [1], 187.0 [2], 1900.0 [3], 4200.0 [4]
6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-IC500.2 [1], 2.0 [2]
4-[4-[[4-(Dimethylamino)cyclohexyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamideIC504.0 [1], 354.81 [2], 758.0 [3], 13489.63 [4]
4-N,4-N-Dimethyl-1-N-thieno[2,3-d]pyrimidin-4-ylcyclohexane-1,4-diamineIC504265.8 [1], 4300.0 [2], 8400.0 [3]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.8 [1], 12.0 [2]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.3 [1], 9.0 [2]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.2 [1], 4.0 [2]
4-N,4-N-Dimethyl-1-N-[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamineIC506.0 [1], 6.17 [2], 59.0 [3]
4-N,4-N-Dimethyl-1-N-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamineIC504.57 [1], 5.0 [2], 140.0 [3]
4-N,4-N-Dimethyl-1-N-(5-propan-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamineIC504.79 [1], 5.0 [2], 29.0 [3]
4-N,4-N-Dimethyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamineIC50630.96 [1], 640.0 [2], 1400.0 [3]
4-N,4-N-Dimethyl-1-N-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)cyclohexane-1,4-diamineIC50140.0 [1], 490.0 [2]
4-N,4-N-Dimethyl-1-N-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)cyclohexane-1,4-diamineKi50.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC5011.0 [1], 375.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-pyrrolidin-1-yl-1H-pyrimidin-6-oneIC5018.0 [1], 78.0 [2]
5-(1,3-Benzothiazol-2-yl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-oneIC507.2 [1], 27.0 [2], 141.0 [3]
2-(Azetidin-1-yl)-5-(1,3-benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-oneIC5067.0 [1], 292.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(3R,5R)-5-hydroxypiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC5085.0 [1], 333.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(3R,6R)-6-methylpiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC5093.0 [1], 114.0 [2], 580.0 [3]
1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanoneIC5093.33 [1], 94.0 [2], 416.87 [3]
1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanoneIC5021.88 [1], 22.0 [2], 194.98 [3]
4-[4-[[4-(Dimethylamino)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]cyclohexane-1-carboxamideIC5044.67 [1], 331.13 [2], 8500.0 [3]
N-[2-(4-Methylphenyl)-5-(1-methylsulfonylpiperidin-4-yl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5067.0 [1], 100.0 [2], 2400.0 [3]
N-[5-(4-Methylpiperazin-1-yl)-2-(5-methylpyridin-2-yl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC505.0 [1], 83.0 [2], 100.0 [3]
N-[7-(4-Hydroxycyclohexyl)oxyquinolin-6-yl]thieno[3,2-d]pyrimidine-7-carboxamideIC507.0 [1], 11.0 [2], 24.0 [3]
StaurosporineIC506.19 [1], 34.0 [2]
IRAK inhibitor 1IC5035.0 [1]
6-(1H-Benzo[d]imidazol-1-yl)-N-(piperidin-4-yl)pyridin-2-amineIC5070.0 [1]
N-(5-Fluoro-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamideIC504500.0 [1]
N-(5-Fluoro-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamideKi4500.0 [1]
4-Imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyrimidin-2-amineIC50216.0 [1]
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diolIC5027.0 [1], 216.0 [2]
(1R,2S,3R,5R)-3-[[2-[(2-Cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC5044.0 [1], 341.0 [2]
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diolIC508.0 [1], 25.0 [2]
7-Methoxy-1-[[(2S,3R)-5-oxo-3-propylpyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamideIC501.3 [1], 28.4 [2]
1-[[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC500.5 [1], 9.0 [2]
1-[[(2S,3S,4R)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC501.9 [1], 29.5 [2]
7-Methoxy-1-[[(1S,2S,5R)-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]isoquinoline-6-carboxamideIC504.8 [1], 115.0 [2]
7-Methoxy-1-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamideIC507.6 [1], 347.0 [2]
1-[[(2S,3S,4R)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC500.1 [1], 6.5 [2]
1-[[(2S,3R,4S)-3,4-Dimethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC5029.2 [1], 2836.0 [2]
7-Ethoxy-1-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamideIC5023.9 [1], 672.0 [2]
6-Methoxy-4-[[(2S)-5-oxopyrrolidin-2-yl]methoxy]quinoline-7-carboxamideIC505.9 [1], 2118.0 [2]
1-[[(2S,3S,4S)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC500.3 [1], 12.7 [2]
1-{[(2s)-5-Oxopyrrolidin-2-Yl]methoxy}-7-[(Propan-2-Yl)oxy]isoquinoline-6-CarboxamideIC504.6 [1], 133.0 [2]
7-Methoxy-1-[[(2S,3R)-3-(methoxymethyl)-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamideIC5012.1 [1], 373.0 [2]
1-[[(2S,3R,4R)-3,4-Dimethyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC503.7 [1], 87.1 [2]
7-Methoxy-1-[[(2S,3R)-3-methyl-5-oxopyrrolidin-2-yl]methoxy]isoquinoline-6-carboxamideIC502.7 [1], 52.3 [2]
7-Methoxy-1-[[(1S,2S,5R,6S)-6-methyl-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]isoquinoline-6-carboxamideIC502.4 [1], 52.1 [2]
1-[[(1R,2S,5S,6S)-5-Fluoro-6-methyl-4-oxo-3-azabicyclo[3.1.0]hexan-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamideIC500.6 [1], 16.8 [2]
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC500.74 [1], 55.0 [2]
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC504.0 [1], 87.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC502.0 [1], 40.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyrrolo[1,2-b]pyridazine-7-carboxamideIC505.0 [1], 44.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]thieno[2,3-b]pyrazine-7-carboxamideIC501.0 [1], 20.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC500.5 [1], 10.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[1,2-b]pyridazine-7-carboxamideIC501.0 [1], 25.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]thieno[2,3-b]pyrazine-7-carboxamideIC500.2 [1], 3.0 [2]
5-[[(1R,2S)-2-Amino-5,5-difluorocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5038.0 [1], 280.0 [2]
2-[[(1R,2S)-2-Amino-5,5-difluorocyclohexyl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC503.0 [1], 140.0 [2]
N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-5-[[(3R)-piperidin-3-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.5 [1], 12.0 [2]
N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC502.0 [1], 34.0 [2]
N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[1,2-b]pyridazine-7-carboxamideIC501.0 [1], 17.0 [2]
N-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]thieno[2,3-b]pyrazine-7-carboxamideIC500.8 [1], 7.0 [2]
N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-5-[[(3R)-piperidin-3-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.5 [1], 3.0 [2]
N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC501.0 [1], 24.0 [2]
N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]pyrrolo[1,2-b]pyridazine-7-carboxamideIC500.9 [1], 5.0 [2]
N-[3-(Difluoromethyl)-1-methylpyrazol-4-yl]-2-[[(3R)-piperidin-3-yl]amino]thieno[2,3-b]pyrazine-7-carboxamideIC500.4 [1], 3.0 [2]
5-[[(3R)-Azepan-3-yl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.2 [1], 20.0 [2]
2-[[(3R)-Azepan-3-yl]amino]-N-[3-(difluoromethyl)-1-methylpyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC500.7 [1], 9.0 [2]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamideIC500.5 [1], 12.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC501.0 [1], 26.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)pyrrolo[1,2-b]pyridazine-7-carboxamideIC501.0 [1], 13.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-chloro-1-methylpyrazol-4-yl)thieno[2,3-b]pyrazine-7-carboxamideIC500.3 [1], 7.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine-7-carboxamideIC501.0 [1], 25.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)pyrrolo[1,2-b]pyridazine-7-carboxamideIC500.7 [1], 12.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-N-(3-cyano-1-methylpyrazol-4-yl)thieno[2,3-b]pyrazine-7-carboxamideIC500.4 [1], 9.0 [2]
4-N,4-N-Dimethyl-1-N-(5-methylthieno[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamineIC502400.0 [1], 4300.0 [2]
1-[(3R)-Piperidin-3-yl]oxy-7-propan-2-yloxyisoquinoline-6-carboxamideIC50121.0 [1], 1552.0 [2]
N-[5-Fluoro-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-nitrobenzamideKi1.6 [1], 6.4 [2]
(3As,7aR)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-oneIC502.0 [1], 42.0 [2]
(3Ar,7aS)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-oneIC502.0 [1], 38.0 [2]
(3R)-3-[4-[[4-(4-Acetylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamideIC5021.38 [1], 141.25 [2]
5-(1,3-Benzothiazol-2-yl)-2-(cyclopropylamino)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-oneIC5025.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(3S,4S)-4-fluoropiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC5014.0 [1]
5-(1,3-Benzothiazol-2-yl)-6-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidine-2,4-dioneIC501487.0 [1]
5-(1,3-Benzothiazol-2-yl)-2-cyclobutyloxy-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-oneIC501686.0 [1], 1688.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-piperidin-1-yl-1H-pyrimidin-6-oneIC5043.0 [1]
5-(1,3-Benzothiazol-2-yl)-2-(4,4-difluoropiperidin-1-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-1H-pyrimidin-6-oneIC50134.8 [1], 135.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-(4-methylpiperazin-1-yl)-1H-pyrimidin-6-oneIC5043.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-(dimethylamino)-1H-pyrimidin-6-oneIC50490.0 [1], 542.0 [2]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-ethyl-1H-pyrimidin-6-oneIC50972.0 [1], 1162.0 [2]
(3R)-3-[[5-(1,3-Benzothiazol-2-yl)-2-morpholin-4-yl-6-oxo-1H-pyrimidin-4-yl]amino]azepan-2-oneIC502429.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,3R)-3-hydroxycyclohexyl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC50454.0 [1]
4-[[(3R)-Azepan-3-yl]amino]-5-(1,3-benzothiazol-2-yl)-2-morpholin-4-yl-1H-pyrimidin-6-oneIC5079.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(3R,6S)-6-methylpiperidin-3-yl]amino]-2-morpholin-4-yl-1H-pyrimidin-6-oneIC50565.0 [1], 847.0 [2]
5-(1,3-Benzothiazol-2-yl)-2-morpholin-4-yl-4-(piperidin-4-ylamino)-1H-pyrimidin-6-oneIC50121.0 [1]
4-[(3-Aminocyclohexyl)amino]-5-(1,3-benzothiazol-2-yl)-2-morpholin-4-yl-1H-pyrimidin-6-oneIC50258.0 [1]
5-(1,3-Benzothiazol-2-yl)-4-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]-2-methylsulfanyl-1H-pyrimidin-6-oneIC50352.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Interleukin-1 receptor-associated kinase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/interleukin-1-receptor-associated-kinase-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Interleukin-1 receptor-associated kinase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/interleukin-1-receptor-associated-kinase-4-inhibitors-ic50-ki.
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