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Integrin alpha-V/beta-8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 53340771IC501.2 [1]
CID 72949858IC500.2 [1]
(3S)-3-[3-(3,5-Dimethylpyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5015.85 [1]
(3S)-3-(3-Bromo-5-chloro-2-hydroxyphenyl)-3-[[2-[[5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridine-3-carbonyl]amino]acetyl]amino]propanoic acidIC500.65 [1]
(3S)-3-(3-Bromo-5-chloro-2-hydroxyphenyl)-3-[[2-[[3-hydroxy-5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]benzoyl]amino]acetyl]amino]propanoic acidIC501.71 [1]
3-(3-Fluorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC501584.89 [1]
3-(1,3-Benzodioxol-5-yl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50794.33 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)pyrrolidine-2-carbonyl]amino]-3-[4-[[3-(diaminomethylideneamino)benzoyl]amino]phenyl]propanoic acidIC5040.0 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)pyrrolidine-2-carbonyl]amino]-3-[4-[5-(diaminomethylideneamino)pentanoylamino]phenyl]propanoic acidIC5010000.0 [1]
3-(2-Fluorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC503981.07 [1]
3-(2-Chlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC5010000.0 [1]
3-(2-Methylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC501258.93 [1]
3-(2-Methoxyphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC5010000.0 [1]
3-(3-Chlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50501.19 [1]
3-(3-Methylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50630.96 [1]
3-(3-Methoxyphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50501.19 [1]
3-(4-Fluorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50501.19 [1]
3-(4-Chlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50630.96 [1]
3-(4-Methylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC501000.0 [1]
3-(4-Methoxyphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50501.19 [1]
3-(4-Cyanophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50794.33 [1]
3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[4-(trifluoromethyl)phenyl]propanoic acidIC50794.33 [1]
3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[4-(trifluoromethoxy)phenyl]propanoic acidIC50794.33 [1]
3-(4-Methylsulfonylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50794.33 [1]
3-(4-Phenylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50316.23 [1]
3-(3-Cyanophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC501000.0 [1]
3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[3-(trifluoromethyl)phenyl]propanoic acidIC50158.49 [1]
(3S)-3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[3-(trifluoromethyl)phenyl]propanoic acidIC50125.89 [1]
(3R)-3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[3-(trifluoromethyl)phenyl]propanoic acidIC5010000.0 [1]
3-[5-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]-3-[3-(trifluoromethoxy)phenyl]propanoic acidIC50251.19 [1]
3-(2,3-Dichlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC5010000.0 [1]
3-(3,4-Dichlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50199.53 [1]
3-(3,5-Dichlorophenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC5010000.0 [1]
3-(3,4-Dimethylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50501.19 [1]
3-(2,3-Dihydro-1H-inden-5-yl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50398.11 [1]
3-(3,5-Dimethylphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50630.96 [1]
3-(3,4-Dimethoxyphenyl)-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50398.11 [1]
3-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC5010000.0 [1]
(3S)-3-(3-Morpholin-4-ylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5015.85 [1]
(3S)-3-(3-Cyclopropyl-5-morpholin-4-ylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5015.85 [1]
(3S)-3-[3-(3,5-Dimethylpyrazol-1-yl)-5-morpholin-4-ylphenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3R)-3-(3-Morpholin-4-ylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010000.0 [1]
(3S)-3-[3-(2,5-Dimethyl-1H-imidazol-4-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-4-[(3R)-3-[2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]-3-[3-(1,2,4-triazol-4-yl)phenyl]butanoic acidIC506.31 [1]
3-(3-Imidazol-1-ylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5025.12 [1]
(3S)-3-[3-(5-Methyl-1H-pyrazol-3-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC503.98 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)pyrrolidine-2-carbonyl]amino]-3-[4-[5-(4,5-dihydro-1H-imidazol-2-ylamino)pentanoylamino]phenyl]propanoic acidIC5010000.0 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)pyrrolidine-2-carbonyl]amino]-3-[4-[4-(pyridin-2-ylamino)butanoylamino]phenyl]propanoic acidIC50400.0 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)piperidine-2-carbonyl]amino]-3-[4-[4-(diaminomethylideneamino)butanoylamino]phenyl]propanoic acidIC502500.0 [1]
(2S)-2-[[(2S)-1-(Benzenesulfonyl)piperidine-2-carbonyl]amino]-3-[4-[5-(diaminomethylideneamino)pentanoylamino]phenyl]propanoic acidIC502000.0 [1]
(3S)-3-[3-[(3S)-Oxolan-3-yl]oxyphenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC506.31 [1]
(3S)-3-[3-(Oxan-4-yloxy)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC506.31 [1]
(3S)-3-[3-(Oxetan-3-yloxy)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC502.51 [1]
(3S)-3-[3-[(3R)-Oxolan-3-yl]oxyphenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-3-[3-(Oxolan-3-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-4-[(3R)-3-[2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]-3-[3-(1,2,4-triazol-1-yl)phenyl]butanoic acidIC506.31 [1]
(3S)-3-[3-(2,4-Dimethylpyrazol-3-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC507.94 [1]
(3S)-4-[(3R)-3-[2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]-3-[3-(triazol-1-yl)phenyl]butanoic acidIC505.01 [1]
(3S)-3-[3-(3-Methyl-1,2,4-triazol-4-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-3-[3-(1,4-Dimethylimidazol-2-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC507.94 [1]
(3R)-3-[3-(3,5-Dimethylpyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC50398.11 [1]
(3S)-3-[3-(3,5-Dimethyl-1,2,4-triazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-3-[3-(3-Methylpyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5031.62 [1]
(3S)-3-(3-Pyrazol-1-ylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-3-[3-(5-Methylpyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5010.0 [1]
(3S)-3-(3-Cyclopropylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC506.31 [1]
(3S)-3-[3-(4-Methylpyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC5039.81 [1]
(3R)-3-(3-Cyclopropylphenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC50125.89 [1]
(3S)-3-(3-Bromophenyl)-4-[(3R)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acidIC503.16 [1]
3-Phenyl-3-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoylamino]propanoic acidIC50794.33 [1]
Items per page: 1 - 10 of 70
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References

This online tool may be cited as follows

MLA

"Quest Database™ Integrin alpha-V/beta-8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/integrin-alpha-v-beta-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Integrin alpha-V/beta-8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/integrin-alpha-v-beta-8-inhibitors-ic50-ki.
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