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Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-(pyridin-3-ylmethoxycarbonyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC505600.0 [1]
(2S)-3-[[(5S,8S)-7-Phenylmethoxycarbonyl-8-[(pyridin-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC50100000.0 [1]
(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC501400.0 [1]
(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC5034000.0 [1]
(2S)-3-[[(5S,8S)-8-[(1H-Imidazol-2-ylamino)methyl]-7-methoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC507300.0 [1]
(2S)-3-[[(5S,8S)-7-Butoxycarbonyl-8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC5011000.0 [1]
(2S)-3-[[(5S,8S)-8-[(1H-Benzimidazol-2-ylamino)methyl]-7-methoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC50100000.0 [1]
(2S)-2-(2,6-Dichlorophenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acidIC50490.0 [1]
(2S)-3-[[(5S,8S)-8-[(1H-Benzimidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC50100000.0 [1]
(2S)-3-[[8-(1H-Imidazol-2-ylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acidIC5033000.0 [1]
(2S)-3-[[8-[(1H-Imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acidIC501000.0 [1]
(2S)-2-(2,6-Dimethyl-4-phenylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acidIC508300.0 [1]
(2S)-2-(Benzenesulfonyl)-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acidIC50830.0 [1]
(2S)-2-(2,6-Dichloro-4-phenylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acidIC508300.0 [1]
(2S)-3-[[(5S,8S)-8-[(2H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC507300.0 [1]
(2S)-2-(2,6-Dimethylphenyl)sulfonyl-3-[[8-[(1H-imidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]propanoic acidIC50310.0 [1]
(2S)-3-[[8-[(1H-Benzimidazol-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acidIC507100.0 [1]
(2S)-3-[[8-[(1,4,5,6-Tetrahydropyrimidin-2-ylamino)methyl]-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carbonyl]amino]-2-(2,4,6-trimethylphenyl)sulfonylpropanoic acidIC50800.0 [1]
(2S)-3-[[(5R,8S)-8-[(2H-Imidazol-2-ylamino)methyl]-7-phenylmethoxycarbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acidIC509200.0 [1]
Items per page: 1 - 10 of 19
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References

This online tool may be cited as follows

MLA

"Quest Database™ Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/integrin-alpha-v-beta-3-and-alpha-iib-beta-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Integrin alpha-V/beta-3 and alpha-IIb/beta 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/integrin-alpha-v-beta-3-and-alpha-iib-beta-3-inhibitors-ic50-ki.
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