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Insulin receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
CrizotinibIC50102.0 [1], 201.0 [2], 650.0 [3], 1643.0 [4], 2887.0 [5]
N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC5019.0 [1], 25.0 [2], 100.0 [3]
N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideKi1.3 [1]
StaurosporineIC508.5 [1], 14.73 [2], 73.6 [3], 300.0 [4]
CeritinibIC507.0 [1], 24.0 [2], 93.0 [3], 319.5 [4]
Nvp-aew541IC50244.0 [1], 892.0 [2], 1000.0 [3], 1018.0 [4]
LinsitinibIC5016.0 [1], 18.0 [2], 34.0 [3], 126.0 [4]
Nvp-tae 684IC501.9 [1], 20.0 [2], 43.7 [3], 10000.0 [4]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC505.0 [1], 100.0 [2]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideKi2.2 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-[4-(2-methylsulfonylethyl)piperazin-1-yl]cyclohexyl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]thiophene-2-carboxamideIC50110.0 [1], 145.0 [2], 150.0 [3]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC50638.0 [1], 3800.0 [2]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5064.0 [1], 930.0 [2]
N-(2,6-Difluorophenyl)-3-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC507.0 [1], 100.0 [2]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5065.0 [1], 471.0 [2], 510.0 [3]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5093.0 [1], 166.0 [2], 175.0 [3]
1-[4-[3-[4-Amino-5-[2-fluoro-3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5036.0 [1], 94.0 [2], 102.0 [3]
ErlotinibIC5012500.0 [1], 100000.0 [2]
DasatinibIC5050000.0 [1]
NintedanibIC504000.0 [1], 10000.0 [2]
PD173074IC5050000.0 [1]
Bms-777607IC502000.0 [1], 12500.0 [2]
2-({5-Chloro-2-[(2-Methoxy-4-Morpholin-4-Ylphenyl)amino]pyrimidin-4-Yl}amino)-N-MethylbenzamideIC5025.0 [1], 40.0 [2]
Bms-536924IC5073.0 [1]
Unii-NA856793UTIC5050000.0 [1]
CID 25182616IC501.8 [1], 79.0 [2]
1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]ureaIC5050000.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC5016000.0 [1], 23000.0 [2]
Cep-37440IC5065.0 [1], 2000.0 [2]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC5050000.0 [1]
(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC50662.0 [1], 10000.0 [2]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-cyanobenzamideIC506000.0 [1], 10000.0 [2]
3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanolIC501690.0 [1]
4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-olIC5010000.0 [1], 11000.0 [2]
2-[[5-Chloro-2-[(1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N-methylbenzamideIC5023.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-chlorobenzamideIC505600.0 [1], 10000.0 [2]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]benzamideIC50120.0 [1], 560.0 [2]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-1,2-oxazole-5-carboxamideIC506000.0 [1], 10000.0 [2]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-5-cyanothiophene-2-carboxamideIC503800.0 [1], 10000.0 [2]
2-[[5-Chloro-2-[(5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamideIC50153.0 [1]
1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC5050000.0 [1]
6-Arylpyrido[2,3-d]pyrimidine deriv. 32IC5050000.0 [1]
6-Arylpyrido[2,3-d]pyrimidine deriv. 47IC5050000.0 [1]
6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC50310.0 [1]
1-[4-[4-[(5-Chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]ethanoneIC509.0 [1], 12.0 [2]
N-[4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-ethylamino)-[1,3,5]triazin-2-yl]-hydroxylamineIC50420.0 [1], 10000.0 [2]
4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-ethylamino)-[1,3,5]triazin-2-olIC50550.0 [1], 10000.0 [2]
4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-[1,3,5]triazin-2-olIC504000.0 [1], 10000.0 [2]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl)benzamideIC50189.0 [1], 707.0 [2]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-(4-pyrrolidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
3-[3-[2-[4-[4-(4-Acetylpiperazin-1-yl)piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)benzamideIC50100.0 [1]
Infigratinib phosphateIC503371.0 [1], 10000.0 [2]
5-[3-[2-[5-Chloro-2-ethoxy-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-ethoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-methoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-[4-[4-(2-fluoroethyl)piperazin-1-yl]piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-methoxy-5-methyl-4-[1-(2-methylsulfonylethyl)piperidin-4-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[7-fluoro-3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[2-ethoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[2-ethoxy-4-(4-propan-2-ylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
3-[3-[2-[5-Chloro-4-[4-[4-(2-fluoroethyl)piperazin-1-yl]piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-(4-piperidin-1-ylpiperidin-1-yl)-2-propylanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-[4-(2-methylsulfonylethyl)piperidin-1-yl]piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-4-(1-propylpiperidin-4-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-ethoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-4-[3-(4-methylpiperazin-1-yl)propyl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-4-(4-propylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-[1-(2-methylsulfonylethyl)piperidin-4-yl]-2-propylanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-(3-piperidin-1-ylpropyl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-propan-2-yloxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[4-[4-[4-(2-fluoroethyl)piperazin-1-yl]piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1], 500.0 [2]
N-(2,6-Difluorophenyl)-5-[3-[2-[2-ethoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-propan-2-yloxybenzamideIC50100.0 [1], 1000.0 [2]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-ethoxy-5-ethyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1], 1000.0 [2]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]-8-methylimidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
3-[3-[2-[5-Chloro-2-methoxy-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]-8-methylimidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[1-[1-(2-methylsulfonylethyl)piperidin-4-yl]piperidin-4-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[7-fluoro-3-[2-[2-methoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[4-(4-hydroxypiperidin-1-yl)-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-methoxy-4-[4-[4-(2-methylsulfonylethyl)piperazin-1-yl]piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2,5-dimethoxy-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
3-[3-[2-[4-[4-[Bis(2-methoxyethyl)amino]piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-ethoxy-5-methyl-4-[4-(2-methylsulfonylethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methoxy-5-methyl-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-methoxy-3-methyl-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-3-[3-[2-[2-methyl-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-ethoxy-5-[3-[2-[2-ethoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
N-(2,6-Difluorophenyl)-2-methoxy-5-[3-[2-[2-methoxy-5-methyl-4-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]benzamideIC50100.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Insulin receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/insulin-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Insulin receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/insulin-receptor-inhibitors-ic50-ki.
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