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Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
Mycophenolic acidIC5015.0 [1]
Mycophenolic acidKi10.0 [1]
C2-Mycophenolic adenine dinucleotideKi250.0 [1]
1-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-m-tolyl-ureaIC5019.0 [1], 19000.0 [2]
[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC5090.0 [1]
[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateKi110.0 [1], 430.0 [2], 440.0 [3]
4-Morpholineacetamide, N-(2-(2-((3-methoxy-4-(5-oxazolyl)phenyl)amino)-5-oxazolyl)phenyl)-N-methyl-IC5012.0 [1], 16.0 [2]
(3-Methoxy-4-oxazol-5-yl-phenyl)-(5-phenyl-oxazol-2-yl)-amineIC5016.0 [1], 20.0 [2]
7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-oneIC508.0 [1]
7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-oneKi7.0 [1]
MerimepodibIC5010.0 [1], 11.0 [2]
[(2R,3S,4R,5R)-5-(6-Amino-2-ethylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)ethoxy]phosphoryl]methyl]phosphinic acidKi38.0 [1], 40.0 [2]
Tiazofurin adenine dinucleotideKi100.0 [1], 110.0 [2]
RockoutIC501150.0 [1]
3-CyanoindoleIC5020900.0 [1]
N~2~-(2,3-Dichlorophenyl)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]-L-AlaninamideIC505000.0 [1]
N~2~-(2,3-Dichlorophenyl)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]-L-AlaninamideKi5000.0 [1]
[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl]phosphinic acidIC50110.0 [1]
[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl]phosphinic acidKi110.0 [1]
1-Methyl-1H-indole-3-carbonitrileIC507660.0 [1]
(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamideIC505000.0 [1]
(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamideKi5000.0 [1]
[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acidIC50300.0 [1]
[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acidKi300.0 [1]
N'-Tert-butyl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]oxamideIC505000.0 [1], 10000.0 [2]
N'-Tert-butyl-N-[4-(1,3-oxazol-5-yl)phenyl]oxamideIC505000.0 [1], 10000.0 [2]
[(2R,3S,4R,5R)-5-(6-Amino-2-phenylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)ethoxy]phosphoryl]methyl]phosphinic acidKi108.0 [1], 110.0 [2]
Mycophenolic hydroxamic acidIC50420.0 [1]
Mycophenolic hydroxamic acidKi30.0 [1]
O-Desmethyl Mycophenolic AcidIC5087.7 [1], 170.0 [2]
2-(4-Methoxyphenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamideIC505000.0 [1]
2-(4-Methoxyphenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamideKi5000.0 [1]
N'-Tert-butyl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]oxamideIC5010.0 [1]
N'-Tert-butyl-N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]oxamideIC5055.0 [1]
[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-2-methylbut-2-enoxy]phosphoryl]methyl]phosphinic acidKi380.0 [1]
7-Methoxy-3-methyl-6-oxazol-5-yl-1H-quinazoline-2,4-dioneIC50104.0 [1]
3-Furan-2-yl-N-(3-methoxy-4-oxazol-5-yl-phenyl)-acrylamideIC5028.0 [1]
[2-[N-Methyl-2-[2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl]anilino]-2-oxoethyl] acetateIC507.0 [1]
(3-Methoxy-4-oxazol-5-yl-phenyl)-(4-methoxy-6-phenyl-[1,3,5]triazin-2-yl)-amineIC5041.0 [1]
2-N-[3-Methoxy-4-(1,3-oxazol-5-yl)phenyl]-4-N-methyl-6-phenyl-1,3,5-triazine-2,4-diamineIC5076.0 [1]
N-[3-Bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butyloxamideIC5050.0 [1]
1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-ureaIC5011.0 [1]
(3-Oxazol-5-yl-1H-indol-6-yl)-(5-phenyl-oxazol-2-yl)-amineIC5093.0 [1]
Selenazole-4-carboxyamide-adenine dinucleotideKi21.0 [1], 26.0 [2]
1-(3-Cyano-1-methyl-1H-indol-6-yl)-3-phenylureaIC50630.0 [1], 722.0 [2]
3-N-[3-Methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamineIC50150.0 [1]
1-[3-Methoxy-4-(5-oxazolyl)phenyl]-2-cyano-3-phenylguanidineIC50240.0 [1], 250.0 [2]
N-(3-Methoxy-4-oxazol-5-yl-phenyl)-2-oxo-3-phenyl-butyramideIC5052.0 [1]
[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylselenophen-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateKi270.0 [1], 1100.0 [2]
[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylthiophen-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateKi320.0 [1], 340.0 [2]
[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylfuran-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateKi57900.0 [1], 99100.0 [2]
AdenosineKi100000.0 [1]
Indole-3-carboxaldehydeIC5022700.0 [1]
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC5010000.0 [1]
1-Methyl-1H-indole-3-carbaldehydeIC506840.0 [1]
N-(4-Chloro-phenyl)-2-(2-thiazol-4-yl-benzoimidazol-1-yl)-acetamideIC505000.0 [1]
2-(2,4-Dichlorophenoxy)-N-[2-(4-pyridinyl)-1,3-benzoxazol-5-yl]propanamideIC505000.0 [1]
Unii-9688E11ZQ0IC5017.0 [1]
1-(2-Oxo-1,3-dihydrobenzimidazol-5-yl)-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]ureaIC505000.0 [1]
1,1-Dioxido-1-benzothien-3-yl 5-phenyl-1,3,4-oxadiazol-2-yl sulfideIC502100.0 [1]
2-(4-Chlorophenoxy)-2-methyl-N-[2-(4-pyridinyl)-1,3-benzoxazol-5-yl]propanamideIC505000.0 [1]
N-Naphthalen-2-yl-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamideIC505000.0 [1]
N-[1-(3-Isopropenylphenyl)-1-methylethyl]-N'-(4-methoxyphenyl)ureaIC505000.0 [1]
2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-oneIC5010000.0 [1]
2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
8-Methyl-2-phenylquinazolin-4(3H)-oneIC5010000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-2-methylbut-2-enoxy]phosphoryl]methyl]phosphinic acidKi380.0 [1]
2-Chloro-N,N-Dimethyl-5-[({2-[3-(Prop-1-En-2-Yl)phenyl]propan-2-Yl}carbamoyl)amino]benzamideIC505000.0 [1]
8-Methyl-2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC5010000.0 [1]
N-(4-Bromophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamideIC505000.0 [1]
N-(4-Fluorophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamideIC505000.0 [1]
N-(3-Chlorophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamideIC505000.0 [1]
N-(4-Bromophenyl)-2-[2-(1,3-Thiazol-2-Yl)-1h-Benzimidazol-1-Yl]acetamideIC505000.0 [1]
N-(Naphthalen-2-Yl)-2-[2-(Pyridin-2-Yl)-1h-Benzimidazol-1-Yl]acetamideIC505000.0 [1]
CID 52589406IC505000.0 [1]
N-(4-Cyanophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamideIC505000.0 [1]
(E,3S)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-3-hydroxy-4-methylhex-4-enoic acidIC5028860.0 [1]
Methyl mycophenolateIC501400.0 [1]
7-Hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-oneIC50790.0 [1]
(2s)-2-(Naphthalen-1-Yloxy)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]propanamideIC505000.0 [1]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[1-(3-isopropenylphenyl)-1-methyl-ethyl]ureaIC505000.0 [1]
(2S)-2-Phenyl-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamideIC505000.0 [1]
(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-6-yl)propanamideIC505000.0 [1]
[[(2S,3R,4R,5S)-5-(6-Aminopurin-9-yl)-3-fluoro-4-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateIC50700.0 [1]
1-Phenyl-3-(alpha,alpha-dimethyl-3-isopropenylbenzyl)ureaIC505000.0 [1]
8-Methyl-2-(4-Methylphenyl)-3,4-Dihydroquinazolin-4-OneIC5010000.0 [1]
[(2S,3R,4S)-3,4-Dihydroxy-5-[6-oxo-2-[(E)-2-phenylethenyl]-1H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphateIC5037000.0 [1]
[(2S,3R,4S)-3,4-Dihydroxy-5-(2-methyl-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphateIC501000000.0 [1]
CID 136042356IC505000.0 [1]
2-(4-Chlorophenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
2-(4-Fluorophenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
Benzyl N-[[4-(8-methyl-4-oxo-3H-quinazolin-2-yl)phenyl]methyl]carbamateIC5010000.0 [1]
2-(4-Bromophenyl)-8-methyl-3H-quinazolin-4-oneIC5010000.0 [1]
(2S)-2-Naphthalen-1-yloxy-N-[2-(1H-pyrrol-2-yl)-1,3-benzoxazol-5-yl]propanamideIC505000.0 [1]
2-(2,4-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamideIC505000.0 [1]
3-[[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-benzothiophene 1,1-dioxideIC501500.0 [1]
3-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-benzothiophene 1,1-dioxideIC5030000.0 [1]
N-(1-Oxo-3H-2-benzofuran-5-yl)-2-[4-[(E)-3-thiophen-2-ylprop-2-enoyl]phenoxy]acetamideIC504540.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc.20 Dec2024https://www.aatbio.com/data-sets/inosine-5-monophosphate-dehydrogenase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 20). Quest Database™ Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inosine-5-monophosphate-dehydrogenase-2-inhibitors-ic50-ki.
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