Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Mycophenolic acid	IC50	15.0 [1]
	Mycophenolic acid	Ki	10.0 [1]
	C2-Mycophenolic adenine dinucleotide	Ki	250.0 [1]
	1-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-m-tolyl-urea	IC50	19.0 [1], 19000.0 [2]
	[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	IC50	90.0 [1]
	[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Ki	110.0 [1], 430.0 [2], 440.0 [3]
	4-Morpholineacetamide, N-(2-(2-((3-methoxy-4-(5-oxazolyl)phenyl)amino)-5-oxazolyl)phenyl)-N-methyl-	IC50	12.0 [1], 16.0 [2]
	(3-Methoxy-4-oxazol-5-yl-phenyl)-(5-phenyl-oxazol-2-yl)-amine	IC50	16.0 [1], 20.0 [2]
	7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one	IC50	8.0 [1]
	7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one	Ki	7.0 [1]
	Merimepodib	IC50	10.0 [1], 11.0 [2]
	[(2R,3S,4R,5R)-5-(6-Amino-2-ethylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)ethoxy]phosphoryl]methyl]phosphinic acid	Ki	38.0 [1], 40.0 [2]
	Tiazofurin adenine dinucleotide	Ki	100.0 [1], 110.0 [2]
	Rockout	IC50	1150.0 [1]
	3-Cyanoindole	IC50	20900.0 [1]
	N~2~-(2,3-Dichlorophenyl)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]-L-Alaninamide	IC50	5000.0 [1]
	N~2~-(2,3-Dichlorophenyl)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]-L-Alaninamide	Ki	5000.0 [1]
	[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl]phosphinic acid	IC50	110.0 [1]
	[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl]phosphinic acid	Ki	110.0 [1]
	1-Methyl-1H-indole-3-carbonitrile	IC50	7660.0 [1]
	(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamide	IC50	5000.0 [1]
	(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamide	Ki	5000.0 [1]
	[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acid	IC50	300.0 [1]
	[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]-difluoromethyl]phosphinic acid	Ki	300.0 [1]
	N'-Tert-butyl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]oxamide	IC50	5000.0 [1], 10000.0 [2]
	N'-Tert-butyl-N-[4-(1,3-oxazol-5-yl)phenyl]oxamide	IC50	5000.0 [1], 10000.0 [2]
	[(2R,3S,4R,5R)-5-(6-Amino-2-phenylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)ethoxy]phosphoryl]methyl]phosphinic acid	Ki	108.0 [1], 110.0 [2]
	Mycophenolic hydroxamic acid	IC50	420.0 [1]
	Mycophenolic hydroxamic acid	Ki	30.0 [1]
	O-Desmethyl Mycophenolic Acid	IC50	87.7 [1], 170.0 [2]
	2-(4-Methoxyphenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamide	IC50	5000.0 [1]
	2-(4-Methoxyphenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamide	Ki	5000.0 [1]
	N'-Tert-butyl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]oxamide	IC50	10.0 [1]
	N'-Tert-butyl-N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]oxamide	IC50	55.0 [1]
	[(2S,3R,4S,5S)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-2-methylbut-2-enoxy]phosphoryl]methyl]phosphinic acid	Ki	380.0 [1]
	7-Methoxy-3-methyl-6-oxazol-5-yl-1H-quinazoline-2,4-dione	IC50	104.0 [1]
	3-Furan-2-yl-N-(3-methoxy-4-oxazol-5-yl-phenyl)-acrylamide	IC50	28.0 [1]
	[2-[N-Methyl-2-[2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl]anilino]-2-oxoethyl] acetate	IC50	7.0 [1]
	(3-Methoxy-4-oxazol-5-yl-phenyl)-(4-methoxy-6-phenyl-[1,3,5]triazin-2-yl)-amine	IC50	41.0 [1]
	2-N-[3-Methoxy-4-(1,3-oxazol-5-yl)phenyl]-4-N-methyl-6-phenyl-1,3,5-triazine-2,4-diamine	IC50	76.0 [1]
	N-[3-Bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butyloxamide	IC50	50.0 [1]
	1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-urea	IC50	11.0 [1]
	(3-Oxazol-5-yl-1H-indol-6-yl)-(5-phenyl-oxazol-2-yl)-amine	IC50	93.0 [1]
	Selenazole-4-carboxyamide-adenine dinucleotide	Ki	21.0 [1], 26.0 [2]
	1-(3-Cyano-1-methyl-1H-indol-6-yl)-3-phenylurea	IC50	630.0 [1], 722.0 [2]
	3-N-[3-Methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamine	IC50	150.0 [1]
	1-[3-Methoxy-4-(5-oxazolyl)phenyl]-2-cyano-3-phenylguanidine	IC50	240.0 [1], 250.0 [2]
	N-(3-Methoxy-4-oxazol-5-yl-phenyl)-2-oxo-3-phenyl-butyramide	IC50	52.0 [1]
	[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylselenophen-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Ki	270.0 [1], 1100.0 [2]
	[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylthiophen-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Ki	320.0 [1], 340.0 [2]
	[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoylfuran-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Ki	57900.0 [1], 99100.0 [2]
	Adenosine	Ki	100000.0 [1]
	Indole-3-carboxaldehyde	IC50	22700.0 [1]
	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one	IC50	10000.0 [1]
	1-Methyl-1H-indole-3-carbaldehyde	IC50	6840.0 [1]
	N-(4-Chloro-phenyl)-2-(2-thiazol-4-yl-benzoimidazol-1-yl)-acetamide	IC50	5000.0 [1]
	2-(2,4-Dichlorophenoxy)-N-[2-(4-pyridinyl)-1,3-benzoxazol-5-yl]propanamide	IC50	5000.0 [1]
	Unii-9688E11ZQ0	IC50	17.0 [1]
	1-(2-Oxo-1,3-dihydrobenzimidazol-5-yl)-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea	IC50	5000.0 [1]
	1,1-Dioxido-1-benzothien-3-yl 5-phenyl-1,3,4-oxadiazol-2-yl sulfide	IC50	2100.0 [1]
	2-(4-Chlorophenoxy)-2-methyl-N-[2-(4-pyridinyl)-1,3-benzoxazol-5-yl]propanamide	IC50	5000.0 [1]
	N-Naphthalen-2-yl-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamide	IC50	5000.0 [1]
	N-[1-(3-Isopropenylphenyl)-1-methylethyl]-N'-(4-methoxyphenyl)urea	IC50	5000.0 [1]
	2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one	IC50	10000.0 [1]
	2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	8-Methyl-2-phenylquinazolin-4(3H)-one	IC50	10000.0 [1]
	[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-2-methylbut-2-enoxy]phosphoryl]methyl]phosphinic acid	Ki	380.0 [1]
	2-Chloro-N,N-Dimethyl-5-[({2-[3-(Prop-1-En-2-Yl)phenyl]propan-2-Yl}carbamoyl)amino]benzamide	IC50	5000.0 [1]
	8-Methyl-2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-One	IC50	10000.0 [1]
	N-(4-Bromophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamide	IC50	5000.0 [1]
	N-(4-Fluorophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamide	IC50	5000.0 [1]
	N-(3-Chlorophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamide	IC50	5000.0 [1]
	N-(4-Bromophenyl)-2-[2-(1,3-Thiazol-2-Yl)-1h-Benzimidazol-1-Yl]acetamide	IC50	5000.0 [1]
	N-(Naphthalen-2-Yl)-2-[2-(Pyridin-2-Yl)-1h-Benzimidazol-1-Yl]acetamide	IC50	5000.0 [1]
	CID 52589406	IC50	5000.0 [1]
	N-(4-Cyanophenyl)-2-[2-(1,3-thiazol-4-yl)benzimidazol-1-yl]acetamide	IC50	5000.0 [1]
	(E,3S)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-3-hydroxy-4-methylhex-4-enoic acid	IC50	28860.0 [1]
	Methyl mycophenolate	IC50	1400.0 [1]
	7-Hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-one	IC50	790.0 [1]
	(2s)-2-(Naphthalen-1-Yloxy)-N-[2-(Pyridin-4-Yl)-1,3-Benzoxazol-5-Yl]propanamide	IC50	5000.0 [1]
	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[1-(3-isopropenylphenyl)-1-methyl-ethyl]urea	IC50	5000.0 [1]
	(2S)-2-Phenyl-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)propanamide	IC50	5000.0 [1]
	(2S)-2-(2,3-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-6-yl)propanamide	IC50	5000.0 [1]
	[[(2S,3R,4R,5S)-5-(6-Aminopurin-9-yl)-3-fluoro-4-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	IC50	700.0 [1]
	1-Phenyl-3-(alpha,alpha-dimethyl-3-isopropenylbenzyl)urea	IC50	5000.0 [1]
	8-Methyl-2-(4-Methylphenyl)-3,4-Dihydroquinazolin-4-One	IC50	10000.0 [1]
	[(2S,3R,4S)-3,4-Dihydroxy-5-[6-oxo-2-[(E)-2-phenylethenyl]-1H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate	IC50	37000.0 [1]
	[(2S,3R,4S)-3,4-Dihydroxy-5-(2-methyl-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate	IC50	1000000.0 [1]
	CID 136042356	IC50	5000.0 [1]
	2-(4-Chlorophenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	2-(4-Fluorophenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	Benzyl N-[[4-(8-methyl-4-oxo-3H-quinazolin-2-yl)phenyl]methyl]carbamate	IC50	10000.0 [1]
	2-(4-Bromophenyl)-8-methyl-3H-quinazolin-4-one	IC50	10000.0 [1]
	(2S)-2-Naphthalen-1-yloxy-N-[2-(1H-pyrrol-2-yl)-1,3-benzoxazol-5-yl]propanamide	IC50	5000.0 [1]
	2-(2,4-Dichlorophenoxy)-N-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamide	IC50	5000.0 [1]
	3-[[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-benzothiophene 1,1-dioxide	IC50	1500.0 [1]
	3-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-benzothiophene 1,1-dioxide	IC50	30000.0 [1]
	N-(1-Oxo-3H-2-benzofuran-5-yl)-2-[4-[(E)-3-thiophen-2-ylprop-2-enoyl]phenoxy]acetamide	IC50	4540.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/inosine-5-monophosphate-dehydrogenase-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Inosine-5'-monophosphate dehydrogenase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inosine-5-monophosphate-dehydrogenase-2-inhibitors-ic50-ki.
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