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Inhibitor of nuclear factor kappa B kinase epsilon subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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IKK-3 InhibitorIC5039.81 [1], 469.0 [2]
N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamideIC5076.0 [1]
N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamideIC5021.0 [1]
5-[2-[[1-(4-Hydroxycyclohexyl)pyrazol-4-yl]amino]pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrileIC505.0 [1], 10.0 [2]
AmlexanoxIC505128.61 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamideIC50100000.0 [1]
DanusertibIC5010000.0 [1]
CID 53469448IC501064.0 [1]
N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamideIC50100000.0 [1]
MilciclibIC5010000.0 [1]
2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrileIC5020000.0 [1]
CID 11634725Ki5000.0 [1]
2-Amino-3-phenyl-5-(pyridin-4-yl)benzamideIC503981.07 [1]
3-Methyl-4-phenyl-1H-pyrazol-5-amineIC50100000.0 [1]
N-[3-[[5-Cyclopropyl-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5030.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amineIC50100000.0 [1]
2-Amino-3-(4-methanesulfonamidophenyl)-5-phenylbenzamideIC5015848.93 [1]
2-Amino-5-(4-fluorophenyl)-3-(pyridin-4-yl)benzamideIC5015848.93 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
N,12-Dimethyl-4-phenyl-5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC5017000.0 [1]
2-Amino-5-phenylbenzamideIC5015848.93 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC504000.0 [1]
N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]acetamideIC5012000.0 [1]
5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamideIC503162.28 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC5010000.0 [1]
5-[5,6-Bis(Methyloxy)-1h-Benzimidazol-1-Yl]-3-{[1-(2-Chlorophenyl)ethyl]oxy}-2-ThiophenecarboxamideIC5019952.62 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
2-Amino-5-phenyl-3-[4-(sulfamoylmethyl)phenyl]benzamideIC5015848.93 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC501700.0 [1]
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamideIC5015848.93 [1]
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carbonitrileIC50251.19 [1]
N,5,12-Trimethyl-4-phenyl-3,5,7,10,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC5014000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
4-{3-[2-Amino-5-(2-Methoxyethoxy)pyrimidin-4-Yl]-1h-Indol-5-Yl}-2-Methylbut-3-Yn-2-OlIC50100000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
CID 71553154IC5030000.0 [1]
6-Chloro-N-methyl-2-[4-(2-morpholin-4-ylethoxy)phenyl]-1H-imidazo[4,5-b]pyridin-7-amineIC5016100.0 [1]
5-Phenyl-3-(3-piperidinyl)-1H-indole-7-carboxamideIC503162.28 [1]
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[2-(morpholin-4-yl)ethoxy]thiophene-2-carbonitrileIC501584.89 [1]
5-[5-(3-Hydroxypropoxy)-6-methoxybenzimidazol-1-yl]-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carbonitrileIC5025.12 [1]
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxolan-2-ylmethoxy)thiophene-2-carbonitrileIC50794.33 [1]
3-[(1R)-1-(2-Chlorophenyl)ethoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carbonitrileIC501584.89 [1]
5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carbonitrileIC503981.07 [1]
5-[6-Methoxy-5-(2-morpholin-4-ylethoxy)benzimidazol-1-yl]-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carbonitrileIC5050.12 [1]
5-(1H-Benzimidazol-1-yl)-3-[(phenylmethyl)oxy]-2-thiophenecarbonitrileIC501000.0 [1]
(2S,4R)-1-[(2S)-2-[[2-[3-[4-[3-[4-[[5-Bromo-4-[3-[cyclobutanecarbonyl(methyl)amino]propylamino]pyrimidin-2-yl]amino]phenoxy]propoxy]butoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamideIC508.7 [1]
2-Amino-7-(dimethylamino)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC501584.89 [1]
2-Amino-7-cyclopropyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5010600.0 [1]
2-Amino-5-oxo-7-(thian-4-yl)chromeno[2,3-b]pyridine-3-carboxylic acidIC501202.26 [1]
2-Amino-7-morpholin-4-yl-5-oxo-N-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridine-3-carboxamideIC501200.0 [1]
2-Amino-7-(2-methylpropyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC504897.79 [1]
2-Amino-5-oxo-8-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC504677.35 [1]
2-Amino-5-oxo-7-(4-oxocyclohexyl)chromeno[2,3-b]pyridine-3-carboxylic acidIC501513.56 [1]
2-Amino-5-oxo-8-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC507244.36 [1]
2-Amino-7-(cyclohexen-1-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC505400.0 [1]
2-Amino-7-cyclopentyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC506300.0 [1]
2-Amino-7-cyclobutyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC503100.0 [1]
5-Amino-9-oxo-12-propan-2-yl-2-oxa-4,13-diazatricyclo[8.4.0.03,8]tetradeca-1(14),3,5,7,10,12-hexaene-6-carboxylic acidIC503090.3 [1]
5-Amino-9-oxo-12-prop-1-en-2-yl-2-oxa-4,13-diazatricyclo[8.4.0.03,8]tetradeca-1(14),3,5,7,10,12-hexaene-6-carboxylic acidIC505248.07 [1]
2-Amino-7-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC502100.0 [1]
7-(1-Acetylpiperidin-4-yl)-2-amino-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC501905.46 [1]
2-Amino-7-(3-methylbutyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC503388.44 [1]
2-Amino-7-(3,6-dihydro-2H-pyran-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC501995.26 [1]
2-Amino-7-(1,1-dioxothian-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5011000.0 [1]
2-Amino-8-fluoro-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC505370.32 [1]
2-Amino-7-(1-formylpiperidin-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC505200.0 [1]
2-Amino-7-cyclohexyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50100000.0 [1]
2-Amino-7-(oxan-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5011000.0 [1]
2-Amino-7-(3-methylbut-1-ynyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5019952.62 [1]
2-Amino-8-fluoro-5-oxo-7-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC501698.24 [1]
2-Amino-7-(1,4-dioxaspiro[4.5]decan-8-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC503200.0 [1]
2-Amino-7-morpholin-4-yl-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50309.03 [1]
2-Amino-7-cyclohexyl-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC501000.0 [1]
2-Amino-5-oxo-7-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC501288.25 [1]
3-[4-(Dimethylsulfamoyl)phenyl]-2-hydroxy-5-(pyridin-4-yl)benzamideIC5015848.93 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC503430.0 [1]
4-Oxo-N-[3-(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamideIC50100000.0 [1]
4-Oxo-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboxamideIC50100000.0 [1]
2-Amino-7-(cyclohexen-1-yl)-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50208.93 [1]
2-Amino-5-oxo-6-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC506025.6 [1]
2-Amino-7-(dimethylamino)-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50575.44 [1]
2-Amino-3-(4-sulfamoylphenyl)-5-(4-chlorophenyl)benzamideIC5015848.93 [1]
5-(4-Chlorophenyl)-2-hydroxy-3-(4-sulfamoylphenyl)benzamideIC5015848.93 [1]
2-Amino-5-(4-fluorophenyl)-3-(4-sulfamoylphenyl)benzamideIC5015848.93 [1]
2-Amino-5-(pyridin-4-yl)-3-(4-sulfamoylphenyl)benzamideIC501584.89 [1]
2-Amino-5-(4-fluorophenyl)-3-[4-(pyrrolidine-1-sulfonyl)phenyl]benzamideIC5015848.93 [1]
2-Azanyl-5-Phenyl-3-(4-Sulfamoylphenyl)benzamideIC5015848.93 [1]
2-Amino-5-(4-chlorophenyl)-3-(4-methanesulfonamidophenyl)benzamideIC5015848.93 [1]
2-Amino-5-phenyl-3-(3-sulfamoylphenyl)benzamideIC5015848.93 [1]
5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrileIC505011.87 [1]
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxolan-2-ylmethoxy)thiophene-2-carboxamideIC5015848.93 [1]
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-hydroxythiophene-2-carbonitrileIC502511.89 [1]
3-(Cyclopropylmethoxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carbonitrileIC503162.28 [1]
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[2-(piperidin-1-yl)ethoxy]thiophene-2-carbonitrileIC505011.87 [1]
4-({[2-Cyano-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophen-3-yl]oxy}methyl)benzamideIC5012589.25 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Inhibitor of nuclear factor kappa B kinase epsilon subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-epsilon-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Inhibitor of nuclear factor kappa B kinase epsilon subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-epsilon-subunit-inhibitors-ic50-ki.
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