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Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC50490.0 [1]
BMS-345541 free baseIC50200.0 [1]
BMS-345541 free baseKi300.0 [1]
2-Amino-6-(2-hydroxyphenyl)-4-(piperidin-3-yl)nicotinonitrileIC5025.12 [1]
N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamideIC5087.0 [1], 150.0 [2], 186.0 [3], 250.0 [4]
N-(2-Hydroxyethyl)-N-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC5015.0 [1], 39.81 [2], 794.33 [3]
(5Z)-5-[(3-Chloro-4-morpholin-4-ylphenyl)methylidene]-3-[4-[3-[4-(cyclopropylmethyl)piperazin-1-yl]propoxy]phenyl]-1,3-thiazolidine-2,4-dioneIC50250.61 [1], 252.35 [2], 287.74 [3], 372.39 [4], 700.0 [5]
(5Z)-3-[4-[5-[4-(Cyclopropylmethyl)piperazin-1-yl]pentoxy]phenyl]-5-[[4-(4-fluorophenoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC50240.44 [1], 298.54 [2], 340.41 [3], 400.0 [4], 1096.48 [5]
Bms-345541IC50240.0 [1], 300.0 [2], 644.0 [3], 4000.0 [4]
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamideIC5018.0 [1], 19.5 [2], 19.95 [3]
1-(5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dioneIC508.0 [1], 62.0 [2], 67.0 [3]
N,12-Dimethyl-4-phenyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC506.0 [1], 6.03 [2]
3,4-Dichloro-2-ethoxy-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzenesulfonamideIC5032700.0 [1], 35400.0 [2], 55800.0 [3], 56100.0 [4]
N-[3-[2-Amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]phenyl]-5-oxooxolane-2-carboxamideIC501500.0 [1]
3-Amino-5-(3-thiophenyl)-2-thiophenecarboxamideIC501300.0 [1], 2000.0 [2], 11200.0 [3]
CID 22291652IC501.6 [1], 25.0 [2], 1000.0 [3]
[3-[8-(2-Aminoethylamino)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]methanolIC507.94 [1], 8.0 [2]
Ikk-IN-3IC5019.0 [1], 21.88 [2], 22.0 [3]
N,12-Dimethyl-4-phenyl-5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC5010.96 [1], 11.0 [2]
2-Amino-5-phenylbenzamideIC5014500.0 [1], 15848.93 [2]
3-(3-Methyl-ureido)-5-phenyl-thiophene-2-carboxylic acid amideIC5050.0 [1], 50.12 [2], 1600.0 [3]
2-Amino-6-[2-(cyclobutylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrileIC503.98 [1], 4.0 [2]
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrileIC503.0 [1], 3.02 [2]
2-Amino-6-(2-hydroxy-6-propoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC505.0 [1], 5.01 [2]
2-Amino-4-(1-amino-2-phenyl-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrileIC5060.0 [1]
2-Amino-6-(2-heptoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrileIC5050.0 [1], 50.12 [2]
2-Amino-6-(2-hydroxy-6-pentoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC506.0 [1], 6.03 [2]
N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]acetamideIC5021.88 [1], 22.0 [2]
N-(2-Hydroxyethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC5019.95 [1]
N'-[4-(Furan-3-yl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC5028.84 [1], 29.0 [2]
4-[3-(Aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-amineIC508.0 [1], 8.5 [2], 8.51 [3]
12-Methyl-8-(methylamino)-4-[3-[2-(sulfamoylamino)ethyl]phenyl]-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaeneIC507.0 [1], 7.08 [2]
2-Amino-N-methyl-3-[3-[12-methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]propanamideIC5036.0 [1], 36.31 [2]
3-Amino-5-phenylthiophene-2-carboxamideIC501100.0 [1], 3235.94 [2], 8000.0 [3]
3-Methoxy-N-[[3-[3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]propanamideIC5012.02 [1], 13.0 [2], 2620.0 [3]
4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-2-ylamino}-benzonitrileIC5043.65 [1], 44.0 [2]
N-(1,1-Dioxothian-4-yl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC5019.95 [1]
N-[[3-[3-Methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]acetamideIC5014.0 [1], 14.13 [2], 633.0 [3]
12-Methyl-N-(2-piperidin-1-ylethyl)-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amineIC5045.71 [1], 46.0 [2], 600.0 [3]
8-[[5-Chloro-2-[4-(2-methoxyethyl)piperazin-1-yl]pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamideIC501.9 [1], 59.0 [2], 1000.0 [3]
5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamideIC5012.59 [1], 158.49 [2]
N,12-Dimethyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amineIC5018.0 [1], 18.2 [2], 340.0 [3]
N,12-Dimethyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-amineIC5010.96 [1], 11.0 [2], 8300.0 [3]
N-Methyl-N'-(12-methyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-yl)ethane-1,2-diamineIC5034.67 [1], 35.0 [2], 1500.0 [3]
2-[(12-Methyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-yl)amino]ethanolIC5018.0 [1], 18.2 [2], 1400.0 [3]
DoramapimodIC5020000.0 [1], 30000.0 [2]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamideIC50218.0 [1], 100000.0 [2]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
IKK-3 InhibitorIC5015848.93 [1]
IKK Inhibitor VIIIC5039.81 [1], 40.0 [2]
(4R,4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-4-[(Z)-2-methylbut-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidIC502620.0 [1]
2-Amino-3-phenyl-5-(pyridin-4-yl)benzamideIC503981.07 [1]
3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamideIC502200.0 [1], 2700.0 [2]
N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-3-piperidin-1-yl-propionamideIC50600.0 [1]
4-Phenyl-1H-pyrrolo[2,3-b]pyridineIC503162.28 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamideIC50200.0 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamideIC5055.0 [1]
5-(4-Chlorophenyl)thiophene-2-carboxamideIC5050000.0 [1]
5-Phenyl-2-Ureidothiophene-3-CarboxamideIC5012.88 [1], 13.0 [2]
Reduced Lantadene BIC504240.0 [1]
4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymethoxy)-phenyl]-3-oxo-propenyl}-benzoic acidIC507000.0 [1], 11830.0 [2]
3-Amino-6-(4-hydroxypiperidin-1-yl)-4-methylthieno[2,3-b]pyridine-2-carboxamideIC50750.0 [1], 1000.0 [2]
N'-(12-Methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamineIC50170.0 [1]
3-(Carbamoylamino)-5-Phenylthiophene-2-CarboxamideIC5025.12 [1], 10300.0 [2]
5-Pyrimidin-5-yl-1H-indole-7-carboxamideIC505011.87 [1]
5-Phenyl-3-(1-propan-2-ylsulfonylpiperidin-4-yl)-1H-indole-7-carboxamideIC5019.95 [1]
3-[1-(Ethanesulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamideIC5025.12 [1]
3-Dimethylamino-5-(4-fluoro-phenyl)-thiophene-2-carboxylic acid amideIC5023500.0 [1]
5-Amino-2-(4-methoxy-phenyl)-oxazole-4-carboxylic acid amideIC5017700.0 [1], 18000.0 [2]
5-Amino-2-(1-benzothiophen-2-yl)-1,3-oxazole-4-carboxamideIC504600.0 [1]
3-Amino-4-hydroxymethyl-6-methyl-thieno[2,3-b]pyridine-2-carboxamideIC5012700.0 [1], 13500.0 [2]
4-(4-(5-Methylthiophen-2-yl)pyrimidin-2-ylamino)benzenesulfonamideIC5019.0 [1], 1710.0 [2]
4-(4-(4-Methoxyphenyl)pyrimidin-2-ylamino)benzenesulfonamideIC5040.0 [1], 640.0 [2]
5-Amino-2-(4-chloro-phenyl)-oxazole-4-carboxylic acid amideIC5013600.0 [1], 14000.0 [2]
5-Amino-2-phenyloxazole-4-carboxylic acid amideIC5011000.0 [1]
N,3-Dimethyl-11-phenyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-7-amineIC5039.81 [1], 1670.0 [2]
2-Amino-6-[2-(cyclobutylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-ylpyridine-3-carbonitrileIC5012.0 [1], 12.02 [2]
2-Amino-4-(4-dimethylamino-phenyl)-6-(2-hydroxy-phenyl)-nicotinonitrileIC5019952.62 [1], 20000.0 [2]
2-Amino-6-(2-hydroxy-6-phenylmethoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC509.0 [1], 9.12 [2]
2-Amino-6-(2-hexoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrileIC5025.0 [1], 25.12 [2]
2-Amino-6-(2-hydroxy-phenyl)-4-(4-nitro-phenyl)-nicotinonitrileIC5019952.62 [1], 20000.0 [2]
2-Amino-4-[1-amino-2-(4-fluorophenyl)ethyl]-6-(2-hydroxyphenyl)-3-pyridinecarbonitrileIC5039.81 [1], 40.0 [2]
2-Amino-4-(1-amino-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrileIC50150.0 [1]
2-Amino-4-(2-amino-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrileIC5070.0 [1]
2-Amino-6-(2,6-dihydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC5015.0 [1], 15.14 [2]
2-Amino-6-(2-butoxy-6-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrileIC5015.0 [1], 15.14 [2]
2-Amino-6-[2-(cyclohexylmethoxy)-6-hydroxyphenyl]-4-piperidin-3-ylpyridine-3-carbonitrileIC5026.0 [1], 26.3 [2]
2-Amino-6-(2-ethoxy-6-hydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC5014.0 [1], 14.13 [2]
2-Amino-6-(2-heptoxy-6-hydroxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC5014.0 [1], 14.13 [2]
2-Amino-6-[2-hydroxy-6-(2-methylpropoxy)phenyl]-4-piperidin-3-ylpyridine-3-carbonitrileIC505.0 [1], 5.01 [2]
2-Amino-6-[2-hydroxy-6-(2-methylpropoxy)phenyl]-4-piperidin-4-ylpyridine-3-carbonitrileIC5015.0 [1], 15.14 [2]
2-Amino-6-(2-hydroxy-6-methoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC5033.88 [1], 34.0 [2]
2-Amino-6-(2-hydroxy-6-pentoxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrileIC5019.95 [1], 20.0 [2]
2-Amino-6-(2-hydroxyphenyl)-4-piperidin-4-ylpyridine-3-carbonitrileIC50300.0 [1]
3-[3-(12-Methyl-8-methylimino-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-4-yl)phenyl]propanoic acidIC509.0 [1], 9.12 [2]
N,12-Dimethyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-8-imineIC5021.88 [1], 27.0 [2]
2-Amino-6-(2-hydroxy-4-methoxyphenyl)-4-piperidin-3-ylpyridine-3-carbonitrileIC50560.0 [1]
2-Amino-4-[3-[2-amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]anilino]-4-oxobutanoic acidIC50600.0 [1]
3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-N-(2-piperidin-1-yl-ethyl)-benzamideIC501800.0 [1], 1819.7 [2]
2-[3-(12-Methyl-8-methylimino-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,11-trien-4-yl)phenyl]acetamideIC507.94 [1], 8.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-beta-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Inhibitor of nuclear factor kappa B kinase beta subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-beta-subunit-inhibitors-ic50-ki.
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