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Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
BMS-345541 free baseIC504000.0 [1], 7000.0 [2], 7400.0 [3]
N,12-Dimethyl-4-phenyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC503500.0 [1]
StaurosporineIC5039.0 [1], 233.0 [2]
N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamideIC50100.0 [1], 100000.0 [2]
IKK-3 InhibitorIC5015848.93 [1]
2-Amino-6-(2-hydroxyphenyl)-4-(piperidin-3-yl)nicotinonitrileIC5025.0 [1], 640.0 [2]
N-(2-Hydroxyethyl)-N-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC503162.28 [1]
Ikk-IN-3IC50400.0 [1], 910.0 [2]
N,12-Dimethyl-4-phenyl-5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC50270.0 [1]
N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]acetamideIC501900.0 [1]
N-(2-Hydroxyethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC50316.23 [1]
N-(1,1-Dioxothian-4-yl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC5012.59 [1]
N,5,12-Trimethyl-4-phenyl-3,5,7,10,12-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC504280.0 [1], 4300.0 [2]
N-(5-(4-(Cyclopropylamino)-1-methyl-1H-pyrazolo[5,1-b]purin-7-yl)-2-fluorobenzyl)acetamideIC509700.0 [1]
9H-Pyrido[3,4-B]indoleIC5015000.0 [1]
WedelolactoneIC5010000.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamideIC50100000.0 [1]
Bms-345541IC504000.0 [1]
CID 46215815IC5025118.0 [1]
1-(5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dioneIC501300.0 [1]
CID 22291652IC5014000.0 [1]
3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridineIC50591.0 [1]
A-770041IC5025000.0 [1]
CID 44219749IC5050000.0 [1]
2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrileIC50250.0 [1]
JNK Inhibitor VIIIKi1500.0 [1]
IKK Inhibitor VIIIC50200.0 [1]
CID 59604787IC5010000.0 [1]
2-Amino-3-phenyl-5-(pyridin-4-yl)benzamideIC503162.28 [1]
3-Methyl-4-phenyl-1H-pyrazol-5-amineIC50100000.0 [1]
Unii-BL7xsd8R7BIC504960.0 [1]
4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amineIC50100000.0 [1]
N-[3-[2-Amino-3-cyano-6-(2-hydroxyphenyl)pyridin-4-yl]phenyl]-5-oxooxolane-2-carboxamideIC5020000.0 [1]
2-Amino-3-(4-methanesulfonamidophenyl)-5-phenylbenzamideIC5012589.25 [1]
2-Amino-5-(4-fluorophenyl)-3-(pyridin-4-yl)benzamideIC505011.87 [1]
[3-[8-(2-Aminoethylamino)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]methanolIC50450.0 [1]
2-Amino-5-(4-fluorophenyl)-N-methyl-3-[4-(pyrrolidine-1-sulfonyl)phenyl]benzamideIC5015848.93 [1]
2-Methoxy-5-(pyridin-4-yl)benzamideIC5015848.93 [1]
5-(4-Chlorophenyl)-2-methoxy-3-(4-sulfamoylphenyl)benzamideIC5015848.93 [1]
3-(7-Phenylmethoxyisoquinolin-6-yl)benzenesulfonamideIC5025118.86 [1]
4-(7-Phenylmethoxyisoquinolin-6-yl)benzenesulfonamideIC5025118.86 [1]
3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamideIC502800.0 [1]
Unii-8FX9DP2Y1WIC5010000.0 [1]
2-Amino-5-phenylbenzamideIC5015848.93 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi1500.0 [1]
2-Amino-4-[4-(hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrileKi650.0 [1]
N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-3-piperidin-1-yl-propionamideIC5020000.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi3800.0 [1]
Eudistomin NIC50600.0 [1]
4-Phenyl-1H-pyrrolo[2,3-b]pyridineIC503981.07 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamideIC50100000.0 [1]
N'-[4-(Furan-3-yl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC50940.0 [1]
4-[3-(Aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-amineIC50220.0 [1]
12-Methyl-8-(methylamino)-4-[3-[2-(sulfamoylamino)ethyl]phenyl]-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaeneIC50440.0 [1]
2-Amino-N-methyl-3-[3-[12-methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]propanamideIC50330.0 [1]
3-Amino-5-phenylthiophene-2-carboxamideIC5030000.0 [1]
3-Methoxy-N-[[3-[3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]propanamideIC5012.0 [1]
4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-2-ylamino}-benzonitrileIC503802.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi3750.0 [1]
N-[[3-[3-Methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-11-yl]phenyl]methyl]acetamideIC5014.0 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamideIC5040000.0 [1]
6-Methoxy-9H-pyrido[3,4-b]indoleIC504000.0 [1]
12-Methyl-N-(2-piperidin-1-ylethyl)-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amineIC501700.0 [1]
N'-(12-Methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamineIC5012100.0 [1]
6,8-Dichloro-9h-pyrido[3,4-b]indoleIC50200.0 [1]
5-Pyrimidin-5-yl-1H-indole-7-carboxamideIC5015848.93 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
5-Phenyl-3-(1-propan-2-ylsulfonylpiperidin-4-yl)-1H-indole-7-carboxamideIC503162.28 [1]
3-[1-(Ethanesulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamideIC501995.26 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
5-Bromo-6-methoxy-beta-carbolineIC501000.0 [1]
5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamideIC501995.26 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi970.0 [1]
5-Amino-2-phenyloxazole-4-carboxylic acid amideIC5030000.0 [1]
N,3-Dimethyl-11-phenyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-7-amineIC5040.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneIC5050000.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
2-Amino-5-phenyl-3-[4-(sulfamoylmethyl)phenyl]benzamideIC507943.28 [1]
N,12-Dimethyl-11,14,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,12,14,16-octaen-16-amineIC50230.0 [1]
N,12-Dimethyl-14,15,17-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaen-16-amineIC50670.0 [1]
2-[(12-Methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)amino]acetamideIC5025000.0 [1]
8-Methoxy-12-methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaeneIC50100000.0 [1]
4-(4-Fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC503100.0 [1]
N-[[3-[12-Methyl-8-(methylamino)-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl]methyl]methanesulfonamideIC501000.0 [1]
N-Ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2(6),3,7,10-pentaen-8-amineIC503400.0 [1]
N-(2-Aminoethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC50251.19 [1]
4-(4-Pyrrolidin-1-ylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridineIC501258.93 [1]
2-[2-[3-[12-Methyl-8-(methylamino)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-4-yl]phenyl]ethylamino]acetamideIC50390.0 [1]
N-(2-Aminoethyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamideIC50125.89 [1]
2-[4-[4-(2-Aminoethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-2-yl]acetamideIC50158.49 [1]
N'-[12-Methyl-4-(1H-pyrrol-2-yl)-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC501260.0 [1]
N'-(12-Methyl-4-pyridin-2-yl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)ethane-1,2-diamineIC501240.0 [1]
N'-[4-(2-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC5013000.0 [1]
N'-[4-(3-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC50690.0 [1]
N'-[4-(4-Methoxyphenyl)-12-methyl-3-thia-1,7,10-triazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl]ethane-1,2-diamineIC502800.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nuclear-factor-kappa-b-kinase-alpha-subunit-inhibitors-ic50-ki.
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