Inhibitor of NF-kappa-B kinase (IKK) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	IKK Inhibitor VII	IC50	300.0 [1]
	[4-[[4-[5-(3-Hydroxy-3-methylbutyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	50.0 [1], 450.0 [2], 500.0 [3], 600.0 [4], 2000.0 [5]
	[4-[[4-[5-(4-Hydroxybutyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	40.0 [1], 200.0 [2], 2000.0 [3]
	4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)benzamide	IC50	300.0 [1], 500.0 [2], 5000.0 [3]
	[4-[[4-(1-Benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-[4-(dimethylamino)piperidin-1-yl]methanone	IC50	80.0 [1], 300.0 [2], 400.0 [3], 2000.0 [4]
	(4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(pyrrolidin-1-yl)methanone	IC50	2000.0 [1], 8500.0 [2], 20000.0 [3]
	4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)benzoic acid	IC50	18000.0 [1], 50000.0 [2], 100000.0 [3]
	[4-[[4-[5-(3-Methoxypropyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	100.0 [1], 400.0 [2], 500.0 [3], 600.0 [4], 1000.0 [5]
	Dasatinib	IC50	10000.0 [1]
	Lfm-a13	IC50	500000.0 [1]
	10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine	IC50	10000.0 [1]
	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	IC50	10000.0 [1]
	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	IC50	10000.0 [1]
	[4-[[4-[5-(3-Amino-3-methylbutyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	40.0 [1]
	[4-[[4-(1-Benzothiophen-2-yl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	150.0 [1]
	4-[[4-(1-Benzothiophen-2-yl)pyrimidin-2-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzamide	IC50	500.0 [1]
	N-(2-Aminoethyl)-4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)benzamide	IC50	4400.0 [1]
	2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)benzoic acid	IC50	100000.0 [1]
	[4-[[4-[5-(3-Amino-3-methylbut-1-ynyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	200.0 [1]
	[4-[[4-(1-Benzothiophen-2-yl)pyrimidin-2-yl]amino]-2-chlorophenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	250.0 [1]
	N-[2-Methyl-4-[5-[2-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)anilino]pyrimidin-4-yl]thiophen-2-yl]butan-2-yl]acetamide	IC50	800.0 [1]
	[4-[[4-[5-(3-Amino-3-ethylpentyl)thiophen-2-yl]pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	30.0 [1]
	(1E,6E)-4-[(2,3-Dimethoxyphenyl)methylidene]-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	5000.0 [1]
	(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylidene]hepta-1,6-diene-3,5-dione	IC50	2800.0 [1]
	(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylidene]hepta-1,6-diene-3,5-dione	IC50	2200.0 [1]
	Thieno[3,2-b]-pyridine-6-carbonitrile 12	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 26 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Inhibitor of NF-kappa-B kinase (IKK) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 30 Mar. 2025, https://www.aatbio.com/data-sets/inhibitor-of-nf-kappa-b-kinase-ikk-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 30). Quest Database™ Inhibitor of NF-kappa-B kinase (IKK) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/inhibitor-of-nf-kappa-b-kinase-ikk-inhibitors-ic50-ki.
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