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Induced myeloid leukemia cell differentiation protein Mcl-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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GossypolIC50170.0 [1], 4800.0 [2]
GossypolKi200.0 [1]
Abt-737IC501000.0 [1]
Abt-737Ki20000.0 [1]
4-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-6-carboxylic acidKi1.4 [1]
8-Oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC5035.0 [1], 46.0 [2], 95.0 [3]
8-Oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi58.0 [1], 62.0 [2]
(2S)-N-(4-Methylphenyl)sulfonyl-2-[(5Z)-4-oxo-5-[(4-phenylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanamideKi250.0 [1], 290.0 [2], 440.0 [3], 470.0 [4]
VenetoclaxKi444.0 [1], 780.0 [2]
2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidIC502400.0 [1]
2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi490.0 [1], 1870.0 [2]
3-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]benzoic acidKi2.1 [1], 7.0 [2], 8.4 [3], 50.0 [4]
2-[[[3-[3-(4-Chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carbonyl]amino]methyl]pyridine-4-carboxylic acidKi7.0 [1], 41.0 [2], 50.0 [3], 165.0 [4]
7-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1,3-benzodioxole-5-carboxylic acidKi0.77 [1], 1.0 [2], 3.3 [3], 5.8 [4]
5-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]naphthalene-1-carboxylic acidKi0.31 [1], 1.0 [2], 1.2 [3], 2.7 [4]
7-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-5-carboxylic acidKi1.8 [1], 3.4 [2], 6.4 [3], 8.8 [4]
6-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-4-carboxylic acidKi0.7 [1], 1.0 [2], 2.3 [3], 2.8 [4]
8-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]quinoline-5-carboxylic acidKi1.0 [1], 1.4 [2], 4.4 [3], 5.0 [4]
7-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-3-carboxylic acidKi0.65 [1], 1.0 [2], 1.6 [3], 5.2 [4]
3-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-5-carboxylic acidKi0.11 [1], 0.37 [2], 1.0 [3]
3-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-7-carboxylic acidKi0.46 [1], 1.0 [2], 1.4 [3], 2.1 [4]
3-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-6-carboxylic acidKi0.24 [1], 0.63 [2], 1.0 [3]
7-[8-Chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethylpyrazol-4-yl)-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indol-2-yl]-1-methylindole-4-carboxylic acidKi2.4 [1], 3.6 [2], 8.0 [3], 11.0 [4]
7-(2-Methylphenyl)-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylic acidKi9.0 [1], 21.0 [2], 470.0 [3], 1230.0 [4]
1-(2-Morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)-7-(1,3,5-trimethylpyrazol-4-yl)indole-2-carboxylic acidKi1.5 [1], 4.0 [2], 10.0 [3], 35.0 [4]
NavitoclaxIC50500.0 [1], 30000.0 [2]
NavitoclaxKi550.0 [1]
(2Z)-2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indoleIC502900.0 [1]
(2Z)-2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indoleKi1000.0 [1]
2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetic acidIC507120.0 [1]
2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetic acidKi1550.0 [1]
3-(3-(Naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acidKi330.0 [1], 340.0 [2], 7300.0 [3]
Isopropyl-3-(4-isopropylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC50321.0 [1]
Isopropyl-3-(4-isopropylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi99.0 [1]
5-Benzyl-2-(5-benzyl-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl)-3-methylnaphthalene-1,4,6,7-tetroneIC5025.0 [1], 240.0 [2]
5-Benzyl-2-(5-benzyl-1,4,6,7-tetrahydroxy-3-methylnaphthalen-2-yl)-3-methylnaphthalene-1,4,6,7-tetroneKi160.0 [1]
2-[1-Hydroxy-4-[[(4-phenoxyphenyl)sulfonyl]amino]-2-naphthylthio]acetic acidIC50180.0 [1], 1450.0 [2]
2-[1-Hydroxy-4-[[(4-phenoxyphenyl)sulfonyl]amino]-2-naphthylthio]acetic acidKi180.0 [1]
N-(Benzenesulfonyl)-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi10.0 [1], 17.0 [2], 64.0 [3]
N-(Benzenesulfonyl)-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(2-methylpyridin-3-yl)-1H-indole-2-carboxamideKi10.0 [1], 18.0 [2], 146.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[(3-methylbutanoylamino)methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi5.6 [1], 10.0 [2], 92.0 [3]
N-[5-(Benzylcarbamoyl)furan-2-yl]sulfonyl-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi2.4 [1], 10.0 [2], 84.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[5-(pyridin-4-ylmethylcarbamoyl)furan-2-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi8.5 [1], 10.0 [2], 20.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[2-(3-methylbutylamino)pyridin-4-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi5.6 [1], 10.0 [2], 179.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[2-(2-phenylethylamino)pyridin-4-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi1.2 [1], 10.0 [2], 78.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[2-[methyl(2-phenylethyl)amino]pyridin-4-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi2.5 [1], 10.0 [2], 226.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[2-(2,3-dihydro-1H-inden-2-ylamino)pyridin-4-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi1.0 [1], 10.0 [2], 61.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[[[2-(trifluoromethyl)benzoyl]amino]methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi5.0 [1], 10.0 [2], 80.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[[[3-(trifluoromethyl)benzoyl]amino]methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi7.0 [1], 10.0 [2], 78.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[[(1-methylpyrrole-2-carbonyl)amino]methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi10.0 [1], 91.0 [2]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[(furan-3-carbonylamino)methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi2.9 [1], 10.0 [2], 69.0 [3]
N-[3-(Acetamidomethyl)phenyl]sulfonyl-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi10.0 [1], 11.1 [2], 42.0 [3]
6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[(2-methylpropanoylamino)methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamideKi10.0 [1], 16.0 [2], 54.0 [3]
2-[4-[[4-(4-Chlorophenyl)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidIC50170.0 [1], 880.0 [2]
2-[4-[[4-(4-Chlorophenyl)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi170.0 [1]
2-[4-[[4-(4-Fluorophenoxy)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidIC50170.0 [1], 900.0 [2]
2-[4-[[4-(4-Fluorophenoxy)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi290.0 [1]
2-[4-[[4-(2,4-Difluorophenyl)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidIC50170.0 [1], 920.0 [2]
2-[4-[[4-(2,4-Difluorophenyl)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi240.0 [1]
Indole-2-carboxylic acidKi1000000.0 [1]
ApogossypoloneIC50540.0 [1]
ApogossypoloneKi430.0 [1]
ApogossypolIC502600.0 [1]
ApogossypolKi2600.0 [1]
7-[5-[[4-[4-(Dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylic acidKi0.45 [1], 7.9 [2]
2,3,5-Trihydroxy-7-methyl-N-(2-phenylpropyl)-6-[1,6,7-trihydroxy-3-methyl-5-(2-phenylpropylcarbamoyl)naphthalen-2-yl]naphthalene-1-carboxamideIC50280.0 [1], 330.0 [2]
Nvp-cgm097IC5050000.0 [1]
AnthragallolKi270.0 [1], 1211.0 [2]
[(4-{[(4-Chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)thio]acetic acidIC502700.0 [1]
[(4-{[(4-Chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)thio]acetic acidKi820.0 [1]
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamideIC501030.0 [1]
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamideKi300.0 [1]
[(1-Hydroxy-4-{[(4-methoxyphenyl)sulfonyl]amino}-2-naphthyl)thio]acetic acidIC507170.0 [1]
[(1-Hydroxy-4-{[(4-methoxyphenyl)sulfonyl]amino}-2-naphthyl)thio]acetic acidKi9310.0 [1]
7-[3-[[4-(4-Acetylpiperazin-1-yl)phenoxy]methyl]-1,5-dimethylpyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1-(pyridin-3-ylmethyl)indole-2-carboxylic acidKi1.8 [1], 98.0 [2]
[(4-{[(4-Ethylphenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)thio]acetic acidIC508680.0 [1]
[(4-{[(4-Ethylphenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)thio]acetic acidKi1550.0 [1]
4-[(E)-(2-Cyclohexylimino-4-methyl-1,3-thiazol-3-yl)iminomethyl]benzene-1,2,3-triolIC504700.0 [1], 4720.0 [2]
2-({1-Hydroxy-4-[4-(propan-2-yl)benzenesulfonamido]naphthalen-2-yl}sulfanyl)acetic acidIC504000.0 [1]
2-({1-Hydroxy-4-[4-(propan-2-yl)benzenesulfonamido]naphthalen-2-yl}sulfanyl)acetic acidKi1060.0 [1]
(4-Phenoxyphenyl)-(2,3,4-trihydroxy-5-propan-2-ylphenyl)methanoneKi380.0 [1]
4-(4-Chlorophenyl)-1-[(3S)-3,4-dihydroxybutyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-phenylpyrrole-2-carboxamideIC50100000.0 [1]
N-(4-Hydroxynaphthalen-1-yl)benzenesulfonamideIC50100000.0 [1]
N-(4-Hydroxynaphthalen-1-yl)benzenesulfonamideKi27000.0 [1]
[(1-Hydroxy-4-{[(4-methylphenyl)sulfonyl]amino}-2-naphthyl)thio]acetic acidIC5011570.0 [1]
[(1-Hydroxy-4-{[(4-methylphenyl)sulfonyl]amino}-2-naphthyl)thio]acetic acidKi3130.0 [1]
[(4-{[(4-Fluorophenyl)sulfonyl]amino}-1-hydroxynaphthalen-2-yl)sulfanyl]acetic acidIC505010.0 [1]
[(4-{[(4-Fluorophenyl)sulfonyl]amino}-1-hydroxynaphthalen-2-yl)sulfanyl]acetic acidKi4230.0 [1]
({1-Hydroxy-4-[(2-naphthylsulfonyl)amino]-2-naphthyl}sulfanyl)acetic acidIC502760.0 [1]
({1-Hydroxy-4-[(2-naphthylsulfonyl)amino]-2-naphthyl}sulfanyl)acetic acidKi730.0 [1]
2-Methyl-3-phenyl-5,6,7-trihydroxy-8-isobutylchromoneKi400.0 [1]
Benzo[d]thiazol-2-yl(2,3,4-trihydroxy-5-(4-phenoxybenzoyl)phenyl)methanoneKi37.0 [1]
1,4-Bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo-4H-chromen-3-yl)benzeneKi18.0 [1]
5,6,7-Trihydroxy-8-isobutyl-2-methyl-4H-chromen-4-oneKi1690.0 [1]
Phenyl-(2,3,4-trihydroxy-5-propan-2-ylphenyl)methanoneKi4600.0 [1]
2-Methyl-1-[2,3,4-trihydroxy-5-(4-phenoxybenzoyl)phenyl]propan-1-oneKi340.0 [1]
3-(p-Tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi174.0 [1], 1915.0 [2]
3-(Biphenyl-4-yloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi1281.0 [1]
3-(4-Methoxyphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileKi122.0 [1], 258.0 [2]
3-(4-Methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileIC50388.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Induced myeloid leukemia cell differentiation protein Mcl-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/induced-myeloid-leukemia-cell-differentiation-protein-mcl-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Induced myeloid leukemia cell differentiation protein Mcl-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/induced-myeloid-leukemia-cell-differentiation-protein-mcl-1-inhibitors-ic50-ki.
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