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Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
N-OxalylglycineIC50842.0 [1], 2100.0 [2]
Pyridine-2,4-dicarboxylic acidIC501500.0 [1], 624800.0 [2]
Pyridine-2,4-dicarboxylic acidKi7000.0 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC500.2 [1]
MolidustatIC50480.0 [1], 490.0 [2]
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acidIC50100000.0 [1]
3-[[1-Cyano-4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino]-3-methylbutanoic acidIC50240.0 [1]
Salicyluric acidIC501000000.0 [1]
2,5-Pyridinedicarboxylic acidKi300000.0 [1]
N,3-DihydroxybenzamideIC5018370.0 [1]
PicolinoylglycineIC501000000.0 [1]
4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acidIC5054000.0 [1]
N-[(3-Hydroxypyridin-2-Yl)carbonyl]glycineIC5091090.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.2 [1]
(1-Hydroxy-2,5-dioxo-pyrrolidin-3-yl)-acetic acidIC501000000.0 [1]
5-Phenyl-[1,2,4]triazolo[1,5-a]pyridineIC5030000.0 [1]
4-(2-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50570.0 [1]
1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)piperidine-4-carbonitrileIC50280.0 [1]
3-Amino-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5057.0 [1]
2,6-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5034.0 [1]
2,3-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5067.0 [1]
4-(6-Amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50770.0 [1]
PHD-1 Inhibitor C53IC5090.0 [1]
4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)piperazine-1-carbonitrileIC501800.0 [1]
3-Chloro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50140.0 [1]
3-Fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5050.0 [1]
4-(7-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5039.0 [1]
3-Methoxy-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50140.0 [1]
4-(7-Amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5013.0 [1]
5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrazine-2-carbonitrileIC501280.0 [1]
3-Fluoro-5-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50220.0 [1]
2-Chloro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC503900.0 [1]
6-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridazine-3-carbonitrileIC501370.0 [1]
2-Fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5010.0 [1]
5-(2,4-Dichlorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC50670.0 [1]
N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]acetamideIC508.0 [1]
5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrimidine-2-carbonitrileIC5084.0 [1]
5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridine-2-carbonitrileIC50170.0 [1]
3-Ethyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC506100.0 [1]
4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-2-(trifluoromethyl)benzonitrileIC501870.0 [1]
5-(4-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC50550.0 [1]
PHD-1 Inhibitor C39IC5074.0 [1]
2-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50830.0 [1]
2-Fluoro-3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5052.0 [1]
2-Fluoro-5-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50140.0 [1]
4-(6-Fluoro-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50460.0 [1]
4-[7-(Ethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrileIC5025.0 [1]
PHD-1 Inhibitor C17IC5034.0 [1]
3,5-Dimethyl-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50200.0 [1]
3,5-Difluoro-4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50160.0 [1]
4-(6-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC50460.0 [1]
PHD-1 Inhibitor C54IC5070.0 [1]
6-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyridine-3-carbonitrileIC50270.0 [1]
2-(3-Hydroxyphenyl)-2-oxo-ethanoic acidIC501000000.0 [1]
3-[4-(1,3-Benzothiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.2 [1]
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC500.5 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC501.3 [1]
3-(4-Cyclohexylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC501.9 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(2-oxoazetidin-1-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5017.0 [1]
3-[4-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5011.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrazol-1-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5038.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC504.5 [1]
3-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.4 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrimidin-5-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC505.6 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC502.0 [1]
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC501.1 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(4-morpholin-4-ylphenyl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.5 [1]
7-(2,4-Dichlorophenyl)pyrazolo[1,5-a]pyrimidineIC50100000.0 [1]
5-(4-Methylphenyl)-[1,2,4]triazolo[1,5-a]pyridineIC505600.0 [1]
5-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5055000.0 [1]
5-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridineIC50100000.0 [1]
N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamideIC502500.0 [1]
4-(8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5080000.0 [1]
4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-3-(trifluoromethyl)benzonitrileIC5010000.0 [1]
4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)thiophene-2-carbonitrileIC5010000.0 [1]
5-(3-Methylphenyl)-[1,2,4]triazolo[1,5-a]pyridineIC50100000.0 [1]
5-(2-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5024000.0 [1]
5-(2-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5048000.0 [1]
5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5026000.0 [1]
N-[5-(4-Cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]acetamideIC5010000.0 [1]
1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)imidazole-4-carbonitrileIC5010000.0 [1]
5-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)furan-2-carbonitrileIC5010000.0 [1]
1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrrolidine-3-carbonitrileIC5010000.0 [1]
4-(8-Fluoro-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrileIC509600.0 [1]
N-[5-Cyano-2-([1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl]acetamideIC5010000.0 [1]
1-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)pyrazole-4-carbonitrileIC5010000.0 [1]
2-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)-2-azaspiro[3.3]heptane-6-carbonitrileIC5010000.0 [1]
5-(4-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC501300.0 [1]
4-[6-(Dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrileIC5010000.0 [1]
4-[2-(Dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrileIC5018000.0 [1]
5-(3-Fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5028000.0 [1]
3-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)benzonitrileIC5061000.0 [1]
5-(3-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridineIC5026000.0 [1]
5-(2,4-Dichlorophenyl)imidazo[1,2-a]pyrimidineIC5024000.0 [1]
3-[Acetyl(hydroxy)amino]propanoic acidIC50100000.0 [1]
N-[(1,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycineIC503.5 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC501.8 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(2-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC500.3 [1]
4-[5-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC501.1 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(2-oxo-1H-pyrimidin-6-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC501.4 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-hydroxylase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Hypoxia-inducible factor prolyl hydroxylase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-hydroxylase-1-inhibitors-ic50-ki.
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