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Hypoxia-inducible factor prolyl 4-hydroxylase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
2,5-Pyridinedicarboxylic acidIC505180.0 [1], 5500.0 [2]
Picolinic acidIC50100000.0 [1], 111500.0 [2]
5-{[(4-Fluorophenyl)methyl]amino}pyridine-2-carboxylic acidIC5031000.0 [1], 80000.0 [2]
2,2'-BipyridineIC5034200.0 [1]
Fusaric acidIC50149000.0 [1]
2,2'-Bipyridine-5,5'-dicarboxylic acidIC50190.0 [1]
5-(Benzoylamino)pyridine-2-carboxylic acidIC5025600.0 [1]
5-Benzenesulfonylaminocarbonyl-pyridine-2-carboxylic acidIC501100.0 [1]
Ethyl 2-[[(2S)-3-methylidene-1-[(2S)-3-phenyl-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetateIC50200000.0 [1]
2-Carboxypyridine-5-acetic acidIC509600.0 [1]
6-[5-[(4-Ethoxyphenyl)carbamoyl]pyridin-2-yl]pyridine-3-carboxylic acidIC50320.0 [1]
N-(Benzenesulfonyl)-6-pyridin-2-ylpyridine-3-carboxamideIC5033800.0 [1]
N-(Benzenesulfonyl)-6-[5-(benzenesulfonylcarbamoyl)pyridin-2-yl]pyridine-3-carboxamideIC505040.0 [1]
N-Methylsulfonylpyridine-2-carboxamideIC50500000.0 [1]
5-(4-Ethoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC505000.0 [1]
5-(Phenylcarbamoyl)picolinic acidIC5026500.0 [1]
5-(2-Chlorophenylaminocarbonyl)pyridine-2-carboxylic acidIC5016300.0 [1]
5-(3-Chlorophenylaminocarbonyl)pyridine-2-carboxylic acidIC5032200.0 [1]
5-(4-Chlorophenylaminocarbonyl)pyridine-2-carboxylic acidIC5017400.0 [1]
5-(2-Fluorophenylaminocarbonyl)pyridine-2-carboxylic acidIC5011000.0 [1]
5-(4-Fluorophenylaminocarbonyl)pyridine-2-carboxylic acidIC5016100.0 [1]
5-(4-Methylphenylaminocarbonyl)pyridine-2-carboxylic acidIC508300.0 [1]
5-(2-Ethoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC5032900.0 [1]
5-(4-Dimethylaminophenylaminocarbonyl)pyridine-2-carboxylic acidIC504100.0 [1]
5-(2-Methoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC5014800.0 [1]
5-(4-Methoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC5021100.0 [1]
5-(2,4-Dimethoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC5016600.0 [1]
5-(3,4,5-Trimethoxyphenylaminocarbonyl)pyridine-2-carboxylic acidIC5026500.0 [1]
5-(4-Nitro-phenylcarbamoyl)-pyridine-2-carboxylic acidIC5044000.0 [1]
5-[(4-Methylbenzoyl)amino]pyridine-2-carboxylic acidIC5016500.0 [1]
5-(4-Chlorobenzoylamino)pyridine-2-carboxylic acidIC5022500.0 [1]
5-(4-Ethoxybenzoylamino)pyridine-2-carboxylic acidIC5011200.0 [1]
5-(4-Fluorobenzoylamino)pyridine-2-carboxylic acidIC5051200.0 [1]
5-(4-Dimethylaminobenzoylamino)pyridine-2-carboxylic acidIC5011300.0 [1]
5-(2-Fluorobenzamido)pyridine-2-carboxylic acidIC5033800.0 [1]
5-[2-(4-Chlorophenyl)ethenyl]pyridine-2-carboxylic acidIC50150000.0 [1]
5-(Benzyloxy)pyridine-2-carboxylic acidIC5039000.0 [1]
Potassium;6-pyridin-2-ylpyridine-3-carboxylateIC5013200.0 [1]
1-[2-[6-(3,3-Difluoroazetidin-1-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]triazole-4-carbonitrileIC5070.0 [1]
5-[(1-Naphthalenyl)sulfonylaminocarbonyl]pyridine-2-carboxylic acidIC504400.0 [1]
5-[Benzylsulfonylaminocarbonyl]pyridine-2-carboxylic acidIC503000.0 [1]
5-(2-Benzenesulfonylamino-2-oxo-ethyl)-pyridine-2-carboxylic acidIC5017000.0 [1]
5-(1-Carboxy-2-phenyl-ethyl)-pyridine-2-carboxylic acidIC5027000.0 [1]
2-Carboxypyridine-5-propenoic acidIC5010600.0 [1]
5-(2-Carboxy-ethyl)-pyridine-2-carboxylic acidIC509600.0 [1]
5-(Propan-2-ylsulfonylcarbamoyl)pyridine-2-carboxylic acid;hydrochlorideIC501600.0 [1]
5-(Methylsulfonylcarbamoyl)pyridine-2-carboxylic acid;hydrochlorideIC501800.0 [1]
Disodium;5-[(Z)-N-(4,5-dibromothiophen-2-yl)sulfonyl-C-oxidocarbonimidoyl]pyridine-2-carboxylateIC508500.0 [1]
Disodium;5-[(Z)-N-(5-chlorothiophen-2-yl)sulfonyl-C-oxidocarbonimidoyl]pyridine-2-carboxylate;hydrateIC502400.0 [1]
Disodium;5-[(Z)-C-oxido-N-quinolin-8-ylsulfonylcarbonimidoyl]pyridine-2-carboxylate;hydrateIC501800.0 [1]
Disodium;5-[(Z)-N-[4-(4,7-dichloroquinolin-2-yl)phenyl]sulfonyl-C-oxidocarbonimidoyl]pyridine-2-carboxylateIC506600.0 [1]
Sodium;5-[(4-methoxyphenyl)sulfonylcarbamoyl]pyridine-2-carboxylateIC501000.0 [1]
N-Tert-butyl-6-(3-oxo-4-pyridin-3-yl-1H-pyrazol-2-yl)pyridine-3-carboxamideIC50910.0 [1]
2-(6-Morpholin-4-ylpyrimidin-4-yl)-4-pyridin-3-yl-1H-pyrazol-3-oneIC50180.0 [1]
6-[4-(5-Bromopyridin-3-yl)-3-oxo-1H-pyrazol-2-yl]pyridine-3-carboxylic acidIC50260.0 [1]
4-(6-Chloropyridin-3-yl)-2-(6-morpholin-4-ylpyrimidin-4-yl)-1H-pyrazol-3-oneIC50480.0 [1]
2-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC50880.0 [1]
2-(1,3-Benzothiazol-2-yl)-4-pyridin-3-yl-1H-pyrazol-3-oneIC502800.0 [1]
2-[6-(3,5-Dimethylpyrazol-1-yl)pyrimidin-4-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC50700.0 [1]
2-[6-(4-Cyclobutylpiperazin-1-yl)pyrimidin-4-yl]-4-(triazol-1-yl)-1H-pyrazol-3-oneIC50880.0 [1]
2-[6-[3-(Dimethylamino)azetidin-1-yl]pyrimidin-4-yl]-4-(triazol-1-yl)-1H-pyrazol-3-oneIC50760.0 [1]
1-[2-[6-(3,3-Difluoropyrrolidin-1-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]triazole-4-carbonitrileIC50130.0 [1]
1-[2-[6-(1,4-Oxazepan-4-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]imidazole-4-carbonitrileIC50180.0 [1]
1-[2-[6-(1,4-Oxazepan-4-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]triazole-4-carbonitrileIC50380.0 [1]
1-[2-[6-(3,3-Difluoroazetidin-1-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]imidazole-4-carbonitrileIC5090.0 [1]
1-[6-(4-Imidazol-1-yl-3-oxo-1H-pyrazol-2-yl)pyrimidin-4-yl]azetidine-3-carboxylic acidIC50540.0 [1]
1-[2-[6-(Oxazinan-2-yl)pyrimidin-4-yl]-3-oxo-1H-pyrazol-4-yl]triazole-4-carbonitrileIC50170.0 [1]
2-[5-[(2-Methoxyethylamino)methyl]pyridin-2-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC506300.0 [1]
1-(2,6-Dichlorophenyl)-3-[[2-(3-oxo-4-pyridin-3-yl-1H-pyrazol-2-yl)pyridin-4-yl]methyl]ureaIC50900.0 [1]
2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-oneIC503700.0 [1]
4-Pyridin-3-yl-2-[5-(pyrrol-1-ylmethyl)pyridin-2-yl]-1H-pyrazol-3-oneIC503240.0 [1]
5-[2-(4-Methylpyridin-2-yl)-3-oxo-1H-pyrazol-4-yl]pyridine-3-carbonitrileIC505200.0 [1]
[6-(3-Oxo-4-pyridin-3-yl-1H-pyrazol-2-yl)pyridin-3-yl]methyl N-(2-methylphenyl)carbamateIC501600.0 [1]
2-[6-[4-(2-Methoxyethyl)piperazin-1-yl]pyrimidin-4-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC50890.0 [1]
5-[3-Oxo-2-(6-piperidin-1-ylpyrimidin-4-yl)-1H-pyrazol-4-yl]pyridine-3-carbonitrileIC501120.0 [1]
2-[6-[2-(Dimethylamino)ethoxy]pyrimidin-4-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC504000.0 [1]
2-(6-Phenylpyridazin-3-yl)-4-pyridin-3-yl-1H-pyrazol-3-oneIC502700.0 [1]
2-[6-[6-(Diethylamino)hexylamino]pyrimidin-4-yl]-4-pyridin-3-yl-1H-pyrazol-3-oneIC501700.0 [1]
2-Pyrazin-2-yl-4-pyridin-3-yl-1H-pyrazol-3-oneIC50930.0 [1]
Items per page: 1 - 10 of 79
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hypoxia-inducible factor prolyl 4-hydroxylase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-4-hydroxylase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Hypoxia-inducible factor prolyl 4-hydroxylase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxia-inducible-factor-prolyl-4-hydroxylase-inhibitors-ic50-ki.
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