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Hypoxia-inducible factor 1 alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
LificiguatIC501500.0 [1], 2000.0 [2], 9210.0 [3], 13800.0 [4], 30000.0 [5]
7,18-Bis[3-(dimethylamino)propyl]-7,18-diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,24]hexacosa-1(23),2,4,9,11,13,15,20(24),21,25-decaene-6,8,17,19-tetroneIC503000.0 [1]
ChaetocinIC5040.0 [1], 100.0 [2], 12500.0 [3]
Moracin PIC500.65 [1], 10600.0 [2], 10700.0 [3]
CID 16124726IC502440.0 [1], 4400.0 [2], 21000.0 [3]
3-[2-(4-Adamant-1-yl-phenoxy)-acetylamino]-benzoic acid methyl esterIC50700.0 [1], 2600.0 [2], 5030.0 [3]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-(3-imidazol-1-yl-propyl)-isonicotinamideIC50900.0 [1], 11000.0 [2], 11200.0 [3]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-isonicotinamideIC50600.0 [1], 1800.0 [2], 3100.0 [3]
5-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-furan-2-ylmethyl-nicotinamideIC504100.0 [1], 30000.0 [2]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid methyl esterIC501030.0 [1], 1200.0 [2], 2000.0 [3]
5-[2-(4-Adamantan-1-yl-phenoxy)acetylamino]-nicotinic acid methyl esterIC505000.0 [1], 5900.0 [2], 30000.0 [3]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acidIC50800.0 [1], 1000.0 [2], 2000.0 [3]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-furan-2-ylmethyl-isonicotinamideIC5030000.0 [1]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-(2-pyridin-4-yl-ethyl)-isonicotinamideIC503400.0 [1], 5200.0 [2]
2-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-(4-chloro-phenyl)-isonicotinamideIC502500.0 [1], 18600.0 [2], 30000.0 [3]
5-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-nicotinic acidIC5030000.0 [1]
5-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-(2-pyridin-4-yl-ethyl)-nicotinamideIC501300.0 [1], 30000.0 [2]
5-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-N-(3-imidazol-1-yl-propyl)-nicotinamideIC501900.0 [1], 10000.0 [2]
5-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-nicotinamideIC50900.0 [1], 10000.0 [2], 11900.0 [3]
TopotecanIC5060.0 [1], 3000.0 [2]
AlvespimycinIC5057.0 [1], 57.2 [2]
5-[(6R)-6-Hydroxy-7,7-dimethyl-5,6-dihydrofuro[3,2-g]chromen-2-yl]benzene-1,3-diolIC500.65 [1], 10.7 [2]
Moracin OIC500.14 [1], 6.76 [2]
3-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-benzoic acidIC50350.0 [1], 400.0 [2]
(E)-3-[3-(4-Adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl esterIC50740.0 [1]
2-Chloro-N-[6-[4-(chloromethyl)-6-oxo-1H-pyrimidin-2-yl]pyridin-3-yl]acetamideIC501500.0 [1], 5500.0 [2]
2-Chloro-N-[6-[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]pyridin-3-yl]acetamideIC50800.0 [1], 8000.0 [2]
2-(5-Aminopyridin-2-yl)-6-(chloromethyl)pyrimidin-4-olIC506000.0 [1], 22000.0 [2]
2-Chloro-N-[6-(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)pyridin-3-yl]acetamideIC501500.0 [1], 5500.0 [2]
N-[6-(5-Benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)pyridin-3-yl]-2-chloroacetamideIC504000.0 [1], 10000.0 [2]
2-Chloro-N-[6-(5-fluoro-4-methyl-6-oxo-1H-pyrimidin-2-yl)pyridin-3-yl]acetamideIC502000.0 [1], 6000.0 [2]
2-Chloro-N-[6-(5-ethyl-4-methyl-6-prop-2-enoxypyrimidin-2-yl)pyridin-3-yl]acetamideIC501800.0 [1], 22000.0 [2]
2-Chloro-N-[6-(5-chloro-4-methyl-6-prop-2-enoxypyrimidin-2-yl)pyridin-3-yl]acetamideIC501500.0 [1], 8000.0 [2]
2-Chloro-N-[6-[4-methoxy-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-3-yl]acetamideIC503500.0 [1], 15000.0 [2]
2-Chloro-N-[6-[4-prop-2-enoxy-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-3-yl]acetamideIC502000.0 [1], 30000.0 [2]
2-Chloro-N-[6-[4-chloro-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-3-yl]acetamideIC501400.0 [1], 10000.0 [2]
(1S,3S,11R,14R)-14-(Hydroxymethyl)-3-[3-[[(1S,4R)-4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]octan-1-yl]methyl]indol-1-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dioneIC501900.0 [1]
Moracin MIC5050000.0 [1]
Sanggenon CIC501260.0 [1]
VomifoliolIC5015800.0 [1]
Mulberrofuran GIC502600.0 [1]
2-(3,4-Dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanoneIC502150.0 [1]
Makaluvamine FIC508300.0 [1]
3-Dihydrodiscorhabdin CIC5035200.0 [1]
3-(2-Ethoxyphenyl)-2-{[4-(2-furoyl)-1-piperazinyl]methyl}-4(3H)-quinazolinoneIC50430.0 [1]
Sanggenon OIC501030.0 [1]
Mulberrofuran WIC503620.0 [1]
(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-oneIC504100.0 [1]
Mulberrofuran DIC504050.0 [1]
(2,4-Dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC5030000.0 [1]
(6-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC5030000.0 [1]
(1S,14S)-19-Bromo-11-hydroxy-15-thia-4,9,13-triazahexacyclo[12.6.1.13,7.01,16.02,12.010,22]docosa-2,7(22),8,10,12,16,19-heptaen-18-oneIC503700.0 [1]
(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-oneIC503170.0 [1]
(E)-1-[3-[(1S,5S,6R)-6-[3,5-Dihydroxy-4-(3-methylbut-2-enyl)benzoyl]-5-(4-hydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-oneIC508320.0 [1]
Albafuran AIC503510.0 [1]
2-(3,4-Dimethoxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)propan-1-oneIC501360.0 [1]
N-(3-Methoxyphenyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amineIC506100.0 [1]
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)-phenyl amineIC5030000.0 [1]
(5-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC5030000.0 [1]
(7-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamineIC5030000.0 [1]
Ethyl 5-[(4-bromophenyl)sulfonylamino]-3-methyl-1-benzofuran-2-carboxylateIC5029900.0 [1]
Ethyl 5-[(4-chlorophenyl)sulfonylamino]-3-methyl-1-benzofuran-2-carboxylateIC5050000.0 [1]
Ethyl 3-methyl-5-[[4-(trifluoromethyl)phenyl]sulfonylamino]-1-benzofuran-2-carboxylateIC5041700.0 [1]
3-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-4-hydroxy-benzoic acidIC503100.0 [1]
Mulberrofuran HIC50140.0 [1]
1-(4-Aminophenyl)-3-[3-(1,3-benzodioxol-5-yl)-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]ureaIC50214.0 [1]
Methyl 3-[({4-[(phenylcarbamoyl)amino]phenyl}amino)methyl]benzoateIC507210.0 [1]
(E)-1-[3-[(1R,4R,6R)-6-[2,4-Dihydroxy-3-(3-methylbut-2-enyl)benzoyl]-4-(4-hydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2,4-dihydroxyphenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-oneIC503800.0 [1]
PX-478 free baseIC5020200.0 [1]
4-Chloro-1-[cyclohexyl-(5-methoxy-2,2-dimethylchromen-6-yl)methyl]benzimidazoleIC507500.0 [1]
3-(2-Ethoxyphenyl)-2-(piperazin-1-ylmethyl)quinazolin-4-oneIC5090.0 [1]
Prop-2-ynyl 4-hydroxy-3-[(2-phenoxyacetyl)amino]benzoateIC5030000.0 [1]
2-[4-(1-Adamantyl)phenoxy]-N-[3-(4-prop-2-ynoxybenzoyl)phenyl]acetamideIC5030000.0 [1]
(E)-3-[4-(1-Adamantyl)phenoxy]-N-[3-(4-prop-2-ynoxybenzoyl)phenyl]prop-2-enamideIC5030000.0 [1]
[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]methyl 3-[4-[2-(2-hydroxy-5-prop-2-ynoxycarbonylanilino)-2-oxoethoxy]phenyl]adamantane-1-carboxylateIC5011400.0 [1]
[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]methyl 3-(4-prop-2-ynoxyphenyl)adamantane-1-carboxylateIC5030000.0 [1]
Prop-2-ynyl 4-hydroxy-3-[[2-[2-[3-(trifluoromethyl)diazirin-3-yl]phenoxy]acetyl]amino]benzoateIC5030000.0 [1]
2-(3,4-Dimethoxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)-3-phenylpropan-1-oneIC5012030.0 [1]
2-(2-Hydroxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC50940.0 [1]
2-(3,4-Dimethoxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)pent-4-en-1-oneIC508450.0 [1]
2-(3-Fluorophenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC50360.0 [1]
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC501330.0 [1]
2-(3,4-Dimethoxyphenyl)-2-fluoro-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC506350.0 [1]
2-(2-Fluorophenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC50100.0 [1]
1-(5-Methoxy-2,2-dimethylchromen-6-yl)-2-(3-methoxyphenyl)ethanoneIC50820.0 [1]
1-(5-Methoxy-2,2-dimethylchromen-6-yl)-2-phenylethanoneIC50880.0 [1]
2-(3-Hydroxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC501440.0 [1]
2-(4-Hydroxyphenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC50790.0 [1]
1-(5-Methoxy-2,2-dimethylchromen-6-yl)-2-(2-methoxyphenyl)ethanoneIC503210.0 [1]
2-(4-Fluorophenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC501020.0 [1]
2-(3,4-Difluorophenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC501270.0 [1]
1-(5-Methoxy-2,2-dimethylchromen-6-yl)-2-(4-methoxyphenyl)ethanoneIC506210.0 [1]
2-(3,4-Dichlorophenyl)-1-(5-methoxy-2,2-dimethylchromen-6-yl)ethanoneIC502880.0 [1]
Ethyl 5-[(3,4-dimethoxyphenyl)sulfonylamino]-3-methyl-1-benzofuran-2-carboxylateIC5012500.0 [1]
Methyl 3-[4-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]butanoylamino]benzoateIC501400.0 [1]
(1R,14S,19S,20R)-11,20-Dihydroxy-15-thia-9,13-diaza-4-azoniaheptacyclo[12.6.1.13,7.01,16.02,12.04,19.010,22]docosa-2(12),3,7(22),8,10,16-hexaen-18-oneIC50730.0 [1]
6-(4-Chlorophenyl)-2-[5-methyl-1-[(4-methylphenyl)methyl]pyrazol-3-yl]-1H-benzimidazoleIC503.0 [1]
2-(5-Aminopyridin-2-yl)-5-chloro-6-methylpyrimidin-4-olIC5030000.0 [1]
2-(5-Aminopyridin-2-yl)-6-trifluoromethylpyrimidin-4-olIC5030000.0 [1]
2-(5-Aminopyridin-2-yl)-5,6-dimethylpyrimidin-4-olIC5030000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hypoxia-inducible factor 1 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/hypoxia-inducible-factor-1-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Hypoxia-inducible factor 1 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxia-inducible-factor-1-alpha-inhibitors-ic50-ki.
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