Hypoxanthine-guanine phosphoribosyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-(2,2-Dichloroacetamido)chrysene	Ki	500.0 [1], 16000.0 [2], 25000.0 [3]
	5-(2,4-Dichlorophenoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-c]quinazoline	Ki	11800.0 [1], 28800.0 [2], 48100.0 [3]
	3,5-Diphenyl-4'-methyl-2-nitrobiphenyl	Ki	2000.0 [1], 10900.0 [2], 13900.0 [3]
	Guanosine-5'-monophosphate	Ki	5800.0 [1]
	9-[2,2-Bis(phosphonomethoxymethyl)ethyl]-1,6-dihydro-6-oxo-9H-purine	Ki	1000.0 [1]
	2-[1-(2-Amino-6-oxo-1H-purin-9-yl)-3-(2-phosphonoethoxy)propan-2-yl]oxyethylphosphonic acid	Ki	600.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-cyanoethyl)amino]ethylphosphonic acid	Ki	70.0 [1]
	9-Dicyanomethylene-2,4,7-trinitrofluorene	Ki	2200.0 [1], 5400.0 [2]
	CID 136206394	Ki	2400.0 [1]
	2-[1-(6-Oxo-1H-purin-9-yl)-3-(2-phosphonoethoxy)propan-2-yl]oxyethylphosphonic acid	Ki	700.0 [1], 4000.0 [2]
	2-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethylphosphonic acid	Ki	29000.0 [1], 55900.0 [2]
	2-Amino-9-[[(5R)-2-hydroxy-2-oxo-1,4,2lambda5-dioxaphosphinan-5-yl]methyl]-7,8-dihydro-1H-purin-6-one	Ki	12300.0 [1], 19000.0 [2]
	2-Amino-9-[[(5S)-2-hydroxy-2-oxo-1,4,2lambda5-dioxaphosphinan-5-yl]methyl]-7,8-dihydro-1H-purin-6-one	Ki	90000.0 [1], 115100.0 [2]
	Inosinic acid	Ki	5400.0 [1]
	Chrysene	Ki	8980.0 [1]
	6-Nitrochrysene	Ki	6700.0 [1]
	6-Chrysenamine	Ki	600.0 [1]
	[(1S)-1-[(2-Amino-6-oxo-1H-purin-9-yl)methyl]-2-fluoro-ethoxy]methylphosphonic acid	Ki	250000.0 [1]
	[(1R)-1-[(2-Amino-6-oxo-1H-purin-9-yl)methyl]-2-fluoro-ethoxy]methylphosphonic acid	Ki	300000.0 [1]
	9-(5-Phosphonopentyl)Guanine	Ki	500.0 [1]
	[{2-[(Guanine-9-Yl)methyl]propane-1,3-Diyl}bis(Oxymethylene)]bis(Phosphonic Acid)	Ki	30.0 [1]
	5-(6-Oxidanylidene-3~{h}-Purin-9-Yl)pentylphosphonic Acid	Ki	100000.0 [1]
	9-[1-(Phosphonoethoxy)Methyl]Guanine	Ki	31000.0 [1]
	4-[(2-Amino-6-oxo-1H-purin-9-yl)methoxy]butylphosphonic acid	Ki	400.0 [1]
	7-(2-Amino-6-oxo-1H-purin-9-yl)heptylphosphonic acid	Ki	5000.0 [1]
	[2-(2-Amino-6-oxo-1H-purin-9-yl)-3-(phosphonomethoxy)propoxy]methylphosphonic acid	Ki	37000.0 [1]
	9-(4-Phosphonobutyl)guanine	Ki	21000.0 [1]
	3-[(2-Amino-6-oxo-1H-purin-9-yl)methoxy]propylphosphonic acid	Ki	3000.0 [1]
	[3-(2-Amino-6-oxo-1H-purin-9-yl)-2-hydroxypropoxy]methylphosphonic acid	Ki	4000.0 [1]
	CID 135566946	Ki	80.0 [1]
	CID 135566948	Ki	1000.0 [1]
	[6-(2-Amino-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)hexyl]phosphonic Acid	Ki	500.0 [1]
	9-(4-Phosphonobutyl)hypoxanthine	Ki	100000.0 [1]
	[1-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)-3-fluoropropan-2-yl]oxymethylphosphonic acid	Ki	22700.0 [1]
	9-(2-Phosphonoethyl)Guanine	Ki	100000.0 [1]
	9-(2-Phosphonoethyl)hypoxanthine	Ki	3400.0 [1]
	9-(3-Phosphonopropyl)Guanine	Ki	100000.0 [1]
	9-(3-Phosphonopropyl)hypoxanthine	Ki	100000.0 [1]
	9-[1-(2-Phosphonoethoxy)methyl]hypoxanthine	Ki	56000.0 [1]
	6-(6-Oxo-1H-purin-9-yl)hexylphosphonic acid	Ki	77000.0 [1]
	9-[1-(4-Phosphonobutoxy)methyl]hypoxanthine	Ki	28000.0 [1]
	7-(6-Oxo-1H-purin-9-yl)heptylphosphonic acid	Ki	100000.0 [1]
	9-(1-Phosphonomethyl)Guanine	Ki	100000.0 [1]
	9-(1-Phosphonomethyl)hypoxanthine	Ki	1900.0 [1]
	2-[(3-Methoxy-3-oxopropyl)-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	200000.0 [1]
	3-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-phosphonoethyl)amino]propanoic acid	Ki	150.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-ethoxy-2-oxo-ethyl)amino]ethylphosphonic acid	Ki	100.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(3-methoxy-3-oxo-propyl)amino]ethylphosphonic acid	Ki	500.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(4-methoxy-4-oxo-butyl)amino]ethylphosphonic acid	Ki	100.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(3-cyanopropyl)amino]ethylphosphonic acid	Ki	600.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-hydroxyethyl)amino]ethylphosphonic acid	Ki	70.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-phosphonoethyl)amino]acetic acid	Ki	1400.0 [1]
	4-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-phosphonoethyl)amino]butanoic acid	Ki	100.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethyl-(2-phosphonoethyl)amino]ethylphosphonic acid	Ki	200.0 [1]
	2-[2-(2-Amino-6-oxo-1H-purin-9-yl)ethylamino]ethylphosphonic acid	Ki	3000.0 [1]
	[(1S)-1-(Fluoromethyl)-2-(6-oxo-1H-purin-9-yl)ethoxy]methylphosphonic acid	Ki	250000.0 [1]
	2-[(2S)-1-Fluoro-3-(6-oxo-1H-purin-9-yl)propan-2-yl]oxyethylphosphonic acid	Ki	1600.0 [1]
	2-[(2R)-1-(2-Amino-6-oxo-1H-purin-9-yl)-3-fluoropropan-2-yl]oxyethylphosphonic acid	Ki	4700.0 [1]
	2-[1-(Fluoromethyl)-2-(6-oxo-1H-purin-9-yl)ethoxy]ethylphosphonic acid	Ki	5400.0 [1]
	2-[(2S)-1-(2-Amino-6-oxo-1H-purin-9-yl)-3-fluoropropan-2-yl]oxyethylphosphonic acid	Ki	100.0 [1]
	[(1R)-1-(Fluoromethyl)-2-(6-oxo-1H-purin-9-yl)ethoxy]methylphosphonic acid	Ki	200000.0 [1]
	2-[(1R)-1-(Fluoromethyl)-2-(6-oxo-1H-purin-9-yl)ethoxy]ethylphosphonic acid	Ki	200000.0 [1]
	2-[1-(2-Amino-6-oxo-1H-purin-9-yl)-3-fluoropropan-2-yl]oxyethylphosphonic acid	Ki	3700.0 [1]
	[(3S)-4-Hydroxy-3-[(4-oxo-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)methylamino]butyl]phosphonic acid	Ki	380.0 [1]
	CID 135566944	Ki	40.0 [1]
	CID 135566954	Ki	10.0 [1]
	[3-[(3R,4R)-3-(2-Amino-6-oxo-1H-purin-9-yl)-4-[(2S)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl]-3-oxopropyl]phosphonic acid	Ki	3.0 [1]
	9-[(3R,4S)-4-(Phosphonomethoxy)pyrrolidine-3-yl]-1H-purine-6(9H)-one	Ki	327000.0 [1]
	[(3~{s},4~{r})-4-(2-Azanyl-6-Oxidanylidene-1~{h}-Purin-9-Yl)pyrrolidin-3-Yl]oxymethylphosphonic Acid	Ki	29000.0 [1]
	CID 135567202	Ki	4000.0 [1]
	[3-[(3R,4R)-3-(2-Amino-6-oxo-1H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl]-3-oxopropyl]phosphonic acid	Ki	8.0 [1]
	2-(2-Amino-8-bromo-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethylphosphonic acid	Ki	400000.0 [1]
	[1-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid	Ki	5900.0 [1]
	9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine	Ki	100.0 [1]
	9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine	Ki	300.0 [1]
	9-[2-(1-Phosphonopropan-2-yloxy)ethyl]hypoxanthine	Ki	2000.0 [1]
	9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine	Ki	10000.0 [1]
	2-(6-Oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethylphosphonic acid	Ki	182300.0 [1]
	(S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]guanine	Ki	176800.0 [1]
	[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-oxo-7,8-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate	Ki	5400.0 [1]
	2-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethyl-(6-methylheptoxy)phosphinic acid	Ki	1000000.0 [1]
	[(2S)-1-(5-Amino-7-oxo-2,6-dihydro-1H-triazolo[4,5-d]pyrimidin-3-yl)propan-2-yl]oxymethylphosphonic acid	Ki	15000.0 [1]
	[(2R)-1-(2-Amino-8-bromo-6-oxo-7,8-dihydro-1H-purin-9-yl)propan-2-yl]oxymethylphosphonic acid	Ki	41000.0 [1]
	2-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethyl-propan-2-yloxyphosphinic acid	Ki	140000.0 [1]
	2-(5-Amino-7-oxo-2,6-dihydro-1H-triazolo[4,5-d]pyrimidin-3-yl)ethoxymethylphosphonic acid	Ki	175000.0 [1]
	2-(2-Amino-8-hydroxy-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxymethylphosphonic acid	Ki	68000.0 [1]
	2-[2-(2-Amino-6-oxo-7,8-dihydro-1H-purin-9-yl)ethoxy]ethylphosphonic acid	Ki	1000.0 [1]
	2-[2-(6-Oxo-7,8-dihydro-1H-purin-9-yl)ethoxy]ethylphosphonic acid	Ki	3600.0 [1]
	CID 136035750	Ki	30.0 [1]
	CID 136035751	Ki	300.0 [1]
	CID 136035752	Ki	190.0 [1]
	2-[1-(2-Amino-6-oxo-1H-purin-9-yl)-3-(phosphonomethoxy)propan-2-yl]oxyacetic acid	Ki	5000.0 [1]
	[(2S)-1-(2-Amino-8-bromo-6-oxo-7,8-dihydro-1H-purin-9-yl)propan-2-yl]oxymethylphosphonic acid	Ki	300000.0 [1]
	2-(4-Oxo-3,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-1-yl)ethoxymethylphosphonic acid	Ki	4300.0 [1]
	2-[(2-Ethoxy-2-oxoethyl)-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	2600.0 [1]
	2-[(4-Methoxy-4-oxobutyl)-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	22000.0 [1]
	2-[Cyanomethyl-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	35000.0 [1]
	2-[3-Cyanopropyl-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	29000.0 [1]
	2-[2-Hydroxyethyl-[2-(6-oxo-1H-purin-9-yl)ethyl]amino]ethylphosphonic acid	Ki	5500.0 [1]
	2-[2-(6-Oxo-1H-purin-9-yl)ethyl-(2-phosphonoethyl)amino]acetic acid	Ki	32000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hypoxanthine-guanine phosphoribosyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/hypoxanthine-guanine-phosphoribosyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Hypoxanthine-guanine phosphoribosyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hypoxanthine-guanine-phosphoribosyltransferase-inhibitors-ic50-ki.
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