![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_eeee657d685332dfcad1bdbf13f04b70.svg) | Lovastatin | IC50 | 37.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_b03a82411601ac2483b9406eae5a6277.svg) | Simvastatin | IC50 | 39.81 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_b03a82411601ac2483b9406eae5a6277.svg) | Simvastatin | Ki | 2.6 [1], 68000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_ff5a8ef20cbc71ea2a6380eebf7a8baf.svg) | Rosuvastatin | IC50 | 3.1 [1], 4.0 [2], 5.0 [3], 5.4 [4] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_ff5a8ef20cbc71ea2a6380eebf7a8baf.svg) | Rosuvastatin | Ki | 0.9 [1], 71000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_12e2d2d9c2a61b9aef304c1c9b1dcd19.svg) | Atorvastatin | IC50 | 6.0 [1], 11.6 [2], 12.9 [3] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_97bafc2e6dc2099a2b313147efe6ffe9.svg) | Unii-B99nwa524X | IC50 | 1340.0 [1], 1600.0 [2], 3000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_3a0f00e65276e49752e5c62956dc21ed.svg) | Pravastatin | IC50 | 30.0 [1], 400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_7f75f2375d0f4899b468af8844eda552.svg) | Pravastatin sodium | IC50 | 30.0 [1], 1370.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_403b832729a4c215a5195e14911a88aa.svg) | Vorinostat | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_734886274540e86d3b81207370d5d664.svg) | Mevastatin | IC50 | 23.0 [1], 28.4 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_f4ad38320bb5b3dc51cf4108f9236d65.svg) | alpha-Asarone | IC50 | 36.31 [1], 5860.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_aa9aad5084d595f202ccb6031c729a4b.svg) | Meglutol | IC50 | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_aa9aad5084d595f202ccb6031c729a4b.svg) | Meglutol | Ki | 23.5 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_39df3d35ddb4b1277e57b0e55ad17c9d.svg) | 1-[(3S,10R,13R,14S,17R)-3-Hydroxy-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-14-yl]ethanone | IC50 | 1000.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_0d1864b5555db3fa2bf52d84639680fe.svg) | Methyl 2-(5-hydroxy-2-methoxy-4-propylphenoxy)acetate | IC50 | 39.81 [1], 6110.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_7b426c8082336452a9db3222dbb3e70e.svg) | Dfgyvae | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_7b426c8082336452a9db3222dbb3e70e.svg) | Dfgyvae | Ki | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_8fa58b757e64c22ef8c6f811c003bdb3.svg) | 4,5-Dimethoxy-2-propylphenol | IC50 | 22.91 [1], 4790.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_6ff17a34b92868cb4904ad5033d2532f.svg) | Methyl 2-(4-butanoyl-5-hydroxy-2-methoxyphenoxy)acetate | IC50 | 44.67 [1], 6430.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_cbbae41bab66b98b6af987ed93a48bd4.svg) | (3S,10R,13R,14S,17R)-14-(1-Hydroxyethyl)-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol | IC50 | 3000.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_4108693ecf11531c8f1a6f7dbe1dcce8.svg) | 2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-3-(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetic acid | IC50 | 4820.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_4108693ecf11531c8f1a6f7dbe1dcce8.svg) | 2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-3-(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetic acid | Ki | 260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_f6f75fd60da105ec65ab77a3eae8de4f.svg) | 1-(2-Hydroxy-4,5-dimethoxyphenyl)propan-1-one | IC50 | 24.55 [1], 4940.0 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_38317eb8348ab72a370b3023fc3949e1.svg) | [(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[7-(hydroxyamino)-7-oxoheptyl]carbamate | IC50 | 54.1 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_9338513adf40fcc7551e951b24b705f6.svg) | [(1S,3R,7S,8S,8Ar)-8-[(3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 11.4 [1], 13.1 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_3cac4dfafcccb3bd3d97cf082f55fa3a.svg) | 1-[(3R,5R)-3,5-Dihydroxy-7-(hydroxyamino)-7-oxoheptyl]-5-(4-fluorophenyl)-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide | IC50 | 9.2 [1], 12.3 [2] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_35ec31f198eee86babb34a0c434c0ea5.svg) | (E,3R,5S)-7-[4-(4-Fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-N,3,5-trihydroxyhept-6-enamide | IC50 | 43.7 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_baeea457ab8c2f79bba308069e5aab95.svg) | [(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[4-[1-[7-(hydroxyamino)-7-oxoheptyl]triazol-4-yl]phenyl]carbamate | IC50 | 36.5 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_aa1ac4282029d0efc3122aa2ed769e97.svg) | [(1S,3R,7S,8S,8Ar)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] N-[[4-[1-[7-(hydroxyamino)-7-oxoheptyl]triazol-4-yl]phenyl]methyl]carbamate | IC50 | 53.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_16f499e9c486fb216537dd71b443728b.svg) | Calcium | IC50 | 8900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e98cb4b72d9d20fe04eaddfa2b1869ac.svg) | Epilovastatin | IC50 | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_a0f376a714f6f6e660ef2c90486780f1.svg) | (6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_42352b871cd67149e56e8535b49aa673.svg) | 25-Hydroxycholesterol | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_a21a6cd0d7e46d7fc98b740e48a362d8.svg) | Cerivastatin | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_4618c0ac5f7601c899ffeb55e0f14f4e.svg) | 9-Octadecynoic acid | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_d7f71dac4492251c1b88369f9c2f9c7f.svg) | Glenvastatin | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_535f82d430a9bed4b11c81e121ec6870.svg) | 7-Oxo-ganoderic acid Z | IC50 | 22300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_cdc50dcdb0aa1476604b40f705255cdd.svg) | Ganoderic acid TR | IC50 | 21700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_a605dd8d14bfdea126d4d5ee9caf833b.svg) | [(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 12.1 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_4a16e8958afc25bd5f35658a8ab107bb.svg) | (E,3R,5R)-7-[4,5-Bis(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 5.7 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_c7c6784570e0407b15b1fc140429a164.svg) | (2S)-3-[2-[(1S,2R,4Ar,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-2-hydroxy-2H-furan-5-one | IC50 | 30200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_8d12727116cf4f452f3242927abc734b.svg) | (4S)-4-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid | IC50 | 201120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e33fd1aa4988dac4202f76db4376c4da.svg) | (3S)-3-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-[[2-(carboxymethylamino)-2-oxoethyl]amino]-4-oxobutanoic acid | IC50 | 22310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_482f595005da90c2e105dd0c16858fde.svg) | 3,5-Dihydroxy-7-(4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl)-6-heptenoic acid | IC50 | 6.15 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_37c5578d57fbf7f4990e56a3294aeded.svg) | [(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_c0dc6b4b73f4d41a23c3ba3820821e45.svg) | 7-[4,5-Bis-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_03e91c05a7fe918443328e4107a1ace7.svg) | [(1S,3R,4Ar,7S,8S,8aS)-3-hydroxy-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoate | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_f071dcd62d838eb511b8e3619bf588e6.svg) | Lovastatin sodium salt | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_41e6adf4d3b7f4f6708b6a6e81421297.svg) | Tenivastatin sodium | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_21d11538e45b7327416bd53c2c4e5625.svg) | Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-3-propan-2-yl-1-pyridin-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoate | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_fa58537d345ac4ff25bc094088027d47.svg) | Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-3-propan-2-yl-1-pyrazin-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoate | IC50 | 66.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_88877ae03344b4a2ed60fb6c55fb3edf.svg) | Sodium;(E,3R,5S)-7-[5-(4-fluorophenyl)-1-phenyl-3-propan-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoate | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e6e4e296f36421efa255ed3c17f607a1.svg) | Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(phenylcarbamoyl)-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoate | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_4554ba947c5bab51693b9c25cfa7cf91.svg) | Gfpdgg | IC50 | 1520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_8e065673cdc74421c97108e5201ca7c5.svg) | Gfpegg | IC50 | 1780.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_9e64ab88b079a89553dc00328909368b.svg) | L-Isoleucyl-L-alanyl-L-valyl-L-glutamic acid | IC50 | 75230.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_bbb3686702913079990aa08137853b7f.svg) | L-Tyrosyl-L-alanyl-L-valyl-L-glutamic acid | IC50 | 44810.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_6da6d2e184ba07fa839710ae216fa147.svg) | L-Isoleucyl-L-valyl-L-alanyl-L-glutamic acid | IC50 | 52670.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_915bf4dae22fcc0cb7771001bd792dd7.svg) | L-Tyrosyl-L-valyl-L-alanyl-L-glutamic acid | IC50 | 41210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_d35646f68c0ab14164042821f3adef00.svg) | Glptgg | IC50 | 19430.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_00df96361b57671ad0e694040052b289.svg) | Gfptgg | IC50 | 16940.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_75aa590cc134e9ec0e072feb540c3576.svg) | (4R)-6-[[2-(4-Fluorophenyl)-4,6-di(propan-2-yl)phenoxy]methyl]-4-hydroxyoxan-2-one | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_2f8348444699be211478781e1ab5c3a8.svg) | (4R)-6-[2-[4-(4-Fluorophenyl)-6-phenyl-2-propan-2-ylpyridin-3-yl]ethyl]-4-hydroxyoxan-2-one | IC50 | 370.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_48a9419675ccbc8efb4fe80f38354285.svg) | (E,3R,5S)-7-[4-(4-Fluorophenyl)-1-phenyl-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_085d87d5386c6d228bd1163d2f3f42a1.svg) | (E,3R,5S)-7-[2,3-Bis(4-fluorophenyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 6.98 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_774752605aa952bf4e5be09d7d258100.svg) | L-Leucyl-L-prolyl-L-tyrosyl-L-proline | IC50 | 484720.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_9c9e43e55cd4669ffe5e650ab80b7de5.svg) | (4S)-4-[[(2S)-1-[(2S)-2-[(2-Aminoacetyl)amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[2-(carboxymethylamino)-2-oxoethyl]amino]-5-oxopentanoic acid | IC50 | 27280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_cc462f4ac0bf35d35dce996810c0c381.svg) | F(4-Fluoro)VAE | IC50 | 3840.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_005cd4174ad46877e3a6584c68f26b77.svg) | FPYVAE peptide [PMID: 20494585] | IC50 | 1470.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_bde3bdca72555a0d639f7c64a51181e0.svg) | (2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoic acid | IC50 | 152190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_55216edf92d01c0bef36dd77b0725e3b.svg) | CID 73348335 | IC50 | 4.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_991256d696ff2d64ab54e5cb8337068c.svg) | 4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_25a1456488828b87927f080592c6c7d3.svg) | (3R,5R)-7-[3,4-Bis(4-fluorophenyl)-5-(phenylcarbamoyl)-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoic acid | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e81cec633c2f07e0163958c31a0958de.svg) | [(1R,2S,3S,7S,8S)-2-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 13.3 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_076a9f4b73897c41e885dbc17dfa2269.svg) | [(1R,2S,3S,7S,8S)-8-[2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl]-2-[(R)-hydroxy(phenyl)methyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 19.7 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_7c458b6abd74a2ec086aec1dcfed78b5.svg) | [(1R,2S,3S,7S,8S)-2-[(1S)-1-Hydroxyethyl]-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 7.6 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_12389aa3fdd5c1734056b6a934b135fc.svg) | [(1R,2S,3S,7S,8S)-2-(Hydroxymethyl)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate | IC50 | 10.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_05b08a57fcf76bc6afc6ff0bc0d32388.svg) | [(1S,3R,4S,6S,7R,8S,8Ar)-4,6-dihydroxy-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoate | IC50 | 387000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_d64c11791751517941dde523475417e3.svg) | (4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2,6-dimethylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_c7278b289d379ce6ded006143372a8f5.svg) | (4R,6S)-6-[(Z)-2-[4-(4-Fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_591e15f5669a83837793c0b0c529a483.svg) | (4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 90.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_6e0c8e69d985735207684f2c5e4cf847.svg) | (E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_9f18517867da379d2b066b60daa1747a.svg) | (4R,6S)-6-[(E)-2-[6-Cyclohexyl-4-(4-fluorophenyl)-2-propan-2-ylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 9.5 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e2e769b27aa1cd659dca45f68273d7b5.svg) | (4R,6S)-6-[(E)-2-[2-Cyclohexyl-4-(4-fluorophenyl)-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_e203cc1905984178300581547ffd03f0.svg) | (4R,6S)-6-[(E)-2-[4-(4-Fluorophenyl)-2-phenyl-6-propan-2-ylpyrimidin-5-yl]ethenyl]-4-hydroxyoxan-2-one | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_1a6e34406452f51d4f464eaf90a82d68.svg) | Sodium;(E,3R,5S)-7-[1-(1,3-benzothiazol-2-yl)-5-(4-fluorophenyl)-3-propan-2-ylpyrazol-4-yl]-3,5-dihydroxyhept-6-enoate | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_971c0e6e5cfc9fd0f9914863ce922760.svg) | Sodium;(3R,5R)-7-[1-(4-fluorophenyl)-4-oxo-5-phenyl-3-propan-2-ylpyrrolo[2,3-c]quinolin-2-yl]-3,5-dihydroxyheptanoate | IC50 | 16.7 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_7ce6e8c18e3410ddc2167150b3efc7b1.svg) | Sodium;7-[4-(4-fluorophenyl)-1-phenyl-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyheptanoate | IC50 | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_19186d78957323cfd4506354c6e93194.svg) | Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-5-[(4-methoxyphenyl)methylcarbamoyl]-4-phenyl-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoate | IC50 | 0.8 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_3d5e1704404f8c66860d91b8a7366eb4.svg) | Sodium;(3R,5R)-7-[5-(ethylcarbamoyl)-3-(4-fluorophenyl)-4-phenyl-1-propan-2-ylpyrrol-2-yl]-3,5-dihydroxyheptanoate | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_6075fe44018b51981d1ffc2c85e1890c.svg) | Sodium;(3R,5R)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-propan-2-yl-5,6-dihydro-4H-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoate | IC50 | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_d0084c1be54ba9dadbaa8d5f8e7b154c.svg) | (4R)-6-[[2-[Chloro(cyclohexyl)methyl]-4,6-dimethylphenoxy]methyl]-4-hydroxyoxan-2-one | IC50 | 6500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_db164c7e078684b5d1b269f3a193edce.svg) | (E,3R,5S)-7-[5-(4-Fluoro-3,5-dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 7.52 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_bb403519738e2f6842a98fac0bc9bc6a.svg) | (E,3R,5S)-7-[5-(4-Fluoro-2-methylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 8.4 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_97ea0bb400566821742a4645165134d6.svg) | (E,3R,5S)-7-[4,5-Bis(4-fluorophenyl)-2-(trifluoromethyl)imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 7.89 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_ac715b8c0a0e8c5008a3a912c8b9fe1a.svg) | (E,3R,5S)-7-[5-(3,5-Dimethylphenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 7.25 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_21d346e3212131e35a22c185009086c3.svg) | (E,3R,5S)-7-[5-(3,5-Dichlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 7.66 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_d96fea940b92432f5abf1e3ef63b478f.svg) | (E,3R,5S)-7-[5-(3-Chlorophenyl)-4-(4-fluorophenyl)-2-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 8.1 [1] |
![](https://images.aatbio.com/dataset/ic50/hmg-coa-reductase_30364a15ec0c9d27affd0a1bb5a86b50.svg) | (E,3R,5S)-7-[2,4-Bis(4-fluorophenyl)-5-propan-2-ylimidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid | IC50 | 9.0 [1] |