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Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amineIC501900.0 [1]
Unc-0638IC5055.0 [1]
Unc-0638Ki3.7 [1]
CID 44251522IC5043.0 [1]
CID 44251522Ki2.6 [1]
CID 53315878IC5040.0 [1]
CID 53315878Ki3.7 [1]
CID 53315868IC5025.0 [1]
CID 53315882IC5012.0 [1]
ChaetocinIC502500.0 [1]
CID 44604812IC50230.0 [1]
N2,N2-Diethyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamineIC50910.0 [1]
6,7-Dimethoxy-N2,N2-dimethyl-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamineIC50900.0 [1]
6,7-Dimethoxy-N-(1-methylpiperidin-4-yl)-2-(piperidin-1-yl)quinazolin-4-amineIC5031.0 [1], 510.0 [2], 550.0 [3], 591.0 [4], 510000.0 [5]
6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC50200.0 [1], 680.0 [2], 200000.0 [3]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineIC5020.0 [1], 25.0 [2], 910.0 [3], 20000.0 [4]
6,7-Dimethoxy-N-(1-Methylpiperidin-4-Yl)-2-(Morpholin-4-Yl)quinazolin-4-AmineIC50440.0 [1], 810.0 [2], 1600.0 [3], 810000.0 [4], 1600000.0 [5]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC508.0 [1], 2200.0 [2], 8000.0 [3], 11000.0 [4]
CID 46901937IC509.0 [1], 6000.0 [2], 9000.0 [3], 11000.0 [4]
CID 76285486IC503.0 [1], 3.3 [2]
(1R,4R,7R,9R)-4-(Hydroxymethyl)-9-[(1R,4R,7R,9R)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dioneIC5050000.0 [1], 100000.0 [2]
6-Methoxy-2-piperidin-1-yl-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC502.5 [1], 16.0 [2], 150.0 [3]
2-(Azepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC502.5 [1], 20.0 [2], 100.0 [3]
7-[2-(Dimethylamino)ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC50110.0 [1], 120.0 [2], 110000.0 [3], 120000.0 [4]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(4-methylpentoxy)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC503400.0 [1], 5200.0 [2], 3400000.0 [3], 5200000.0 [4]
Ent-ChaetocinIC501700.0 [1], 6400.0 [2]
N-Cyclohexyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amineIC503877.0 [1], 10000.0 [2], 10000000.0 [3]
2-Cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC500.5 [1], 0.7 [2]
1-[2-[4-(4-Methoxybenzoyl)oxyphenyl]ethyl]-2-[[4-(trifluoromethyl)benzoyl]amino]benzimidazole-5-carboxylic acidIC50106.0 [1], 4700.0 [2], 5000.0 [3]
SodiumIC509200.0 [1], 100000.0 [2]
S-Adenosyl-L-homocysteineIC502000.0 [1]
S-Adenosyl-L-homocysteineKi570.0 [1]
GliotoxinIC50530.0 [1], 6400.0 [2]
SinefunginIC50100.0 [1], 509000.0 [2]
N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamideIC5010000.0 [1], 59000.0 [2]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC508.0 [1]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methylpiperazin-1-yl)quinazolin-4-amineIC50101.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC502.0 [1]
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(piperidin-4-yl)quinazolin-4-amineIC5010000.0 [1], 10000000.0 [2]
6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(oxan-4-yl)quinazolin-4-amineIC5010000.0 [1], 10000000.0 [2]
N-Cyclopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amineIC505100.0 [1], 5100000.0 [2]
N-Isopropyl-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amineIC505800.0 [1], 5800000.0 [2]
2-Chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC509100.0 [1], 9100000.0 [2]
(1S,4S,7S,9S)-4-(Hydroxymethyl)-9-[(1S,4S,7S,9S)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dioneIC5050000.0 [1], 100000.0 [2]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinolin-4-amineIC5013.0 [1]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methylpiperazin-1-yl)quinolin-4-amineIC5021.0 [1], 31.0 [2]
(1S,4S)-5,7-Dibenzyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dioneIC504900.0 [1], 5105.05 [2]
CID 46899643IC50910000.0 [1], 1900000.0 [2]
7-[4-(Dimethylamino)butoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC50110000.0 [1], 140000.0 [2]
7-[5-(Dimethylamino)pentoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC5049000.0 [1], 95000.0 [2]
7-[6-(Dimethylamino)hexoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC503200000.0 [1], 15100000.0 [2]
6-Methoxy-7-[3-(methylamino)propoxy]-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC5041000.0 [1], 120000.0 [2]
7-[3-(Diethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC5052000.0 [1], 65000.0 [2]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[3-[methyl(propyl)amino]propoxy]quinazolin-4-amineIC5045000.0 [1], 51000.0 [2]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amineIC50780000.0 [1], 880000.0 [2]
CID 46901785IC5010000.0 [1], 10000000.0 [2]
7-(5-Aminopentoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amineIC50110000.0 [1], 235000.0 [2]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[2-(2-pyrrolidin-1-ylethoxy)ethoxy]quinazolin-4-amineIC5057000.0 [1], 110000.0 [2]
N'-[2-[6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-[(1-methylpiperidin-4-yl)amino]quinazolin-7-yl]oxyethyl]-N,N,N'-trimethylethane-1,2-diamineIC50173000.0 [1], 345000.0 [2]
CID 46901936IC501500000.0 [1], 5100000.0 [2]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-piperidin-1-ylquinazolin-4-amineIC50472.0 [1]
6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC5010.0 [1], 520.0 [2]
6-Methoxy-7-(3-piperidin-1-ylpropoxy)-2-(4-propan-2-yl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amineIC508.0 [1], 54.0 [2]
2-(Azepan-1-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amineIC5031.0 [1], 240.0 [2]
6-Methoxy-2-(4-propan-2-yl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC502.0 [1], 340.0 [2]
2-(4-Cyclohexyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC5022.0 [1], 100.0 [2]
2-[4-(Cyclohexylmethyl)-1,4-diazepan-1-yl]-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC507.0 [1], 93.0 [2]
2-(4-Ethyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC505.0 [1], 470.0 [2]
2-(4-Benzyl-1,4-diazepan-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC509.0 [1], 58.0 [2]
2-Cyclohexyl-7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amineIC5021.0 [1], 180.0 [2]
2-Cyclohexyl-6-methoxy-7-(3-piperidin-1-ylpropoxy)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amineIC50110.0 [1], 260.0 [2]
6-Methoxy-2-(4-phenyl-1,4-diazepan-1-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC5010.0 [1], 220.0 [2]
N-(1-Cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineIC5011.0 [1], 56.0 [2]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-pyridin-2-ylpiperazin-1-yl)quinazolin-4-amineIC503190.0 [1]
6-Methoxy-2-morpholin-4-yl-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC502.5 [1], 180.0 [2]
N-(1-Cyclopropylpiperidin-4-yl)-2-(4,4-difluoropiperidin-1-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC503.0 [1], 310.0 [2]
N-(1-Cyclopropylpiperidin-4-yl)-2-(1,1-dioxo-1,4-thiazinan-4-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC504.0 [1], 590.0 [2]
6-Methoxy-2-(oxan-4-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC509.0 [1], 310.0 [2]
GlutathioneIC50100000.0 [1]
AzacitidineIC5010000.0 [1]
DecitabineIC5010000.0 [1]
OxiglutationeIC50100000.0 [1]
CysteamineIC50100000.0 [1]
DisulfiramIC50600.0 [1]
AnthraquinoneIC50100000.0 [1]
Cystamine dihydrochlorideIC5015000.0 [1]
NinhydrinIC5054000.0 [1]
1,4-NaphthoquinoneIC502000.0 [1]
EbselenIC50400.0 [1]
ThiramIC50550.0 [1]
Diphenyl diselenideIC50550.0 [1]
2,2'-DithiodipyridineIC50650.0 [1]
AzodicarbonamideIC50500.0 [1]
ChetominIC50170.0 [1]
CID 71268957IC50100000.0 [1]
Bisdethiobis(methylthio)gliotoxinIC50100000.0 [1]
VerticillinIC50630.0 [1]
Benzeneseleninic acidIC504400.0 [1]
(2S)-2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acidKi20000.0 [1]
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amineIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-9-specific-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-9-specific-3-inhibitors-ic50-ki.
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