Histone-lysine N-methyltransferase, H3 lysine-79 specific Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Pinometostat	IC50	7.0 [1]
	Pinometostat	Ki	0.01 [1], 0.07 [2], 0.08 [3]
	CID 56962336	IC50	0.4 [1]
	CID 56962336	Ki	0.3 [1], 300.0 [2]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	Ki	290.0 [1], 300.0 [2], 1100.0 [3]
	5'-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino}propyl)(Propan-2-Yl)amino]-5'-Deoxyadenosine	IC50	14.0 [1], 100.0 [2]
	5'-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino}propyl)(Propan-2-Yl)amino]-5'-Deoxyadenosine	Ki	0.46 [1], 0.5 [2], 0.72 [3]
	S-Adenosyl-L-homocysteine	IC50	600.0 [1]
	S-Adenosyl-L-homocysteine	Ki	160.0 [1]
	Dot1L-IN-1	IC50	0.1 [1], 3.0 [2], 17.0 [3]
	Dot1L-IN-1	Ki	0.0 [1]
	1-{[6-(3-Fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole	IC50	8290.0 [1], 21910.0 [2], 28080.0 [3], 55780.0 [4]
	5-Iodotubercidin	IC50	18000.0 [1], 18200.0 [2]
	S-Adenosyl-3-thiopropylamine	Ki	100000.0 [1]
	CID 56962337	IC50	0.3 [1], 8.8 [2]
	Bromo-deaza-SAH	IC50	77.0 [1]
	CID 2231443	IC50	8400.0 [1], 40730.0 [2]
	3-(Benzotriazol-1-ylmethyl)-6-benzyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	19390.0 [1], 48800.0 [2]
	1-{[6-(3,4-Dimethylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-benzimidazole	IC50	17370.0 [1], 63970.0 [2]
	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid	IC50	38.0 [1]
	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid	IC50	120.0 [1]
	1-(4-Tert-butylphenyl)-3-[3-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-propan-2-ylamino]propyl]urea	Ki	0.76 [1], 0.8 [2]
	Benzyl N-[3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]propyl]carbamate	Ki	46000.0 [1]
	Benzyl N-[3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]carbamate	Ki	22000.0 [1]
	5-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-phenylpentanamide	Ki	22000.0 [1]
	3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl N-phenylcarbamate	Ki	16000.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-benzylurea	Ki	1900.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-phenylurea	Ki	550.0 [1]
	1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-phenylurea	Ki	18000.0 [1]
	1-[4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butyl]-3-phenylurea	Ki	1100.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-(4-chlorophenyl)urea	Ki	82.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-[4-(trifluoromethyl)phenyl]urea	Ki	58.0 [1]
	1-[3-[[(3R,4S,5R)-3-(6-Aminopurin-9-yl)-4,5-dihydroxycyclopenten-1-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	Ki	1.3 [1]
	1-[3-[[(1R,2R,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	Ki	1.1 [1]
	1-[3-[[(1S,2R,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	Ki	50000.0 [1]
	1-{[6-(3-Bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-benzimidazole	IC50	4090.0 [1], 26780.0 [2]
	1-{[6-(3-Methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-benzotriazole	IC50	6470.0 [1], 64150.0 [2]
	1-{[6-(4-Fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole	IC50	4640.0 [1], 8000.0 [2]
	6-(1,3-Benzodioxol-5-yl)-3-(benzotriazol-1-ylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	3960.0 [1], 6750.0 [2]
	1-{[6-(4-Tert-butylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-benzotriazole	IC50	4480.0 [1], 13050.0 [2]
	4-{6-[(E)-2-(Furan-2-yl)ethenyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl}-N,N-dimethylaniline	IC50	20940.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[[propan-2-yl-[3-[2-[6-(trifluoromethoxy)-1H-benzimidazol-2-yl]ethyl]cyclobutyl]amino]methyl]oxolane-3,4-diol	IC50	2.18 [1], 2.92 [2]
	Adenosine	IC50	100000.0 [1]
	Sinefungin	IC50	33710.0 [1]
	CID 71268957	IC50	100000.0 [1]
	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	IC50	100000.0 [1]
	3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propanoic acid	Ki	100000.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-(2-hydroxyethylsulfanylmethyl)oxolane-3,4-diol	Ki	100000.0 [1]
	5'-Deoxy-5'-[2-(amino)ethylthio]adenosine	Ki	25000.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	Ki	1100.0 [1]
	2-Amino-N-[4-(2-amino-3-cyano-1-ethylindol-5-yl)oxyphenyl]acetamide	IC50	99000.0 [1]
	2-Amino-N-[4-(2-amino-3-cyano-1-methylindol-5-yl)oxyphenyl]acetamide	IC50	100000.0 [1]
	(2R)-2-Amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxypropanamide	IC50	100000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	170.0 [1]
	5'-Deoxy-5'-(Dimethylamino)adenosine	Ki	38000.0 [1]
	5'-S-Benzyl-5'-thioadenosine	Ki	100000.0 [1]
	(2s)-2-Amino-N-[4-[(2-Amino-3-Cyano-1h-Indol-5-Yl)oxy]phenyl]-3-Hydroxy-Propanamide	IC50	100000.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(propan-2-ylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	Ki	3800.0 [1]
	PRMT5 Inhibitor C17	IC50	100000.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-[6-(cyclopropylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	Ki	2000.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-[6-(butylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	Ki	2800.0 [1]
	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-[6-(tert-butylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	Ki	7800.0 [1]
	(2S)-2-Amino-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]butanoic acid	IC50	16000.0 [1]
	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-(3-carbamoylphenyl)ethyl]amino]pentanoic acid	IC50	1300.0 [1]
	2-[[1-(2-Chlorophenyl)indol-6-yl]carbamoylamino]-N-[3-[[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]amino]propyl]acetamide	IC50	3.98 [1]
	2-[[1-(2-Chlorophenyl)indol-6-yl]carbamoylamino]-N-[4-[[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]amino]butyl]acetamide	IC50	3.98 [1]
	2-[[1-(2-Chlorophenyl)indol-6-yl]carbamoylamino]-N-[3-[methyl-[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]amino]propyl]acetamide	IC50	0.15 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(1S)-1-[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-cyclobutylamino]ethyl]oxolane-3,4-diol	IC50	1430.0 [1]
	1-[3-[[(1S)-1-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]ethyl]-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	IC50	6.34 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(1S)-1-[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]amino]ethyl]oxolane-3,4-diol	IC50	690.0 [1]
	2-[[1-(2-Chlorophenyl)indol-6-yl]carbamoylamino]acetamide	IC50	7943.28 [1]
	(3R)-N-Methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine	IC50	141000.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(1S)-1-[bis[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]amino]ethyl]oxolane-3,4-diol	IC50	2160.0 [1]
	2-Amino-N-[4-[2-amino-3-cyano-1-(cyclopropylmethyl)indol-5-yl]oxyphenyl]acetamide	IC50	96000.0 [1]
	5-Benzyloxy-2-amino-1H-indole-3-carbonitrile	IC50	100000.0 [1]
	5-Benzyloxy-2-amino-1-methyl-1H-indole-3-carbonitrile	IC50	100000.0 [1]
	5-(3-Aminobenzyloxy)-2-amino-1-methyl-1H-indole-3-carbonitrile	IC50	100000.0 [1]
	6-[(E)-2-(Furan-2-yl)ethenyl]-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	7010.0 [1]
	6-[(E)-2-(Furan-2-yl)ethenyl]-3-(pyridin-4-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	13660.0 [1]
	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	IC50	100000.0 [1]
	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid	IC50	110.0 [1]
	5'-Deoxy-5'-(Prop-2-Yn-1-Ylamino)adenosine	Ki	100000.0 [1]
	5'-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino}propyl)(Methyl)amino]-5'-Deoxyadenosine	Ki	13.0 [1]
	5'-S-(3-Aminophenyl)-5'-thioadenosine	Ki	100000.0 [1]
	6-[2-(2-Furyl)vinyl]-3-(3-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	9410.0 [1]
	(3R)-1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine	IC50	251188.64 [1]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	IC50	100000.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-(4-tert-butylphenyl)urea	Ki	70.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-(2-ethylphenyl)urea	Ki	690.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-(3-ethylphenyl)urea	Ki	130.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-(2,4-difluorophenyl)urea	Ki	1000.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-[3,5-bis(trifluoromethyl)phenyl]urea	Ki	80.0 [1]
	1-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-3-naphthalen-1-ylurea	Ki	2700.0 [1]
	1-(4-Tert-butylphenyl)-3-[3-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(prop-2-enylamino)purin-9-yl]oxolan-2-yl]methyl-propan-2-ylamino]propyl]urea	Ki	12.0 [1]
	1-[3-[[(2R,3S,4R,5R)-5-[6-(Benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	Ki	22.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(pyridin-2-ylmethylamino)methyl]oxolane-3,4-diol	Ki	100000.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(pyridin-4-ylmethylamino)methyl]oxolane-3,4-diol	Ki	100000.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(thiophen-2-ylmethylamino)methyl]oxolane-3,4-diol	Ki	100000.0 [1]
	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(furan-2-ylmethylamino)methyl]oxolane-3,4-diol	Ki	100000.0 [1]
	(2R,3S,4R,5R)-2-[[(3-Aminophenyl)methyl-prop-2-enylamino]methyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Ki	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-79 specific Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-79-specific-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Histone-lysine N-methyltransferase, H3 lysine-79 specific Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-n-methyltransferase-h3-lysine-79-specific-inhibitors-ic50-ki.
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