![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_d7483d5101c61095835e20b848a3f165.svg) | S-Adenosyl-L-homocysteine | IC50 | 4800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_20b863183f321606d2c4c48b6ae83790.svg) | CID 68210102 | IC50 | 1.0 [1], 2.0 [2], 280.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_20b863183f321606d2c4c48b6ae83790.svg) | CID 68210102 | Ki | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_477453d5b5b1193ba58fb7148094e1af.svg) | 5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-ethylbenzamide | IC50 | 2.9 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_13740805901319ea5126f3abbdb3e18b.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-(pyrrolidine-1-carbonyl)cyclohexyl]amino]-2-methylbenzamide | IC50 | 21.4 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_94ffe89227395c1fd44411073f92c9b4.svg) | Ethyl 4-[5-chloro-3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-N-ethyl-2-methylanilino]cyclohexane-1-carboxylate | IC50 | 3.2 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_93d30272c7a7b3405d425965b292c1e2.svg) | 4-[5-Chloro-3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-N-ethyl-2-methylanilino]cyclohexane-1-carboxylic acid | IC50 | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_bc8f8fbf140a210f6900667684acd035.svg) | Tazemetostat | IC50 | 11.07 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_bc8f8fbf140a210f6900667684acd035.svg) | Tazemetostat | Ki | 2.5 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_b6e01f1c5cf4b24fbb8ca6babe64fe67.svg) | CID 60160561 | IC50 | 75.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_b6e01f1c5cf4b24fbb8ca6babe64fe67.svg) | CID 60160561 | Ki | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_7d4f4658845d0e36244b77456bc0299e.svg) | Ezh2-in-3 | IC50 | 190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_7447e405cb052faeea5a05b6915788a1.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl)phenyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 184.6 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_878b96f4497953e54e8f9b0f5850782f.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-pyrazin-2-ylbenzamide | IC50 | 2.9 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_fc8afb25c9d7df9fb6ec1ca30a6c51a2.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylpyrazol-4-yl)benzamide | IC50 | 1.9 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4d294485c66da36fee66335f64290f99.svg) | 2-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | IC50 | 5.1 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_6bbb6e02f3598cc05612b85056e0a985.svg) | N-[(5-Bromo-4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | IC50 | 3287.59 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_bc786e588674aac67a8db4ef476edbd4.svg) | 3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | IC50 | 10.35 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_f3b7828db9dc3e982f0da2b2d699d7b7.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-(3-hydroxypropylcarbamoyl)phenyl]-2-methylbenzamide | IC50 | 2.9 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_c01c5210885728901fb85cf1fd9ebde5.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(6-piperazin-1-ylpyridin-3-yl)benzamide | IC50 | 10.1 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ceb50f9fe2e7514aca05ae95ef7a3041.svg) | 3-[Ethyl(oxan-4-yl)amino]-N-[(5-fluoro-4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | IC50 | 183.5 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_61fc05b3c401f95afbecde7896022cb8.svg) | 3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]benzamide | IC50 | 3.9 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_0127bf78fbd9f55ec7ffa7451ee1cc3c.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(5-methylpyrazin-2-yl)benzamide | IC50 | 9.55 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4574ab2a6a564d10739c804c8ed58051.svg) | 5,8-Dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one | IC50 | 15.0 [1], 17.0 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4574ab2a6a564d10739c804c8ed58051.svg) | 5,8-Dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one | Ki | 0.7 [1], 1.15 [2], 3.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_a99f6f7177aded25994fa22742edc499.svg) | 5-Chloro-N-[(6-ethyl-4-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide | IC50 | 2.2 [1], 5.1 [2], 18.2 [3], 20.0 [4], 22.3 [5] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_12ae73e66a814c7ca4562252ef9fe85a.svg) | 2-Amino-4-[[(3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-[2-(4-chlorophenyl)ethylamino]ethyl]amino]butanoic acid | IC50 | 2500.0 [1], 4100.0 [2], 7180.0 [3], 7560.0 [4], 8950.0 [5] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_51af98c1c8752ae251f9c066f016d505.svg) | CID 67469117 | IC50 | 2.3 [1], 5.5 [2], 9.2 [3], 33.3 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_bb5b3f3c0446124007f09309413c0260.svg) | 3-[Cyclopentyl(methyl)amino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(2,2,6,6-tetramethyl-1,3-dihydropyridin-4-yl)benzamide | IC50 | 19.0 [1], 27.7 [2], 230.0 [3], 311.0 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ec09030a0d94ff940f73c54c1560c05a.svg) | 5-Chloro-3-[(4,4-dimethylcyclohexyl)-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 9.4 [1], 19.3 [2], 29.3 [3], 34.8 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_0c1fb23bc9651a9bb53956673e3bf6d8.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)-1-propan-2-ylindole-4-carboxamide | IC50 | 9.3 [1], 10.6 [2], 19.1 [3], 38.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_939bba8c9a40e907fd878a501461c582.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-(2,2,6,6-tetramethylpiperidin-4-yl)pyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 31.6 [1], 59.9 [2], 292.3 [3], 357.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_504e85d8a3c74234360e1f9b180f4c01.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-(methylamino)-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 213.0 [1], 318.9 [2], 1578.1 [3], 2375.5 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ef25767446ef12e591236f7e0f89684c.svg) | 3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[6-(morpholin-4-ylmethyl)pyridin-3-yl]benzamide | IC50 | 46.24 [1], 48.4 [2], 54.68 [3], 67.5 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_316bde325f25547f97760db7bb3ea700.svg) | 3-[(4-Aminocyclohexyl)-methylamino]-5-[6-[(dimethylamino)methyl]pyridin-3-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 30.53 [1], 56.02 [2], 58.05 [3], 58.37 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_b5403e22bc5cbb05c624ef89ce22096b.svg) | 3-[Ethyl(oxan-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-5-(6-piperazin-1-ylpyridin-3-yl)benzamide | IC50 | 0.8 [1], 0.9 [2], 0.92 [3], 1.1 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_a819430d9fb7dd17da5c5cacb86c8e4c.svg) | 3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | IC50 | 22.06 [1], 25.48 [2], 30.09 [3], 43.22 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_8c84d5a73ce3712639c87435b389482d.svg) | 3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]benzamide | IC50 | 74.26 [1], 96.73 [2], 125.2 [3], 139.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_76c7d14c8060a874ff9609fcfbcae847.svg) | 3-[(4-Aminocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylpyrazol-4-yl)benzamide | IC50 | 62.19 [1], 70.98 [2], 75.46 [3], 99.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_f5804785f4b129b775bd75dc67e163ee.svg) | 3-[(4-Acetamidocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[6-(morpholin-4-ylmethyl)pyridin-3-yl]benzamide | IC50 | 13.67 [1], 15.27 [2], 23.33 [3], 32.26 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_e79ae08b3a9fc257f78a7e4ce051627d.svg) | 3-[(4-Acetamidocyclohexyl)-methylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]benzamide | IC50 | 27.01 [1], 54.92 [2], 66.99 [3], 82.1 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4e284dbdbd2d8e84a2f4880beb3fbdb1.svg) | 5-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylpyridine-3-carboxamide | IC50 | 10.4 [1], 12.5 [2], 17.1 [3], 19.2 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_1fa3037063c3615db710f33d4bb3e6ed.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(1-methylazetidin-3-yl)oxybenzamide | IC50 | 0.8 [1], 1.4 [2], 1.5 [3], 8.7 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_02f97748aaa25325085da9ea79aea916.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-propan-2-ylbenzamide | IC50 | 6.5 [1], 7.3 [2], 15.8 [3], 16.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_d3769e55756c7b47e815b58c6a1c86d0.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethylsulfonyl-2-methylbenzamide | IC50 | 4.8 [1], 5.1 [2], 10.8 [3], 11.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4f1c5767a6ff9e6cd7c5b5a4d45a5ca4.svg) | 5-Chloro-3-[ethyl-(1-methylpiperidin-4-yl)amino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]benzamide | IC50 | 14.6 [1], 17.8 [2], 35.1 [3], 65.7 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_b1d9cc364c8424e422cbc2c47ec1a8fe.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-(3-hydroxy-3-methylbut-1-ynyl)-2-methylbenzamide | IC50 | 1.6 [1], 3.6 [2], 4.6 [3], 12.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ef0ba1a7f6d2d18cb3f6867cc018f95d.svg) | 3-[[4-(Azetidin-1-yl)cyclohexyl]-ethylamino]-5-chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 2.5 [1], 5.8 [2], 6.7 [3], 7.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_382b7594b4ae6070df2954d2dea451b3.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[methyl(oxetan-3-yl)amino]cyclohexyl]amino]-2-methylbenzamide | IC50 | 1.6 [1], 1.7 [2], 6.1 [3], 6.7 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_0040ca98e3086b176df91366971bee81.svg) | 3-[(4-Tert-butylcyclohexyl)-ethylamino]-5-chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 63.8 [1], 118.8 [2], 167.8 [3], 333.3 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_79bd6c286a6c74698e61cf15b8dca679.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-(hydroxymethyl)cyclohexyl]amino]-2-methylbenzamide | IC50 | 1.6 [1], 2.1 [2], 2.7 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_04a6a7ce0de84f4007f94b759e0a56cc.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-methoxy-2-methylbenzamide | IC50 | 10.0 [1], 10.3 [2], 11.6 [3], 11.7 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_53f9670117810140774b1662973ee091.svg) | 5-Bromo-2-chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]benzamide | IC50 | 2.9 [1], 3.2 [2], 3.4 [3], 3.5 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_22538977263fd405b4e8db8b6a57b266.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(4-propan-2-ylcyclohexyl)amino]-2-methylbenzamide | IC50 | 11.1 [1], 12.0 [2], 22.7 [3], 30.0 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_dcfeab1c67b57cde40ec33f5a7ec7c02.svg) | 5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-2-methyl-N-[(1,4,6-trimethyl-2-oxopyridin-3-yl)methyl]benzamide | IC50 | 6.5 [1], 6.8 [2], 7.4 [3], 8.6 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4755032ee2b0d67a22dc3f253626f1be.svg) | 5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-N,2-dimethylbenzamide | IC50 | 12.2 [1], 12.8 [2], 14.3 [3], 20.7 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_0db5aaf917fb8683f403f20b5eeddce6.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-5-(trifluoromethyl)benzamide | IC50 | 8.2 [1], 9.2 [2], 9.4 [3], 9.6 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_e7931fafa8a3e4c3e7dbbe7cfb0610ae.svg) | 5-Chloro-3-[[4-[cyclobutyl(methyl)amino]cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 4.2 [1], 7.1 [2], 8.8 [3], 11.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_1dc07e61e5cc4164feeff8a27d0a5ac9.svg) | 5-(2-Cyclopropylethynyl)-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 1.5 [1], 1.8 [2], 2.5 [3], 4.3 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_fb70f53fe65e8cb4d7792c9c017b26c1.svg) | 5-(Azetidine-1-carbonyl)-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 1.4 [1], 2.9 [2], 9.1 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_962d6f39f20e5b4a0d8c58d4fbe8648f.svg) | 5-Chloro-3-[[4-(dimethylamino)cyclohexyl]-ethylamino]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]benzamide | IC50 | 2.8 [1], 3.8 [2], 4.6 [3], 7.9 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_a7ff8dd296d9f397fe43c58dc5b58299.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-5-(3,3-dimethylbut-1-ynyl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 4.0 [1], 7.6 [2], 10.4 [3], 15.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_c3e3a78a1194c20e0ce8dcd699d20f59.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(1-propan-2-ylpiperidin-4-yl)amino]-2-methylbenzamide | IC50 | 12.1 [1], 20.5 [2], 27.5 [3], 71.5 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_79e9d0e52c4c9f66fc59f58e7c2b8da8.svg) | 5-Chloro-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-(1-methylazetidin-3-yl)amino]-2-methylbenzamide | IC50 | 5.7 [1], 22.2 [2], 25.5 [3], 76.5 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_794d76eefd543b55b408358df9ca12f4.svg) | 3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethynyl-2-methylbenzamide | IC50 | 3.4 [1], 4.0 [2], 8.8 [3], 18.1 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4563c7798bdce352ebdaa3e437a00b1e.svg) | 3-Bromo-5-[[4-(dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,6-dimethylbenzamide | IC50 | 4.5 [1], 5.5 [2], 7.3 [3], 9.6 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_8b89c8a51760e3d08b17aa67f421ee5f.svg) | 5-Chloro-3-[[4-[2,2-difluoroethyl(methyl)amino]cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylbenzamide | IC50 | 2.2 [1], 2.8 [2], 6.9 [3], 9.4 [4] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_d4446dd1ec82f0d692e96313a1171e98.svg) | CID 72551585 | IC50 | 10.0 [1], 124.0 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_d4446dd1ec82f0d692e96313a1171e98.svg) | CID 72551585 | Ki | 4.6 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_6a0eac4b4bd204ad1d67a2f73e50f519.svg) | 6-Cyclopropyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 10632.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_6a0eac4b4bd204ad1d67a2f73e50f519.svg) | 6-Cyclopropyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | Ki | 700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_9c0326cb5f890ed8b8397f61b868036f.svg) | CID 72199293 | IC50 | 13.0 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_9c0326cb5f890ed8b8397f61b868036f.svg) | CID 72199293 | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_dcf8ea88805db673d5c3c509737ab758.svg) | CID 118572065 | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_dcf8ea88805db673d5c3c509737ab758.svg) | CID 118572065 | Ki | 0.1 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_c549790fc3f4d88ec969b57f92deaea8.svg) | CPI-169 R-enantiomer | IC50 | 2.0 [1], 3.0 [2], 80.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_5bad62eac417c394e06cf38e19429dc2.svg) | CID 73442743 | IC50 | 2.0 [1], 4.0 [2], 75.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_31744fbbead69fe5680a3f85c432de7a.svg) | 1-[(1R)-1-(1-Ethylsulfonylpiperidin-4-yl)ethyl]-2-methyl-N-[[6-methyl-2-oxo-4-(2,2,2-trifluoroethoxy)-1H-pyridin-3-yl]methyl]indole-3-carboxamide | IC50 | 40.0 [1], 485.0 [2], 1080.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_9bac1489e5184bf8600c0ced64fb88bb.svg) | 1-[(1R)-1-(1-Ethylsulfonylpiperidin-4-yl)ethyl]-2-methyl-N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]indole-3-carboxamide | IC50 | 5.0 [1], 40.0 [2], 266.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_5458aeadef72454e33e6cd6bed24aef2.svg) | 5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(3,5-dimethyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one | IC50 | 16.0 [1], 82.0 [2], 502.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_c963be5702cfca1e5902d06d2d322dc2.svg) | 5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1,3,5-trimethylpyrazol-4-yl)-3,4-dihydroisoquinolin-1-one | IC50 | 1500.0 [1], 6000.0 [2], 15308.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_3aea57077ec4cca205cc45bdef67e88a.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-phenylethyl]indole-3-carboxamide | IC50 | 7.0 [1], 34.0 [2], 484.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_0590efca40f6ef50f49362cb97f00872.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(2R)-1-methoxypropan-2-yl]-2-methylindole-3-carboxamide | IC50 | 5.0 [1], 43.0 [2], 703.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4006127f0795b8c99640f6dee5ef3196.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-(oxan-4-yl)ethyl]indole-3-carboxamide | IC50 | 1.0 [1], 4.0 [2], 98.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_3a54e932d07396ac46d36a729f98635c.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-(1-methylpiperidin-4-yl)ethyl]indole-3-carboxamide | IC50 | 2.0 [1], 7.0 [2], 568.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_2ee6084270d258d4b67ee20571484d02.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-(1-ethylsulfonylpiperidin-4-yl)ethyl]-2-methylindole-3-carboxamide | IC50 | 1.0 [1], 3.0 [2], 59.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_1a3b0ec0f9cb9d8b9190c56db1232459.svg) | 5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one | IC50 | 51.0 [1], 270.0 [2], 1726.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_25071c8bba8f498c0a3bbe2a962bf21c.svg) | 8-Chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one | IC50 | 105.0 [1] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_25071c8bba8f498c0a3bbe2a962bf21c.svg) | 8-Chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one | Ki | 2.0 [1], 6.3 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_f58d6ea0f18918a6d46ebeab514c3905.svg) | 5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(5-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one | IC50 | 24.0 [1], 110.0 [2], 873.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_4cdccab970cd1b70d65d7fbc1e7a64b6.svg) | 1-Butan-2-yl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide | IC50 | 14.0 [1], 118.0 [2], 929.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_b44baa39afa15de44ae072285a59355c.svg) | 5,8-Dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one | IC50 | 5.6 [1], 18.0 [2], 170.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ed49d6c83924124b46f8e37cabaab69f.svg) | 8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-methyl-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one | IC50 | 18.0 [1], 61.0 [2], 290.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_1b3116cdc16fa440d1209733f55209ff.svg) | 8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one | IC50 | 28.0 [1], 110.0 [2], 796.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_ca9bc6788a4d372945996d9e77c02178.svg) | 8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-fluoro-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one | IC50 | 56.0 [1], 260.0 [2], 994.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_cbf298a986fe54ff73725d779d8642f8.svg) | 8-Chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-propan-2-yloxy-3,4-dihydroisoquinolin-1-one | IC50 | 41.0 [1], 160.0 [2], 1187.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_8ff51cf3cb91dcf26661917791143a5c.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(3-methoxypropyl)amino]-2-methylbenzamide | IC50 | 12.7 [1], 88.2 [2], 132.0 [3] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_d1b46ad43bfa9535a88bae9f99c692e9.svg) | 6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide | IC50 | 500.0 [1], 620.0 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_8518cd8c4726e9bc82cf396f8c3e4dd4.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)indole-3-carboxamide | IC50 | 1760.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/histone-lysine-n-methyltransferase-ezh2_584c5d0a7b4339a8d53a2262efb45339.svg) | N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-(1-phenylethyl)indole-3-carboxamide | IC50 | 1640.0 [1], 10000.0 [2] |