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Histone lysine demethylase PHF8 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DaminozideIC50550.0 [1], 19000.0 [2]
N-OxalylglycineIC50250000.0 [1], 640000.0 [2]
Trimethyl-[3-[4-(2-methyl-1-benzofuran-3-carbonyl)phenoxy]propyl]azanium;iodideIC50126000.0 [1], 310000.0 [2]
3-[4-(2-Butyl-1-benzofuran-3-carbonyl)phenoxy]propyl-trimethylazanium;iodideIC50120000.0 [1], 355000.0 [2]
3-[4-[C-(1-Benzofuran-3-yl)-N-methylcarbonimidoyl]phenoxy]propyl-trimethylazanium;iodideIC50300000.0 [1], 697000.0 [2]
AmiodaroneIC50252000.0 [1]
4,6-Dioxoheptanoic acidIC502300.0 [1]
Pyridine-2,4-dicarboxylic acidIC50250000.0 [1]
4-(Hydroxyamino)-4-oxobutanoic acidIC501700.0 [1]
Kdm5A-IN-1IC5025000.0 [1]
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acidIC5019000.0 [1]
4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acidIC5010000.0 [1]
3-[[(1R)-6-(N-Methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acidIC504000.0 [1]
[3-[6-Methyl-4-(1-methylpyrazol-4-yl)pyridin-2-yl]pyrrolidin-1-yl]-(5-propan-2-yl-1H-pyrazol-3-yl)methanoneIC5025000.0 [1]
2-[[(1-Ethyl-2-oxopyrrolidin-3-yl)methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[(2-Methyl-5,6,8,9-tetrahydroimidazo[1,2-d][1,4]diazepin-7-yl)methyl]pyridine-4-carboxylic acidIC50250.0 [1]
3-[5-[Butyl(methyl)amino]pentanoyl-hydroxyamino]propanoic acidIC50100000.0 [1]
3-[Hydroxy-[5-[methyl(pentyl)amino]pentanoyl]amino]propanoic acidIC50100000.0 [1]
3-[5-[Hexyl(methyl)amino]pentanoyl-hydroxyamino]propanoic acidIC5073000.0 [1]
3-[5-[Butyl(hexyl)amino]pentanoyl-hydroxyamino]propanoic acidIC5029000.0 [1]
3-[5-[Butyl(octyl)amino]pentanoyl-hydroxyamino]propanoic acidIC5024000.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]piperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-1-[(1R)-1-(4-Methoxyphenyl)ethyl]-2-oxopiperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
3-[4-(2-Butyl-1-benzofuran-3-carbonyl)-2,6-difluorophenoxy]propyl-trimethylazanium;iodideIC50242000.0 [1]
3-[2-(2-Butyl-1-benzofuran-3-carbonyl)phenoxy]propyl-trimethylazanium;iodideIC50496000.0 [1]
[(5S)-6-[[(2S)-5-Amino-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S,3R)-1-[[2-[[2-[[(2S)-6-amino-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-oxohexyl]-trimethylazaniumIC501700.0 [1]
(2-Butyl-1-benzofuran-3-yl)-[4-[3-(dimethylamino)propoxy]phenyl]methanoneIC50397000.0 [1]
Trimethyl-[3-[2-(2-methyl-1-benzofuran-3-carbonyl)phenoxy]propyl]azanium;iodideIC50286000.0 [1]
3-[4-(2-Butyl-1-benzofuran-3-carbonyl)-2,6-dimethoxyphenoxy]propyl-trimethylazanium;iodideIC50240000.0 [1]
[4-(3-Aminopropoxy)phenyl]-(2-butyl-1-benzofuran-3-yl)methanoneIC50386000.0 [1]
Trimethyl-[3-[4-(2-methyl-1-benzothiophene-3-carbonyl)phenoxy]propyl]azanium;iodideIC50377000.0 [1]
3-[4-(2-Butyl-1-benzofuran-3-carbonyl)phenoxy]propyl-triethylazanium;iodideIC50221000.0 [1]
4-Hydrazinyl-4-oxobutanoic acidIC50480.0 [1]
N'1,N'1,N'4,N'4-TetramethylsuccinohydrazideIC50117000.0 [1]
4-(Isopropylamino)-4-oxobutanoic acidIC50100000.0 [1]
3-[6-[Butyl(methyl)amino]hexanoyl-hydroxyamino]propanoic acidIC5058000.0 [1]
N-(Carboxycarbonyl)-S-(3-Nitrobenzyl)-L-CysteineIC501000000.0 [1]
N-(Carboxycarbonyl)-S-(Naphthalen-2-Ylmethyl)-L-CysteineIC501000000.0 [1]
(2R)-3-(Naphthalen-1-ylmethylsulfanyl)-2-(oxaloamino)propanoic acidIC501000000.0 [1]
3-[4-(2-Butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]propyl-trimethylazaniumIC50390000.0 [1]
4-((Dimethylamino)oxy)-4-oxobutanoic acidIC506900.0 [1]
4-[Dimethylamino(methyl)amino]-4-oxobutanoic acidIC5011500.0 [1]
(3-Carboxypropanoylamino)-trimethylazaniumIC5035000.0 [1]
4-(2-Methylhydrazinyl)-4-oxobutanoic acidIC503400.0 [1]
3-(9-Cyclohexylnonanoylhydroxyamino)propionic acidIC5017000.0 [1]
3-(Decanoylhydroxyamino)propionic acidIC5014000.0 [1]
3-(9-Phenylnonanoylhydroxyamino)propionic acidIC5023000.0 [1]
3-(9-Cyclopentylnonanoylhydroxyamino)propionic acidIC5043000.0 [1]
3-(9-Cycloheptylnonanoylhydroxyamino)propionic acidIC509100.0 [1]
N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-beta-alanineIC501200.0 [1]
3-(10-Methylundecanoylhydroxyamino)propionic acid methyl esterIC50150000.0 [1]
3-(10-Methylundecanoylhydroxyamino)propionic acidIC5024000.0 [1]
2-[[[(3R)-2-Oxo-1-[(1R)-1-phenylethyl]piperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
4-(5-Iodo-2H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridineIC5010000.0 [1]
2-[1-[2-(2-Chlorophenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Ethoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroethoxy)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
4-(5-Chloro-2H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridineIC501000.0 [1]
6-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-[1-(2-Naphthalen-1-ylethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(trifluoromethyl)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
2-[1-(1-Phenylethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-(1,2,3,4-Tetrahydronaphthalen-1-ylmethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(2-Chlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
6-(1-Benzylimidazol-4-yl)-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[[2-Fluoro-3-(trifluoromethoxy)phenyl]methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
2-[1-(1-Phenylpropan-2-yl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
6-[1-(2,2,2-Trifluoroethyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
5-[2-[1-(1,2,3,4-Tetrahydronaphthalen-1-ylmethyl)imidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC50100.0 [1]
4-(5-Chloro-2H-triazol-4-yl)-2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]pyridineIC5010000.0 [1]
6-[1-[(3-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(5-iodo-2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-[(4-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-(1-Methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Methoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Phenoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
6-[1-[(2-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-[1-[2-(2-Phenylmethoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
2-[1-[(3-Chloro-2-fluorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-[2-[1-(2-Naphthalen-1-ylethyl)imidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC50100.0 [1]
2-[1-[(2-Chlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2-Fluoro-3-methylphenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-(4-Fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazoleIC501000.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(trifluoromethoxy)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
2-[5-(4-Fluoro-3-methoxyphenyl)-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(5-fluoro-2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-[(3,4-Dichlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-[1-[2-(2-Phenylphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
2-[1-[2-(2-Chlorophenyl)-2-methylpropyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(4-Chlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
1-(Cyclopropylmethyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazoleIC501000.0 [1]
6-[1-(3,5-Dichlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC501000.0 [1]
2-[5-Bromo-1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2-Fluoro-3-methoxyphenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-[2-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC501000.0 [1]
2-[5-(3-Ethoxy-4-fluorophenyl)-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC501000.0 [1]
2-[1-(3,4-Dihydro-2H-chromen-4-ylmethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone lysine demethylase PHF8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-lysine-demethylase-phf8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone lysine demethylase PHF8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-lysine-demethylase-phf8-inhibitors-ic50-ki.
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