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Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC50130.0 [1]
1,1,1-Trifluoro-8-(4-biphenylyloxy)-2-octanoneIC502.9 [1], 2900.0 [2]
7-(Benzoylamino)heptanehydroxamic acidIC501006.0 [1], 1010.0 [2]
N-Methyl-2-oxo-N'-phenylnonanediamideIC50338.0 [1], 340.0 [2]
7-(1H-Indole-2-ylcarbonylamino)heptanehydroximic acidIC5014.6 [1]
UbenimexIC50100000.0 [1]
EntinostatIC502000.0 [1]
BelinostatIC5025.0 [1]
Luotonin AIC506400.0 [1]
3,4-Bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxideIC501000000.0 [1]
9,9,9-Trifluoro-8-Oxo-N-PhenylnonanamideIC506700.0 [1]
Heptanamide, 7-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-IC509.2 [1]
N-Hydroxy-4-(3-phenylpropanoylamino)benzamideIC501100.0 [1]
5-Carboxy-2,1,3-benzoxadiazol-1-ium-1-olateIC501000000.0 [1]
N-Methyl-2-oxo-8-(4-phenylphenoxy)octanamideIC500.11 [1]
9,9,9-Trifluoro-8-oxo-N-(4-phenoxyphenyl)nonanamideIC50300.0 [1]
CID 25023793IC50380.0 [1]
N-Methyl-2-oxo-N'-(3-phenylphenyl)nonanediamideIC503.7 [1]
7-[4-[4-[[[(2S,3R,4S,6R)-2-[[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadec-11-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyheptanamideIC5013.9 [1]
(2S)-N-Hydroxy-4-methyl-2-(phenylcarbamoylamino)pentanamideIC50100000.0 [1]
7-[5-(4-Methoxyphenyl)-2-oxazolyl]heptanehydroximic acidIC502.1 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]pyridine-2-carboxamideIC501680.0 [1]
7-(1H-Pyrrole-2-ylcarbonylamino)heptanehydroximic acidIC50524.0 [1]
8-Phenyl-octanoic acid hydroxyamideIC50560.0 [1]
N-Hydroxy-7-(4-phenylphenoxy)heptanamideIC500.02 [1]
7-[4-[4-[[[(2S,3R,4S,6R)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyheptanamideIC504.1 [1]
Azithromycin-N-benzyltriazolylhexahydroxamic AcidIC5091.6 [1]
6-[4-[4-[[[(2S,3R,4S,6R)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-3-hydroxy-6-methyloxan-4-yl]-methylamino]methyl]phenyl]triazol-1-yl]-N-hydroxyhexanamideIC5037.0 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-7-carboxamideIC5041.0 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-6-carboxamideIC5056.5 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]-1H-indole-4-carboxamideIC5080.3 [1]
5-Chloro-N-[7-(hydroxyamino)-7-oxoheptyl]-1-benzofuran-2-carboxamideIC5015.0 [1]
7-(1H-Indole-5-ylcarbonylamino)heptanehydroximic acidIC5031.4 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]-5-methoxy-1-benzofuran-2-carboxamideIC5015.0 [1]
7-(1H-Indole-3-ylcarbonylamino)heptanehydroximic acidIC5037.5 [1]
N-[7-(Hydroxyamino)-7-oxoheptyl]-4,6-dimethoxy-1H-indole-2-carboxamideIC503.1 [1]
5-Fluoro-N-[7-(hydroxyamino)-7-oxoheptyl]-1H-indole-2-carboxamideIC505.4 [1]
7-(1-Methyl-2-indanylcarbonylamino)heptanehydroximic acidIC50732.0 [1]
7-(5-Bromo-1H-indole-2-ylcarbonylamino)heptanehydroximic acidIC503.5 [1]
7-(5-Methoxy-1H-indole-2-ylcarbonylamino)heptanehydroximic acidIC506.5 [1]
7-(4-Methoxy-1H-indole-2-ylcarbonylamino)heptanehydroximic acidIC503.1 [1]
2-Oxo-8-(4-phenylphenoxy)octanamideIC5050.0 [1]
N-Ethyl-2-oxo-8-(4-phenylphenoxy)octanamideIC504.9 [1]
N-[2-(Dimethylamino)ethyl]-2-oxo-8-(4-phenylphenoxy)octanamideIC5050.0 [1]
N,N-Dimethyl-2-oxo-8-(4-phenylphenoxy)octanamideIC505.0 [1]
Methyl 2-oxo-9-(4-phenylphenoxy)nonanoateIC500.11 [1]
Methyl 2-oxo-8-(4-phenylphenoxy)octanoateIC500.06 [1]
8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acidIC503.7 [1]
2-[[2-Oxo-8-(4-phenylphenoxy)octanoyl]amino]acetic acidIC5050.0 [1]
Methyl 2-oxo-7-(4-phenylphenoxy)heptanoateIC500.08 [1]
N'-[4-[4-[2-(Dimethylamino)ethyl]phenyl]-1,3-thiazol-2-yl]-N-methyl-2-oxononanediamideIC503.1 [1]
1,1,1-Trifluoro-7-(4-biphenylyloxy)-2-heptanoneIC502600.0 [1]
1,1,1-Trifluoro-8-(4-biphenylyloxy)-3-octyne-2-oneIC508600.0 [1]
9,9,9-Trifluoro-8-oxo-N-(2-phenylphenyl)nonanamideIC5016000.0 [1]
9,9,9-Trifluoro-8-oxo-N-(4-phenylphenyl)nonanamideIC503000.0 [1]
N-Phenyl-2-[4-[(E)-4,4,4-trifluoro-3-oxobut-1-enyl]phenoxy]acetamideIC502200.0 [1]
N-Phenyl-3-[4-(2,2,2-trifluoroacetyl)phenyl]propanamideIC5050000.0 [1]
9,9,9-Trifluoro-8-oxo-N-(3-phenoxyphenyl)nonanamideIC503200.0 [1]
8-(4-Biphenylyloxy)-2-octanoneIC5050000.0 [1]
2,2,2-Trifluoro-1-[2-[4-(4-phenylphenoxy)butyl]cyclopropyl]ethanoneIC502900.0 [1]
7-[5-(4-Bromophenyl)-2-oxazolyl]heptanehydroximic acidIC502.7 [1]
7-[2-(4-Bromophenyl)-5-oxazolyl]heptanehydroximic acidIC504.4 [1]
7-[4-(3-Bromophenyl)-2-thiazolyl]heptanehydroximic acidIC505.8 [1]
7-[4-[4-(Trifluoromethoxy)phenyl]-2-thiazolyl]heptanehydroximic acidIC5074.0 [1]
7-(5-Phenyl-2-oxazolyl)heptanehydroximic acidIC509.8 [1]
7-[4-(2-Naphthyl)-2-thiazolyl]heptanehydroximic acidIC504.3 [1]
7-[4-(2,6-Dimethoxyphenyl)-2-thiazolyl]heptanehydroximic acidIC504.3 [1]
7-[4-[4-(Trifluoromethyl)phenyl]-2-thiazolyl]heptanehydroximic acidIC5042.0 [1]
7-[4-(4-Biphenylyl)-2-thiazolyl]heptanehydroximic acidIC5011.0 [1]
7-[4-(4-Bromophenyl)-2-thiazolyl]heptanehydroximic acidIC508.5 [1]
7-[4-(4-Methoxyphenyl)-2-thiazolyl]heptanehydroximic acidIC502.5 [1]
7-[2-(4-Fluorophenyl)-5-oxazolyl]heptanehydroximic acidIC5023.0 [1]
7-[2-(4-Biphenylyl)-5-oxazolyl]heptanehydroximic acidIC5012.0 [1]
7-(4-Phenyl-2-thiazolyl)heptanehydroximic acidIC5019.0 [1]
N-Hydroxy-7-[2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-5-yl]heptanamideIC5089.0 [1]
7-(2-Phenyl-5-oxazolyl)heptanehydroximic acidIC5013.0 [1]
N-Hydroxy-4-[3-[3-methoxy-4-(thiophen-2-ylmethoxy)phenyl]propanoylamino]benzamideIC50300.0 [1]
2-[[2-(5'-Bromo-2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)acetyl]amino]-N-hydroxyacetamideIC5050000.0 [1]
6-[[4-(Benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]hexan-1-olIC501000000.0 [1]
N-(2-Aminophenyl)-4-[[2-(5'-bromo-2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetyl]amino]benzamideIC50310.0 [1]
N'-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-N-methyl-2-oxononanediamideIC509.1 [1]
7-[5-[4-(4-Chlorophenyl)phenyl]-1,3-oxazol-2-yl]-N-hydroxyheptanamideIC506.8 [1]
9,9,9-Trifluoro-8-oxo-N-(4-phenyl-1,3-thiazol-2-yl)nonanamideIC50310.0 [1]
1-Butyl-3-[4-[(Z)-N'-hydroxycarbamimidoyl]phenyl]ureaIC50591.0 [1]
N-Hydroxy-3-(phenylsulfamoyl)benzamideIC5020000.0 [1]
N'-Hydroxy-N-[5-(4-morpholin-4-ylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC505000.0 [1]
N-[5-[4-(Dimethylamino)phenyl]-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC505000.0 [1]
N'-Hydroxy-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC50437.0 [1]
N-[5-(3,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC50487.0 [1]
N'-Hydroxy-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC50422.0 [1]
N'-Hydroxy-N-[5-(4-phenylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC505000.0 [1]
N-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC50741.0 [1]
N-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC50988.0 [1]
N-[5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC50847.0 [1]
N-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC50507.0 [1]
N-[5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl]-N'-hydroxyheptanediamideIC501285.0 [1]
N'-Hydroxy-N-[5-(4-iodophenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC50875.0 [1]
N'-Hydroxy-N-[5-(4-methylsulfonylphenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC50721.0 [1]
N'-Hydroxy-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]heptanediamideIC50709.0 [1]
N'-Hydroxy-N-[5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]heptanediamideIC501154.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-hdac1-and-hdac2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Histone deacetylase (HDAC1 and HDAC2) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-hdac1-and-hdac2-inhibitors-ic50-ki.
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