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Histone deacetylase 6 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
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▼
VorinostatIC5034.0 [1]
VorinostatKi21.0 [1]
Trichostatin AIC506.0 [1]
Trichostatin AKi0.58 [1], 0.99 [2], 1.0 [3], 3.02 [4]
Tubastatin AIC5015.0 [1]
Tubastatin AKi3.3 [1], 7.56 [2]
EntinostatIC5013000.0 [1]
RomidepsinIC50670.0 [1]
RomidepsinKi9.5 [1], 10.0 [2], 300.1 [3]
PanobinostatIC5010.5 [1]
PanobinostatKi0.7 [1], 1.5 [2], 54.0 [3]
TubacinIC504.0 [1]
TubacinKi0.9 [1], 16.0 [2], 142.0 [3]
RicolinostatIC504.7 [1]
BelinostatIC509.85 [1], 15.0 [2], 27.0 [3], 50.0 [4]
BelinostatKi1.6 [1], 10.0 [2]
ApicidinIC5010000.0 [1]
ApicidinKi123.4 [1]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamideIC504570.0 [1]
MocetinostatIC5010000.0 [1]
LargazoleIC50165.6 [1], 340.0 [2], 1850.0 [3], 9290.0 [4], 11500.0 [5]
DacinostatIC505.93 [1], 8.3 [2]
DacinostatKi9.5 [1]
HDAC6 InhibitorIC500.0 [1], 0.33 [2], 27.0 [3], 40.0 [4]
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamideIC5036.0 [1], 210.0 [2]
N-[[4-(Hydroxycarbamoyl)phenyl]methyl]-1-methylpyrrole-2-carboxamideIC5019.0 [1], 460.0 [2]
LovastatinIC5016283.0 [1], 16285.0 [2]
ScriptaidIC502.9 [1], 10.0 [2]
ScriptaidKi0.25 [1]
TacedinalineIC5040000.0 [1], 100000.0 [2]
QuisinostatIC5076.8 [1]
QuisinostatKi16.9 [1], 350.0 [2]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC5010000.0 [1], 20000.0 [2]
Nexturastat AIC505.02 [1], 5.2 [2]
Azumamide EIC5012000.0 [1], 50000.0 [2]
Azumamide EKi5000.0 [1]
Tert-butyl N-[(2S)-1-(cyclopentylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamateIC5029.0 [1], 54.0 [2], 1120.0 [3]
CID 24857909IC5089.0 [1], 90.0 [2]
CID 25023797IC50230.0 [1]
CID 25023798IC50150.0 [1], 210.0 [2]
N-Hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanamideIC5031.0 [1]
6-[(2S,5S,8S,11S)-2-Benzyl-8-(1H-indol-3-ylmethyl)-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]-N-hydroxyhexanamideIC5070.0 [1]
6-[(2S,5S,8S,11S)-2-Methyl-11-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC504900.0 [1]
2,2,2-Trifluoro-1-(5-(3-(methylsulfonylmethyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanoneIC50230.0 [1], 320.0 [2], 640.0 [3]
2,2,2-Trifluoro-1-(5-(3-(propylsulfonylmethyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanoneIC50240.0 [1], 500.0 [2]
(3S,6S,9S,13S)-9-Methyl-13-(2-methylpropyl)-3-(naphthalen-1-ylmethyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5010000.0 [1]
3-Hydroxy-1-[[4-(2-methylphenyl)phenyl]methyl]pyridine-2-thioneIC50306.0 [1], 7750.0 [2]
N-[5-(Hydroxyamino)-5-oxopentyl]-5-(2-methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamideIC50122.55 [1], 1217.0 [2], 1230.0 [3]
5-Cyclopropyl-N-[5-(hydroxyamino)-5-oxopentyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamideIC5067.82 [1], 785.0 [2], 790.0 [3]
4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamideIC5048.0 [1], 3110.0 [2], 5440.0 [3]
3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamideIC5091.0 [1], 126.0 [2], 143.0 [3]
AtorvastatinIC5014151.0 [1], 14466.0 [2]
AbexinostatKi17.0 [1], 20.0 [2]
n,n'-DihydroxyoctanediamideIC502030.0 [1]
n,n'-DihydroxyoctanediamideKi14.5 [1]
GivinostatKi4.2 [1]
FimepinostatIC5027.0 [1]
3-Hydroxypyridine-2-thiolIC50681.0 [1]
Thailandepsin AIC50830.0 [1], 9900.0 [2]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideIC504.0 [1]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideKi0.7 [1]
N-Hydroxy-4-phenylbutanamideIC50500.0 [1]
N-Hydroxy-4-phenylbutanamideKi150.0 [1]
7-Mercapto-heptanoic acid phenylamideIC5019.0 [1], 74.0 [2]
N-Hydroxy-2,2-diphenylacetamideIC5010000.0 [1], 11000.0 [2]
N-(Quinolin-8-YL)-6-(2-sulfanylacetamido)hexanamideIC5021.0 [1], 95.3 [2]
4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-BenzamideIC5056.0 [1]
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamideIC5030000.0 [1], 100000.0 [2]
N-Hydroxy-4-methoxy-3-phenylmethoxybenzamideIC502900.0 [1]
N'-Hydroxy-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamideIC509.6 [1]
Largazole ThiolIC5035.0 [1], 49.0 [2]
Azumamide CIC5050000.0 [1]
Azumamide CKi2000.0 [1]
6-(1-Adamantylcarbamoylamino)-N-hydroxyhexanamideIC5073.0 [1], 102.0 [2]
CID 24853793IC50340.0 [1]
2,2,2-Trifluoro-1-[5-(3-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carbonyl)thiophen-2-yl]ethanoneIC50310.0 [1]
N-(4-Hydroxybiphenyl-3-yl)benzamideIC5050000.0 [1]
(2r)-2-Amino-3-(2,4-Dichlorophenyl)-1-(1,3-Dihydro-2h-Isoindol-2-Yl)propan-1-OneIC5030000.0 [1]
Thailandepsin BIC501190.0 [1], 11000.0 [2]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi20.0 [1], 20.6 [2]
3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acidIC502300.0 [1], 3500.0 [2]
(2S)-N'-Hydroxy-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-N-phenyloctanediamideIC503.0 [1], 6.0 [2]
(2R)-5-Oxo-N-[(2S)-1-oxo-7-sulfanyl-1-[3-(trifluoromethyl)anilino]heptan-2-yl]pyrrolidine-2-carboxamideIC505.0 [1]
3-(4-Fluorophenyl)-N-(6-sulfanylhexyl)-1H-pyrazole-5-carboxamideIC50758.0 [1], 760.0 [2]
4-[[[4-(Dimethylamino)benzoyl]-[2-(4-methylanilino)-2-oxoethyl]amino]methyl]-N-hydroxybenzamideIC503.0 [1], 30.0 [2]
CID 15984018IC50360.0 [1]
Ethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonateIC501220.0 [1], 1258.93 [2]
(5R,8S,11S)-5-Methyl-8-propan-2-yl-11-[(E)-4-sulfanylbut-1-enyl]-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trioneIC5028.11 [1], 42.0 [2]
N-Ethyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamideIC50310.0 [1]
1-[5-(2,3-Dihydro-1H-indol-1-ylcarbonyl)thiophen-2-yl]-2,2,2-trifluoroethan-1-oneIC50130.0 [1], 200.0 [2]
1-[5-(2,3-Dihydroindole-1-carbonyl)-1H-pyrrol-2-yl]-2,2,2-trifluoroethanoneIC50580.0 [1], 880.0 [2]
2,2,2-Trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanoneIC50650.0 [1]
(6R)-6-[(1R,3As,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-N-(2-aminophenyl)heptanamideIC5081000.0 [1], 81100.0 [2]
(S)-Benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamateIC50180.0 [1]
3-(4-Methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acidIC5065000.0 [1], 70000.0 [2]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5010000.0 [1]
(4S,7S,10S,13S)-7-(1H-Indol-3-ylmethyl)-4-(2-methylpropyl)-10-(6-oxooctyl)-1,5,8,11-tetrazabicyclo[11.3.0]hexadecane-2,6,9,12-tetroneIC5010000.0 [1]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5010000.0 [1]
6-[(2S,5S,8S,11S)-8-(1H-Indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC502300.0 [1], 2310.0 [2]
(2R,5S,8S,11S)-8-(1H-Indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-5-(6-oxooctyl)-1,4,7,10,14,15-hexazabicyclo[10.3.0]pentadeca-12,14-diene-3,6,9-trioneIC506100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone deacetylase 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-6-inhibitors-ic50-ki.
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