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Histone deacetylase 5 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC503000.0 [1]
VorinostatKi33.0 [1], 36.0 [2], 3600.0 [3], 12000.0 [4]
Trichostatin AIC5016.0 [1]
Trichostatin AKi260.0 [1], 4120.0 [2]
PanobinostatIC5092.0 [1], 190.0 [2], 190.3 [3], 300.0 [4]
PanobinostatKi0.7 [1], 57.0 [2], 80.0 [3]
Tubastatin AIC5030000.0 [1]
TubacinIC503350.0 [1], 30000.0 [2]
TubacinKi1500.0 [1], 1919.6 [2]
CID 53344908IC5080.0 [1], 108.4 [2], 263.0 [3], 990.0 [4]
CID 53344908Ki86.9 [1]
EntinostatIC501400.0 [1], 10000.0 [2], 50000.0 [3]
DacinostatIC505.58 [1], 190.0 [2]
DacinostatKi420.0 [1]
RomidepsinIC5010000.0 [1]
RomidepsinKi550.0 [1]
BelinostatKi25.0 [1], 175.0 [2]
MocetinostatIC5010000.0 [1]
RicolinostatIC505000.0 [1], 10000.0 [2]
ScriptaidIC50300.0 [1]
ScriptaidKi1000.0 [1]
QuisinostatKi2.1 [1], 4.3 [2]
GivinostatKi600.0 [1]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC5010000.0 [1], 20000.0 [2]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideIC501570.0 [1]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideKi701.0 [1]
N-Hydroxy-4-phenylbutanamideIC5025000.0 [1]
N-Hydroxy-4-phenylbutanamideKi16000.0 [1]
N-Hydroxy-2,2-diphenylacetamideIC50140.0 [1], 160.0 [2]
CID 24853793IC501.0 [1], 10000.0 [2]
N-(4-Hydroxybiphenyl-3-yl)benzamideIC5050000.0 [1]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi17.0 [1], 17.2 [2]
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamideIC5050000.0 [1]
(1r,2r,3r)-2-[4-(5-Fluoranylpyrimidin-2-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-CarboxamideIC5030.0 [1]
N-[[4-(Hydroxycarbamoyl)phenyl]methyl]-1-methylpyrrole-2-carboxamideIC503300.0 [1]
Valproic acidIC502000000.0 [1]
Butyric acidIC502000000.0 [1]
4-Phenylbutyric acidIC502000000.0 [1]
HinokitiolKi2500.0 [1]
N-HydroxybenzamideIC5033330.0 [1]
LargazoleIC5010000.0 [1]
PracinostatKi21.0 [1]
n,n'-DihydroxyoctanediamideKi9500.0 [1]
Cudc-101IC5011.4 [1]
FimepinostatIC50674.0 [1]
PyroxamideKi4750.0 [1]
N-(2-Aminophenyl)benzamideIC5050000.0 [1]
1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanoneIC50100000.0 [1]
Nexturastat AIC5011700.0 [1]
CID 71520717IC504.22 [1]
Azumamide EIC5010000.0 [1]
NanatinostatIC50200.0 [1]
N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamideIC50180000.0 [1]
2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamideIC50100000.0 [1]
2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanoneIC50100000.0 [1]
N-(Quinolin-8-YL)-6-(2-sulfanylacetamido)hexanamideIC50890.0 [1]
N-(4-Aminobiphenyl-3-yl)benzamideIC5050000.0 [1]
4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-BenzamideIC5010000.0 [1]
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamideIC50100000.0 [1]
N-(2-Aminophenyl)-N'-phenylheptanediamideIC50180000.0 [1]
N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamideIC507.1 [1]
HDAC inhibitorIC503040.0 [1]
N-(4-{[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}phenyl)acetamideIC5027900.0 [1]
CID 46852450IC50458.0 [1]
(S)-Benzyl (6-acetamido-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)carbamateIC501308.0 [1]
N-(2-Amino-phenyl)-nicotinamideIC5050000.0 [1]
6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-oneIC50100000.0 [1]
N-Hydroxy-5-[[6-oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanamideIC5050000.0 [1]
(E)-N-Hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamideIC5029600.0 [1]
N-[(2S)-1,8-Dioxo-1-[(4-phenyl-1,3-thiazol-2-yl)amino]nonan-2-yl]-1-methylpiperidine-2-carboxamideIC501900.0 [1]
1-Methyl-N-[(1S)-1-(5-naphthalen-2-yl-1H-imidazol-2-yl)-7-oxooctyl]piperidine-4-carboxamideIC501.0 [1]
Pimelic Diphenylamide 106IC50100000.0 [1]
6-(1-Adamantylcarbamoylamino)-N-hydroxyhexanamideIC50310.0 [1]
N-HydroxybutanamideIC50360000.0 [1]
N-Hydroxy-9H-xanthene-9-carboxamideIC50110.0 [1]
N-[1-[[3-Azido-5-(azidomethyl)phenyl]methyl]pyrazol-4-yl]-N'-hydroxyoctanediamideIC50892.0 [1]
3-N-Hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamideIC5033000.0 [1]
N-Hydroxy-2-propylpentanamideIC5037000.0 [1]
2-Hydroxy-7-phenyl-2,4,6-cycloheptatriene-1-oneKi2500.0 [1]
2-Hydroxy-4-phenyl-2,4,6-cycloheptatrien-1-oneKi2500.0 [1]
Benzamide, N-(((6-(hydroxyamino)-6-oxohexyl)amino)carbonyl)-Ki46.0 [1]
N-[(1S)-1-[5-(2-Methoxyquinolin-3-yl)-1H-imidazol-2-yl]-7-oxononyl]-1-methylazetidine-3-carboxamideIC5010000.0 [1]
N-Hydroxy-4-[(quinolin-8-ylamino)methyl]benzamideIC503112.0 [1]
6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-oneIC50100000.0 [1]
2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidineIC50100000.0 [1]
PandacostatKi180.0 [1]
5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamideIC5010000.0 [1]
N-Hydroxy-7-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]octanamideIC507400.0 [1]
(E)-N-Hydroxy-3-[4-(4-hydroxyphenyl)phenyl]prop-2-enamideIC5011200.0 [1]
2-(4-Methoxybenzyloxy)-N8-hydroxy-N1-phenyloctanediamideIC50134.0 [1]
(2E,4E)-N-Hydroxy-5-[4-(4-methoxyphenyl)phenyl]penta-2,4-dienamideIC50100000.0 [1]
N-(2-Amino-5-thiophen-2-ylphenyl)benzamideIC5050000.0 [1]
N-(4-Aminobiphenyl-3-yl)nicotinamideIC5050000.0 [1]
N-(2-Amino-5-(thiophen-2-yl)phenyl)nicotinamideIC5050000.0 [1]
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamideKi11500.0 [1]
1-[5-[3-[4-(1,3,4-Oxadiazole-2-yl)phenoxymethyl]-1,2,4-oxadiazole-5-yl]-2-thienyl]trifluoroethanoneIC5010.0 [1]
(E)-3-[1-[3-(Dimethylamino)-2,2-dimethylpropyl]-2-(2-phenylethyl)benzimidazol-5-yl]-N-hydroxyprop-2-enamideKi16.0 [1]
(3S,6S,9S,13S)-9-Methyl-13-(2-methylpropyl)-3-(naphthalen-1-ylmethyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5010000.0 [1]
5-[4-[[3-Azido-5-(azidomethyl)benzoyl]amino]phenyl]-N-[7-(hydroxyamino)-7-oxoheptyl]-1,2-oxazole-3-carboxamideIC50932.0 [1]
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]prop-2-enamideIC5034700.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Histone deacetylase 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-5-inhibitors-ic50-ki.
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