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Histone deacetylase 4 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC508800.0 [1]
VorinostatKi16.0 [1], 20.0 [2], 14000.0 [3]
Trichostatin AIC5034.0 [1]
Trichostatin AKi400.0 [1], 980.0 [2], 1400.0 [3], 14547.0 [4]
DacinostatIC504.0 [1]
DacinostatKi2250.0 [1]
EntinostatIC5010000.0 [1]
PanobinostatIC50200.0 [1], 300.0 [2], 337.8 [3], 338.0 [4], 373.0 [5]
PanobinostatKi0.6 [1], 170.0 [2], 550.0 [3]
Tubastatin AIC5030000.0 [1]
RomidepsinIC50510.0 [1], 647.0 [2], 8670.0 [3], 10000.0 [4], 50000.0 [5]
RomidepsinKi20.5 [1]
TubacinIC5017300.0 [1], 30000.0 [2]
TubacinKi9124.2 [1], 17000.0 [2]
BelinostatIC5024.0 [1], 1000.0 [2]
BelinostatKi15.0 [1], 380.0 [2]
ApicidinIC501.0 [1], 1.2 [2], 2.4 [3], 3600.0 [4], 8700.0 [5]
CID 53344908IC50127.0 [1], 130.0 [2], 134.4 [3], 353.0 [4]
CID 53344908Ki90.5 [1]
(1r,2r,3r)-2-[4-(1,3-Oxazol-5-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-CarboxamideIC5020.0 [1], 30.0 [2], 220.0 [3], 230.0 [4], 50000.0 [5]
(1r,2r,3r)-2-[4-(5-Fluoranylpyrimidin-2-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-CarboxamideIC5050.0 [1], 310.0 [2], 330.0 [3], 50000.0 [4]
N-Hydroxy-2,2-diphenylacetamideIC50250.0 [1], 750.0 [2], 2900.0 [3], 50000.0 [4]
1-[5-[3-[4-(1,3,4-Oxadiazole-2-yl)phenoxymethyl]-1,2,4-oxadiazole-5-yl]-2-thienyl]trifluoroethanoneIC507.0 [1], 10.0 [2], 260.0 [3], 850.0 [4]
RicolinostatIC507000.0 [1], 10000.0 [2]
CID 24853793IC501.0 [1], 6000.0 [2], 10000.0 [3]
CID 25023797IC50170.0 [1], 510.0 [2]
CID 25023798IC50170.0 [1], 280.0 [2]
2,2,2-Trifluoro-1-[5-(3-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carbonyl)thiophen-2-yl]ethanoneIC50320.0 [1], 367.0 [2], 370.0 [3]
CID 15984018IC5076.0 [1], 160.0 [2]
N-Ethyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamideIC501000.0 [1], 1700.0 [2]
CID 54030066IC50310.0 [1], 970.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(5-Chloro-2,3-dihydro-1,4-benzodioxin-7-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5020.0 [1], 130.0 [2], 50000.0 [3]
(1S,2R,3R)-2-Cyclopentyl-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC509000.0 [1], 48000.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-(1-methylpyrazol-4-yl)-3-phenylcyclopropane-1-carboxamideIC50540.0 [1], 2600.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyrimidin-5-ylcyclopropane-1-carboxamideIC501800.0 [1], 20000.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5030.0 [1], 620.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyridazin-4-ylcyclopropane-1-carboxamideIC501100.0 [1], 23000.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(2-Cyclopropylpyridin-4-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5020.0 [1], 670.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-[6-(trifluoromethyl)pyridin-3-yl]cyclopropane-1-carboxamideIC50340.0 [1], 5700.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-[2-(trifluoromethyl)pyridin-4-yl]cyclopropane-1-carboxamideIC50300.0 [1], 2600.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[1-oxo-2-(2,2,2-trifluoroethyl)-3H-isoindol-5-yl]-3-phenylcyclopropane-1-carboxamideIC5030.0 [1], 280.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[3-(1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC5040.0 [1], 390.0 [2], 50000.0 [3]
(1R,2R,3R)-2-[4-(2-Cyclopropyl-1,3-oxazol-5-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5040.0 [1], 300.0 [2], 50000.0 [3]
(1R,2R,3R)-2-[3-(5-Fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC50100.0 [1], 1000.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyridazin-3-ylphenyl)cyclopropane-1-carboxamideIC5080.0 [1], 620.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyrimidin-2-ylphenyl)cyclopropane-1-carboxamideIC5060.0 [1], 620.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyrimidin-5-ylphenyl)cyclopropane-1-carboxamideIC50100.0 [1], 1200.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(5-methyl-1H-imidazol-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC50100.0 [1], 460.0 [2], 50000.0 [3]
(1R,2R,3R)-2-[4-(3,3-Difluoropyrrolidin-1-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC50150.0 [1], 1800.0 [2], 50000.0 [3]
(1R,2R,3R)-2-[4-(3,3-Dimethylazetidin-1-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC50330.0 [1], 3200.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC50150.0 [1], 1300.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(1,3-oxazol-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC5050.0 [1], 350.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(1-methylimidazol-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC50290.0 [1], 2000.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-[5-(trifluoromethyl)pyridin-3-yl]cyclopropane-1-carboxamideIC50230.0 [1], 2300.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(2-Cyclopropylpyrimidin-5-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC50500.0 [1], 3400.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(6-Cyclopropylpyridazin-4-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC50280.0 [1], 4400.0 [2], 50000.0 [3]
(1R,2R,3S)-N-Hydroxy-2-(2-methyl-1,3-thiazol-5-yl)-3-phenylcyclopropane-1-carboxamideIC50100.0 [1], 1400.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(8-Chloro-1,2,3,4-tetrahydroquinolin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5040.0 [1], 470.0 [2], 50000.0 [3]
(1R,2R,3R)-2-[3-Fluoro-4-(5-methyl-1H-imidazol-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5060.0 [1], 400.0 [2], 50000.0 [3]
(2R,3R)-N-Hydroxy-2,3-diphenylcyclopropane-1-carboxamideIC50340.0 [1], 2520.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(3-Cyclopropylquinoxalin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5020.0 [1], 130.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(2-methyl-1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC5030.0 [1], 330.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyrazolo[1,5-a]pyridin-2-ylcyclopropane-1-carboxamideIC50670.0 [1], 5600.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-(2-methyl-1,3-benzothiazol-5-yl)-3-phenylcyclopropane-1-carboxamideIC5010.0 [1], 150.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-[3-(trifluoromethyl)quinoxalin-6-yl]cyclopropane-1-carboxamideIC5080.0 [1], 630.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(2-Cyclopropyl-1,3-benzoxazol-5-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5040.0 [1], 410.0 [2], 50000.0 [3]
(1S,2R)-N-Hydroxy-2-phenylcyclopropane-1-carboxamideIC5050000.0 [1], 51000.0 [2]
(1R,2R,3R)-N-Hydroxy-2-imidazo[1,2-a]pyridin-2-yl-3-phenylcyclopropane-1-carboxamideIC501500.0 [1], 7100.0 [2], 50000.0 [3]
(1R,2S,3R)-N-Hydroxy-2-phenyl-3-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-2-yl]cyclopropane-1-carboxamideIC50200.0 [1], 1700.0 [2], 50000.0 [3]
(1R,2R,3S)-N-Hydroxy-2-(5-methyl-1,3-thiazol-2-yl)-3-phenylcyclopropane-1-carboxamideIC50530.0 [1], 2300.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(2-Cyclopropylquinoxalin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5030.0 [1], 110.0 [2], 50000.0 [3]
(1R,2R,3R)-2-(5-Chloro-2,2-dimethyl-3H-1,4-benzodioxin-7-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamideIC5040.0 [1], 560.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-[4-(1,3-oxazol-4-yl)phenyl]-3-phenylcyclopropane-1-carboxamideIC5060.0 [1], 500.0 [2], 50000.0 [3]
(1R,2R,3R)-N-Hydroxy-2-phenyl-3-quinoxalin-6-ylcyclopropane-1-carboxamideIC5020.0 [1], 160.0 [2], 50000.0 [3]
(2R,3S)-N-Hydroxy-2,3-diphenylcyclopropane-1-carboxamideIC5050000.0 [1]
(1S,2S)-N-Hydroxy-2-phenylcyclopropane-1-carboxamideIC5050000.0 [1], 904000.0 [2]
MocetinostatIC5010000.0 [1]
ScriptaidIC50300.0 [1]
ScriptaidKi7500.0 [1]
LargazoleIC503000.0 [1], 10000.0 [2]
QuisinostatKi0.3 [1], 6.7 [2]
GivinostatKi1050.0 [1]
Thailandepsin AIC5037220.0 [1], 50000.0 [2]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC5010000.0 [1], 20000.0 [2]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideIC503820.0 [1]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideKi1821.0 [1]
Tert-butyl N-[(2S)-1-(cyclopentylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamateIC501030.0 [1]
CID 24857909IC5087.0 [1], 98.0 [2]
CID 25023793IC5033.0 [1], 200.0 [2]
N-(4-Hydroxybiphenyl-3-yl)benzamideIC5050000.0 [1]
Thailandepsin BIC5022000.0 [1], 57440.0 [2]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi8.5 [1], 9.6 [2]
Tert-butyl N-[(2S)-1-(cyclohexylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamateIC501140.0 [1]
Tert-butyl N-[(2S)-1-(cycloheptylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamateIC50840.0 [1]
1-[5-(2,3-Dihydro-1H-indol-1-ylcarbonyl)thiophen-2-yl]-2,2,2-trifluoroethan-1-oneIC50130.0 [1], 300.0 [2]
Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-)IC501.8 [1], 18.0 [2]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-)IC505.2 [1], 52.0 [2]
N-Hydroxy-6-[(1S,7R,10S,13R)-2,8,11,25-tetraoxo-3,9,12,24-tetrazatricyclo[11.10.2.03,7]pentacosan-10-yl]hexanamideIC505.5 [1]
N-Hydroxy-6-[(3S,6R,9S,12R)-2,5,8,11-tetraoxo-3,6-dipentyl-1,4,7,10-tetrazabicyclo[10.3.0]pentadecan-9-yl]hexanamideIC5012.0 [1]
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamideIC5050000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone deacetylase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-4-inhibitors-ic50-ki.
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