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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
VorinostatIC5043.0 [1]
VorinostatKi2.0 [1], 5.42 [2], 22.0 [3]
RomidepsinIC503.0 [1], 18.0 [2], 20.0 [3], 39.0 [4], 41.0 [5]
RomidepsinKi24.9 [1]
Tubastatin AIC50770.0 [1], 1270.0 [2], 2260.0 [3], 30000.0 [4]
N-(2-Aminophenyl)-4-[[[(2S)-3-(1H-indol-3-yl)-2-[(4-methoxybenzoyl)amino]propanoyl]amino]methyl]benzamideIC50134.7 [1], 138.4 [2], 183.8 [3], 433.0 [4], 938.5 [5]
N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[[4-(propylaminocarbamoyl)phenyl]methylamino]propan-2-yl]-4-methoxybenzamideIC505.63 [1], 5.7 [2], 8.5 [3], 14.4 [4], 17.9 [5]
Trichostatin AIC5011.07 [1], 12.7 [2]
Trichostatin AKi0.26 [1], 0.84 [2]
ApicidinIC5013.0 [1], 29.0 [2]
ApicidinKi1.5 [1]
TubacinIC501270.0 [1], 30000.0 [2]
3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamideIC50239.0 [1], 279.0 [2], 322.0 [3]
RicolinostatIC5037.0 [1], 51.0 [2]
Azumamide CKi9.67 [1], 18.0 [2]
N-(2-Amino-4-fluorophenyl)-4-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]benzamideIC50199.99 [1], 200.0 [2]
N-(2-Amino-4-fluorophenyl)-4-[(2-phenylacetyl)amino]benzamideIC50179.89 [1], 180.0 [2]
N-(2-Amino-4-fluorophenyl)-4-[[(2R)-2-phenylpropanoyl]amino]benzamideIC50210.0 [1], 579.43 [2]
N-(2-Amino-4-fluorophenyl)-4-[[(2S)-2-phenylbutanoyl]amino]benzamideIC50170.0 [1], 529.66 [2]
N-(2-Amino-4-fluorophenyl)-4-[[(2R)-3-methyl-2-phenylbutanoyl]amino]benzamideIC501000.0 [1], 1698.24 [2]
N-(2-Amino-4-fluorophenyl)-4-[[2-(4-fluorophenyl)acetyl]amino]benzamideIC50199.99 [1], 200.0 [2]
N-(2-Amino-4-fluorophenyl)-5-[[2-(4-fluorophenyl)acetyl]amino]pyridine-2-carboxamideIC50389.94 [1], 390.0 [2]
N-(2-Amino-4-fluorophenyl)-4-(3-phenylpropanoylamino)benzamideIC50799.83 [1], 800.0 [2]
N-(2-Amino-4-fluorophenyl)-5-[(2-phenylacetyl)amino]pyridine-2-carboxamideIC50520.0 [1]
N-(2-Amino-4-fluorophenyl)-4-[[(2R)-2-phenylbutanoyl]amino]benzamideIC50110.0 [1], 169.82 [2]
N-(2-Amino-4-fluorophenyl)-4-[(2-methyl-2-phenylpropanoyl)amino]benzamideIC50349.95 [1], 350.0 [2]
N-(2-Amino-4-fluorophenyl)-4-[[(2S)-2-phenylpropanoyl]amino]benzamideIC50230.0 [1], 230.14 [2]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5030.0 [1], 550.0 [2]
(3S,6S,9S,13S)-9-Methyl-13-(2-methylpropyl)-3-(naphthalen-1-ylmethyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5032.0 [1], 180.0 [2]
N'-(2-Aminophenyl)-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamideIC50119.95 [1], 120.0 [2]
(3S,6S,9S,13S)-3-[[1-[(Dimethylamino)methyl]indol-3-yl]methyl]-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC50800.0 [1]
(3S,6S,9S,13S)-3-[[1-[(Dimethylamino)methyl]indol-3-yl]methyl]-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneKi37.0 [1]
(3R,6R,9R,12S,13R)-3-[(4-Hydroxyphenyl)methyl]-6,12-dimethyl-9-propan-2-yl-13-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneKi780.0 [1], 3000.0 [2]
EntinostatIC502312.06 [1]
PanobinostatIC502.27 [1]
MocetinostatIC5045.0 [1]
ScriptaidIC506.8 [1]
SplitomicinKi75000.0 [1]
QuisinostatIC504.86 [1]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamideIC507100.0 [1]
FimepinostatIC501.8 [1]
Thailandepsin AIC5087.0 [1]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideKi306.0 [1]
4-Amino-1-naphtholIC5080000.0 [1]
N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamideIC5063.0 [1]
N-(2-Aminophenyl)-N'-phenylheptanediamideIC5069.0 [1]
7-[[(16E)-14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaen-11-yl]oxy]-N-hydroxyheptanamideIC502170.0 [1]
N-Hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanamideIC5018.0 [1]
N-[4-[[3-Azido-5-(azidomethyl)phenyl]methoxy]phenyl]-N'-hydroxyoctanediamideIC501480.0 [1]
(3S,6S,9S,13S)-9-Benzyl-3-(1H-indol-3-ylmethyl)-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5044.0 [1]
6-[(2S,5S,8S,11S)-2-Benzyl-8-(1H-indol-3-ylmethyl)-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]-N-hydroxyhexanamideIC5031.0 [1]
6-[(2S,5S,8S,11S)-2-Methyl-11-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC50990.0 [1]
N-[1-[[3-Azido-5-(azidomethyl)phenyl]methyl]pyrazol-4-yl]-N'-hydroxyoctanediamideIC50128.0 [1]
Thailandepsin BIC5023.0 [1]
(2S)-N'-Hydroxy-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-N-phenyloctanediamideIC5089.0 [1]
N-Hydroxy-4-[(quinolin-8-ylamino)methyl]benzamideIC507750.0 [1]
5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamideIC502090.0 [1]
5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxyfuran-2-carboxamideIC5020000.0 [1]
N-Hydroxy-7-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]octanamideIC5024.0 [1]
N-(2-Amino-4-fluorophenyl)-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamideIC5079.98 [1]
3-(Benzylamino)propionohydroxamic acid monohydrochlorideIC5072000.0 [1]
N,N'-Bis(2-aminophenyl)octanediamideIC50988.55 [1]
(5R,8S,11S)-5-Methyl-8-propan-2-yl-11-[(E)-4-sulfanylbut-1-enyl]-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trioneIC500.7 [1]
N'-Hydroxy-N-(2-phenylethyl)octanediamideIC503610.0 [1]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC50140.0 [1]
(4S,7S,10S,13S)-7-(1H-Indol-3-ylmethyl)-4-(2-methylpropyl)-10-(6-oxooctyl)-1,5,8,11-tetrazabicyclo[11.3.0]hexadecane-2,6,9,12-tetroneIC50280.0 [1]
6-[(2S,5S,8S,11S)-8-(1H-Indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC50610.0 [1]
(2R,5S,8S,11S)-8-(1H-Indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-5-(6-oxooctyl)-1,4,7,10,14,15-hexazabicyclo[10.3.0]pentadeca-12,14-diene-3,6,9-trioneIC509.0 [1]
(3S,6R,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(4-oxohexylsulfanylmethyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5062.0 [1]
(3S,6R,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(3-oxopentylsulfanylmethyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5010000.0 [1]
N'-Hydroxy-N-[3-(trifluoromethyl)phenyl]octanediamideIC50185.0 [1]
5-[4-[[3-Azido-5-(azidomethyl)benzoyl]amino]phenyl]-N-[7-(hydroxyamino)-7-oxoheptyl]-1,2-oxazole-3-carboxamideIC5045.0 [1]
(1r,2r,3r)-2-[4-(5-Fluoranylpyrimidin-2-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-CarboxamideIC509700.0 [1]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC501400.0 [1]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(7,7,7-trifluoro-6-oxoheptyl)-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC5062.0 [1]
(2S)-N'-Hydroxy-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]-N-[3-(trifluoromethyl)phenyl]octanediamideIC502.0 [1]
(2S)-N'-Hydroxy-2-[[(2S)-4-oxoazetidine-2-carbonyl]amino]-N-phenyloctanediamideIC5062.0 [1]
(2S)-N'-Hydroxy-N-(3-methylphenyl)-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]octanediamideIC5011.0 [1]
N-Hydroxy-4-[2-[(E)-2-phenylethenyl]-1,3-thiazol-4-yl]butanamideIC5017790.0 [1]
N-Hydroxy-7-[3-[4-[[(7-hydroxy-21-methyl-14-oxo-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4(9),5,7,15(20),16,18-heptaen-17-yl)amino]methyl]phenyl]-1,2,4-oxadiazol-5-yl]heptanamideIC5071.0 [1]
N-(2-Aminophenyl)-4-[[[(5S)-5-phenyl-4,5-dihydro-1H-imidazol-2-yl]amino]methyl]benzamideIC5015.0 [1]
N-(2-Aminophenyl)-4-[[(5S)-5-phenyl-4,5-dihydro-1H-imidazol-2-yl]sulfanylmethyl]benzamideIC5038.0 [1]
N-(2-Aminophenyl)-4-[[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]sulfanylmethyl]benzamideIC5066.0 [1]
N-(2-Aminophenyl)-4-[[(4S)-4-pyridin-3-yl-4,5-dihydro-1,3-oxazol-2-yl]sulfanylmethyl]benzamideIC5056.0 [1]
N-(2-Aminophenyl)-4-[[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]sulfanylmethyl]benzamideIC5071.0 [1]
N-(2-Aminophenyl)-4-[[[(5R)-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl]amino]methyl]benzamideIC5011.0 [1]
N-(2-Aminophenyl)-4-[[[(5S)-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl]amino]methyl]benzamideIC5035.0 [1]
N-Hydroxy-2-[[2-(4-methoxyphenyl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]pyrimidine-5-carboxamideIC502.55 [1]
2-[[2-(4-Aminophenyl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]-N-hydroxypyrimidine-5-carboxamideIC503.4 [1]
N-Hydroxy-2-[[2-(6-methoxypyridin-3-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]pyrimidine-5-carboxamideIC504.65 [1]
2-[[2-(2-Aminopyrimidin-5-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl-methylamino]-N-hydroxypyrimidine-5-carboxamideIC503.29 [1]
N-Hydroxy-2-[methyl-[(9-methyl-6-morpholin-4-yl-2-pyridin-4-ylpurin-8-yl)methyl]amino]pyrimidine-5-carboxamideIC502.7 [1]
(E)-N-Hydroxy-3-[4-[2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]phenyl]phenyl]prop-2-enamideIC503900.0 [1]
3-(Dibenzylamino)-N-hydroxypropanamideIC5052000.0 [1]
N-Hydroxy-4-[(quinolin-5-ylamino)methyl]benzamideIC505480.0 [1]
HDAC Inhibitor C4jIC506.5 [1]
1-N-[(2S)-1-[[(2S)-1-(Benzylamino)-1-oxopropan-2-yl]amino]-4-(2,2-dimethylpropylamino)-1,4-dioxobutan-2-yl]-4-N-hydroxybenzene-1,4-dicarboxamideIC5015000.0 [1]
N-(2-Aminophenyl)-4-[[[(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamideIC506.0 [1]
2-[4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]-N-hydroxypyrimidine-5-carboxamideIC5036.0 [1]
4-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxybenzamideIC501350.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/histone-deacetylase-3-nuclear-receptor-corepressor-2-hdac3-ncor2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-3-nuclear-receptor-corepressor-2-hdac3-ncor2-inhibitors-ic50-ki.
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