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Histone deacetylase 2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC50163.6 [1]
VorinostatKi7.0 [1]
Trichostatin AIC5020.5 [1]
Trichostatin AKi0.65 [1], 0.7 [2], 0.76 [3], 1.06 [4], 3.55 [5]
EntinostatIC50500.0 [1]
EntinostatKi65.0 [1]
Tubastatin AIC5030000.0 [1]
Tubastatin AKi1130.0 [1]
PanobinostatIC503.28 [1]
PanobinostatKi0.65 [1], 0.7 [2], 1.9 [3], 22.0 [4]
MocetinostatIC50180.0 [1]
MocetinostatKi32.4 [1]
TubacinIC50260.0 [1], 6270.0 [2]
TubacinKi42.0 [1], 1180.7 [2]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC50100.0 [1]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideKi1.5 [1]
RicolinostatIC5048.0 [1]
DacinostatIC505.0 [1], 7.0 [2], 10.0 [3], 15.7 [4]
DacinostatKi1.4 [1]
N-(4-Aminobiphenyl-3-yl)benzamideIC50350.0 [1]
N-(2-Aminophenyl)-4-[[[(2S)-3-(1H-indol-3-yl)-2-[(4-methoxybenzoyl)amino]propanoyl]amino]methyl]benzamideIC50157.1 [1]
RomidepsinIC501.0 [1], 6070.0 [2]
RomidepsinKi0.04 [1]
BelinostatIC5049.0 [1], 50.0 [2]
BelinostatKi0.85 [1], 0.9 [2], 22.0 [3]
ApicidinIC501.0 [1], 34.0 [2], 35.0 [3]
ApicidinKi0.12 [1]
TacedinalineIC50900.0 [1], 1200.0 [2], 3850.0 [3]
TacedinalineKi190.0 [1]
N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[[4-(propylaminocarbamoyl)phenyl]methylamino]propan-2-yl]-4-methoxybenzamideIC50194.0 [1], 259.9 [2], 287.1 [3], 366.9 [4], 423.7 [5]
LargazoleIC5018.65 [1], 900.0 [2], 1010.0 [3], 1720.0 [4]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamideIC5031000.0 [1], 50000.0 [2], 100000.0 [3]
LovastatinIC5025933.0 [1]
QuisinostatIC500.33 [1]
QuisinostatKi0.06 [1], 31.0 [2]
N-(2-Aminophenyl)benzamideIC503100.0 [1], 3300.0 [2], 10000.0 [3]
N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamideIC50820.0 [1]
(5R,8S,11S)-5-Methyl-8-propan-2-yl-11-[(E)-4-sulfanylbut-1-enyl]-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trioneIC500.9 [1], 4.19 [2]
[4-(4-Amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid benzyl esterIC50740.0 [1], 14000.0 [2], 38000.0 [3]
(3S,6S,9S,13S)-3-[[1-[(Dimethylamino)methyl]indol-3-yl]methyl]-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC501400.0 [1], 1430.0 [2]
(3S,6S,9S,13S)-3-[[1-[(Dimethylamino)methyl]indol-3-yl]methyl]-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneKi33.0 [1]
4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamideIC5020000.0 [1]
3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamideIC50490.0 [1], 729.0 [2], 1220.0 [3]
N-(2-Amino-5-phenylphenyl)-4-azidobenzamideIC50210.0 [1], 1050.0 [2], 5130.0 [3]
N-(2-Amino-5-thiophen-2-ylphenyl)-4-azidobenzamideIC50110.0 [1], 690.0 [2], 3200.0 [3]
N-(2-Amino-5-thiophen-2-ylphenyl)-3-azido-5-(azidomethyl)benzamideIC502400.0 [1], 5200.0 [2], 18000.0 [3]
N-(2-Amino-5-phenylphenyl)-3-azido-5-(azidomethyl)benzamideIC5010000.0 [1], 21000.0 [2], 32000.0 [3]
N-(2-Amino-5-phenylphenyl)-3-azido-4-(2-azidoethoxy)benzamideIC50830.0 [1], 6500.0 [2], 34000.0 [3]
N-(2-Amino-5-thiophen-2-ylphenyl)-3-azido-4-(2-azidoethoxy)benzamideIC50750.0 [1], 6600.0 [2], 17000.0 [3]
N-(2-Amino-5-azidophenyl)-4-(3-azidopropanoylamino)benzamideIC5077000.0 [1], 94000.0 [2], 120000.0 [3]
(3-Azidophenyl)methyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamateIC50320.0 [1], 1000.0 [2], 3800.0 [3]
[3-Azido-5-(azidomethyl)phenyl]methyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamateIC50350.0 [1], 1100.0 [2], 7000.0 [3]
[3-Azido-5-(azidomethyl)phenyl]methyl N-[[4-[(2-amino-5-thiophen-2-ylphenyl)carbamoyl]phenyl]methyl]carbamateIC50300.0 [1], 1000.0 [2], 7100.0 [3]
AtorvastatinIC5022547.0 [1]
ScriptaidIC50700.0 [1]
ScriptaidKi2.2 [1]
AbexinostatKi19.0 [1], 20.0 [2]
PracinostatKi16.0 [1], 27.0 [2]
n,n'-DihydroxyoctanediamideIC508230.0 [1]
n,n'-DihydroxyoctanediamideKi29.0 [1]
GivinostatKi3.0 [1]
FimepinostatIC505.0 [1]
HDAC6 InhibitorIC5093.0 [1], 252.0 [2]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideIC507450.0 [1]
N-Hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamideKi774.0 [1]
Azumamide EIC50100.0 [1]
Azumamide EKi50.0 [1]
N-Hydroxy-4-phenylbutanamideIC50600.0 [1]
N-Hydroxy-4-phenylbutanamideKi430.0 [1]
N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamideIC501280.0 [1], 1980.0 [2]
9,9,9-Trifluoro-8-Oxo-N-PhenylnonanamideIC501400.0 [1]
9,9,9-Trifluoro-8-Oxo-N-PhenylnonanamideKi11000.0 [1]
N-(Quinolin-8-YL)-6-(2-sulfanylacetamido)hexanamideIC501250.0 [1], 7380.0 [2]
4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-BenzamideIC504400.0 [1]
N'-Hydroxy-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamideIC5063.9 [1]
Largazole ThiolIC500.9 [1]
(E)-N-Hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamideIC501160.0 [1]
Azumamide CKi10.0 [1], 40.0 [2]
6-(1-Adamantylcarbamoylamino)-N-hydroxyhexanamideIC501050.0 [1], 2580.0 [2]
CID 24853793IC50110.0 [1]
N-(4-Hydroxybiphenyl-3-yl)benzamideIC50200.0 [1]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi36.0 [1], 36.2 [2]
(2S)-N'-Hydroxy-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-N-phenyloctanediamideIC5089.0 [1], 143.0 [2]
(2R)-5-Oxo-N-[(2S)-1-oxo-7-sulfanyl-1-[3-(trifluoromethyl)anilino]heptan-2-yl]pyrrolidine-2-carboxamideIC5012.0 [1]
(E)-N-Hydroxy-3-[4-(4-hydroxyphenyl)phenyl]prop-2-enamideIC50590.0 [1]
(S)-Benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-yl)-2-methylpiperazine-1-carboxylateIC50272.0 [1], 308.0 [2]
Pyridin-3-ylmethyl N-[[4-[(2-amino-5-thiophen-2-ylphenyl)carbamoyl]phenyl]methyl]carbamateIC506.0 [1], 100.0 [2]
N-(2-Amino-5-thiophen-2-ylphenyl)-4-methoxybenzamideIC50200.0 [1]
2-(4-Methoxybenzyloxy)-N8-hydroxy-N1-phenyloctanediamideIC5050.0 [1], 254.0 [2]
(2E,4E)-N-Hydroxy-5-[4-(4-methoxyphenyl)phenyl]penta-2,4-dienamideIC505000.0 [1]
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamideIC5050000.0 [1]
(E)-3-[1'-[(4-Fluorophenyl)methyl]-4-oxospiro[3H-chromene-2,4'-piperidine]-6-yl]-N-hydroxyprop-2-enamideIC50310.0 [1], 320.0 [2]
(E)-N-Hydroxy-3-[4-oxo-1'-(2-phenylethyl)spiro[3H-chromene-2,4'-piperidine]-6-yl]prop-2-enamideIC50190.0 [1], 199.0 [2]
(3S,6S,9S,13S)-3-(1H-Indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-propyl-1,4,7,10-tetrazacyclotridecane-2,5,8,11-tetroneIC501500.0 [1], 1580.0 [2]
N-[(2S)-1-[4-[(E)-3-(Hydroxyamino)-3-oxoprop-1-enyl]-2-methoxyphenoxy]-3-(1H-indol-3-yl)propan-2-yl]-2-propylpentanamideIC50321.6 [1], 1420.0 [2]
(2S)-N'-Hydroxy-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]-N-[3-(trifluoromethyl)phenyl]octanediamideIC508.0 [1]
(2S)-N'-Hydroxy-2-[[(2S)-4-oxoazetidine-2-carbonyl]amino]-N-phenyloctanediamideIC5089.0 [1], 143.0 [2]
(2S)-N'-Hydroxy-N-(3-methylphenyl)-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]octanediamideIC5027.0 [1]
N-[[4-(Hydroxycarbamoyl)phenyl]methyl]-1-methylpyrrole-2-carboxamideIC5016000.0 [1]
(1R,5S)-N-[2-Amino-5-(4-fluorophenyl)phenyl]-8-oxabicyclo[3.2.1]octane-3-carboxamideIC501590.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone deacetylase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-2-inhibitors-ic50-ki.
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