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Histone deacetylase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VorinostatIC5069.0 [1]
VorinostatKi10.0 [1]
Trichostatin AIC508.5 [1]
Trichostatin AKi0.2 [1], 0.23 [2], 0.64 [3], 0.87 [4]
EntinostatIC50300.0 [1]
EntinostatKi22.0 [1]
Tubastatin AIC5014350.0 [1]
Tubastatin AKi3823.3 [1]
MocetinostatIC50150.0 [1]
MocetinostatKi9.0 [1]
RomidepsinIC503.6 [1]
RomidepsinKi0.0 [1]
PanobinostatIC502.5 [1]
PanobinostatKi0.54 [1], 1.0 [2], 2.5 [3], 3.0 [4]
ApicidinIC5022.0 [1]
ApicidinKi0.04 [1]
DacinostatIC508.0 [1]
DacinostatKi0.55 [1], 0.6 [2]
BelinostatIC5020.0 [1]
BelinostatKi0.85 [1], 0.9 [2], 26.0 [3]
TubacinIC50240.0 [1], 1400.0 [2]
TubacinKi28.0 [1], 326.4 [2], 995.0 [3]
TacedinalineIC501090.0 [1]
TacedinalineKi50.0 [1]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideIC5040.0 [1]
4-Acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideKi0.2 [1]
LargazoleIC5069.8 [1]
RicolinostatIC5058.0 [1]
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamideIC5014410.0 [1]
N-(2-Aminophenyl)-4-[[[(2S)-3-(1H-indol-3-yl)-2-[(4-methoxybenzoyl)amino]propanoyl]amino]methyl]benzamideIC5034.5 [1]
N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[[4-(propylaminocarbamoyl)phenyl]methylamino]propan-2-yl]-4-methoxybenzamideIC5032.9 [1], 50.1 [2], 63.28 [3], 77.5 [4], 91.2 [5]
QuisinostatIC500.11 [1]
QuisinostatKi0.03 [1], 0.48 [2], 7.3 [3]
HDAC6 InhibitorIC5012.7 [1], 271.0 [2], 340.0 [3], 3567.0 [4]
3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acrylamideIC50200.0 [1]
3-[4-(4-Methoxyphenylsulfonylamino)phenyl]-2-propenehydroximic acidIC5060.0 [1], 200.0 [2]
N-Hydroxy-8-(4-methoxyphenyl)-8-oxooctanamideIC5015.0 [1]
3-[4-(Tosylamino)phenyl]-2-propenehydroxamic acidIC50300.0 [1]
3-[4-(3,4-Dimethoxyphenylsulfonylamino)phenyl]-2-propenehydroximic acidIC5090.0 [1]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideIC5029.0 [1], 35.0 [2], 52.0 [3]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi11.0 [1]
[4-(4-Amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid benzyl esterIC5017.0 [1], 58.0 [2], 1880.0 [3], 14500.0 [4]
(E)-3-[1-[3-(Dimethylamino)-2,2-dimethylpropyl]-2-(2-phenylethyl)benzimidazol-5-yl]-N-hydroxyprop-2-enamideIC5024.0 [1], 41.0 [2], 42.0 [3]
(E)-3-[1-[3-(Dimethylamino)-2,2-dimethylpropyl]-2-(2-phenylethyl)benzimidazol-5-yl]-N-hydroxyprop-2-enamideKi15.0 [1]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-piperidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideIC5023.0 [1], 26.0 [2], 39.0 [3]
(E)-N-Hydroxy-3-[2-(2-phenylethyl)-1-(2-piperidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamideKi12.0 [1]
LovastatinIC5011214.0 [1], 11911.0 [2]
N-HydroxybenzamideIC504730.0 [1], 20000.0 [2]
ScriptaidIC5071.0 [1], 200.0 [2]
ScriptaidKi1.5 [1]
ChidamideIC50540.0 [1], 864.0 [2], 2700.0 [3]
Azumamide EIC5050.0 [1], 1220.0 [2]
Azumamide EKi67.0 [1]
CID 11427204IC5048.0 [1], 96.0 [2]
Tert-butyl N-[(2S)-1-(cyclopentylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamateIC501210.0 [1], 1731.0 [2]
N-(4-Aminobiphenyl-3-yl)benzamideIC5052.0 [1], 60.0 [2], 410.0 [3]
Largazole ThiolIC500.4 [1], 1.2 [2]
(8E)-N-Hydroxy-8-hydroxyimino-8-(4-phenylphenyl)octanamideIC504.0 [1]
3-[4-(Biphenyl-4-ylsulfamoyl)-phenyl]-N-hydroxy-acrylamideIC5040.0 [1]
8-(Biphenyl-4-yl)-N-hydroxy-8-oxooctanamideIC505.0 [1]
3-[4-(4-Tert-Butyl-benzenesulfonylamino)-phenyl]-N-hydroxy-acrylamideIC50100.0 [1], 200.0 [2]
N-Hydroxy-8-(naphthalen-2-yl)oct-7-enamideIC506.0 [1]
(8E)-N-Hydroxy-8-hydroxyimino-8-naphthalen-2-yloctanamideIC508.5 [1]
N-Hydroxy-7-oxo-7-phenylheptanamideIC50500.0 [1]
N-Hydroxy-8-oxo-8-[4-(trifluoromethyl)phenyl]octanamideIC5045.0 [1]
N-Hydroxy-6-oxo-6-phenylhexanamideIC501500.0 [1]
N,8-Dihydroxy-8-(naphthalen-2-yl)octanamideIC5035.0 [1]
8-Oxo-8-phenyl-octanoic acid hydroxyamideIC5065.0 [1]
8-(4-Bromophenyl)-N-hydroxy-8-oxooctanamideIC5045.0 [1]
N-Hydroxy-8-oxo-8-(pyridin-3-yl)octanamideIC50153.0 [1]
N-Hydroxy-9-oxo-9-phenylnonanamideIC50135.0 [1]
N-(2-Amino-phenyl)-nicotinamideIC502600.0 [1], 2630.0 [2], 12400.0 [3]
N-Hydroxy-8-(2-methoxyphenyl)-8-oxooctanamideIC5095.0 [1]
N-Hydroxy-8-(naphthalen-2-yl)non-8-enamideIC508.0 [1]
N-Hydroxy-8-(naphthalen-2-yl)octanamideIC5025.0 [1]
N-(2-Aminophenyl)-4-[(3,4-dimethoxyanilino)methyl]benzamideIC50440.0 [1], 2000.0 [2]
N-[(2S)-1,8-Dioxo-1-[(4-phenyl-1,3-thiazol-2-yl)amino]nonan-2-yl]-1-methylpiperidine-2-carboxamideIC5055.0 [1]
Azumamide CIC501170.0 [1]
Azumamide CKi20.0 [1], 32.0 [2]
4-(Phenylsulfonylamino)benzenebutanehydroximic acidIC501000.0 [1]
3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-methyl-propionamideIC5017000.0 [1]
CID 24853793IC5027.0 [1], 59.0 [2]
CID 24857909IC50580.0 [1]
CID 25023797IC50890.0 [1], 1800.0 [2]
CID 25023798IC505000.0 [1], 5300.0 [2]
4-(Phenylsulfonylamino)benzenepropanehydroximic acidIC50100.0 [1]
N-Hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanamideIC502.0 [1]
6-[(2S,5S,8S,11S)-2-Methyl-11-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]hexanoic acidIC50200.0 [1]
3-[4-(Biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-acrylamideIC5010.0 [1]
3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-methyl-acrylamideIC502000.0 [1]
3-[4-(Benzenesulfonyl-methyl-amino)-phenyl]-N-hydroxy-acrylamideIC50570.0 [1], 600.0 [2]
8-[4-(4-Bromophenyl)phenyl]-N-hydroxy-8-oxooctanamideIC502.0 [1]
N-(2-Amino-phenyl)-3-[4-(3,4-dimethoxy-benzenesulfonylamino)-phenyl]-acrylamideIC504000.0 [1]
N-(2-Amino-phenyl)-3-[4-(biphenyl-4-sulfonylamino)-phenyl]-acrylamideIC501000.0 [1]
N-(2-Amino-phenyl)-3-[4-(biphenyl-4-ylsulfamoyl)-phenyl]-acrylamideIC501000.0 [1], 1200.0 [2]
N-(2-Amino-phenyl)-3-[4-(3,4-dimethoxy-phenylsulfamoyl)-phenyl]-acrylamideIC502300.0 [1], 3000.0 [2]
N-Hydroxy-3-(4-p-tolylsulfamoyl-phenyl)-acrylamideIC5050.0 [1], 200.0 [2]
N-(2-Amino-phenyl)-3-(4-p-tolylsulfamoyl-phenyl)-acrylamideIC501500.0 [1], 2000.0 [2]
3-[4-(3,4-Dimethoxy-phenylsulfamoyl)-phenyl]-N-hydroxy-acrylamideIC5050.0 [1], 60.0 [2]
3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-hydroxy-acrylamideIC50480.0 [1], 1000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Histone deacetylase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/histone-deacetylase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Histone deacetylase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-deacetylase-1-inhibitors-ic50-ki.
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