Histone acetyltransferase PCAF Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Anacardic acid	IC50	5000.0 [1], 33900.0 [2]
	N-(3-Aminopropyl)-4-methyl-2-nitrobenzenamine	IC50	1600.0 [1]
	2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	720.0 [1], 1640.0 [2], 9700.0 [3], 9740.0 [4]
	2-Hydroxy-6-((8Z,11Z)-pentadeca-8,11,14-trienyl)benzoic acid	IC50	8500.0 [1], 667050.0 [2], 1000000.0 [3]
	4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	IC50	39.81 [1], 60.0 [2]
	4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	Ki	1.4 [1]
	2-[[4-(Trifluoromethyl)phenyl]methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	25500.0 [1], 130000.0 [2]
	Garcinol	IC50	5000.0 [1], 6000.0 [2]
	2-Phenyl-isothiazolo[5,4-b]pyridin-3-one	IC50	6100.0 [1], 7850.0 [2]
	[[(3R)-4-[[3-[2-[2-[[(5S)-5-Acetamido-6-amino-6-oxohexyl]amino]-2-oxoethyl]sulfanylethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate	IC50	108300.0 [1], 200000.0 [2]
	5-Chloro-2-ethylisothiazol-3(2H)-one	IC50	3000.0 [1]
	2-(4-Chlorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	3530.0 [1]
	4-Bromo-2-methyl-5-[[(3S,5S)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	IC50	10000.0 [1], 12589.25 [2]
	2-(4-Nitrophenyl)isothiazolo[5,4-b]pyridin-3-one	IC50	2990.0 [1], 4100.0 [2]
	Methyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoate	IC50	1800.0 [1]
	Methyl 3-(5-chloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate	IC50	5600.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]-6-[[2-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-methylpentanoic acid	IC50	300.0 [1], 2270.0 [2]
	4-Chloro-2-methyl-5-[[(3R,5S)-1-methyl-5-(2-methylpropyl)piperidin-3-yl]amino]pyridazin-3-one	IC50	13.0 [1]
	2-[(4-Chlorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	17450.0 [1], 17500.0 [2]
	6-[[(1S,2S)-1-[4-(Benzenesulfonyl)phenyl]-1-(dimethylamino)propan-2-yl]amino]-2,4-dimethyl-1,2,4-triazine-3,5-dione	IC50	70.0 [1]
	N-(3-Aminopropyl)-2-nitrobenzenamine	IC50	5000.0 [1], 5600.0 [2]
	2-(4-Bromophenyl)-5-nitro-isothiazolo[5,4-b]pyridin-3-one	IC50	860.0 [1], 4910.0 [2]
	5-Nitro-2-(4-nitrophenyl)isothiazolo[5,4-b]pyridin-3-one	IC50	11800.0 [1], 15800.0 [2]
	2-(4-Methoxyphenyl)-5-nitro-isothiazolo[5,4-b]pyridin-3-one	IC50	1830.0 [1], 3420.0 [2]
	2-(4-Nitrophenyl)-5-methylisothiazolo[5,4-b]pyridin-3(2H)-one	IC50	2720.0 [1], 15300.0 [2]
	2-[(3,4-Dichlorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	6940.0 [1]
	2-Benzyl-6-nitro-1,2-benzothiazol-3-one	IC50	7660.0 [1], 51300.0 [2]
	N'-[[6-(3-Aminopropylimino)-1-hydroxypyridin-3-yl]methyl]propane-1,3-diamine	IC50	900.0 [1], 930.0 [2]
	[[(3S)-4-[[3-[2-[[1-[(5S)-5-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-3-phosphonooxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]-6-[[(2S)-1-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-6-oxohexyl]triazol-4-yl]methylsulfanyl]ethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate	IC50	1700.0 [1], 33000.0 [2]
	[[(3S)-4-[[3-[2-[[1-[(5S)-5-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]-6-[[(2S)-1-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-6-oxohexyl]triazol-4-yl]methylsulfanyl]ethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate	IC50	2800.0 [1], 117000.0 [2]
	(-)-Epigallocatechin gallate	IC50	60000.0 [1]
	Coenzyme A	IC50	41910.0 [1]
	Plumbagin	IC50	50000.0 [1]
	4-Aminophenol	IC50	500000.0 [1]
	Embelin	IC50	7200.0 [1]
	1-Methyl-2-quinolone	IC50	70000.0 [1]
	Sgc-cbp30	IC50	20000.0 [1]
	4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic Acid	IC50	7943.28 [1]
	Guttiferone E	IC50	5000.0 [1]
	4-Amino-1-naphthol	IC50	3600.0 [1]
	CID 72201043	IC50	35000.0 [1]
	4-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamide	Ki	5520.0 [1]
	2-(4-Methylpyrimidin-2-yl)-1,2-benzothiazol-3-one	IC50	13600.0 [1]
	3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide	IC50	20000.0 [1]
	2-(4-Pyrrolidin-1-ylsulfonylphenyl)-1,2-benzothiazol-3-one	IC50	6190.0 [1]
	2-(1,3-Thiazol-2-yl)-1,2-benzothiazol-3-one	IC50	5770.0 [1]
	Ethyl 4-(3-oxo-1,2-benzisothiazol-2(3H)-yl)benzoate	IC50	6950.0 [1]
	2-(1,3-Benzothiazol-2-yl)-1,2-benzothiazol-3-one	IC50	4550.0 [1]
	4,6-Dimethyl-2-(thiophene-2-carbonyl)-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	9300.0 [1]
	4-Nitro-1-naphthol	IC50	221000.0 [1]
	2-(3-Chloro-4-fluorophenyl)-3(2H)-isothiazolone	IC50	4200.0 [1]
	2-(3-Chloro-2-fluorophenyl)-3(2H)-isothiazolone	IC50	5400.0 [1]
	2-(3-Methoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	5030.0 [1]
	2-Phenylisothiazol-3(2H)-one	IC50	28000.0 [1]
	4-[(2-Amino-3-chloro-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamide	Ki	3340.0 [1]
	4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide	IC50	100000.0 [1]
	[(3,5-Dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate	IC50	34700.0 [1]
	2-(4-Bromophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	4430.0 [1]
	2-(4-Methoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	5710.0 [1]
	2-(2-Pyridyl)-isothiazol-3(2H)-one	IC50	19000.0 [1]
	Ethyl 2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetate	IC50	13600.0 [1]
	(Z)-2-Hydroxy-6-(4-(pentyloxy)styryl)benzoic acid	IC50	662000.0 [1]
	Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(phenylmethyl)-	IC50	22960.0 [1]
	N-[3-(3-Methyl-4-Oxo-4,5,6,7-Tetrahydro-2h-Isoindol-1-Yl)-4-Phenoxyphenyl]methanesulfonamide	IC50	1000.0 [1]
	1-(3-Phenylazanyl-1,4,6,7-Tetrahydropyrazolo[4,3-C]pyridin-5-Yl)ethanone	IC50	20000.0 [1]
	2-Ethylisothiazol-3(2H)-one	IC50	10000.0 [1]
	4-Chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one	IC50	19952.62 [1]
	2-[4-(Dimethylamino)phenyl]-1,2-thiazol-3-one	IC50	5400.0 [1]
	4-Chloro-2-methyl-5-[(1-methylpiperidin-4-yl)amino]pyridazin-3-one	IC50	15848.93 [1]
	4-Chloro-2-methyl-5-[(4-methyl-1,3-thiazol-5-yl)methylamino]pyridazin-3-one	IC50	7943.28 [1]
	4-Chloro-2-methyl-5-(propan-2-ylamino)pyridazin-3-one	IC50	31622.78 [1]
	4-Chloro-2-methyl-5-[(1-methylpiperidin-3-yl)amino]pyridazin-3-one	IC50	1258.93 [1]
	4-Chloro-2-methyl-5-[(1-methylpyrrolidin-3-yl)amino]pyridazin-3-one	IC50	15848.93 [1]
	8-[[(1R,2R)-1-(Dimethylamino)-1-phenylpropan-2-yl]amino]-6-methylpyrido[2,3-d]pyridazin-5-one	IC50	19.0 [1]
	1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20000.0 [1]
	1-[3-[2-Fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20000.0 [1]
	4-Chloro-2-methyl-5-[[(3S)-1-methylpiperidin-3-yl]amino]pyridazin-3-one	IC50	6309.57 [1]
	4-Chloro-2-methyl-5-[[(3R)-1-methylpiperidin-3-yl]amino]pyridazin-3-one	IC50	501.19 [1]
	4-(Dimethylamino)naphthalen-1-ol hydrochloride	IC50	4200.0 [1]
	(1S,3E,5R,7S)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-7-[(Z)-3-methylbut-1-enyl]-5-(3-methylbut-2-enyl)-1-[(E,2R)-5-methyl-2-prop-1-en-2-ylhex-3-enyl]bicyclo[3.3.1]nonane-2,4,9-trione	IC50	5000.0 [1]
	4,5-Dichloro-2-ethylisothiazol-3(2H)-one	IC50	2400.0 [1]
	Methyl 3-(3-Oxo-2-isothiazolyl)propanoate	IC50	10000.0 [1]
	2-Pentylisothiazol-3(2H)-one	IC50	10000.0 [1]
	5-(N-Benzylamino)-4-chloro-2-methyl-3(2H)-pyridazinone	IC50	12589.25 [1]
	4-Chloro-2-methyl-5-[(2-methyl-3,4-dihydro-1H-isoquinolin-5-yl)amino]pyridazin-3-one	IC50	316.23 [1]
	8-Aminoisoquinolin-5-ol	IC50	7100.0 [1]
	2-p-Tolylisothiazolo[5,4-b]pyridine-3(2H)-one	IC50	4630.0 [1]
	4-[(E)-(2-Amino-4-Hydroxy-3,5-Dimethylphenyl)diazenyl]-N-(Pyridin-2-Yl)benzenesulfonamide	Ki	3340.0 [1]
	5-Anilino-4-chloro-2-methylpyridazin-3-one	IC50	10000.0 [1]
	4-Chloro-2-methyl-5-[[(3S,5S)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	IC50	25118.86 [1]
	4-Chloro-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	IC50	79.43 [1]
	4-Chloro-2-methyl-5-[[(3R,5S)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	IC50	39810.72 [1]
	4-Chloro-2-methyl-5-(3-methylanilino)pyridazin-3-one	IC50	6309.57 [1]
	5-[2-(Aminomethyl)anilino]-4-chloro-2-methylpyridazin-3-one	IC50	1000.0 [1]
	3-[(1-Acetyl-5-methoxyindole-3-carbonyl)amino]-5-(furan-2-yl)benzoic acid	IC50	20000.0 [1]
	3-[(1-Acetyl-5-methoxyindole-3-carbonyl)amino]-4-fluoro-5-(1-methylpyrazol-4-yl)benzoic acid	IC50	20000.0 [1]
	CID 145948689	IC50	300.0 [1]
	3-[(1-Acetylindole-3-carbonyl)amino]-4-fluorobenzoic acid	IC50	20000.0 [1]
	3-[(1-Acetylindole-3-carbonyl)amino]benzoic acid	IC50	20000.0 [1]
	3-[(1-Acetylindole-3-carbonyl)amino]-5-(oxan-2-yloxymethyl)benzoic acid	IC50	20000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Histone acetyltransferase PCAF Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/histone-acetyltransferase-pcaf-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Histone acetyltransferase PCAF Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-acetyltransferase-pcaf-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan