Histone acetyltransferase GCN5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2R,3S)-4-Methylidene-5-oxo-2-propyloxolane-3-carboxylic acid	IC50	100000.0 [1]
	2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	8390.0 [1], 8400.0 [2]
	Butyrolactone 3	IC50	100000.0 [1]
	2-[(4-Chlorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	89900.0 [1], 89910.0 [2]
	4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic Acid	IC50	316.23 [1]
	2-(4-Methylpyrimidin-2-yl)-1,2-benzothiazol-3-one	IC50	19900.0 [1]
	3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide	IC50	20000.0 [1]
	2-(4-Pyrrolidin-1-ylsulfonylphenyl)-1,2-benzothiazol-3-one	IC50	6270.0 [1]
	2-(1,3-Thiazol-2-yl)-1,2-benzothiazol-3-one	IC50	7870.0 [1]
	Ethyl 4-(3-oxo-1,2-benzisothiazol-2(3H)-yl)benzoate	IC50	8530.0 [1]
	2-(1,3-Benzothiazol-2-yl)-1,2-benzothiazol-3-one	IC50	23300.0 [1]
	4,6-Dimethyl-2-(thiophene-2-carbonyl)-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	6130.0 [1]
	2-(4-Chlorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one	IC50	15470.0 [1]
	CID 118021718	IC50	80000.0 [1]
	4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one	Ki	1.4 [1]
	[(3,5-Dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate	IC50	33900.0 [1]
	Ethyl 2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetate	IC50	8370.0 [1]
	N-[3-(3-Methyl-4-Oxo-4,5,6,7-Tetrahydro-2h-Isoindol-1-Yl)-4-Phenoxyphenyl]methanesulfonamide	IC50	1000.0 [1]
	1-(3-Phenylazanyl-1,4,6,7-Tetrahydropyrazolo[4,3-C]pyridin-5-Yl)ethanone	IC50	20000.0 [1]
	PRMT5 Inhibitor C17	IC50	100000.0 [1]
	1-[3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20000.0 [1]
	1-[3-[2-Fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone	IC50	20000.0 [1]
	(2R,3R)-4-Methylidene-5-oxo-3-propyloxolane-2-carboxylic acid	IC50	100000.0 [1]
	5-Nitro-2-(4-phenoxyphenyl)isothiazolo[5,4-b]pyridin-3-one	IC50	2040.0 [1]
	2-(4-Butylphenyl)-5-phenylisothiazolo[5,4-b]pyridin-3(2H)-one	IC50	8650.0 [1]
	2-(3-Oxo-1,2-benzothiazol-2(3H)-yl)-N-(1,3-thiazol-2-yl)acetamide	IC50	21700.0 [1]
	1,2-Benzisothiazole-2(3H)-butanoic acid, 3-oxo-	IC50	66700.0 [1]
	2-[[4-(Trifluoromethyl)phenyl]methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	87360.0 [1]
	2-[(3,4-Dichlorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	IC50	23700.0 [1]
	3-[2-(2,4-Difluorophenoxy)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one	IC50	1000.0 [1]
	6-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid	IC50	47000.0 [1]
	6-[(5Z)-5-[1-[(4-Fluorophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid	IC50	209600.0 [1]
	2-(3-Oxo-1,2-benzothiazol-2(3H)-yl)-N-(pyridin-2-ylmethyl)acetamide	IC50	11200.0 [1]
	2-(4-Methyl-1,3-thiazol-2-yl)-1,2-benzothiazol-3-one	IC50	7110.0 [1]
	N-(2-Methoxyethyl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide	IC50	15500.0 [1]
	N-(2-Methylpropyl)-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)propanamide	IC50	34900.0 [1]
	N-(2-Methylpropyl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide	IC50	20800.0 [1]
	6-[(5Z)-5-[1-[(4-Methoxyphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid	IC50	54700.0 [1]
	6-[(5Z)-5-[1-[(4-Nitrophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid	IC50	69600.0 [1]
	8-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]octanoic acid	IC50	63500.0 [1]
	4-[[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]methyl]cyclohexane-1-carboxylic acid	IC50	46400.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 41 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Histone acetyltransferase GCN5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/histone-acetyltransferase-gcn5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Histone acetyltransferase GCN5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histone-acetyltransferase-gcn5-inhibitors-ic50-ki.
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