 | Thioperamide | IC50 | 16.0 [1], 120.0 [2], 517.5 [3] |
 | 1-[4-(3-Piperidinopropoxy)benzyl]piperidine | IC50 | 0.53 [1] |
 | (R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile | IC50 | 0.63 [1] |
 | Pitolisant | IC50 | 12.0 [1] |
| Pitolisant | Ki | 0.3 [1] |
 | Ciproxifan | Ki | 46.0 [1], 63.1 [2] |
 | Clobenpropit | IC50 | 1.0 [1] |
| Clobenpropit | Ki | 2.4 [1] |
 | (R)-alpha-Methylhistamine | IC50 | 2.3 [1] |
| (R)-alpha-Methylhistamine | Ki | 0.88 [1], 4.37 [2] |
 | Immepip | Ki | 0.48 [1] |
 | Histamine | Ki | 9.33 [1] |
 | 6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridinecarboxamide | IC50 | 0.55 [1] |
| 6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridinecarboxamide | Ki | 0.2 [1] |
 | 2-Methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one | IC50 | 1.7 [1] |
| 2-Methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one | Ki | 0.53 [1], 0.63 [2], 1.7 [3], 6.8 [4] |
 | 5-[(3-Cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyrazine-2-carboxamide | IC50 | 0.63 [1] |
| 5-[(3-Cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyrazine-2-carboxamide | Ki | 0.19 [1], 0.2 [2], 0.21 [3] |
 | Imetit | Ki | 0.57 [1], 0.7 [2], 1.58 [3] |
 | 4-(1H-Imidazol-5-yl)butan-1-amine | Ki | 3.98 [1], 4.07 [2], 4.3 [3] |
 | [4-[4-[3-[(2S,5S)-2,5-Dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone | Ki | 0.49 [1], 1.58 [2], 2.0 [3], 12.0 [4] |
 | Fluoxetine | Ki | 7300.0 [1] |
 | Conessine | Ki | 3.47 [1], 5.01 [2], 5.37 [3] |
 | 4-(3-(4-(Piperidinyl)but-1-ynyl)benzyl)morpholine | Ki | 0.8 [1], 1.0 [2], 1.18 [3], 1.3 [4] |
 | (2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-one | Ki | 758.58 [1], 760.0 [2], 794.33 [3] |
 | 1-(6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-YL)oxy)pyridin-3-YL)pyrrolidin-2-one | Ki | 0.1 [1], 0.12 [2], 0.2 [3], 10.0 [4] |
 | Immethridine | Ki | 0.77 [1], 0.79 [2], 0.85 [3] |
 | 2-[[(2R)-1-[4-[4-[3-(Azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one | Ki | 0.25 [1] |
 | 4-(4-((1-Isopropylpiperidin-4-yl)oxy)benzyl)morpholine | Ki | 2.1 [1], 2.14 [2] |
 | 2-(4-Piperidinopropoxyphenyl)-7-methylimidazo[1,2-a]pyridine | Ki | 2.0 [1] |
 | (R)-2-(2,7-Dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | Ki | 0.24 [1] |
 | (S)-1-(2-(Pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one | Ki | 4.7 [1], 5.0 [2], 6.7 [3], 7.0 [4] |
 | 2-Methyl-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one | Ki | 1.0 [1], 1.4 [2] |
 | 1-[[4-(3-Piperidin-1-ylpropoxy)phenyl]methyl]piperidin-4-ol | IC50 | 0.72 [1] |
| 1-[[4-(3-Piperidin-1-ylpropoxy)phenyl]methyl]piperidin-4-ol | Ki | 0.59 [1], 0.74 [2] |
 | Azelastine | Ki | 147.91 [1], 158.49 [2] |
 | Proxyfan | Ki | 2.51 [1], 2.7 [2], 12.59 [3] |
 | Iodoproxyfan | Ki | 0.63 [1], 41.0 [2] |
 | (5-Chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone | Ki | 3981.07 [1], 14053.0 [2], 20000.0 [3] |
 | Impentamine | Ki | 5.01 [1], 5.13 [2] |
 | Unii-5P909hkp24 | Ki | 93.0 [1], 93.33 [2], 100.0 [3] |
 | Methimepip | Ki | 1.0 [1] |
 | CID 11452311 | IC50 | 2.51 [1] |
| CID 11452311 | Ki | 0.13 [1], 0.32 [2] |
 | 4,4'-Bis(piperidinomethyl)-1,1'-biphenyl | Ki | 0.3 [1], 0.34 [2], 3.39 [3] |
 | 4-(3-Piperidin-1-ylpropoxy)benzonitrile | Ki | 11.0 [1], 25.0 [2], 25.12 [3] |
 | 2-(2-(4-Tert-Butylphenylthio)ethyl)-1H-imidazole | Ki | 0.17 [1], 0.43 [2] |
 | 4-[4-[3-[(2R)-2-Methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one | Ki | 2.8 [1], 3.0 [2], 15.0 [3] |
 | 4-[2-(1H-Imidazol-4-yl)ethyl]piperidine | Ki | 19.95 [1] |
 | [4-(3-Piperidin-1-yl-propoxy)-phenyl]-quinolin-4-yl-amine; Oxalic acid | Ki | 0.09 [1], 0.1 [2], 0.5 [3] |
 | 1-Cyano-3-[[(2R,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine | Ki | 1995.26 [1], 2187.76 [2], 2200.0 [3] |
 | 4-[3-(1h-Imidazol-4-yl)propyl]piperidine | Ki | 4.47 [1] |
 | 2-[1-(6-Ethoxypyridazin-3-yl)-5-methylpyrazol-4-yl]-6-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]quinoline | Ki | 0.19 [1], 0.2 [2] |
 | 3-Methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one | IC50 | 0.68 [1] |
| 3-Methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one | Ki | 0.22 [1], 4.2 [2] |
 | (R)-2-(5-Methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | Ki | 0.26 [1] |
 | (R)-2-(4-Methyl-2-(pyrrolidin-1-yl)pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | Ki | 0.29 [1], 0.3 [2] |
 | 2-Methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one | IC50 | 1.7 [1], 3.5 [2] |
| 2-Methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one | Ki | 1.09 [1] |
 | (R)-2-Methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1,8-naphthyridine | Ki | 0.3 [1], 0.34 [2] |
 | 1-[4-[4-[(Dimethylamino)methyl]phenyl]phenyl]-N,N-dimethylmethanamine | Ki | 1.32 [1], 1.86 [2] |
 | (R)-2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | Ki | 0.45 [1], 0.5 [2] |
 | 1-[2-[4-[4-(2-Piperidin-1-ylethyl)phenyl]phenyl]ethyl]piperidine | Ki | 1.18 [1], 1.2 [2] |
 | 4-[4-[4-(3-Piperidin-1-ylpropoxy)phenyl]cyclohexyl]morpholine | Ki | 0.41 [1], 0.67 [2] |
 | N,N-Dimethyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]cyclohexan-1-amine | Ki | 0.2 [1], 0.21 [2], 0.3 [3] |
 | 5-(3-Benzhydryloxypropyl)-1H-imidazole | Ki | 17.0 [1], 24.0 [2] |
 | N-Ethyl-4-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]phenyl]benzenesulfonamide | Ki | 1.0 [1], 4.57 [2], 8.0 [3] |
 | 4-[4-[2-[(2R)-2-Methylpyrrolidin-1-yl]ethyl]phenyl]-N-(oxan-4-yl)benzenesulfonamide | Ki | 1.0 [1], 1.58 [2], 7.0 [3] |
 | 4-[4-[4-[2-[(2R)-2-Methylpyrrolidin-1-yl]ethyl]phenyl]phenyl]sulfonylmorpholine | Ki | 1.0 [1], 1.58 [2], 3.0 [3] |
 | (2S,3S)-8-Methoxy-3-methyl-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-2,3-dihydro-1,4lambda6-benzoxathiine 4,4-dioxide | IC50 | 0.43 [1] |
| (2S,3S)-8-Methoxy-3-methyl-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-2,3-dihydro-1,4lambda6-benzoxathiine 4,4-dioxide | Ki | 0.4 [1], 1.0 [2] |
 | 1-[4-[4-(3-Piperidin-1-ylpropoxy)phenyl]cyclohexyl]piperidin-4-ol | Ki | 0.57 [1], 0.92 [2] |
 | 2-[4-[3-(Dibutylamino)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine | Ki | 4.0 [1], 2700.0 [2], 4000.0 [3] |
 | (4-Fluorophenyl)(2-(2-((2R)-2-methyl-1-pyrrolidinyl)ethyl)-1-benzofuran-5-yl)methanone | Ki | 0.27 [1], 1.9 [2] |
 | 2-[4-(3-Piperidin-1-yl-propoxy)-benzyl]-1,2,3,4-tetrahydro-isoquinoline | Ki | 1.7 [1], 2.95 [2] |
 | 2-(1-Cyclobutylpiperidin-4-yl)-6-(1-cyclobutylpiperidin-4-yl)oxy-3,4-dihydroisoquinolin-1-one | IC50 | 4.8 [1] |
| 2-(1-Cyclobutylpiperidin-4-yl)-6-(1-cyclobutylpiperidin-4-yl)oxy-3,4-dihydroisoquinolin-1-one | Ki | 0.03 [1], 0.8 [2] |
 | 4-(1-Propan-2-ylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide | IC50 | 323.8 [1] |
| 4-(1-Propan-2-ylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide | Ki | 0.9 [1], 5.7 [2] |
 | 4-(1-Cyclopentylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide | IC50 | 273.9 [1] |
| 4-(1-Cyclopentylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide | Ki | 1.0 [1], 8.6 [2] |
 | N-[1-(2-Methylpropyl)pyrrolidin-3-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide | IC50 | 458.7 [1] |
| N-[1-(2-Methylpropyl)pyrrolidin-3-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide | Ki | 1.0 [1], 1.2 [2] |
 | 6-(1-Propan-2-ylpiperidin-4-yl)oxy-2-(1-propan-2-ylpyrrolidin-3-yl)-3,4-dihydroisoquinolin-1-one | IC50 | 14.3 [1] |
| 6-(1-Propan-2-ylpiperidin-4-yl)oxy-2-(1-propan-2-ylpyrrolidin-3-yl)-3,4-dihydroisoquinolin-1-one | Ki | 0.1 [1], 2.1 [2] |
 | Clozapine | Ki | 631.0 [1], 1000.0 [2] |
 | (R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)-ethyl)benzofuran-5-yl)benzonitrile | Ki | 0.95 [1] |
 | 2-(Diaminomethylideneamino)ethylsulfanylmethanimidamide | Ki | 316.23 [1], 1000.0 [2] |
 | Cipralisant | Ki | 2.14 [1], 3.98 [2] |
 | N,N-Diallyl-5-methoxytryptamine | Ki | 1698.24 [1], 10000.0 [2] |
 | PF-03654746 | Ki | 1.7 [1], 2.29 [2] |
 | 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile | Ki | 2.75 [1], 4.0 [2] |
 | Aplysamine-1 | Ki | 30.0 [1] |
 | 5-[2-(5,5-Dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole | Ki | 2.14 [1], 2.15 [2] |
 | 3-(1H-Imidazol-5-yl)propyl carbamimidothioate | Ki | 2.51 [1], 3.16 [2] |
 | 1H-Imidazole-4-propanamine | Ki | 48.98 [1], 50.12 [2] |
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