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Histamine H2 receptor Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
CimetidineIC50140.0 [1], 270.0 [2], 781.0 [3], 1000.0 [4]
CimetidineKi70.0 [1], 170.0 [2], 490.0 [3], 5431.0 [4]
HistamineKi5000.0 [1], 50118.72 [2], 25118900000000.0 [3]
BurimamideKi3981.07 [1]
ImmepipKi1000.0 [1], 10000.0 [2]
2-(2-(4-Tert-Butylphenylthio)ethyl)-1H-imidazoleKi1000.0 [1]
3-Ethyl-1-[5-(1H-imidazol-4-yl)pentyl]thioureaKi10000.0 [1]
(8S)-N-[(3-Fluorophenyl)methyl]pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amineKi2148.0 [1]
(8S)-N-[2-(3-Fluorophenyl)ethyl]pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amineKi4423.0 [1]
(8S)-N-[2-(3-Fluorophenyl)ethyl]-N-methylpentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amineKi4450.0 [1]
5-[(3,4-Dimethoxyphenyl)methyl]-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-olKi3581.0 [1]
7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-AmineKi100.0 [1]
1-[(4-Chlorophenyl)methyl]-3-[5-(1H-imidazol-4-yl)pentyl]thioureaKi1584.89 [1]
1-{4-[3-((S)-3-Amino-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanoneKi31000.0 [1], 50000.0 [2]
VerapamilKi2547.0 [1]
ImatinibKi1930.0 [1]
TamoxifenKi9240.0 [1]
ChlorpromazineKi2582.0 [1]
HaloperidolKi1147.0 [1]
ClozapineKi3550.0 [1]
RisperidoneKi1458.0 [1]
AmiodaroneKi10379.0 [1]
AmitriptylineKi718.0 [1]
KetoconazoleKi21507.0 [1]
Medroxyprogesterone acetateKi27453.0 [1]
ImiquimodKi1481.0 [1]
ClomipramineKi2015.0 [1]
QuinacrineKi3476.0 [1]
PromethazineKi1146.0 [1]
MianserinKi992.0 [1]
MiconazoleKi6637.0 [1]
ClotrimazoleKi5079.0 [1]
ThioridazineKi934.0 [1]
FluphenazineKi1205.0 [1]
Gentian violetKi1136.0 [1]
NortriptylineKi2295.0 [1]
CyproheptadineKi195.0 [1]
LoperamideKi3030.0 [1]
PepcidKi41.0 [1]
KetotifenKi4060.0 [1]
PromazineKi2810.0 [1]
DoxepinKi1836.0 [1]
MaprotilineKi393.0 [1]
LisurideKi1022.0 [1]
DesloratadineKi1080.0 [1]
AstemizoleKi1654.0 [1]
EconazoleKi1565.0 [1]
BenztropineKi1185.0 [1]
ThioperamideKi10000.0 [1]
MetergolineKi959.0 [1]
OrphenadrineKi6845.0 [1]
DimapritKi25118.86 [1]
DicyclomineKi1598.0 [1]
ClemastineKi364.0 [1]
TirilazadKi13884.0 [1]
EbastineKi2867.1 [1]
DexchlorpheniramineKi8228.0 [1]
ImpromidineKi501.19 [1]
PenfluridolKi1000.0 [1]
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazineKi8511.38 [1]
CiproxifanKi10000.0 [1]
4-MethylhistamineKi7943.28 [1]
TiotidineIC5022.0 [1]
(1S,2R)-2-(Octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanolKi88.5 [1]
ConessineKi10000.0 [1]
alpha-MethyltryptamineKi10000.0 [1]
AmthamineKi6309.57 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC5010000.0 [1]
6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridinecarboxamideKi3162.28 [1]
CipargaminIC5010000.0 [1]
4-(4-Butylpiperidin-1-yl)-1-o-tolylbutan-1-oneKi1000.0 [1]
N-Desmethyl loperamideKi1.7 [1]
2-Methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-oneIC5010000.0 [1]
ImpentamineKi3981070000000.0 [1]
Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-Ki10000.0 [1]
N,N-Diallyl-5-methoxytryptamineKi4265.8 [1]
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-oneKi70794.58 [1]
4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrileKi10000.0 [1]
MethimepipKi10000.0 [1]
N4-(2,6-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamineKi1000.0 [1]
2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-Ki100000000.0 [1]
4-(1H-Imidazol-5-yl)butan-1-amineKi794328.23 [1]
Unii-N4Y2V13I7FKi2126.0 [1]
1-(6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-YL)oxy)pyridin-3-YL)pyrrolidin-2-oneKi3162.28 [1]
5-[(3-Cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyrazine-2-carboxamideKi3162.28 [1]
3-Amino-2-[4-(4-quinolin-2-ylpiperazin-1-yl)butyl]-5,6,7,8-tetrahydroquinazolin-4-oneIC501000.0 [1]
2-[[(2R)-1-[4-[4-[3-(Azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-oneIC5010000.0 [1]
ThalictruberineKi672.0 [1]
CID 11496610Ki850.0 [1]
2-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepineKi8709.64 [1]
(Z)-But-2-enedioic acid;9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaeneKi5.7 [1]
1-Cyano-2-[4-(1H-imidazol-5-yl)butyl]-3-(2-phenylsulfanylethyl)guanidineKi4073.8 [1]
(4S,5S)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5-methyl-2-oxo-1,3-oxazolidine-3-carboxamideKi1000.0 [1]
1H-Imidazole-4-propanamineKi1000000000000.0 [1]
(7As,11aS)-4-piperazin-1-yl-5,6,7a,8,9,10,11,11a-octahydro-[1]benzofuro[2,3-h]quinazolin-2-amineKi9120.11 [1]
1-[(1-Benzyl-1H-tetrazol-5-yl)-phenyl-methyl]-4-methyl-piperazineIC5020000.0 [1]
Ethyl 4-[3-(4-hexanoylphenoxy)propyl]piperazine-1-carboxylateKi12589.25 [1]
[4-[4-[3-[(2S,5S)-2,5-Dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanoneKi10000.0 [1]
N-[1-[3-(3-Oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamideKi1000.0 [1]
6-(1H-Imidazol-5-yl)hexan-1-amineKi5011870000000.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Histamine H2 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc.21 Dec2024https://www.aatbio.com/data-sets/histamine-h2-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 21). Quest Database™ Histamine H2 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/histamine-h2-receptor-inhibitors-ic50-ki.
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