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Hexokinase type IV Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC504.0 [1]
2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC506.0 [1]
1,1,1,3,3,3-Hexafluoro-2-{4-[4-(Thiophen-2-Ylsulfonyl)piperazin-1-Yl]phenyl}propan-2-OlIC501420.0 [1]
(2R)-2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC509.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50176.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-chloropyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50201.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-bromopyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50112.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-methoxypyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501110.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-cyclopropylpyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50601.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(2-cyclopropylethynyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5033.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(3-hydroxyprop-1-ynyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5014.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(3-methoxyprop-1-ynyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC505.0 [1]
4-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2-methylbut-3-yn-2-olIC5049.0 [1]
4-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]but-3-yn-1-olIC5017.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1H-pyrazol-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50201.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-methylpyrazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-ethylpyrazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC505.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-propan-2-ylpyrazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5023.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-tert-butylpyrazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5087.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,5-dimethylpyrazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5040.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5030000.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(furan-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5019.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(4-methylthiophen-2-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC505.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-phenylpyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC507.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(2-fluorophenyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC507.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(3-fluorophenyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC508.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(4-fluorophenyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5011.0 [1]
2-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]phenolIC506.0 [1]
N-[3-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]phenyl]methanesulfonamideIC50309.0 [1]
3-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]benzamideIC5050.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(4-methylsulfonylphenyl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5042.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-pyridin-4-ylpyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5021.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(4-fluoropyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5024.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(5-fluoropyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5011.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(5-methylpyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5029.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(6-methylpyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5040.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(6-methoxypyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5016.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(5-methoxypyridin-3-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5017.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-benzothiophen-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5047.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,3-benzothiazol-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5035.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,3-benzoxazol-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5020.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(2-methyl-1,3-benzoxazol-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5015.0 [1]
5-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1-methyl-3H-indol-2-oneIC5020.0 [1]
5-[2-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1,3-dihydroindol-2-oneIC5033.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1H-indazol-5-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5060.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1H-indazol-4-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501950.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1H-indol-2-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5027.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-(1-benzothiophen-2-yl)pyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5048.0 [1]
N-[(3R,4R,5S,6R)-6-[[(2,3-Dichlorophenyl)sulfonylamino]methyl]-2,4,5-trihydroxyoxan-3-yl]-3-phenylbenzamideIC503500.0 [1]
1,1,1-Trifluoro-2-[4-[(2S)-2-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC50524.0 [1]
2-[4-[(2S)-2-[(1,1-Dioxo-1,4-thiazinan-4-yl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC50343.0 [1]
(2S)-2-[4-[(2S)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC506.0 [1]
1,1,1-Trifluoro-2-[4-[(2S)-2-[(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC5090.0 [1]
1,1,1-Trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC507.0 [1]
(1R,5R,6R)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5016.0 [1]
(1S,5S,6S)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5025.0 [1]
(1S,5S,6S)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5056.0 [1]
(1R,5R,6R)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5014.0 [1]
2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-2-but-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC5056.0 [1]
2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-2-(3,3-dimethylbut-1-ynyl)piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501430.0 [1]
2-[6-[4-(6-Aminopyridin-3-yl)sulfonylpiperazin-1-yl]-5-pyridin-3-ylpyridin-3-yl]-1,1,1,3,3,3-hexafluoropropan-2-olIC505.0 [1]
2-(4-{4-[(6-Aminopyridin-3-Yl)sulfonyl]piperazin-1-Yl}phenyl)-1,1,1,3,3,3-Hexafluoropropan-2-OlIC5087.0 [1]
2-[4-[(2S)-2-[(4,4-Difluoropiperidin-1-yl)methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]-1,1,1-trifluoropropan-2-olIC50439.0 [1]
(1R,5S,6S)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5026.0 [1]
2-[4-[4-(Benzenesulfonyl)piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC501010.0 [1]
(1R,5S,6R)-8-[[(2S)-4-Thiophen-2-ylsulfonyl-1-[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]piperazin-2-yl]methyl]-3-oxa-8-azabicyclo[3.2.1]octan-6-olIC5044.0 [1]
2-(4-(4-((4-Amino-2-thiophenyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanolIC50324.0 [1]
1,1,1-Trifluoro-2-[4-[(2S)-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-ylmethyl)-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-olIC502.0 [1]
2-[4-[4-(5-Aminothiophen-2-yl)sulfonylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50252.0 [1]
2-[4-[4-(3-Aminophenyl)sulfonylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50645.0 [1]
2-[4-[(2R)-4-(6-Aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50484.0 [1]
2-(4-(4-(2-Aminophenylsulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanolIC50445.0 [1]
2-(4-(4-((2-Amino-5-pyrimidinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanolIC50316.0 [1]
2-[4-[4-(6-Aminopyridin-3-yl)sulfonyl-2-(2-cyclopropylethynyl)piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC50779.0 [1]
2-[4-[4-(2-Aminopyridin-4-yl)sulfonylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-olIC508630.0 [1]
2-[4-[4-(4-Aminophenylsulfonyl)piperazino]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanolIC50484.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Hexokinase type IV Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/hexokinase-type-iv-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Hexokinase type IV Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hexokinase-type-iv-inhibitors-ic50-ki.
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