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HERG Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TerfenadineIC50128.82 [1]
TerfenadineKi56.0 [1], 320.0 [2]
CisaprideIC5039.81 [1]
CisaprideKi139.4 [1]
AstemizoleIC508.0 [1]
AstemizoleKi2.9 [1], 12.8 [2], 20.0 [3]
DofetilideIC5010.0 [1]
DofetilideKi6.4 [1], 7.7 [2]
MibefradilIC501400.0 [1]
MibefradilKi190.0 [1], 353.0 [2]
RisperidoneIC50162.18 [1]
RisperidoneKi920.0 [1], 3432.8 [2]
HaloperidolIC5030.2 [1]
HaloperidolKi120.0 [1], 512.0 [2]
ClozapineIC50323.59 [1]
ClozapineKi3080.0 [1], 4060.0 [2], 8660.6 [3], 17000.0 [4]
PimozideIC5020.0 [1]
PimozideKi42.0 [1]
SparfloxacinIC5026302.68 [1]
SparfloxacinKi38619.4 [1]
SertindoleIC5010.0 [1]
ThioridazineIC5095.5 [1]
ThioridazineKi869.0 [1], 1301.0 [2]
BepridilIC50549.54 [1]
BepridilKi184.0 [1], 291.0 [2], 444.0 [3]
VerapamilIC50141.25 [1]
LevofloxacinIC501100000.0 [1]
LevofloxacinKi150000.0 [1]
MoxifloxacinIC50128824.96 [1]
FexofenadineIC5023000.0 [1]
FexofenadineKi23000.0 [1]
HalofantrineIC50199.53 [1]
HalofantrineKi7500.0 [1]
N-(4-((1-(2-(6-Methyl-2-pyridinyl)ethyl)-4-piperidinyl)carbonyl)phenyl)methanesulfonamideIC5019.95 [1]
1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidine dihydrochlorideIC5089.0 [1]
1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidine dihydrochlorideKi18.7 [1], 19.4 [2]
SildenafilIC503311.31 [1]
AmitriptylineIC5010000.0 [1]
AmitriptylineKi14410.6 [1]
GrepafloxacinIC5050118.72 [1]
ChlorpromazineIC501479.11 [1]
ChlorpromazineKi4774.3 [1]
DroperidolIC5032.36 [1]
DroperidolKi759.6 [1]
MizolastineIC50436.52 [1]
MizolastineKi7258.0 [1]
N-[4-[2-(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamideIC50630.96 [1], 676.08 [2], 1995.26 [3]
N-[4-[2-(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamideKi630.96 [1]
OlanzapineIC50181.97 [1]
OlanzapineKi36000.0 [1]
ImipramineIC503388.44 [1]
ZiprasidoneIC50125.89 [1]
GatifloxacinIC50128824.96 [1]
CiprofloxacinIC50954992.59 [1]
CiprofloxacinKi100000.0 [1]
FluoxetineIC5010.0 [1], 457.09 [2], 1513.56 [3]
FluoxetineKi10066.0 [1]
DiltiazemIC5017378.01 [1]
DesipramineIC501380.38 [1]
DesipramineKi22816.6 [1]
AripiprazoleIC50630.96 [1], 1000.0 [2], 3860.0 [3]
AripiprazoleKi598.0 [1], 1020.0 [2]
LoratadineIC50169.82 [1], 173.78 [2]
LoratadineKi32022.8 [1]
AzimilideIC50562.34 [1]
CID 56927659IC501700.0 [1], 1740.0 [2], 3400.0 [3]
CID 56927659Ki1701.0 [1]
CocaineIC505754.4 [1], 7244.36 [2]
NifedipineIC5050118.72 [1]
ChloroquineIC502500.0 [1], 2511.89 [2]
ChloroquineKi3162.28 [1], 7500.0 [2]
CitalopramIC5010.0 [1], 3981.07 [2]
CitalopramKi13661.8 [1]
QuinidineIC50323.59 [1]
DiphenhydramineIC502570.4 [1], 5200.0 [2], 26915.35 [3]
DiphenhydramineKi26101.3 [1]
CarvedilolIC50350.0 [1], 10471.29 [2], 12589.25 [3]
CarvedilolKi3374.9 [1]
DomperidoneIC5057.54 [1], 162.18 [2]
CetirizineIC5030199.52 [1]
PerhexilineIC507762.47 [1]
DolasetronIC506025.6 [1], 12022.64 [2]
TecastemizoleIC5027.54 [1], 28.18 [2]
6-[[[1-[(1S)-2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC5018000.0 [1]
NicotineIC50244299.74 [1], 245470.89 [2]
AmiodaroneIC5030.0 [1], 1000.0 [2], 10000.0 [3]
Bupivacaine hydrochlorideIC5022000.0 [1], 32000.0 [2], 95000.0 [3], 265000.0 [4], 866000.0 [5]
ClarithromycinIC5033113.11 [1], 46000.0 [2], 58884.37 [3]
OfloxacinIC501412537.54 [1], 1420000.0 [2]
KetoconazoleIC501900.0 [1], 1905.46 [2]
SunitinibIC50251.19 [1], 500.0 [2], 7943.28 [3], 10000.0 [4]
OndansetronIC50400.0 [1], 812.83 [2]
NitrendipineIC5010000.0 [1]
ChlorpheniramineIC501100.0 [1], 20892.96 [2]
DisopyramideIC5012000.0 [1], 91201.08 [2]
GranisetronIC503715.35 [1], 3730.0 [2], 3801.89 [3]
PaliperidoneIC501000.0 [1], 1258.93 [2], 1288.25 [3], 1300.0 [4]
Levobupivacaine hydrochlorideIC5013000.0 [1], 83000.0 [2], 278000.0 [3], 1013000.0 [4]
AlosetronIC502300.0 [1], 3200.0 [2], 3235.94 [3]
IbutilideIC5010.0 [1], 15.14 [2], 20.0 [3]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ HERG Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 30 Mar. 2025, https://www.aatbio.com/data-sets/herg-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, March 30). Quest Database™ HERG Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/herg-inhibitors-ic50-ki.
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