Hepatocyte nuclear factor 4-alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[(3-Ethoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl]benzoic acid	Ki	110.0 [1]
	4-(3,5,5,8,8-Pentamethyl-4-nitro-6,7-dihydronaphthalene-2-carbonyl)benzoic acid	Ki	165.0 [1]
	4-(1-Hydroxy-3,5,5,8,8-pentamethyl-6,7-dihydronaphthalene-2-carbonyl)benzoic acid	Ki	710.0 [1]
	4-[5,5,8,8-Tetramethyl-3-(2,2,2-trifluoroethoxy)-6,7-dihydronaphthalene-2-carbonyl]benzoic acid	Ki	96.0 [1]
	4-[(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-[[4-(trifluoromethylsulfanyl)phenyl]methoxy]methyl]benzoic acid	Ki	1193.0 [1]
	4-[[3,5,5,8,8-Pentamethyl-4-[(4-methylphenyl)sulfonylamino]-6,7-dihydronaphthalen-2-yl]methyl]benzoic acid	Ki	5206.0 [1]
	4-[(E)-N-(2,5-Dimethylanilino)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Ki	1010.0 [1]
	4-[(E)-C-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-N-hexoxycarbonimidoyl]benzoic acid	Ki	322.0 [1]
	4-[(E)-C-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-N-(3-methylbutoxy)carbonimidoyl]benzoic acid	Ki	244.0 [1]
	4-[(E)-N-[(2,3-Difluorophenyl)methoxy]-C-(3-ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Ki	966.0 [1]
	4-(7-Ethoxy-4,4-dimethyl-2,3-dihydrochromene-6-carbonyl)benzoic acid	Ki	721.0 [1]
	4-(4,4,7-Trimethyl-8-nitro-2,3-dihydrochromene-6-carbonyl)benzoic acid	Ki	2205.0 [1]
	4-[(Z)-N-Anilino-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Ki	514.0 [1]
	4-[(E)-N-(2,5-Difluoroanilino)-C-(3-ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Ki	215.0 [1]
	4-[3-(2,2-Difluoroethoxy)-5,5,8,8-tetramethyl-4-nitro-6,7-dihydronaphthalene-2-carbonyl]benzoic acid	Ki	163.0 [1]
	Methyl 4-[(4aS,5S,10bS)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl]benzoate	Ki	234.0 [1]
	2-[4-[(4As,5S,10bS)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl]phenyl]acetic acid	Ki	219.0 [1]
	4-[(4As,5S,10bS)-8,9-dimethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl]benzoic acid	Ki	135.0 [1]
	4-[(13S,17S)-16-Oxa-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8-pentaen-12-yl]benzoic acid	Ki	1075.0 [1]
	4-[(2S,7S)-3-Oxa-9-azatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaen-8-yl]benzoic acid	Ki	2170.0 [1]
	4-(7-Methoxy-1,4,4,8-tetramethyl-2,3-dihydroquinoline-6-carbonyl)benzoic acid	Ki	4600.0 [1]
	2-[4-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)phenyl]-2-oxoacetic acid	Ki	364.0 [1]
	4-[[(3-Fluorophenyl)methylamino]-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]benzoic acid	Ki	1398.0 [1]
	4-[Butoxy-(3-ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)methyl]benzoic acid	Ki	339.0 [1]
	4-[(2-Fluorophenyl)methoxy-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]benzoic acid	Ki	580.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 25 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hepatocyte nuclear factor 4-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/hepatocyte-nuclear-factor-4-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 19). Quest Database™ Hepatocyte nuclear factor 4-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hepatocyte-nuclear-factor-4-alpha-inhibitors-ic50-ki.
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