Hepatocyte growth factor receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Foretinib	IC50	1.48 [1]
	Crizotinib	IC50	2.93 [1]
	Crizotinib	Ki	2.0 [1], 4.0 [2]
	Cabozantinib	IC50	3.2 [1]
	MK-2461	IC50	2.0 [1]
	N-[4-[2-(Cyclopropanecarbonylamino)imidazo[1,2-a]pyridin-6-yl]oxy-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-3H-pyridin-1-ium-3-carboxamide;hydrochloride	IC50	1.8 [1]
	Staurosporine	IC50	130.0 [1]
	MGCD-265 analog	IC50	37.0 [1]
	MK-8033	IC50	1.2 [1]
	Amg-458	IC50	60.0 [1], 60.1 [2]
	Amg-458	Ki	1.2 [1]
	3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea	IC50	80.0 [1]
	3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea	Ki	1.0 [1], 4.0 [2]
	Bms-777607	IC50	3.9 [1]
	2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol	IC50	4.0 [1], 4.8 [2], 50.12 [3]
	2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol	Ki	5.0 [1], 3900.0 [2], 9400.0 [3]
	N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide	IC50	23.0 [1]
	Met Kinase Inhibitor	IC50	20.0 [1]
	7-Methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline	IC50	9.0 [1]
	N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide	IC50	500.0 [1]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	1.0 [1]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	1.0 [1]
	Pha-665752	IC50	9.0 [1]
	Jnj-38877605	IC50	0.95 [1], 1.0 [2], 4.0 [3], 5.5 [4], 9.5 [5]
	Pyrimidone, 22	IC50	8.9 [1], 10.0 [2], 17.0 [3]
	Pyrimidone, 22	Ki	8.9 [1]
	7-Methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine	IC50	3.0 [1], 5.0 [2], 6.0 [3]
	7-Methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine	Ki	3.2 [1]
	Exelixis	IC50	21.0 [1]
	7-Methoxy-4-[[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]quinoline	IC50	4.0 [1]
	6-[[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]methyl]quinoline	IC50	1.0 [1], 5.0 [2], 6.0 [3]
	6-[[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]methyl]quinoline	Ki	6.0 [1]
	N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide	IC50	30.0 [1], 53.0 [2], 80.0 [3], 90.0 [4]
	N-(4-(6,7-Dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide	Ki	1.7 [1]
	Sunitinib	IC50	2000.0 [1], 5000.0 [2], 10000.0 [3], 20000.0 [4]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	2.7 [1], 50.0 [2], 50.5 [3]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	2.7 [1]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-3-methyl-5-oxo-1-phenyl-2-propylpyrazole-4-carboxamide	IC50	1.0 [1], 48.8 [2], 49.0 [3]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-3-methyl-5-oxo-1-phenyl-2-propylpyrazole-4-carboxamide	Ki	1.0 [1]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	1.0 [1], 37.0 [2], 37.1 [3]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	1.0 [1], 1.1 [2]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-5-methyl-1-(2-methylpropyl)-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	8.0 [1], 204.0 [2], 205.0 [3]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-5-methyl-1-(2-methylpropyl)-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	7.9 [1], 8.0 [2]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	1.0 [1], 23.9 [2], 24.0 [3]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	1.0 [1]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2S)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	1.1 [1], 23.0 [2]
	N-[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-[(2S)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide	Ki	1.1 [1], 1.2 [2]
	N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide	IC50	27.0 [1], 50.0 [2], 80.0 [3], 240.0 [4]
	14-(Dimethylsulfamoylamino)-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene	IC50	4.0 [1], 80.0 [2], 2300.0 [3]
	4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-phenylbutanamide	IC50	120.0 [1], 600.0 [2], 2000.0 [3]
	6-[6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl]-quinoline	IC50	44.0 [1], 69.0 [2], 210.0 [3]
	6-[6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl]-quinoline	Ki	9.1 [1], 74.0 [2]
	4-[6-Amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide	IC50	26.0 [1], 42.0 [2], 72.0 [3], 110.0 [4], 600.0 [5]
	Ceritinib	IC50	1000.0 [1], 1339.0 [2], 3170.0 [3]
	Sgx-523	IC50	3.1 [1], 4.0 [2], 10.0 [3]
	Tepotinib	IC50	1.0 [1], 3.0 [2], 12.0 [3], 100.0 [4]
	2-Anilino-5-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-methylpyrimidin-4-one	IC50	63.0 [1], 204.0 [2]
	2-Anilino-5-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-methylpyrimidin-4-one	Ki	14.0 [1], 63.0 [2]
	4-[[6-(3,4-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]-7-methoxyquinoline	IC50	9.0 [1], 26.0 [2]
	4-[[6-(3,5-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]-7-methoxyquinoline	IC50	7.0 [1], 14.0 [2]
	4-((6-Phenyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)phenol	IC50	2100.0 [1]
	4-((6-Phenyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)phenol	Ki	1231.2 [1]
	N'-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-N-phenylpropanediamide	IC50	28.0 [1], 30.0 [2], 310.0 [3]
	N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-N'-methyl-N'-phenylpropanediamide	IC50	40.0 [1], 43.0 [2], 160.0 [3]
	CID 50942314	IC50	10.0 [1], 44.0 [2]
	5-[8-Fluoro-3-[(1S)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-3-methyl-1,2-oxazole	IC50	1.0 [1], 5.0 [2]
	4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline	IC50	7.0 [1], 20.0 [2]
	4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline	Ki	7.0 [1]
	4-[6-(1-Piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]sulfonyl-2,1,3-benzoxadiazole	IC50	9.0 [1], 130.0 [2], 200.0 [3]
	3-[(1S)-1-[3-(2-Methoxyethoxy)quinolin-6-yl]ethyl]-5-(3-methyl-1,2-thiazol-5-yl)triazolo[4,5-c]pyridin-4-one	IC50	0.6 [1], 1.0 [2], 2.0 [3]
	1-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-ol	IC50	15.0 [1], 35.0 [2], 2810.0 [3], 3600.0 [4]
	1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-amine	IC50	16.0 [1], 1300.0 [2], 2200.0 [3]
	Tert-butyl 4-[4-[1-(2,1,3-benzoxadiazol-4-ylmethyl)pyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate	IC50	33.0 [1], 3080.0 [2], 3280.0 [3]
	1-[4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]ethanone	IC50	12.0 [1], 370.0 [2], 500.0 [3]
	4-[6-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]pyrrolo[3,2-b]pyridin-1-yl]sulfonyl-2,1,3-benzoxadiazole	IC50	15.0 [1], 820.0 [2], 1310.0 [3]
	[4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]-pyridin-3-ylmethanone	IC50	11.0 [1], 430.0 [2], 480.0 [3]
	6-Chloro-5-[6-(1-piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]sulfonylimidazo[2,1-b][1,3]thiazole	IC50	9.0 [1], 90.0 [2], 110.0 [3]
	Tert-butyl 4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]piperazine-1-carboxylate	IC50	15.0 [1], 27.0 [2], 110.0 [3], 1946.0 [4]
	4-[[6-(1-Piperidin-4-ylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1-yl]methyl]-2,1,3-benzoxadiazole	IC50	19.0 [1], 1800.0 [2], 1880.0 [3]
	1-[4-[1-(2,1,3-Benzoxadiazol-4-ylsulfonyl)pyrrolo[3,2-b]pyridin-6-yl]piperazin-1-yl]-2-(methylamino)ethanone	IC50	14.0 [1], 570.0 [2]
	1-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-amine	IC50	10.0 [1], 490.0 [2], 580.0 [3]
	Tert-butyl 4-[4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate	IC50	19.0 [1], 27.0 [2], 147.0 [3], 450.0 [4]
	2-[[5-Chloro-2-[(2-oxo-1,3,4,5-tetrahydro-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamide	IC50	30.0 [1], 99.0 [2]
	2-[[5-Chloro-2-[(5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamide	IC50	10.0 [1], 54.0 [2]
	3-(Quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-amine	IC50	34.0 [1]
	3-(Quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-amine	Ki	15.0 [1]
	N-(2-Oxo-5-phenyl-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl)methanesulfonamide	IC50	31.0 [1], 220.0 [2], 2500.0 [3]
	4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-(4-fluorophenyl)butanamide	IC50	90.0 [1], 370.0 [2], 400.0 [3]
	4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-(2-methoxyphenyl)butanamide	IC50	840.0 [1], 1800.0 [2], 2000.0 [3], 10000.0 [4]
	4,4,4-Trifluoro-N-(4-fluorophenyl)-3-[4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]butanamide	IC50	180.0 [1], 880.0 [2], 2000.0 [3]
	Golvatinib	IC50	14.0 [1], 20.0 [2]
	CID 21081761	IC50	1.8 [1]
	N'-[3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)oxyphenyl]-N-(4-fluorophenyl)propanediamide	IC50	780.0 [1]
	2-(4-Fluorophenyl)-N-[[3-fluoro-4-[(3-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]carbamoyl]acetamide	IC50	2.0 [1]
	1-(4-(2-(Thiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea	IC50	28.0 [1], 65.0 [2]
	N-[[3-Fluoro-4-[2-(1-methylimidazol-2-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-phenylacetamide	IC50	2.0 [1], 51.0 [2]
	N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide	IC50	25.0 [1], 40.0 [2]
	N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(2-fluorophenyl)-2-oxoimidazolidine-1-carboxamide	IC50	21.0 [1], 100.0 [2]
	N-[4-[2-(1-Ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(2-methoxyphenyl)-2-oxoimidazolidine-1-carboxamide	IC50	26.0 [1], 60.0 [2]
	N-[4-[2-[1-[2-(Dimethylamino)ethyl]imidazol-4-yl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide	IC50	34.0 [1], 60.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Hepatocyte growth factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/hepatocyte-growth-factor-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Hepatocyte growth factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hepatocyte-growth-factor-receptor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan