Hepatocyte growth factor activator Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nafamostat	IC50	150.0 [1]
	Nafamostat	Ki	25.0 [1]
	Leupeptin	Ki	188.0 [1]
	Camostat	IC50	32000.0 [1]
	4-Nitrophenyl 4-guanidinobenzoate	IC50	820.0 [1]
	4'-Carbomethoxyphenyl 4-guanidinobenzoate	IC50	1100.0 [1]
	3-[(2S)-3-Oxo-3-[4-(piperidine-4-carbonyl)piperazin-1-yl]-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide	Ki	5500.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	Ki	53.0 [1]
	3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine	Ki	54600.0 [1]
	3-[(2S)-2-(Naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]benzenecarboximidamide	Ki	18200.0 [1]
	4-[4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]piperazine-1-carbonyl]piperidine-1-carboximidamide	Ki	17000.0 [1]
	(2R)-2-(4-Carbamimidoylanilino)-2-(7-ethyl-3-methyl-1-benzofuran-5-yl)-N-(1-methylimidazol-4-yl)sulfonylacetamide	Ki	590.0 [1]
	2-(4-Carbamimidoylanilino)-2-(7-ethyl-3-methyl-1-benzofuran-5-yl)-N-(1-methylimidazol-4-yl)sulfonylacetamide	Ki	7100.0 [1]
	N-[1-[(1-Benzylpiperidin-4-yl)methyl]-3-(3-carbamimidoylphenyl)-2-oxo-1,3-diazinan-5-yl]-2-phenylacetamide	Ki	380.0 [1]
	3-[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	9800.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-(methoxymethyl)-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	160.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-(hydroxymethyl)-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	230.0 [1]
	N-[[1-[(1-Benzylpiperidin-4-yl)methyl]-3-(3-carbamimidoylphenyl)-2-oxo-1,3-diazinan-5-yl]methyl]benzamide	Ki	1100.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-hydroxy-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	880.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-methoxy-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	2490.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-(methanesulfonamido)-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	350.0 [1]
	3-[5-(Benzenesulfonamido)-3-[(1-benzylpiperidin-4-yl)methyl]-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	520.0 [1]
	N-[[1-[(1-Benzylpiperidin-4-yl)methyl]-3-(3-carbamimidoylphenyl)-2-oxo-1,3-diazinan-5-yl]methyl]-2-phenylacetamide	Ki	1080.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-(benzylsulfonylamino)-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	440.0 [1]
	(2S)-2-Acetamido-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide	Ki	96.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	Ki	65.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide	Ki	58.0 [1]
	(2S)-2-Acetamido-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]hexanamide	Ki	80.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	Ki	60.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	Ki	182.0 [1]
	(2S)-2-Acetamido-6-amino-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]hexanamide	Ki	12.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-methylpentanamide	Ki	21.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-6-amino-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide	Ki	81.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-methylpentanamide	Ki	332.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-6-amino-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide	Ki	56.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-6-amino-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]hexanamide	Ki	57.0 [1]
	(2S)-2-Acetamido-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]butanediamide	Ki	79.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-methylpentanamide	Ki	24.0 [1]
	(2S)-2-[[(2S,3R)-2-Acetamido-3-hydroxybutanoyl]amino]-6-amino-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide	Ki	103.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-methylpentanamide	Ki	63.0 [1]
	(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-6-amino-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide	Ki	17.0 [1]
	4-[(2S)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N-hexylpiperazine-1-carboxamide	Ki	50000.0 [1]
	3-[(2S)-3-[4-(1-Benzothiophene-3-carbonyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide	Ki	50000.0 [1]
	Benzyl N-[(3R)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperidin-3-yl]carbamate	Ki	50000.0 [1]
	Benzyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperazine-1-carboxylate	Ki	50000.0 [1]
	3-[(2S)-3-Oxo-3-(4-phenylpiperazin-1-yl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide	Ki	22200.0 [1]
	Methyl 6-[4-(diaminomethylideneamino)benzoyl]oxynaphthalene-2-carboxylate	IC50	600.0 [1]
	Methyl 6-[[4-(diaminomethylideneamino)phenyl]sulfonylamino]naphthalene-2-carboxylate	IC50	50000.0 [1]
	3-[(2S)-2-(Naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzenecarboximidamide	Ki	10100.0 [1]
	N-Benzyl-4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperazine-1-carboxamide	Ki	14000.0 [1]
	Benzyl N-[(3S)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperidin-3-yl]carbamate	Ki	50000.0 [1]
	N-[(4-Bromophenyl)methyl]-4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperazine-1-carboxamide	Ki	16200.0 [1]
	3-[(2S)-2-[(4-Methylphenyl)sulfonylamino]-3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzenecarboximidamide	Ki	20000.0 [1]
	4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]-N-(2-phenylethyl)piperazine-1-carboxamide	Ki	50000.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-2-oxo-5-phenylmethoxy-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	1920.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-2-oxo-5-(phenylmethoxymethyl)-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	430.0 [1]
	4-[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	46500.0 [1]
	3-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide	Ki	100000.0 [1]
	4-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide	Ki	39600.0 [1]
	3-[3-[2-(1-Benzylpiperidin-4-yl)ethyl]-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	1110.0 [1]
	(4-Carbamoylphenyl) 4-(diaminomethylideneamino)benzoate	IC50	6800.0 [1]
	N-[4-(Diaminomethylideneamino)phenyl]benzamide	IC50	50000.0 [1]
	2-[4-[(4-Methylphenyl)sulfonylamino]phenyl]guanidine	IC50	50000.0 [1]
	(3-Nitrophenyl) 4-(diaminomethylideneamino)benzoate	IC50	3000.0 [1]
	(2-Chloro-4-nitrophenyl) 4-(diaminomethylideneamino)benzoate	IC50	300.0 [1]
	4-(Diaminomethylideneamino)-N-phenylbenzamide	IC50	50000.0 [1]
	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Ki	480.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 67 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Hepatocyte growth factor activator Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/hepatocyte-growth-factor-activator-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Hepatocyte growth factor activator Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/hepatocyte-growth-factor-activator-inhibitors-ic50-ki.
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